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Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45\u201351.","DOI":"10.1038\/36285"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Kuro-o M. The Klotho proteins in health and disease. Nat Rev Nephrol 2019; 15: 27\u201344.","DOI":"10.1038\/s41581-018-0078-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Chen CD, Tung TY, Liang J, et al. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry 2014; 53: 5579\u20135587.","DOI":"10.1021\/bi500409n"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Chen Y, Biada J, Sood S, Rabkin R. Uremia attenuates growth hormone-stimulated insulin-like growth factor-1 expression, a process worsened by inflammation. Kidney Int 2010; 78: 89\u201395.","DOI":"10.1038\/ki.2010.85"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Imura A, Iwano A, Tohyama O, et al. 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The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects. J Clin Endocrinol Metab 2011; 96: E1896\u2013E1904.","DOI":"10.1210\/jc.2011-1597"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant 2013; 48: 452\u2013458.","DOI":"10.1038\/bmt.2012.244"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Lindberg K, Amin R, Moe OW, et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol 2014; 25: 2169\u20132175.","DOI":"10.1681\/ASN.2013111209"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Tidblad A. The history, physiology and treatment safety of growth hormone. Acta Paediatr 2022; 111: 215\u2013224.","DOI":"10.1111\/apa.15948"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Mauras N, Haymond MW. 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Multifactorial control of the elimination kinetics of unbound (free) growth hormone (GH) in the human: regulation by age, adiposity, renal function, and steady state concentrations of GH in plasma. J Clin Endocrinol Metab 1996; 81: 22\u201331.","DOI":"10.1210\/jc.81.1.22"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Tran\u00e6us Lindblad Y, Olauson H, Vavilis G, et al. The FGF23-Klotho axis and cardiac tissue Doppler imaging in pediatric chronic kidney disease\u2014a prospective cohort study. Pediatr Nephrol 2018; 33: 147\u2013157.","DOI":"10.1007\/s00467-017-3766-5"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42 Cano FJ, Freundlich M, Ceballos ML, et al. Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis. Clin Kidney J 2014; 7: 457\u2013463.","DOI":"10.1093\/ckj\/sfu074"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Xie J, Yoon J, An SW, Kuro-o M, Huang CL. 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