{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:21:04Z","timestamp":1771579264469,"version":"3.50.1"},"reference-count":67,"publisher":"The Society for Free Radical Research Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2021]]},"DOI":"10.3164\/jcbn.20-116","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T22:09:11Z","timestamp":1616796551000},"page":"171-187","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptome profiling implicated in beneficiary actions of kimchi extracts against &lt;i&gt;Helicobacter pylori&lt;\/i&gt; infection"],"prefix":"10.3164","volume":"69","author":[{"given":"Jong Min","family":"Park","sequence":"first","affiliation":[{"name":"Daejeon University School of Oriental Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Han","sequence":"additional","affiliation":[{"name":"Seoul Center, Korea Basic Science Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Oh","sequence":"additional","affiliation":[{"name":"CJ Food Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"CJ Food Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"CJ Food Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Baik","family":"Hahm","sequence":"additional","affiliation":[{"name":"CHA Cancer Preventive Research Center"},{"name":"Medpacto Research Institute, Medpacto"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Guo Y, Zhao S, Li CI, Sheng Q, Shyr Y. RNAseqPS: a web tool for estimating sample size and power for RNAseq experiment. Cancer Inform 2014; 13 (Suppl 6): 1\u20135.","DOI":"10.4137\/CIN.S17688"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Cloonan N, Grimmond SM. Transcriptome content and dynamics at single-nucleotide resolution. Genome Biol 2008; 9: 234.","DOI":"10.1186\/gb-2008-9-9-234"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Avital G, Hashimshony T, Yanai I. Seeing is believing: new methods for <i>in situ<\/i> single-cell transcriptomics. Genome Biol 2014; 15: 110.","DOI":"10.1186\/gb4169"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Han KJ, Lee JE, Lee NK, Paik HD. Antioxidant and anti-inflammatory effect of probiotic <i>Lactobacillus plantarum<\/i> KU15149 derived from Korean homemade diced-radish kimchi. J Microbiol Biotechnol 2020; 30: 591\u2013598.","DOI":"10.4014\/jmb.2002.02052"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Woo HD, Park S, Oh K, et al. Diet and cancer risk in the Korean population: a meta-analysis. Asian Pac J Cancer Prev 2014; 15: 8509\u20138519.","DOI":"10.7314\/APJCP.2014.15.19.8509"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Kim HJ, Kim MK, Chang WK, Choi HS, Choi BY, Lee SS. Effect of nutrient intake and <i>Helicobacter pylori<\/i> infection on gastric cancer in Korea: a case-control study. Nutr Cancer 2005; 52: 138\u2013146.","DOI":"10.1207\/s15327914nc5202_4"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Kim HJ, Chang WK, Kim MK, Lee SS, Choi BY. Dietary factors and gastric cancer in Korea: a case-control study. Int J Cancer 2002; 97: 531\u2013535.","DOI":"10.1002\/ijc.10111"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Shukla S, Park JH, Chung SH, Kim M. Ochratoxin A reduction ability of biocontrol agent <i>Bacillus subtilis<\/i> isolated from Korean traditional fermented food Kimchi. Sci Rep 2018; 8: 8039.","DOI":"10.1038\/s41598-018-26162-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Chun BH, Kim KH, Jeon HH, Lee SH, Jeon CO. Pan-genomic and transcriptomic analyses of <i>Leuconostoc mesenteroides<\/i> provide insights into its genomic and metabolic features and roles in kimchi fermentation. Sci Rep 2017; 7: 11504.","DOI":"10.1038\/s41598-017-12016-z"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Jeong M, Park JM, Han YM, et al. Dietary prevention of <i>Helicobacter pylori<\/i>-associated gastric cancer with kimchi. Oncotarget 2015; 6: 29513\u201329526.","DOI":"10.18632\/oncotarget.4897"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Kang BK, Cho MS, Park DS. Red pepper powder is a crucial factor that influences the ontogeny of <i>Weissella cibaria<\/i> during kimchi fermentation. Sci Rep 2016; 6: 28232.","DOI":"10.1038\/srep28232"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Balic JJ, Saad MI, Dawson R, et al. Constitutive STAT3 serine phosphorylation promotes <i>Helicobacter<\/i>-mediated gastric disease. Am J Pathol 2020; 190: 1256\u20131270.","DOI":"10.1016\/j.ajpath.2020.01.021"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Ishii Y, Shibata W, Sugimori M, et al. Activation of signal transduction and activator of transcription 3 signaling contributes to <i>Helicobacter<\/i>-associated gastric epithelial proliferation and inflammation. Gastroenterol Res Pract 2018; 2018: 9050715.","DOI":"10.1155\/2018\/9050715"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Park JM, Han YM, Oh JY, et al. Fermented kimchi rejuvenated precancerous atrophic gastritis via mitigating <i>Helicobacter pylori<\/i>-associated endoplasmic reticulum and oxidative stress. J Clin Biochem Nutr 2021; 69: 158\u2013170.","DOI":"10.3164\/jcbn.20-180"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods 2012; 9: 357\u2013359.","DOI":"10.1038\/nmeth.1923"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 2010; 26: 841\u2013842.","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"17","unstructured":"17 Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Huang DW, Sherman BT, Tan Q, et al. The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol 2007; 8: R183.","DOI":"10.1186\/gb-2007-8-9-r183"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K. KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 2017; 45: D353\u2013D361.","DOI":"10.1093\/nar\/gkw1092"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Han YM, Kang EA, Park JM, et al. Dietary intake of fermented kimchi prevented colitis-associated cancer. J Clin Biochem Nutr 2020; 67: 263\u2013273.","DOI":"10.3164\/jcbn.20-77"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Liu X, Li N, Liu S, et al. Normalization methods for the analysis of unbalanced transcriptome data: a review. Front Bioeng Biotechnol 2019; 7: 358.","DOI":"10.3389\/fbioe.2019.00358"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Posey JE. Genome sequencing and implications for rare disorders. Orphanet J Rare Dis 2019; 14: 153.","DOI":"10.1186\/s13023-019-1127-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Narrandes S, Xu W. Gene expression detection assay for cancer clinical use. J Cancer 2018; 9: 2249\u20132265.","DOI":"10.7150\/jca.24744"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Baird M, Woon Ang P, Clark I, et al. The unfolded protein response is activated in <i>Helicobacter<\/i>-induced gastric carcinogenesis in a non-cell autonomous manner. Lab Invest 2013; 93: 112\u2013122.","DOI":"10.1038\/labinvest.2012.131"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Zhu P, Xue J, Zhang ZJ, et al. <i>Helicobacter pylori<\/i> VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway. Cell Death Dis 2017; 8: 3207.","DOI":"10.1038\/s41419-017-0011-x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Akazawa Y, Isomoto H, Matsushima K, et al. Endoplasmic reticulum stress contributes to <i>Helicobacter pylori<\/i> VacA-induced apoptosis. PLoS One 2013; 8: e82322.","DOI":"10.1371\/journal.pone.0082322"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Ogawa T, Wada Y, Takemura K, et al. CHAC1 overexpression in human gastric parietal cells with <i>Helicobacter pylori<\/i> infection in the secretory canaliculi. Helicobacter 2019; 24: e12598.","DOI":"10.1111\/hel.12598"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Wada Y, Takemura K, Tummala P, et al. <i>Helicobacter pylori<\/i> induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells. FEBS Open Bio 2018; 8: 671\u2013679.","DOI":"10.1002\/2211-5463.12402"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Kim JM, Kim JS, Kim N, Ko SH, Jeon JI, Kim YJ. <i>Helicobacter pylori<\/i> vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells. J Gastroenterol Hepatol 2015; 30: 99\u2013108.","DOI":"10.1111\/jgh.12663"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Matsuoka K, Nishiumi S, Yoshida M, Kodama Y. Effects of <i>Helicobacter pylori<\/i> on the glutathione-related pathway in gastric epithelial cells. Biochem Biophys Res Commun 2020; 526: 1118\u20131124.","DOI":"10.1016\/j.bbrc.2020.04.019"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Fu L, Xie C. A lucid review of <i>Helicobacter pylori<\/i>-induced DNA damage in gastric cancer. Helicobacter 2019; 24: e12631.","DOI":"10.1111\/hel.12631"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Benitez J, Marra R, Reyes J, Calvete O. A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours. Gastric Cancer 2020; 23: 52\u201363.","DOI":"10.1007\/s10120-019-00982-4"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Sokolova O, Naumann M. Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis. Curr Top Microbiol Immunol 2019; 421: 107\u2013137.","DOI":"10.1007\/978-3-030-15138-6_5"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Paik JY, Lee HG, Piao JY, et al. <i>Helicobacter pylori<\/i> infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells. Biochem Pharmacol 2019; 162: 89\u201397.","DOI":"10.1016\/j.bcp.2019.02.003"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Shi Y, Wang P, Guo Y, Liang X, Li Y, Ding S. <i>Helicobacter pylori<\/i>-induced DNA damage is a potential driver for human gastric cancer AGS cells. DNA Cell Biol 2019; 38: 272\u2013280.","DOI":"10.1089\/dna.2018.4487"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Kumar S, Dhiman M. Inflammasome activation and regulation during <i>Helicobacter pylori<\/i> pathogenesis. Microb Pathog 2018; 125: 468\u2013474.","DOI":"10.1016\/j.micpath.2018.10.012"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Butcher LD, den Hartog G, Ernst PB, Crowe SE. Oxidative stress resulting from <i>Helicobacter pylori<\/i> infection contributes to gastric carcinogenesis. Cell Mol Gastroenterol Hepatol 2017; 3: 316\u2013322.","DOI":"10.1016\/j.jcmgh.2017.02.002"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 D\u00edaz P, Valenzuela Valderrama M, Bravo J, Quest AFG. <i>Helicobacter pylori<\/i> and gastric cancer: adaptive cellular mechanisms involved in disease progression. Front Microbiol 2018; 9: 5.","DOI":"10.3389\/fmicb.2018.00005"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Luo C, Sun F, Zhu H, et al. Insulin-like growth factor binding protein-1 (IGFBP-1) upregulated by <i>Helicobacter pylori<\/i> and is associated with gastric cancer cells migration. Pathol Res Pract 2017; 213: 1029\u20131036.","DOI":"10.1016\/j.prp.2017.08.009"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Ustundag Y, Sahin H, Ilikhan S, Dogan BG, Kokturk F, Kar F. <i>Helicobacter pylori<\/i> eradication does not change circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels in patients with and without precancerous gastric lesions. Am J Med Sci 2013; 346: 381\u2013384.","DOI":"10.1097\/MAJ.0b013e31827beed3"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Pham TM, Fujino Y, Kikuchi S, et al. A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Eur J Cancer 2007; 43: 1611\u20131616.","DOI":"10.1016\/j.ejca.2007.04.014"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42 Yasui W, Sentani K, Motoshita J, Nakayama H. Molecular pathobiology of gastric cancer. Scand J Surg 2006; 95: 225\u2013231.","DOI":"10.1177\/145749690609500403"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Nardone G, Compare D. Epigenetic alterations due to diet and <i>Helicobacter pylori<\/i> infection in gastric carcinogenesis. Expert Rev Gastroenterol Hepatol 2008; 2: 243\u2013248.","DOI":"10.1586\/17474124.2.2.243"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44 Hagen SJ, Ang LH, Zheng Y, et al. Loss of tight junction protein claudin 18 promotes progressive neoplasia development in mouse stomach. Gastroenterology 2018; 155: 1852\u20131867.","DOI":"10.1053\/j.gastro.2018.08.041"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Lee JY, Kim N, Choi YJ, et al. Expression of tight junction proteins according to functional dyspepsia subtype and sex. J Neurogastroenterol Motil 2020; 26: 248\u2013258.","DOI":"10.5056\/jnm19208"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 Taki M, Oshima T, Li M, et al. Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia. Neurogastroenterol Motil 2019; 31: e13576.","DOI":"10.1111\/nmo.13576"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47 Nakayama I, Shinozaki E, Sakata S, et al. Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults. Cancer Sci 2019; 110: 1352\u20131363.","DOI":"10.1111\/cas.13967"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48 Caron TJ, Scott KE, Fox JG, Hagen SJ. Tight junction disruption: <i>Helicobacter pylori<\/i> and dysregulation of the gastric mucosal barrier. World J Gastroenterol 2015; 21: 11411\u201311427.","DOI":"10.3748\/wjg.v21.i40.11411"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49 Dun XP, Parkinson DB. Role of Netrin-1 signaling in nerve regeneration. <i>Int J Mol Sci<\/i> 2017; 18: 491.","DOI":"10.3390\/ijms18030491"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50 De Vries M, Cooper HM. Emerging roles for neogenin and its ligands in CNS development. J Neurochem 2008; 106: 1483\u20131492.","DOI":"10.1111\/j.1471-4159.2008.05485.x"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51 Schubert AL, Held M, Sommer C, \u00dc\u00e7eyler N. Reduced gene expression of netrin family members in skin and sural nerve specimens of patients with painful peripheral neuropathies. J Neurol 2019; 266: 2812\u20132820.","DOI":"10.1007\/s00415-019-09496-6"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52 Mothe AJ, Tassew NG, Shabanzadeh AP, et al. RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury. Sci Rep 2017; 7: 10529.","DOI":"10.1038\/s41598-017-10987-7"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53 Yamashita T, Mueller BK, Hata K. Neogenin and repulsive guidance molecule signaling in the central nervous system. Curr Opin Neurobiol 2007; 17: 29\u201334.","DOI":"10.1016\/j.conb.2006.12.001"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54 Schlegel M, K\u00f6rner A, Kaussen T, et al. Inhibition of neogenin fosters resolution of inflammation and tissue regeneration. J Clin Invest 2018; 128: 4711\u20134726.","DOI":"10.1172\/JCI96259"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55 Schnichels S, Heiduschka P, Julien S. RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina. Graefes Arch Clin Exp Ophthalmol 2012; 250: 39\u201350.","DOI":"10.1007\/s00417-011-1791-9"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56 Wang W, Reeves WB, Ramesh G. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Am J Physiol Renal Physiol 2009; 296: F723\u2013F729.","DOI":"10.1152\/ajprenal.90686.2008"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57 De Breuck S, Lardon J, Rooman I, Bouwens L. Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 2003; 46: 926\u2013933.","DOI":"10.1007\/s00125-003-1125-5"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58 Shin GJ, Wilson NH. Overexpression of repulsive guidance molecule (RGM) a induces cell death through Neogenin in early vertebrate development. J Mol Histol 2008; 39: 105\u2013113.","DOI":"10.1007\/s10735-007-9138-x"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59 Tassew NG, Mothe AJ, Shabanzadeh AP, et al. Modifying lipid rafts promotes regeneration and functional recovery. Cell Rep 2014; 8: 1146\u20131159.","DOI":"10.1016\/j.celrep.2014.06.014"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60 Liu J, Wang W, Liu M, et al. Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway. Cell Signal 2016; 28: 1842\u20131851.","DOI":"10.1016\/j.cellsig.2016.08.015"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61 Bowyer G, Sharpe H, Venkatraman N, et al. Reduced Ebola vaccine responses in CMV<sup>+<\/sup> young adults is associated with expansion of CD57<sup>+<\/sup>KLRG1<sup>+<\/sup> T cells. J Exp Med 2020; 217:e20200004.","DOI":"10.1084\/jem.20200004"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62 Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B, et al. Skin resident memory CD8<sup>+<\/sup> T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function. Clin Exp Immunol 2018; 194: 79\u201392.","DOI":"10.1111\/cei.13189"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63 Li Y, Li Y, Bai Z, Pan J, Wang J, Fang F. Identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a case-control validation study. J Transl Med 2017; 15: 254.","DOI":"10.1186\/s12967-017-1364-8"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64 Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Immunology 2017; 152: 65\u201373.","DOI":"10.1111\/imm.12749"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65 Yang M, Li H, Li Y, Ruan Y, Quan C. Identification of genes and pathways associated with MDR in MCF-7\/MDR breast cancer cells by RNA-seq analysis. Mol Med Rep 2018; 17: 6211\u20136226.","DOI":"10.3892\/mmr.2018.8704"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66 Silva-Fortes C, Amaral Turkman MA, Sousa L. Arrow plot: a new graphical tool for selecting up and down regulated genes and genes differentially expressed on sample subgroups. BMC Bioinformatics 2012; 13: 147.","DOI":"10.1186\/1471-2105-13-147"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67 Kadota K, Nakai Y, Shimizu K. A weighted average difference method for detecting differentially expressed genes from microarray data. Algorithms Mol Biol 2008; 3: 8.","DOI":"10.1186\/1748-7188-3-8"}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/69\/2\/69_20-116\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T04:38:47Z","timestamp":1715143127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/69\/2\/69_20-116\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.20-116","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"20-116"}}