{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:24:51Z","timestamp":1776407091930,"version":"3.51.2"},"reference-count":35,"publisher":"The Society for Free Radical Research Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2022]]},"DOI":"10.3164\/jcbn.21-67","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T22:09:08Z","timestamp":1630620548000},"page":"175-181","source":"Crossref","is-referenced-by-count":7,"title":["State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities"],"prefix":"10.3164","volume":"70","author":[{"given":"Shuhei","family":"Agawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Gudis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Habiro","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kodaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, St. Marianna University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Motoda","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466\u20131479.","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130: 1377\u20131390.","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Sahai AV, Mishra G, Penman ID, et al. EUS to detect evidence of pancreatic disease in patients with persistent or nonspecific dyspepsia. Gastrointest Endosc 2000; 52: 153\u2013159.","DOI":"10.1067\/mge.2000.107910"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Wakabayashi M, Futagami S, Yamawaki H, et al. Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients. PLoS One 2018; 13: e0205165.","DOI":"10.1371\/journal.pone.0205165"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Hashimoto S, Futagami S, Yamawaki H, et al. Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography. J Clin Biochem Nutr 2017; 61: 140\u2013145.","DOI":"10.3164\/jcbn.17-41"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Ashizawa N, Hashimoto T, Miyake T, Shizuku T, Imaoka T, Kinoshita Y. Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? J Gastroenterol Hepatol 2006; 21: 767\u2013771.","DOI":"10.1111\/j.1440-1746.2005.04041.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Fujikawa Y, Tominaga K, Tanaka F, et al. Postprandial symptoms felt at the lower part of the epigastrium and a possible association of pancreatic exocrine dysfunction with the pathogenesis of functional dyspepsia. Intern Med 2017; 56: 1629\u20131635.","DOI":"10.2169\/internalmedicine.56.8193"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Tominaga K, Fujikawa Y, Tsumoto C, et al. Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia. J Clin Biochem Nutr 2016; 58: 161\u2013165.","DOI":"10.3164\/jcbn.15-140"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Worning H. Exocrine pancreatic function in dyspepsia. Digestion 1987; 37 Suppl 1: 3\u201313.","DOI":"10.1159\/000199527"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Higuchi K, Futagami S, Yamawaki H, et al. Endosonographic features in patients with non-alcoholic early chronic pancreatitis improved with treatment at one year follow up. J Clin Biochem Nutr 2021; 68: 86\u201394.","DOI":"10.3164\/jcbn.19-130"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Ito T, Ishiguro H, Ohara H, et al. Evidence-based clinical practice guidelines for chronic pancreatitis 2015. J Gastroenterol 2016; 51: 85\u201392.","DOI":"10.1007\/s00535-015-1149-x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Svedlund J, Sj\u00f6din I, Dotevall G. GSRS--a clinical rating scale for gastro\u00adintestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988; 33: 129\u2013134.","DOI":"10.1007\/BF01535722"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Engbers LH, van Poppel MN, Chin A Paw M, van Mechelen W. The effects of a controlled worksite environmental intervention on determinants of dietary behavior and self-reported fruit, vegetable and fat intake. BMC Public Health 2006; 6: 253.","DOI":"10.1186\/1471-2458-6-253"},{"key":"14","unstructured":"14 Fukuhara S, Suzukamo Y. Manual of the SF-8 Japanese Version. Kyoto: Institute for Health Outcomes and Process Evaluation Research, 2004. (in Japanese)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Spielberger CD, Goursuch RL, Lushene RE. Manual for the State Trait anxiety inventory. Mountain View, CA: Consulting Psychological Press, 1983.","DOI":"10.1037\/t06496-000"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 de la Iglesia-Garcia D, Vallejo-Senra N, Iglesias-Garcia J, L\u00f3pez-L\u00f3pez A, Nieto L, Dom\u00ednguez-Mu\u00f1oz JE. Increased risk of mortality associated with pancreatic exocrine insufficiency in patients with chronic pancreatitis. J Clin Gastroenterol 2018; 52: e63\u2013e72.","DOI":"10.1097\/MCG.0000000000000917"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Capurso G, Traini M, Piciucchi M, Signoretti M, Arcidiacono PG. Exocrine pancreatic insufficiency: prevalence, diagnosis, and management. Clin Exp Gastroenterol 2019; 12: 129\u2013139.","DOI":"10.2147\/CEG.S168266"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol 2011; 4: 55\u201373.","DOI":"10.2147\/CEG.S17634"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Long WB, Weiss JB. Rapid gastric emptying of fatty meals in pancreatic insufficiency. Gastroenterology 1974; 67: 920\u2013925.","DOI":"10.1016\/S0016-5085(19)32744-1"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Regan PT, Malagelada JR, Dimagno EP, Go VL. Postprandial gastric function in pancreatic insufficiency. Gut 1979; 20: 249\u2013254.","DOI":"10.1136\/gut.20.3.249"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Stevens T, Conwell D, Zuccaro G, et al. Analysis of pancreatic elastase-1 concentrations in duodenal aspirates from healthy subjects and patients with chronic pancreatitis. Dig Dis Sci 2004; 49: 1405\u20131411.","DOI":"10.1023\/B:DDAS.0000042238.80040.cc"},{"key":"22","unstructured":"22 Talamini G. Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis. JOP 2005; 6: 122\u2013127."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Kleveland PM, Johannessen T, Kristensen P, et al. Effect of pancreatic enzymes in non-ulcer dyspepsia. A pilot study. Scand J Gastroenterol 1990; 25: 298\u2013301.","DOI":"10.1080\/00365521.1990.12067107"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Lu CL, Chen CY, Luo JC, et al. Impaired gastric myoelectricity in patients with chronic pancreatitis: role of maldigestion. World J Gastroenterol 2005; 11: 372\u2013376.","DOI":"10.3748\/wjg.v11.i3.372"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Mussa BM, Sood S, Verberne AJ. Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis. World J Gastroenterol 2018; 24: 3821\u20133833.","DOI":"10.3748\/wjg.v24.i34.3821"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Owyang C, Logsdon CD. New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology 2004; 127: 957\u2013969.","DOI":"10.1053\/j.gastro.2004.05.002"},{"key":"27","unstructured":"27 Konturek SJ, Pepera J, Zabielski K, et al. Brain-gut axis in pancreatic secretion and appetite control. J Physiol Pharmacol 2003; 54: 293\u2013317."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Simpson KH, Stakes AF. Effect of anxiety on gastric emptying in preoperative patients. Br J Anaesth 1987; 59: 540\u2013544.","DOI":"10.1093\/bja\/59.5.540"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Mussa BM, Sood S, Verberne AJ. Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis. World J Gastroenterol 2018; 24: 3821\u20133833.","DOI":"10.3748\/wjg.v24.i34.3821"},{"key":"30","unstructured":"30 Roze C. Central regulation of pancreatic secretion. In Tache Y, Wingate DL, eds. Brain-gut Interactions, FL: CRC Press, 1991; 187\u2013198."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Jimenez-Vargas NN, Pattison LA, Zhao P, et al. Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proc Natl Acad Sci U S A 2018; 115: E7438\u2013E7447.","DOI":"10.1073\/pnas.1721891115"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Futagami S, Shindo T, Kawagoe T, et al. Migration of eosinophils and CCR2-\/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am J Gastroenterol 2010; 105: 1835\u20131842.","DOI":"10.1038\/ajg.2010.151"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Du L, Shen J, Kim JJ, Yu Y, Ma L, Dai N. Increased duodenal eosinophil degranulation in patients with functional dyspepsia: a prospective study. Sci Rep 2016; 6: 34305.","DOI":"10.1038\/srep34305"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Vanheel H, Vicario M, Vanuytsel T, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut 2014; 63: 262\u2013271.","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"35","unstructured":"35 Yuan HP, Li Z, Zhang Y, Li XP, Li FK, Li YQ. Anxiety and depression are associated with increased counts and degranulation of duodenal mast cells in functional dyspepsia. Int J Clin Exp Med 2015; 8: 8010\u20138014."}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/70\/2\/70_21-67\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:00:28Z","timestamp":1646452828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/70\/2\/70_21-67\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.21-67","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"21-67"}}