{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:54:40Z","timestamp":1792792480625,"version":"4.5.0"},"reference-count":32,"publisher":"The Society for Free Radical Research Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Biochem. Nutr."],"published-print":{"date-parts":[[2026]]},"DOI":"10.3164\/jcbn.25-203","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:09:08Z","timestamp":1768514948000},"page":"158-167","source":"Crossref","is-referenced-by-count":1,"title":["Icariside II suppresses NF-\u03baB\/STAT3 signaling to \u200dprevent the progression of chronic atrophic gastritis toward gastric cancer"],"prefix":"10.3164","volume":"78","author":[{"given":"Mingzhe","family":"Li","sequence":"first","affiliation":[{"name":"School of Biological Engineering, Jilin Engineering Vocational College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Shang","sequence":"additional","affiliation":[{"name":"Purchasing Department, Changchun GeneScience Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the 964th Hospital of the Joint Logistic Support Force of the Chinese People\u2019s Liberation Army"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1739","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Sundar R, Nakayama I, Markar SR, et al. Gastric cancer. Lancet 2025; 405: 2087\u20132102.","DOI":"10.1016\/S0140-6736(25)00052-2"},{"key":"2","unstructured":"2 Correa P. Human gastric carcinogenesis: a multistep and multifactorial process\u2014First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992; 52: 6735\u20136740."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007; 117: 60\u201369.","DOI":"10.1172\/JCI30111"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Sugano K, Moss SF, Kuipers EJ. Gastric intestinal metaplasia: real culprit or innocent bystander as a precancerous condition for gastric cancer? Gastroenterology 2023; 165: 1352\u20131366.e1.","DOI":"10.1053\/j.gastro.2023.08.028"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Duan Y, Xu Y, Dou Y, Xu D. <i>Helicobacter pylori<\/i> and gastric cancer: mechanisms and new perspectives. J Hematol Oncol 2025; 18: 10.","DOI":"10.1186\/s13045-024-01654-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Wang XQ, Terry PD, Yan H. Review of salt consumption and stomach cancer risk: epidemiological and biological evidence. World J Gastroenterol 2009; 15: 2204\u20132213.","DOI":"10.3748\/wjg.15.2204"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Shah SC, Piazuelo MB, Kuipers EJ, Li D. AGA Clinical Practice Update on the diagnosis and management of atrophic gastritis: expert review. Gastroenterology 2021; 161: 1325\u20131332.e7.","DOI":"10.1053\/j.gastro.2021.06.078"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Taniguchi K, Karin M. NF-\u03baB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol 2018; 18: 309\u2013324.","DOI":"10.1038\/nri.2017.142"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Karin M, Greten FR. NF-\u03baB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749\u2013759.","DOI":"10.1038\/nri1703"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Yu H, Lee H, Herrmann A, Buettner R, Jove R. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014; 14: 736\u2013746.","DOI":"10.1038\/nrc3818"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9: 798\u2013809.","DOI":"10.1038\/nrc2734"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Tan HL, Chan KG, Pusparajah P, et al. Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives. Front Pharmacol 2016; 7: 191.","DOI":"10.3389\/fphar.2016.00191"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Wu H, Kim M, Han J. Icariin metabolism by human intestinal microflora. Molecules 2016; 21: 1158.","DOI":"10.3390\/molecules21091158"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Song J, Feng L, Zhong R, et al. Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt\/NF-\u03baB signaling pathway. Mol Carcinog 2017; 56: 36\u201348.","DOI":"10.1002\/mc.22471"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Xu CQ, Liu BJ, Wu JF, et al. Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K\/Akt and NF-\u03baB signaling pathway. Eur J Pharmacol 2010; 642: 146\u2013153.","DOI":"10.1016\/j.ejphar.2010.05.012"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Li S, Dong P, Wang J, et al. Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS\/JNK-dependent mitochondrial pathway. Cancer Lett 2010; 298: 222\u2013230.","DOI":"10.1016\/j.canlet.2010.07.009"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Wang QS, Wang GF, Zhou J, Gao LN, Cui YL. Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis. Int J Pharm 2016; 515: 176\u2013185.","DOI":"10.1016\/j.ijpharm.2016.10.002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Dou R, Zhu X, Liu X, et al. Icariside II inhibits gastric cancer progression by suppressing the Wnt\/\u03b2-catenin signaling pathway. Cytotechnology 2025; 77: 106.","DOI":"10.1007\/s10616-025-00761-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Eluard B, Thieblemont C, Baud V. NF-\u03baB in the new era of cancer therapy. Trends Cancer 2020; 6: 677\u2013687.","DOI":"10.1016\/j.trecan.2020.04.003"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Guo Q, Jin Y, Chen X, et al. NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 2024; 9: 53.","DOI":"10.1038\/s41392-024-01757-9"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Mao H, Zhao X, Sun SC. NF-\u03baB in inflammation and cancer. Cell Mol Immunol 2025; 22: 811\u2013839.","DOI":"10.1038\/s41423-025-01310-w"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Johnson DE, O&apos;Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 2018; 15: 234\u2013248.","DOI":"10.1038\/nrclinonc.2018.8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Li YJ, Zhang C, Martincuks A, Herrmann A, Yu H. STAT proteins in cancer: orchestration of metabolism. Nat Rev Cancer 2023; 23: 115\u2013134.","DOI":"10.1038\/s41568-022-00537-3"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883\u2013899.","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 He G, Karin M. NF-\u03baB and STAT3\u2014key players in liver inflammation and cancer. Cell Res 2011; 21: 159\u2013168.","DOI":"10.1038\/cr.2010.183"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Hu X, Li J, Fu M, Zhao X, Wang W. The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther 2021; 6: 402.","DOI":"10.1038\/s41392-021-00791-1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Jung YY, Lee JH, Nam D, et al. Anti-myeloma effects of icariin are mediated through the attenuation of JAK\/STAT3-dependent signaling cascade. Front Pharmacol 2018; 9: 531.","DOI":"10.3389\/fphar.2018.00531"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Li C, Yang S, Ma H, Ruan M, Fang L, Cheng J. Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4\/MyD88\/NF-\u03baB and Wnt\/\u03b2-catenin pathways. Cancer Cell Int 2021; 21: 206.","DOI":"10.1186\/s12935-021-01910-2"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Wang Y, Dong H, Zhu M, et al. Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway. Eur J Pharmacol 2010; 635: 40\u201348.","DOI":"10.1016\/j.ejphar.2010.03.017"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Zhang F, Yin Y, Xu W, et al. Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159\/miR-223-3p\/NLRP3 signaling axis. Hum Exp Toxicol 2022; 41: 9603271221097363.","DOI":"10.1177\/09603271221097363"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Koeberle A, Werz O. Multi-target approach for natural products in inflammation. Drug Discov Today 2014; 19: 1871\u20131882.","DOI":"10.1016\/j.drudis.2014.08.006"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Xu Q, Pan G, Wang Z, et al. Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer. Front Pharmacol 2023; 14: 1138658.","DOI":"10.3389\/fphar.2023.1138658"}],"container-title":["Journal of Clinical Biochemistry and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/78\/2\/78_25-203\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:53:21Z","timestamp":1772859201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jcbn\/78\/2\/78_25-203\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3164\/jcbn.25-203","relation":{},"ISSN":["0912-0009","1880-5086"],"issn-type":[{"value":"0912-0009","type":"print"},{"value":"1880-5086","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25-203"}}