{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:15:00Z","timestamp":1768778100510,"version":"3.49.0"},"reference-count":55,"publisher":"American Dairy Science Association","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":1439,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/19059-2"],"award-info":[{"award-number":["2012\/19059-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.3168\/jds.2014-8523","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T21:56:07Z","timestamp":1417298167000},"page":"947-959","source":"Crossref","is-referenced-by-count":40,"title":["Effect of adding a gonadotropin-releasing-hormone treatment at the beginning and a second prostaglandin F2\u03b1 treatment at the end of an estradiol-based protocol for timed artificial insemination in lactating dairy cows during cool or hot seasons of the year"],"prefix":"10.3168","volume":"98","author":[{"given":"M.H.C.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Wiltbank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.F.S.P.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"W.M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.P.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.M.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2014-8523_bib0005","first-page":"139","article-title":"History, evolution and perspectives of timed artificial insemination programs in Brazil","volume":"9","author":"Baruselli","year":"2012","journal-title":"Anim. Reprod."},{"key":"10.3168\/jds.2014-8523_bib0010","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2527\/jas1987.6451512x","article-title":"Effect of heat stress on early embryonic development in the beef cow","volume":"64","author":"Biggers","year":"1987","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8523_bib0015","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.3168\/jds.2012-6038","article-title":"Targeted progesterone supplementation improves fertility in lactating dairy cows without a corpus luteum at the initiation of the timed artificial insemination protocol","volume":"96","author":"Bisinotto","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0020","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.3168\/jds.2010-3516","article-title":"Effect of interval between induction of ovulation and artificial insemination (AI) and supplemental progesterone for resynchronization on fertility of dairy cows subjected to a 5-d timed AI program","volume":"93","author":"Bisinotto","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-4320(95)01389-H","article-title":"Ovarian follicular wave emergence after treatment with progestogen and estradiol in cattle","volume":"39","author":"Bo","year":"1995","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2014-8523_bib0030","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3168\/jds.2008-1289","article-title":"Effects of additional prostaglandin F-2 alpha and estradiol-17 beta during Ovsynch in lactating dairy cows","volume":"92","author":"Brusveen","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-4320(02)00260-9","article-title":"Effect of treatment with progesterone and oestradiol when starting treatment with an intravaginal progesterone releasing insert on ovarian follicular development and hormonal concentrations in Holstein cows","volume":"76","author":"Cavalieri","year":"2003","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2014-8523_bib0040","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3168\/jds.2010-3734","article-title":"Concentration of progesterone during the development of the ovulatory follicle: I. Ovarian and embryonic responses","volume":"94","author":"Cerri","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.theriogenology.2007.06.023","article-title":"Effect of maternal heat-stress on follicular growth and oocyte competence in Bos indicus cattle","volume":"69","author":"de S Torres-J\u00fanior","year":"2008","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0050","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.3168\/jds.2007-0223","article-title":"Factors affecting conception rates following artificial insemination or embryo transfer in lactating Holstein cows","volume":"90","author":"Demetrio","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0055","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3168\/jds.2011-4650","article-title":"Low progesterone concentration during the development of the first follicular wave reduces pregnancy per insemination of lactating dairy cows","volume":"95","author":"Denicol","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0060","unstructured":"FASS. 1999. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching. No. 1. Fed. Anim. Sci. Soc., Champaign, IL."},{"key":"10.3168\/jds.2014-8523_bib0065","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1439-0531.2008.01220.x","article-title":"Factors affecting synchronization and conception rate after the Ovsynch protocol in lactating Holstein cows","volume":"45","author":"Galv\u00e3o","year":"2010","journal-title":"Reprod. Domest. Anim."},{"key":"10.3168\/jds.2014-8523_bib0070","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.3168\/jds.2011-4376","article-title":"An economic decision-making support system for selection of reproductive management programs on dairy farms","volume":"94","author":"Giordano","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0075","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3168\/jds.2011-5155","article-title":"Effect of progesterone on magnitude of the luteinizing hormone surge induced by two different doses of gonadotropin-releasing hormone in lactating dairy cows","volume":"95","author":"Giordano","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0080","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.theriogenology.2013.07.003","article-title":"Effect of increasing GnRH and PGF2\u03b1 dose during Double-Ovsynch on ovulatory response, luteal regression, and fertility of lactating dairy cows","volume":"80","author":"Giordano","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0085","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3168\/jds.2011-4418","article-title":"Increased fertility in lactating dairy cows resynchronized with Double-Ovsynch compared with Ovsynch initiated 32d after timed artificial insemination","volume":"95","author":"Giordano","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0090","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/biolreprod\/81.s1.490","article-title":"Effect of organic zinc, manganese, copper, and cobalt on follicular growth, embryo quality, and tissue mineral concentrations in lactating dairy cows","volume":"81","author":"Hackbart","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2014-8523_bib0095","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1098\/rstb.2009.0131","article-title":"Effects of heat stress on mammalian reproduction","volume":"364","author":"Hansen","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.3168\/jds.2014-8523_bib0100","first-page":"322","article-title":"Cellular and molecular basis of therapies to ameliorate effects of heat stress on embryonic development in cattle","volume":"10","author":"Hansen","year":"2013","journal-title":"Anim. Reprod."},{"issue":"Suppl. 2","key":"10.3168\/jds.2014-8523_bib0105","first-page":"36","article-title":"Strategies for managing reproduction in the heat-stressed dairy cow","volume":"77","author":"Hansen","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2014-8523_bib0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0093-691X(00)00448-9","article-title":"Adverse impact of heat stress on embryo production: Causes and strategies for mitigation","volume":"55","author":"Hansen","year":"2001","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0115","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.theriogenology.2004.11.003","article-title":"Fertility following fixed-time AI or insemination at observed estrus in Ovsynch and Heatsynch programs in lactating dairy cows","volume":"63","author":"Kasimanickam","year":"2005","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0120","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.theriogenology.2012.06.030","article-title":"Prostaglandin F2\u03b1 promotes ovulation in prepubertal heifers","volume":"78","author":"Leonardi","year":"2012","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0125","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3168\/jds.2010-3652","article-title":"Effects of cloprostenol sodium at final prostaglandin F2alpha of Ovsynch on complete luteolysis and pregnancy per artificial insemination in lactating dairy cows","volume":"94","author":"Martins","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0130","series-title":"Nutrient Requirements of Dairy Cattle","year":"2001"},{"key":"10.3168\/jds.2014-8523_bib0135","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3168\/jds.2013-7287","article-title":"Increasing length of an estradiol and progesterone timed artificial insemination protocol decreases pregnancy losses in lactating dairy cows","volume":"97","author":"Pereira","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0140","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.3168\/jds.2012-6260","article-title":"Timed artificial insemination programs during the summer in lactating dairy cows: Comparison of the 5-d Cosynch protocol with an estrogen\/progesterone-based protocol","volume":"96","author":"Pereira","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0145","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3168\/jds.2012-5840","article-title":"Timing of prostaglandin F2\u03b1 treatment in an estrogen-based protocol for timed artificial insemination or timed embryo transfer in lactating dairy cows","volume":"96","author":"Pereira","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3168\/jds.S0022-0302(97)75938-1","article-title":"Reproductive management of lactating dairy cows using synchronization of ovulation","volume":"80","author":"Pursley","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0155","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1071\/RD11917","article-title":"Impact of circulating concentrations of progesterone and antral age of the ovulatory follicle on fertility of high-producing lactating dairy cows","volume":"24","author":"Pursley","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"10.3168\/jds.2014-8523_bib0160","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0093-691X(95)00279-H","article-title":"Synchronization of ovulation in dairy cows using PGF2alpha and GnRH","volume":"44","author":"Pursley","year":"1995","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0165","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0093-691X(95)00410-A","article-title":"Exogenous PGF(2)alpha enhanced GnRH-induced LH release in postpartum cows","volume":"45","author":"Randel","year":"1996","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0170","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.theriogenology.2012.01.012","article-title":"Fertility in dairy cows following presynchronization and administering twice the luteolytic dose of prostaglandin F-2 alpha as one or two injections in the 5-day timed artificial insemination protocol","volume":"78","author":"Ribeiro","year":"2012","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0175","first-page":"370","article-title":"Economic aspects of applying reproductive technologies to dairy herds","volume":"9","author":"Ribeiro","year":"2012","journal-title":"Anim. Reprod."},{"key":"10.3168\/jds.2014-8523_bib0180","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1530\/REP-12-0487","article-title":"Heat stress effects on the cumulus cells surrounding the bovine oocyte during maturation: Altered matrix metallopeptidase 9 and progesterone production","volume":"146","author":"Rispoli","year":"2013","journal-title":"Reproduction"},{"key":"10.3168\/jds.2014-8523_bib0185","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/REP-10-0375","article-title":"Reduced progesterone concentration during growth of the first follicular wave affects embryo quality but has no effect on embryo survival post transfer in lactating dairy cows","volume":"141","author":"Rivera","year":"2011","journal-title":"Reproduction"},{"key":"10.3168\/jds.2014-8523_bib0190","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0093-691X(93)90257-6","article-title":"Comparing early embryo mortality in dairy cows during hot and cool seasons of the year","volume":"39","author":"Ryan","year":"1993","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0195","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3168\/jds.2009-2870","article-title":"Effect of reducing the period of follicle dominance in a timed artificial insemination protocol on reproduction of dairy cows","volume":"93","author":"Santos","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0200","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1590\/S0102-09352006000600027","article-title":"Concentrate intake and plasmatic progesterone concentration in Holstein cows","volume":"58","author":"Santos","year":"2006","journal-title":"Arquivo Brasileiro Med. Veterinaria Zootecnia"},{"key":"10.3168\/jds.2014-8523_bib0205","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.3168\/jds.2007-0172","article-title":"Supplementation with estradiol-17 beta before the last gonadotropin-releasing hormone injection of the Ovsynch protocol in lactating dairy cows","volume":"90","author":"Souza","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.theriogenology.2008.12.025","article-title":"Effects of equine chorionic gonadotropin and type of ovulatory stimulus in a timed-AI protocol on reproductive responses in dairy cows","volume":"72","author":"Souza","year":"2009","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0739-7240(02)00160-1","article-title":"Strategies to optimize reproductive efficiency by regulation of ovarian function","volume":"23","author":"Thatcher","year":"2002","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.3168\/jds.2014-8523_bib0220","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.anireprosci.2011.07.012","article-title":"Associations among milk production and rectal temperature on pregnancy maintenance in lactating recipient dairy cows","volume":"127","author":"Vasconcelos","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2014-8523_bib0225","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.theriogenology.2010.11.027","article-title":"Comparison of progesterone-based protocols with gonadotropin-releasing hormone or estradiol benzoate for timed artificial insemination or embryo transfer in lactating dairy cows","volume":"75","author":"Vasconcelos","year":"2011","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0230","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0093-691X(99)00195-8","article-title":"Synchronization rate, size of the ovulatory follicle, and pregnancy rate after synchronization of ovulation beginning on different days of the estrous cycle in lactating dairy cows","volume":"52","author":"Vasconcelos","year":"1999","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0235","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3168\/jds.S0022-0302(82)82223-6","article-title":"A dairy cow body condition scoring system and its relationship to selected production characteristics","volume":"65","author":"Wildman","year":"1982","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0240","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.3168\/jds.S0022-0302(98)75789-3","article-title":"Effects of controlled heat stress on ovarian function of dairy cattle. 2. Heifers","volume":"81","author":"Wilson","year":"1998","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2014-8523_bib0245","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.theriogenology.2013.09.017","article-title":"The cow as an induced ovulator: Timed AI after synchronization of ovulation","volume":"81","author":"Wiltbank","year":"2014","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0250","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.theriogenology.2011.08.012","article-title":"Managing the dominant follicle in lactating dairy cows","volume":"76","author":"Wiltbank","year":"2011","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2014-8523_bib0255","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1071\/RD11913","article-title":"Improving fertility to timed artificial insemination by manipulation of circulating progesterone concentrations in lactating dairy cattle","volume":"24","author":"Wiltbank","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"10.3168\/jds.2014-8523_bib0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4320(96)01638-7","article-title":"Seasonal and acute heat stress effects on steroid production by dominant follicles in cows","volume":"47","author":"Wolfenson","year":"1997","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2014-8523_bib0265","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0378-4320(00)00102-0","article-title":"Impaired reproduction in heat-stressed cattle: Basic and applied aspects","volume":"60\u201361","author":"Wolfenson","year":"2000","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2014-8523_bib0270","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1095\/biolreprod52.5.1106","article-title":"Effect of heat stress on follicular development during the estrous cycle in lactating dairy cattle","volume":"52","author":"Wolfenson","year":"1995","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2014-8523_bib0275","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3168\/jds.S0022-0302(93)77363-4","article-title":"Estrous and endocrine responses of lactating Holsteins to forced ventilation during summer","volume":"76","author":"Younas","year":"1993","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030214008091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030214008091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030214008091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:27:29Z","timestamp":1731101249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030214008091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0022030214008091"],"URL":"https:\/\/doi.org\/10.3168\/jds.2014-8523","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}