{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:20:46Z","timestamp":1791404446070,"version":"4.3.3"},"reference-count":45,"publisher":"American Dairy Science Association","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":1866,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.3168\/jds.2013-7285","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:30:47Z","timestamp":1382056247000},"page":"7511-7520","source":"Crossref","is-referenced-by-count":74,"title":["Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage"],"prefix":"10.3168","volume":"96","author":[{"given":"W.-R.","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.-W.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-L. S.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-C.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-C.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2013-7285_bib0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-3542(01)00146-2","article-title":"Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts","volume":"51","author":"Andersen","year":"2001","journal-title":"Antiviral Res."},{"key":"10.3168\/jds.2013-7285_bib0010","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0360-3016(01)01467-5","article-title":"Adjuvant radiochemotherapy in the treatment of completely resected, locally advanced gastric cancer","volume":"50","author":"Baeza","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.3168\/jds.2013-7285_bib0015","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/CCLM.1999.049","article-title":"Lactoferrin: A multifunctional glycoprotein involved in the modulation of the inflammatory process","volume":"37","author":"Baveye","year":"1999","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.3168\/jds.2013-7285_bib0020","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2672.1992.tb05007.x","article-title":"Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin","volume":"73","author":"Bellamy","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"10.3168\/jds.2013-7285_bib0025","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0167-4838(92)90346-F","article-title":"Identification of the bactericidal domain of lactoferrin","volume":"1121","author":"Bellamy","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2013-7285_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00189377","article-title":"Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin","volume":"182","author":"Bellamy","year":"1993","journal-title":"Med. Microbiol. Immunol. (Berl.)"},{"key":"10.3168\/jds.2013-7285_bib0035","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/sj.bjc.6601752","volume":"90","author":"Cascinu","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.3168\/jds.2013-7285_bib0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2460\/ajvr.2004.65.131","article-title":"Effects of bovine lactoferrin hydrolysate on the in vitro antimicrobial susceptibility of Escherichia coli strains isolated from baby pigs","volume":"65","author":"Chen","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2013-7285_bib0045","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3168\/jds.2012-6112","article-title":"Antimicrobial potential for the combination of bovine lactoferrin or its hydrolysate with lactoferrin-resistant probiotics against foodborne pathogens","volume":"96","author":"Chen","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2013-7285_bib0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.peptides.2012.05.011","article-title":"Novel cationic antimicrobial peptide GW-H1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines","volume":"36","author":"Chen","year":"2012","journal-title":"Peptides"},{"key":"10.3168\/jds.2013-7285_bib0055","first-page":"247","article-title":"Antimicrobial actions of lactoferrin","volume":"10","author":"Chierici","year":"2001","journal-title":"Adv. Nutr. Res."},{"key":"10.3168\/jds.2013-7285_bib0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijantimicag.2008.04.003","article-title":"Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp","volume":"32","author":"Chou","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.3168\/jds.2013-7285_bib0065","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2174\/138920306779025611","article-title":"Anticancer \u03b1-helical peptides and structure\/function relationships underpinning their interactions with tumour cell membranes","volume":"7","author":"Dennison","year":"2006","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.3168\/jds.2013-7285_bib0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/cdd.2011.146","article-title":"Cell death by autophagy: Facts and apparent artefacts","volume":"19","author":"Denton","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.3168\/jds.2013-7285_bib0075","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/ijc.21886","article-title":"The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.","volume":"119","author":"Eliassen","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.3168\/jds.2013-7285_bib0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0161-5890(03)00152-4","article-title":"Lactoferrin\u2014A multifunctional protein with antimicrobial properties","volume":"40","author":"Farnaud","year":"2003","journal-title":"Mol. Immunol."},{"key":"10.3168\/jds.2013-7285_bib0085","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00018-010-0284-z","article-title":"Regulation of autophagy in mammals and its interplay with apoptosis","volume":"67","author":"Fimia","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.3168\/jds.2013-7285_bib0090","first-page":"1385","article-title":"Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide and tamoxifen","volume":"15","author":"Furlong","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.3168\/jds.2013-7285_bib0095","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.yexmp.2010.02.001","article-title":"Bovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing B-lymphoma xenografts","volume":"88","author":"Furlong","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.3168\/jds.2013-7285_bib0100","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10495-011-0589-x","article-title":"Conversation between apoptosis and autophagy: \u201cIs it your turn or mine?","volume":"16","author":"Giansanti","year":"2011","journal-title":"Apoptosis"},{"key":"10.3168\/jds.2013-7285_bib0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jso.23262","article-title":"Gastric cancer epidemiology and risk factors","volume":"107","author":"Guggenheim","year":"2013","journal-title":"J. Surg. Oncol."},{"key":"10.3168\/jds.2013-7285_bib0110","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbamem.2007.11.008","article-title":"Studies on anticancer activities of antimicrobial peptides","volume":"1778","author":"Hoskin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2013-7285_bib0115","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1021\/bi972323m","article-title":"Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin","volume":"37","author":"Hwang","year":"1998","journal-title":"Biochemistry"},{"key":"10.3168\/jds.2013-7285_bib0120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.3168\/jds.2013-7285_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1002817226110","article-title":"Lactoferrin and its biological functions","volume":"66","author":"Kanyshkova","year":"2001","journal-title":"Biochemistry (Mosc.)"},{"key":"10.3168\/jds.2013-7285_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0895-4356(02)00534-6","article-title":"Gastric cancer epidemiology and risk factors","volume":"56","author":"Kelley","year":"2003","journal-title":"J. Clin. Epidemiol."},{"key":"10.3168\/jds.2013-7285_bib0135","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.3168\/jds.2013-7285_bib0140","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10534-010-9297-1","article-title":"A critical review of the roles of host lactoferrin in immunity","volume":"23","author":"Legrand","year":"2010","journal-title":"Biometals"},{"key":"10.3168\/jds.2013-7285_bib0145","first-page":"252","article-title":"Lactoferrin: A general review","volume":"80","author":"Levay","year":"1995","journal-title":"Haematologica"},{"key":"10.3168\/jds.2013-7285_bib0150","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1158\/0008-5472.CAN-10-4475","article-title":"Following cytochrome C release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1","volume":"71","author":"Li","year":"2011","journal-title":"Cancer Res."},{"key":"10.3168\/jds.2013-7285_bib0155","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-Fluorouracil: Mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.3168\/jds.2013-7285_bib1160","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.yexcr.2007.05.015","article-title":"Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria","volume":"313","author":"Mader","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.3168\/jds.2013-7285_bib0160","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1158\/1535-7163.MCT-04-0077","article-title":"Bovine lactoferricin induces apoptosis in human leukemia and carcinoma cell lines","volume":"4","author":"Mader","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.3168\/jds.2013-7285_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2013.06.001","article-title":"Crosstalk between apoptosis, necrosis and autophagy","author":"Nikoletopoulou","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2013-7285_bib0170","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbrc.2009.08.083","article-title":"Intracellular delivery of bovine lactoferricin\u2019s antimicrobial core (RRWQWR) kills T-leukemia cells","volume":"388","author":"Richardson","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2013-7285_bib0175","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chemphyslip.2011.09.004","article-title":"Membrane-active host defense peptides\u2014Challenges and perspectives for the development of novel anticancer drugs","volume":"164","author":"Riedl","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"10.3168\/jds.2013-7285_bib0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-5793(99)00214-8","article-title":"The structure of the antimicrobial active center of lactoferricin B bound to sodium dodecyl sulfate micelles","volume":"446","author":"Schibli","year":"1999","journal-title":"FEBS Lett."},{"key":"10.3168\/jds.2013-7285_bib0185","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ncb1192","article-title":"Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes","volume":"6","author":"Shimizu","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.3168\/jds.2013-7285_bib0190","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/onc.2009.487","article-title":"Involvement of JNK in the regulation of autophagic cell death","volume":"29","author":"Shimizu","year":"2010","journal-title":"Oncogene"},{"key":"10.3168\/jds.2013-7285_bib0195","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.3168\/jds.S0022-0302(91)78608-6","article-title":"Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin","volume":"74","author":"Tomita","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2013-7285_bib0200","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1442-200X.1994.tb03250.x","article-title":"A review: The active peptide of lactoferrin","volume":"36","author":"Tomita","year":"1994","journal-title":"Acta Paediatr. Jpn."},{"key":"10.3168\/jds.2013-7285_bib0205","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1997.7199","article-title":"Apoptosis induced in human leukemic cells by lactoferricin, a bovine milk protein-derived peptide: Involvement of reactive oxygen species","volume":"237","author":"Yoo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2013-7285_bib0210","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1349-7006.1997.tb00364.x","article-title":"Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice","volume":"88","author":"Yoo","year":"1997","journal-title":"Jpn. J. Cancer Res."},{"key":"10.3168\/jds.2013-7285_bib0215","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1096645","article-title":"Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8","volume":"304","author":"Yu","year":"2004","journal-title":"Science"},{"key":"10.3168\/jds.2013-7285_bib0220","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1742-4658.2010.07965.x","article-title":"Bcl-2 and Bcl-Xl play important roles in the crosstalk between autophagy and apoptosis","volume":"278","author":"Zhou","year":"2011","journal-title":"FEBS J."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030213007224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030213007224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030213007224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:06:06Z","timestamp":1731103566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030213007224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0022030213007224"],"URL":"https:\/\/doi.org\/10.3168\/jds.2013-7285","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}