{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:33:23Z","timestamp":1775126003416,"version":"3.50.1"},"reference-count":57,"publisher":"American Dairy Science Association","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T00:00:00Z","timestamp":1404691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pancosma SA. S. P. Shirazi-Beechey is grateful to John Newbold"},{"name":"Jiangsu Overseas Research Training Program (Jiangsu, China), and National Natural Science Foundation of China","award":["31101703"],"award-info":[{"award-number":["31101703"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.3168\/jds.2014-8004","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T13:52:11Z","timestamp":1401717131000},"page":"4955-4972","source":"Crossref","is-referenced-by-count":84,"title":["Sweet taste receptor expression in ruminant intestine and its activation by artificial sweeteners to regulate glucose absorption"],"prefix":"10.3168","volume":"97","author":[{"given":"A.W.","family":"Moran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Al-Rammahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Calsamiglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.P.","family":"Shirazi-Beechey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2014-8004_bib0005","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jmb.2010.03.017","article-title":"Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor","volume":"398","author":"Assadi-Porter","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.3168\/jds.2014-8004_bib0010","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1152\/ajpregu.00262.2010","article-title":"Intestinal sodium\/glucose cotransporter-1 (SGLT1) and disaccharidase expression in the domestic dog and cat: Two species of different dietary habit","volume":"300","author":"Batchelor","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0015","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1021\/jf0484982","article-title":"Degradation of neohesperidin dihydrochalcone by human intestinal bacteria","volume":"53","author":"Braune","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.3168\/jds.2014-8004_bib0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/es1031272","article-title":"Saccharin and other artificial sweeteners in soils: Estimated inputs from agriculture and households, degradation, and leaching to groundwater","volume":"45","author":"Buerge","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.3168\/jds.2014-8004_bib0025","doi-asserted-by":"crossref","first-page":"G1249","DOI":"10.1152\/ajpgi.2000.279.6.G1249","article-title":"GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis","volume":"279","author":"Burrin","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2014-8004_bib0030","first-page":"R1965","article-title":"Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo","volume":"273","author":"Cheeseman","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0035","doi-asserted-by":"crossref","first-page":"G293","DOI":"10.1152\/ajpgi.00275.2005","article-title":"Glucagon-like peptide-2 protects against TPN-induced intestinal hexose malabsorption in enterally refed piglets","volume":"290","author":"Cottrell","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2014-8004_bib0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0003-2697(64)90115-0","article-title":"Method for assay of intestinal disaccharidases","volume":"7","author":"Dahlqvist","year":"1964","journal-title":"Anal. Biochem."},{"key":"10.3168\/jds.2014-8004_bib0045","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1152\/ajpregu.00031.2012","article-title":"Expression of sweet receptor components in equine small intestine: Relevance to intestinal glucose transport","volume":"303","author":"Daly","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0050","doi-asserted-by":"crossref","first-page":"G271","DOI":"10.1152\/ajpgi.00074.2012","article-title":"Sensing of amino acids by the gut-expressed taste receptor, T1R1-T1R3, stimulates CCK secretion","volume":"304","author":"Daly","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"Suppl. 2","key":"10.3168\/jds.2014-8004_bib0055","doi-asserted-by":"crossref","first-page":"3907S","DOI":"10.1093\/jn\/133.11.3907S","article-title":"Rising consumption of meat and milk in developing countries has created a new food revolution","volume":"133","author":"Delgado","year":"2003","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2014-8004_bib0060","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1073\/pnas.93.15.7911","article-title":"Induction of intestinal epithelial proliferation by glucagon-like peptide 2","volume":"93","author":"Drucker","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2014-8004_bib0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00424-008-0620-4","article-title":"Adaptive response of equine intestinal Na+\/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate","volume":"458","author":"Dyer","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.3168\/jds.2014-8004_bib0070","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1042\/BST0330302","article-title":"Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells","volume":"33","author":"Dyer","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.3168\/jds.2014-8004_bib0075","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1046\/j.1432-1033.2003.03721.x","article-title":"Glucose sensing in the intestinal epithelium","volume":"270","author":"Dyer","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.3168\/jds.2014-8004_bib0080","doi-asserted-by":"crossref","first-page":"E218","DOI":"10.2527\/jas2001.79E-SupplE218x","article-title":"Effects of grain variability and processing on starch utilization by lactating dairy cows","volume":"79","author":"Firkins","year":"2001","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8004_bib0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0005-2736(93)90357-6","article-title":"The expression of the Na+\/glucose cotransporter (SGLT1) gene in lamb small intestine during postnatal development","volume":"1146","author":"Freeman","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2014-8004_bib0090","doi-asserted-by":"crossref","first-page":"915","DOI":"10.5713\/ajas.2009.r.08","article-title":"Understanding starch utilization in the small intestine of cattle","volume":"22","author":"Harmon","year":"2009","journal-title":"Asian-australas. J. Anim. Sci."},{"key":"10.3168\/jds.2014-8004_bib0095","first-page":"2884","article-title":"In vivo and in vitro degradation of glucagon-like peptide-2 in humans","volume":"85","author":"Hartmann","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.3168\/jds.2014-8004_bib0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/360352a0","article-title":"Inhibition of brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF","volume":"360","author":"Helms","year":"1992","journal-title":"Nature"},{"key":"10.3168\/jds.2014-8004_bib0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0092-8674(91)90535-7","article-title":"Selective inhibition of transcytosis in brefeldin A in MDCK cells","volume":"67","author":"Hunziker","year":"1991","journal-title":"Cell"},{"key":"10.3168\/jds.2014-8004_bib0110","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1073\/pnas.0706890104","article-title":"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1","volume":"104","author":"Jang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2014-8004_bib0115","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bj2910435","article-title":"Regulation of the ovine intestinal Na+\/glucose co-transporter (SGLT1) is dissociated from mRNA abundance","volume":"291","author":"Lescale-Matys","year":"1993","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2014-8004_bib0120","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0300-483X(75)90030-X","article-title":"The metabolism of saccharin in animals","volume":"3","author":"Lethco","year":"1975","journal-title":"Toxicology"},{"key":"10.3168\/jds.2014-8004_bib0125","first-page":"A78","article-title":"Gurmarin inhibits the sweet receptor by binding to the venus fly trap module of T1R3","volume":"34","author":"Maillet","year":"2009","journal-title":"Chem. Senses"},{"key":"10.3168\/jds.2014-8004_bib0130","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1073\/pnas.0706678104","article-title":"T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1","volume":"104","author":"Margolskee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2014-8004_bib0135","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/357563a0","article-title":"Gustducin is a taste cell-specific G-protein closely related to transducing","volume":"357","author":"McLaughlin","year":"1992","journal-title":"Nature"},{"key":"10.3168\/jds.2014-8004_bib0140","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0007114510000917","article-title":"Expression of Na+\/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners","volume":"104","author":"Moran","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2014-8004_bib0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1017\/S0007114510000954","article-title":"Expression of sodium\/glucose co-transporter 1 (SGLT1) is the intestine of piglets weaned to different concentrations of dietary carbohydrate","volume":"104","author":"Moran","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2014-8004_bib0150","unstructured":"NRC. 2001, Nutrient Requirements of Dairy Cattle, 7th ed. Natl. Acad. Press, Washington, DC."},{"key":"10.3168\/jds.2014-8004_bib0155","first-page":"R1019","article-title":"Gurmarin inhibition of sweet taste responses in mice","volume":"268","author":"Ninomiya","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0160","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.3168\/jds.S0022-0302(91)78552-4","article-title":"Site of digestion of starch in gastrointestinal tract of dairy cows and its effect on milk yield and composition","volume":"74","author":"Nocek","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8004_bib0165","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/BF00274797","article-title":"Pancreatic and intestinal processing of proglucagon in man","volume":"30","author":"Orskov","year":"1987","journal-title":"Diabetologia"},{"key":"10.3168\/jds.2014-8004_bib0170","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2527\/jas1986.6351634x","article-title":"Limits to starch digestion in the ruminant small intestine","volume":"63","author":"Owens","year":"1986","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8004_bib0175","doi-asserted-by":"crossref","first-page":"G1345","DOI":"10.1152\/ajpgi.00374.2002","article-title":"Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine","volume":"285","author":"Ramsanahie","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2014-8004_bib0180","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s10620-004-9561-8","article-title":"Effect of glucagon-like peptide-2 (GLP-2) on diurnal SGLT1 expression","volume":"49","author":"Ramsanahie","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.3168\/jds.2014-8004_bib0185","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1055\/s-2004-826154","article-title":"A centenary of gastrointestinal endocrinology","volume":"36","author":"Rehfeld","year":"2004","journal-title":"Horm. Metab. Res."},{"key":"10.3168\/jds.2014-8004_bib0190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1439-0396.1999.00215.x","article-title":"Abundance of intestinal Na+\/glucose cotransporter (SGLT1) in roe deer (Capreolus capreolus)","volume":"82","author":"Rowell-Sch\u00e4fer","year":"1999","journal-title":"J. Anim. Physiol. A. Anim. Nutr."},{"key":"10.3168\/jds.2014-8004_bib0195","doi-asserted-by":"crossref","first-page":"G708","DOI":"10.1152\/ajpgi.00282.2012","article-title":"Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion","volume":"304","author":"Sato","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2014-8004_bib0200","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/bj1940803","article-title":"The use of potent inhibitors of alkaline phosphatase to investigate the role of the enzyme in intestinal transport of inorganic phosphate","volume":"194","author":"Shirazi","year":"1981","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2014-8004_bib0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1079\/NRR19950005","article-title":"Molecular biology of intestinal glucose transport","volume":"8","author":"Shirazi-Beechey","year":"1995","journal-title":"Nutr. Res. Rev."},{"key":"10.3168\/jds.2014-8004_bib0210","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/0016-5085(90)90288-C","article-title":"Preparation and properties of brush-border membrane vesicles from human small intestine","volume":"98","author":"Shirazi-Beechey","year":"1990","journal-title":"Gastroenterology"},{"key":"10.3168\/jds.2014-8004_bib0215","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1113\/jphysiol.1991.sp018620","article-title":"Ontogenic development of lamb intestinal sodium-glucose co-transporter is regulated by diet","volume":"437","author":"Shirazi-Beechey","year":"1991","journal-title":"J. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0220","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0305-0491(89)90169-7","article-title":"Changes in the functions of the intestinal brush border membrane during the development of ruminant habit in lambs","volume":"94","author":"Shirazi-Beechey","year":"1989","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.3168\/jds.2014-8004_bib0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0029665111000103","article-title":"Glucose sensing and signalling; regulation of intestinal glucose transport","volume":"70","author":"Shirazi-Beechey","year":"2011","journal-title":"Proc. Nutr. Soc."},{"key":"10.3168\/jds.2014-8004_bib0230","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/SLA.0b013e3181d96e1f","article-title":"Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation","volume":"251","author":"Stearns","year":"2010","journal-title":"Ann. Surg."},{"key":"10.3168\/jds.2014-8004_bib0235","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.clnu.2011.01.007","article-title":"The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)","volume":"30","author":"Steinert","year":"2011","journal-title":"Clin. Nutr."},{"key":"10.3168\/jds.2014-8004_bib0240","doi-asserted-by":"crossref","first-page":"E550","DOI":"10.1152\/ajpendo.00326.2004","article-title":"Human duodenal enteroendocrine cells: Source of both incretin peptides, GLP-1 and GIP","volume":"290","author":"Theodorakis","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.3168\/jds.2014-8004_bib0245","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2527\/jas1986.6351649x","article-title":"Grain processing effects on starch utilization by ruminants","volume":"63","author":"Theurer","year":"1986","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8004_bib0250","first-page":"E77","article-title":"Intestinal growth promoting properties of glucagon like peptide-2 in mice","volume":"273","author":"Tsai","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0255","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.2527\/1995.73123766x","article-title":"Influence of ruminal or abomasal starch hydrolysate infusion on pancreatic exocrine secretion and blood glucose and insulin concentrations in steers","volume":"73","author":"Walker","year":"1995","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8004_bib0260","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2202-6-22","article-title":"Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor","volume":"6","author":"Winnig","year":"2005","journal-title":"BMC Neurosci."},{"key":"10.3168\/jds.2014-8004_bib0265","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0300-9629(86)90370-1","article-title":"Kinetics of d-glucose and l-leucine transport into sheep and pig intestinal brush border membrane vesicles","volume":"84","author":"Wolffram","year":"1986","journal-title":"Comp. Biochem. Physiol. A Comp. Physiol."},{"key":"10.3168\/jds.2014-8004_bib0270","unstructured":"Wood, I. S. 1995. PhD thesis, University of Wales, Aberystwyth, UK."},{"key":"10.3168\/jds.2014-8004_bib0275","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s004240000404","article-title":"Expression of the Na+\/glucose co-transporter (SGLT1) in the intestine of domestic and wild ruminants","volume":"441","author":"Wood","year":"2000","journal-title":"Pfl\u00fcgers. Arch."},{"key":"10.3168\/jds.2014-8004_bib0280","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.3168\/jds.2014-8004_bib0285","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Zhang","year":"2000","journal-title":"J. Comput. Biol."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030214003890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030214003890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030214003890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:23:25Z","timestamp":1731101005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030214003890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0022030214003890"],"URL":"https:\/\/doi.org\/10.3168\/jds.2014-8004","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}