{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:02:41Z","timestamp":1787500961646,"version":"build-2736575974"},"reference-count":36,"publisher":"The Society for Free Radical Research Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2025]]},"DOI":"10.3164\/jcbn.23-70","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T18:10:11Z","timestamp":1721844611000},"page":"16-24","source":"Crossref","is-referenced-by-count":4,"title":["3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes"],"prefix":"10.3164","volume":"76","author":[{"given":"Anayt","family":"Ulla","sequence":"first","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Mizanur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kayaki","sequence":"additional","affiliation":[{"name":"Research Center, Maruzen Pharmaceuticals Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nishitani","sequence":"additional","affiliation":[{"name":"Research Center, Maruzen Pharmaceuticals Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Research Center, Maruzen Pharmaceuticals Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshige","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Research Center, Maruzen Pharmaceuticals Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nikawa","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Kumar N, Pruthi V. Potential applications of ferulic acid from natural sources. Biotechnol Rep (Amst) 2014; 4: 86\u201393.","DOI":"10.1016\/j.btre.2014.09.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 2007; 40: 92\u2013100.","DOI":"10.3164\/jcbn.40.92"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Alam MA. Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action. Front Nutr 2019; 6: 121.","DOI":"10.3389\/fnut.2019.00121"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Mostafa AF, Samir SM. Ferulic acid promotes growth of both fast glycolytic and slow oxidative skeletal muscles in corticosteroid-induced rat myopathy. The Medical Journal of Cairo University 2019; 87: 1703\u20131715.","DOI":"10.21608\/mjcu.2019.53950"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Ohue-Kitano R, Taira S, Watanabe K, et al. 3-(4-Hydroxy-3-methoxyphenyl)propionic acid produced from 4-hydroxy-3-methoxycinnamic acid by gut microbiota improves host metabolic condition in diet-induced obese mice. Nutrients 2019; 11: 1036.","DOI":"10.3390\/nu11051036"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Vitaglione P, Mennella I, Ferracane R, et al. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am J Clin Nutr 2015; 101: 251\u2013261.","DOI":"10.3945\/ajcn.114.088120"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 S\u00e1nchez-Medina A, Redondo-Puente M, Dupak R, Bravo-Clemente L, Goya L, Sarri\u00e1 B. Colonic coffee phenols metabolites, dihydrocaffeic, dihydroferulic, and hydroxyhippuric acids protect hepatic cells from TNF-\u03b1-induced inflammation and oxidative stress. Int J Mol Sci 2023; 24: 1440.","DOI":"10.3390\/ijms24021440"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Lee SH, Yeo D, Hong JH. Effect of dihydroferulic acid obtained from fermented rice bran extract on neuroprotection and behavioral recovery in an ischemic rat model. Food Sci Technol 2020; 40: 475\u2013481.","DOI":"10.1590\/fst.33719"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Abe C, Soma A, Tun TNN, et al. Pharmacokinetic profiles of 3-(4-hydroxy-3-methoxyphenyl) propionic acid and its conjugates in Sprague-Dawley rats. Biosci Biotechnol Biochem 2023; 87: 516\u2013524.","DOI":"10.1093\/bbb\/zbad023"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond) 1998; 94: 557\u2013572.","DOI":"10.1042\/cs0940557"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Schakman O, Kalista S, Barb\u00e9 C, Loumaye A, Thissen JP. Glucocorticoid-induced skeletal muscle atrophy. Int J Biochem Cell Biol 2013; 45: 2163\u20132172.","DOI":"10.1016\/j.biocel.2013.05.036"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Menconi M, Fareed M, O&apos;Neal P, Poylin V, Wei W, Hasselgren PO. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med 2007; 35 (9 Suppl): S602\u2013S608.","DOI":"10.1097\/01.CCM.0000279194.11328.77"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Asada M, Rauch A, Shimizu H, et al. DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Kr\u00fcppel-like factor 15 gene expression. Lab Invest 2011; 91: 203\u2013215.","DOI":"10.1038\/labinvest.2010.170"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Gray S, Wang B, Orihuela Y, et al. Regulation of gluconeogenesis by Kr\u00fcppel-like factor 15. Cell Metab 2007; 5: 305\u2013312.","DOI":"10.1016\/j.cmet.2007.03.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Sasse SK, Mailloux CM, Barczak AJ, et al. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol 2013; 33: 2104\u20132115.","DOI":"10.1128\/MCB.01474-12"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Shimizu N, Yoshikawa N, Ito N, et al. Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab 2011; 13: 170\u2013182.","DOI":"10.1016\/j.cmet.2011.01.001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Sandri M, Sandri C, Gilbert A, et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117: 399\u2013412.","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Edwards SJ, Carter S, Nicholson T, et al. (\u2212)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells. J Nutr Biochem 2022; 110: 109150.","DOI":"10.1016\/j.jnutbio.2022.109150"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Ulla A, Uchida T, Miki Y, et al. Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes. Arch Biochem Biophys 2021; 704: 108873.","DOI":"10.1016\/j.abb.2021.108873"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Hirasaka K, Maeda T, Ikeda C, et al. Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation. J Nutr Sci Vitaminol (Tokyo) 2013; 59: 317\u2013324.","DOI":"10.3177\/jnsv.59.317"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Ulla A, Osaki K, Rahman MM, et al. Morin improves dexamethasone-induced muscle atrophy by modulating atrophy-related genes and oxidative stress in female mice. Biosci Biotechnol Biochem 2022; 86: 1448\u20131458.","DOI":"10.1093\/bbb\/zbac140"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Kim S, Kim K, Park J, Jun W. <i>Curcuma longa<\/i> L. water extract improves dexamethasone-induced sarcopenia by modulating the muscle-related gene and oxidative stress in mice. Antioxidants (Basel) 2021; 10: 1000.","DOI":"10.3390\/antiox10071000"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Rizk FH, Soliman NA, Kashef SM, Elsaadany AA. Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1\u03b1\/Nrf2\/TFAM pathway. J Physiol Biochem 2023; 79: 107\u2013115.","DOI":"10.1007\/s13105-022-00925-1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Lee H, Kim YI, Kim MJ, et al. Castor oil plant (<i>Ricinus communis<\/i> L.) leaves improve dexamethasone-induced muscle atrophy via Nrf2 activation. Front Pharmacol 2022; 13: 891762.","DOI":"10.3389\/fphar.2022.891762"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Katsuki R, Sakata S, Nakao R, Oishi K, Nakamura Y. <i>Lactobacillus curvatus<\/i> CP2998 prevents dexamethasone-induced muscle atrophy in C2C12 myotubes. J Nutr Sci Vitaminol (Tokyo) 2019; 65: 455\u2013458.","DOI":"10.3177\/jnsv.65.455"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Salucci S, Falcieri E. Polyphenols and their potential role in preventing skeletal muscle atrophy. Nutr Res 2020; 74: 10\u201322.","DOI":"10.1016\/j.nutres.2019.11.004"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Nikawa T, Ulla A, Sakakibara I. Polyphenols and their effects on muscle atrophy and muscle health. Molecules 2021; 26; 4887.","DOI":"10.3390\/molecules26164887"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Yin L, Li N, Jia W, et al. Skeletal muscle atrophy: from mechanisms to treatments. Pharmacol Res 2021; 172: 105807.","DOI":"10.1016\/j.phrs.2021.105807"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Bonaldo P, Sandri M. Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech 2013; 6: 25\u201339.","DOI":"10.1242\/dmm.010389"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Schakman O, Gilson H, Thissen JP. Mechanisms of glucocorticoid-induced myopathy. J Endocrinol 2008; 197: 1\u201310.","DOI":"10.1677\/JOE-07-0606"},{"key":"31","unstructured":"31 Nicolaides NC, Chrousos G, Kino T. Glucocorticoid receptor. In: Feingold KR, Anawalt B, Blackman MR, et al., eds. Endotext, South Dartmouth (MA): MDText.com, Inc."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Kim YI, Lee H, Kim MJ, Jung CH, Kim YS, Ahn J. Identification of <i>Peucedanum japonicum<\/i> Thunb. extract components and their protective effects against dexamethasone-induced muscle atrophy. Phytomedicine 2024; 128: 155449.","DOI":"10.1016\/j.phymed.2024.155449"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Yoshioka Y, Kubota Y, Samukawa Y, Yamashita Y, Ashida H. Glabridin inhibits dexamethasone-induced muscle atrophy. Arch Biochem Biophys 2019; 664: 157\u2013166.","DOI":"10.1016\/j.abb.2019.02.006"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Kim YI, Lee H, Nirmala FS, et al. Antioxidant activity of <i>Valeriana fauriei<\/i> protects against dexamethasone-induced muscle atrophy. Oxid Med Cell Longev 2022; 2022: 3645431.","DOI":"10.1155\/2022\/3645431"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Seene T, Kaasik P, Pehme A, Alev K, Riso EM. The effect of glucocorticoids on the myosin heavy chain isoforms\u2019 turnover in skeletal muscle. J Steroid Biochem Mol Biol 2003; 86: 201\u2013206.","DOI":"10.1016\/j.jsbmb.2003.08.002"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Baeza G, Bachmair EM, Wood S, Mateos R, Bravo L, de Roos B. The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of <i>in vitro<\/i> platelet activation than their phenolic precursors. Food Funct 2017; 8: 1333\u20131342.","DOI":"10.1039\/C6FO01404F"}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/76\/1\/76_23-70\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T23:08:24Z","timestamp":1735945704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/76\/1\/76_23-70\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.23-70","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"23-70"}}