{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:55Z","timestamp":1790517415435,"version":"4.1.0"},"reference-count":48,"publisher":"The Society for Free Radical Research Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2017]]},"DOI":"10.3164\/jcbn.17-41","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T22:16:01Z","timestamp":1503008161000},"page":"140-145","source":"Crossref","is-referenced-by-count":26,"title":["Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography"],"prefix":"10.3164","volume":"61","author":[{"given":"Satomi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kodaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sakasegawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Agawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaya","family":"Gudis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akamizu","sequence":"additional","affiliation":[{"name":"The First Department of Medicine, Wakayama Medical Unversity"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Nippon Medical School Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466\u20131479.","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346\u20131352.","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Lunding JA, Tefera S, Gilja OH, et al. Rapid initial gastric emptying and hypersensitivity to gastric filling in functional dyspepsia; effects of duodenal lipids. Scand J Gastroenterol 2006; 41: 1028\u20131036.","DOI":"10.1080\/00365520600590513"},{"key":"4","unstructured":"4 Holtmann G, Goebell H, Talley J. Impaired small intestinal peristaltic refluxes and sensory thresholds are independent functional distarbances in patients with chronic unexplained dyspepsia. Am J Gastroenterol 1996; 91: 485\u2013491."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Takahashi Y, Amano Y, Yuki T, et al. Influence of acid suppressants on gastric emptying: cross-over analysis in healthy volunteers. J Gastroenterol Hepatol 2006; 21: 1664\u20131668.","DOI":"10.1111\/j.1440-1746.2006.04270.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Shimpuku M, Futagami S, Kawagoe T, et al. G-protein \u03b23 submit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. Neurogastroenterol Motil 2011; 23: 1073\u20131080.","DOI":"10.1111\/j.1365-2982.2011.01781.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Shindo T, Futagami S, Hiratsuka T, et al. Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease. Digestion 2009; 79: 65\u201372.","DOI":"10.1159\/000205740"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003; 98: 783\u2013788.","DOI":"10.1111\/j.1572-0241.2003.07389.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 1036\u20131042.","DOI":"10.1053\/gast.1996.v110.pm8612991"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Tominaga K, Fujikawa Y, Tsumoto C, et al. Disorders of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia. J Clin Biochem Nutr 2016; 58: 161\u2013165.","DOI":"10.3164\/jcbn.15-140"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Wang WH, Huang JQ, Zheng GF, et al. Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials. Clin Gastroenterol Hepatol 2007; 5: 178\u2013185.","DOI":"10.1016\/j.cgh.2006.09.012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Talley NJ, Meineche-Schmidt V, Par\u00e9 P, et al. Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther 1998; 12: 1055\u20131065.","DOI":"10.1046\/j.1365-2036.1998.00410.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Peura DA, Kovacs TO, Metz DC, Siepman N, Pilmer BL, Talley NJ. Lansoprazole in the treatment of functional dyspepsia: two double-blind, randomized, placebo-controlled trials. Am J Med 2004; 116: 740\u2013748.","DOI":"10.1016\/j.amjmed.2004.01.008"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Kamiya T, Shikano M, Kubota E, et al. A multicenter randomized trial comparing rabeprazole and itopride in patients with functional dyspepsia in Japan: the NAGOYA study. J Clin Biochem Nutr 2017; 60: 130\u2013135.","DOI":"10.3164\/jcbn.16-106"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Wong WM, Wong BC, Hung WK, et al. Double blind, randomised, placebo controlled study of four weeks of lansoprazole for the treatment of functional dyspepsia in Chinese patients. Gut 2002; 51: 502\u2013506.","DOI":"10.1136\/gut.51.4.502"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Ashizawa N, Hashimoto T, Miyake T, Shizuku T, Imaoka T, Kinoshita Y. Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? J Gastroenterol Heaptol 2006; 21: 767\u2013771.","DOI":"10.1111\/j.1440-1746.2005.04041.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Sahai AV, Mishra G, Penman ID, et al. EUS to detect evidence of pancreatic disease in patients with persistent or nonspecific dyspepsia. Gastrointest Endosc 2000; 52: 153\u2013159.","DOI":"10.1067\/mge.2000.107910"},{"key":"18","unstructured":"18 Andersen BN, Scheel J, Rune SJ, Worning H. Exocrine pancreatic function in patients with dyspepsia. Heaptogastroenterology 1982; 29: 35\u201337."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Smith RC, Talley NJ, Dent OF, Jones M, Waller SL. Exocrine pancreatic function and chronic unexplained dyspepsia: a case-control study. Int J Pancreatol 1991; 8: 253\u2013262.","DOI":"10.1007\/BF02924544"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 DeWitt J, McGreevy K, LeBlanc J, McHenry L, Cummings O, Sherman S. EUS-guided Trucut biopsy of suspected nonfocal chronic pancreatitis. Gastrointest Endosc 2005; 62: 76\u201384.","DOI":"10.1016\/S0016-5107(05)00504-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Chong AK, Hawes RH, Hoffman BJ, Adams DB, Lewin DN, Romagnuolo J. Diagnostic performance of EUS for chronic pancreatitis: a comparison with histopathology. Gastrointest Endosc 2007; 65: 808\u2013814.","DOI":"10.1016\/j.gie.2006.09.026"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Ito T, Ishiguro H, Ohara H, et al. Evidence-based clinical practice guidelines for chronic pancreatitis. J Gastroenterol 2016; 51: 85\u201392.","DOI":"10.1007\/s00535-015-1149-x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130: 1377\u20131390.","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 McColl K, Murray L, El-Omar E, et al. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998; 339: 1869\u20131874.","DOI":"10.1056\/NEJM199812243392601"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Portincasa P, Altomare DF, Moschetta A, et al. The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study. Am J Gastroenterol 2000; 95: 3444\u20133451.","DOI":"10.1111\/j.1572-0241.2000.03282.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Chen CL, Lin HH, Chen MC, Huang LC. Dyspeptic symptoms and water load test in patients with functional dyspepsia and reflux disease. Scand J Gastroenterol 2005; 40: 28\u201332.","DOI":"10.1080\/00365520410009483"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Shimpuku M, Futagami S, Kawagoe T, et al. G-protein \u03b23 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. Neurogastroenterol Motil 2011; 23: 1073\u20131080.","DOI":"10.1111\/j.1365-2982.2011.01781.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Svedlund J, Sj\u00f6din I, Dotevall G. GSRS\u2014a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988; 33: 129\u2013134.","DOI":"10.1007\/BF01535722"},{"key":"29","unstructured":"29 Doi Y, Minowa M, Uchiyama S, Okawa M. Development of the Pittsburgh Sleep Quality Index Japanese version. Jpn J Psychiatr Treat 1998; 13: 755\u2013763."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Doi Y, Minowa M, Okawa M, Uchiyama M. Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population. J Epidemiol 2000; 10: 79\u201386.","DOI":"10.2188\/jea.10.79"},{"key":"31","unstructured":"31 Fukuhara S, Suzukamo Y. Manual of the SF-8 Japanese Version. Institute for Health Outcomes &amp; Process Evaluation Research, Kyoto, 2004."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Spielberger CD, Goursuch RL, Lushene RE, et al. Manual for the State -Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologist Press, 1983.","DOI":"10.1037\/t06496-000"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Hellmig S, Von Schoning F, Gadow C, et al. Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass index. J Gastroenterol Hepatol 2006; 21: 1832\u20131838.","DOI":"10.1111\/j.1440-1746.2006.04449.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Futagami S, Shindo T, Kawagoe T, et al. Migration of eosinophils and CCR2-\/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am J Gastroenterol 2010; 105: 1835\u20131842.","DOI":"10.1038\/ajg.2010.151"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Kusano M, Zai H, Shimoyama Y, et al. Rapid gastric emptying, rather than delayed gastric emptying, might provoke functional dyspepsia. J Gastroenterol Heapatol 2011; 26: 75\u201378.","DOI":"10.1111\/j.1440-1746.2011.06627.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Lee KJ, Vos R, Janssens J, Tack J. Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol 2004; 286: G278\u2013G284.","DOI":"10.1152\/ajpgi.00086.2003"},{"key":"37","unstructured":"37 Tahara T, Arisawa T, Shibata T, et al. 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. Hepatogastroenterology 2009; 56: 1245\u20131248."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Zai H, Kusano M. Investigation of gastric emptying disorders in patients with functional dyspepsia reveals impaired inhibitory gastric emptying regulation in the early postcibal period. Digestion 2009; 79 Suppl 1: 13\u201318.","DOI":"10.1159\/000167861"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Yusoff IF, Sahai AV. A prospective, quantitative assessment of the effect of ethanol and other variables on the endosonographic appearance of the pancreas. Clin Gastroenterol Heaptol 2004; 2: 405\u2013409.","DOI":"10.1016\/S1542-3565(04)00126-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Catalano MF, Sahai A, Levy M, et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc 2009; 69: 1251\u20131261.","DOI":"10.1016\/j.gie.2008.07.043"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Long WB, Weiss JB. Rapid gastric emptying of fatty meals in pancreatic insufficiency. Gastroenterology 1974; 67: 920\u2013950.","DOI":"10.1016\/S0016-5085(19)32744-1"},{"key":"42","unstructured":"42 Meyer JH, Hlinka M, Kao D, et al. Gastric emptying of oil from solid and liquid meals. Effect of human pancreatic insufficiency. Dig Dis Sci 1996; 41: 1691\u20131699."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Chowdhury RS, Forsmark CE, Davis RH, Toskes PP, Verne GN. Prevalence of gastroparesis in patients with small duct chronic pancreatitis. Pancreas 2003; 26: 235\u2013238.","DOI":"10.1097\/00006676-200304000-00005"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44 Yamawaki H, Futagami S, Shimpuku M, et al. Leu72Met408 polymorphism of the ghrelin gene is associated with early phase of gastric emptying in the patients with functional dyspepsia in Japan. J Neurogastroenterol Motil 2015; 21: 93\u2013102.","DOI":"10.5056\/jnm14086"},{"key":"45","unstructured":"45 Shimpuku M, Futagami S, Inamori M, et al. Distinct associations between depression status and initial phase of gastric emptying in functional dyspepsia and healthy volunteers. Int J Gastroenterol Disord Ther 2014; 1: 106\u2013111."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 Pilichiewicz A, O&apos;Donovan D, Feinle C, et al. Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin response to, an oil\/aqueous drink in type 2 diabetes mellitus. J Clin Endocrinol Metab 2003; 88: 3829\u20133834.","DOI":"10.1210\/jc.2003-030199"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47 Sahai AV, Zimmerman M, Aabakken L, et al. Prospective assessment of the ability of endoscopic ultrasound to diagnose, exclude, or establish the severity of chronic pancreatitis found by endoscopic retrograde cholangiopancreatography. Gastrointest Endosc 1998; 48: 18\u201325.","DOI":"10.1016\/S0016-5107(98)70123-3"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48 Catalano MF, Lahoti S, Geenen JE, Hogan WJ. Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis. Gastrointest Endosc 1998; 48: 11\u201317.","DOI":"10.1016\/S0016-5107(98)70122-1"}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/61\/2\/61_17-41\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T10:29:48Z","timestamp":1659349788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/61\/2\/61_17-41\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.17-41","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}