{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:06:19Z","timestamp":1791471979002,"version":"4.3.4"},"reference-count":90,"publisher":"American Dairy Science Association","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.3168\/jds.2017-13707","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T22:34:12Z","timestamp":1521412452000},"page":"5502-5514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription"],"prefix":"10.3168","volume":"101","author":[{"given":"X.","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Saremi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Helmbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Loor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2017-13707_bib1","doi-asserted-by":"crossref","first-page":"36553","DOI":"10.1074\/jbc.M404559200","article-title":"Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2","volume":"279","author":"Anthony","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2017-13707_bib2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3945\/jn.110.136143","article-title":"Essential amino acids regulate both initiation and elongation of mRNA translation independent of insulin in MAC-T cells and bovine mammary tissue slices","volume":"141","author":"Appuhamy","year":"2011","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib3","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3168\/jds.2010-3442","article-title":"Effects of jugular-infused lysine, methionine, and branched-chain amino acids on milk protein synthesis in high-producing dairy cows","volume":"94","author":"Appuhamy","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3945\/jn.111.152595","article-title":"Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices","volume":"142","author":"Appuhamy","year":"2012","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3168\/jds.2013-7189","article-title":"Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of rapamycin (mTOR) signaling and protein synthesis rates in mammary cells","volume":"97","author":"Appuhamy","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3168\/jds.2013-7348","article-title":"Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue","volume":"97","author":"Arriola Apelo","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib7","doi-asserted-by":"crossref","first-page":"E592","DOI":"10.1152\/ajpendo.90645.2008","article-title":"Amino acid regulation of TOR complex 1","volume":"296","author":"Avruch","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.3168\/jds.2017-13707_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1471-2164-9-366","article-title":"Gene networks driving bovine milk fat synthesis during the lactation cycle","volume":"9","author":"Bionaz","year":"2008","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2017-13707_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4137\/BBI.S7003","article-title":"Gene networks driving bovine mammary protein synthesis during the lactation cycle","volume":"5","author":"Bionaz","year":"2011","journal-title":"Bioinform. Biol. Insights"},{"key":"10.3168\/jds.2017-13707_bib10","first-page":"79","article-title":"Selenomethionine as substrate for glutamine transaminase","volume":"32","author":"Blarzino","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.3168\/jds.2017-13707_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00424-013-1393-y","article-title":"The SLC38 family of sodium-amino acid co-transporters","volume":"466","author":"Broer","year":"2014","journal-title":"Pflugers Arch."},{"key":"10.3168\/jds.2017-13707_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00726-012-1280-4","article-title":"Glutamate: A truly functional amino acid","volume":"45","author":"Brosnan","year":"2013","journal-title":"Amino Acids"},{"key":"10.3168\/jds.2017-13707_bib13","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1128\/MCB.24.7.2986-2997.2004","article-title":"A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin","volume":"24","author":"Browne","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.3168\/jds.2017-13707_bib14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3168\/jds.2009-2444","article-title":"Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway","volume":"93","author":"Burgos","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.201403009","article-title":"The general amino acid control pathway regulates mTOR and autophagy during serum\/glutamine starvation","volume":"206","author":"Chen","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib16","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jn\/107.4.631","article-title":"Milk production, nitrogen utilization and glucose synthesis in lactating cows infused postruminally with sodium caseinate and glucose","volume":"107","author":"Clark","year":"1977","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib17","doi-asserted-by":"crossref","first-page":"C115","DOI":"10.1007\/BF02007792","article-title":"Effect of histamine on growth and differentiation of the rat mammary gland","volume":"41","author":"Davio","year":"1994","journal-title":"Agents Actions"},{"key":"10.3168\/jds.2017-13707_bib18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jn\/127.5.738","article-title":"Dietary protein and amino acid levels alter threonine dehydrogenase activity in hepatic mitochondria of Gallus domesticus","volume":"127","author":"Davis","year":"1997","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/jn\/104.2.151","article-title":"Effect of abomasal infusion of sodium caseinate on milk yield, nitrogen utilization and amino acid nutrition of the dairy cow","volume":"104","author":"Derrig","year":"1974","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib20","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.3168\/jds.2015-9819","article-title":"Branched-chain amino acid and lysine deficiencies exert different effects on mammary translational regulation","volume":"98","author":"Doelman","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1101\/gr.203201","article-title":"Systematic identification of novel protein domain families associated with nuclear functions","volume":"12","author":"Doerks","year":"2002","journal-title":"Genome Res."},{"key":"10.3168\/jds.2017-13707_bib22","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3168\/jds.2017-13351","article-title":"Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription","volume":"101","author":"Dong","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1079\/BJN19960189","article-title":"In vivo threonine oxidation in growing pigs fed on diets with graded levels of threonine","volume":"75","author":"Floc'h","year":"1996","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","article-title":"The SLC3 and SLC7 families of amino acid transporters","volume":"34","author":"Fotiadis","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.3168\/jds.2017-13707_bib25","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1631\/jzus.B1400337","article-title":"Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway","volume":"16","author":"Gao","year":"2015","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.3168\/jds.2017-13707_bib26","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.3168\/jds.2015-10822","article-title":"Effects of rumen-protected methionine, lysine, and histidine on lactation performance of dairy cows","volume":"99","author":"Giallongo","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0021-9258(18)66077-6","article-title":"Catalytic role of glutamate derivatives in citrulline biosynthesis","volume":"204","author":"Grisolia","year":"1953","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2017-13707_bib28","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3168\/jds.S0022-0302(94)77165-4","article-title":"Effect of graded levels of duodenal infusions of casein on mammary uptake in lactating cows. 1. Major nutrients","volume":"77","author":"Guinard","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib29","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/stem.1335","article-title":"Regulation of L-threonine dehydrogenase in somatic cell reprogramming","volume":"31","author":"Han","year":"2013","journal-title":"Stem Cells"},{"key":"10.3168\/jds.2017-13707_bib30","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.3168\/jds.2014-8656","article-title":"Changes in mammary metabolism in response to the provision of an ideal amino acid profile at 2 levels of metabolizable protein supply in dairy cows: Consequences on efficiency","volume":"98","author":"Haque","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib31","author":"Haque"},{"key":"10.3168\/jds.2017-13707_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3168\/jds.2012-5610","article-title":"Milk protein responses in dairy cows to changes in postruminal supplies of arginine, isoleucine, and valine","volume":"96","author":"Haque","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib33","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1038\/onc.2010.177","article-title":"Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation","volume":"29","author":"Heublein","year":"2010","journal-title":"Oncogene"},{"key":"10.3168\/jds.2017-13707_bib34","doi-asserted-by":"crossref","first-page":"e0142633","DOI":"10.1371\/journal.pone.0142633","article-title":"Insulin sensitivity in adipose and skeletal muscle tissue of dairy cows in response to dietary energy level and 2,4-thiazolidinedione (TZD)","volume":"10","author":"Hosseini","year":"2015","journal-title":"PLoS One"},{"key":"10.3168\/jds.2017-13707_bib35","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.3168\/jds.2008-1352","article-title":"A meta-analysis of the effects of dietary protein concentration and degradability on milk protein yield and milk N efficiency in dairy cows","volume":"92","author":"Huhtanen","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib36","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib37","series-title":"Proteomic and Metabolomic Approaches to Biomarker Discovery","author":"Issaq","year":"2013"},{"key":"10.3168\/jds.2017-13707_bib38","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1093\/emboj\/16.12.3693","article-title":"Rapamycin suppresses 5\u2032 TOP mRNA translation through inhibition of p70 s6k","volume":"16","author":"Jefferies","year":"1997","journal-title":"EMBO J."},{"key":"10.3168\/jds.2017-13707_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrm3522","article-title":"Amino acid signalling upstream of mTOR","volume":"14","author":"Jewell","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib40","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.3168\/jds.2008-1932","article-title":"Peroxisome proliferator-activated receptor-\u03b3 activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents","volume":"92","author":"Kadegowda","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib41","first-page":"G614","article-title":"Dependence of intestinal amino acid uptake on dietary protein or amino acid levels","volume":"252","author":"Karasov","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.3168\/jds.2017-13707_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/mrdd.1040","article-title":"Disorders of glutamate metabolism","volume":"7","author":"Kelly","year":"2001","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.3168\/jds.2017-13707_bib43","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/(SICI)1097-0010(199909)79:12<1703::AID-JSFA424>3.0.CO;2-5","article-title":"Determination of the first-limiting amino acid for milk production in dairy cows consuming a diet of grass silage and a cereal-based supplement containing feather meal","volume":"79","author":"Kim","year":"1999","journal-title":"J. Sci. Food Agric."},{"key":"10.3168\/jds.2017-13707_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1357-2725(98)00128-9","article-title":"Eukaryotic initiation factor eIF2","volume":"31","author":"Kimball","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib45","doi-asserted-by":"crossref","first-page":"500S","DOI":"10.1093\/ajcn\/83.2.500S","article-title":"New functions for amino acids: effects on gene transcription and translation","volume":"83","author":"Kimball","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2017-13707_bib46","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1074\/jbc.274.17.11647","article-title":"Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6","volume":"274","author":"Kimball","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2017-13707_bib47","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jnutbio.2011.06.012","article-title":"L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells","volume":"23","author":"Kong","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.3168\/jds.2017-13707_bib48","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.2527\/jas.2011-4645","article-title":"Triennial Lactation Symposium: Mammary metabolism of amino acids in dairy cows","volume":"90","author":"Lapierre","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2017-13707_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5713\/ajas.2012.12585","article-title":"Effects of dietary levels of glycine, threonine and protein on threonine efficiency and threonine dehydrogenase activity in hepatic mitochondria of chicks","volume":"27","author":"Lee","year":"2014","journal-title":"Asian-australas. J. Anim. Sci."},{"key":"10.3168\/jds.2017-13707_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/vetsci2040349","article-title":"Metabolite profiles of male and female Humboldt penguins","volume":"2","author":"Levengood","year":"2015","journal-title":"Veterinary Sciences"},{"key":"10.3168\/jds.2017-13707_bib51","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.3168\/jds.2017-12681","article-title":"Optimal ratios of essential amino acids stimulate beta-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants","volume":"100","author":"Li","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib52","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.3168\/jds.2016-11973","article-title":"Methionine, leucine, isoleucine, or threonine effects on mammary cell signaling and pup growth in lactating mice","volume":"100","author":"Liu","year":"2017","journal-title":"J. Dairy Sci."},{"issue":"Suppl","key":"10.3168\/jds.2017-13707_bib53","doi-asserted-by":"crossref","first-page":"2525S","DOI":"10.1093\/jn\/131.9.2525S","article-title":"Glutamine in animal science and production","volume":"131","author":"Lobley","year":"2001","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev-animal-031412-103728","article-title":"Systems physiology in dairy cattle: Nutritional genomics and beyond","volume":"2013","author":"Loor","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.3168\/jds.2017-13707_bib55","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s00726-014-1818-8","article-title":"Linking our understanding of mammary gland metabolism to amino acid nutrition","volume":"46","author":"Manjarin","year":"2014","journal-title":"Amino Acids"},{"key":"10.3168\/jds.2017-13707_bib56","doi-asserted-by":"crossref","first-page":"13962","DOI":"10.18632\/oncotarget.3920","article-title":"AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1\/4E\u2013BP1 axis","volume":"6","author":"Mi","year":"2015","journal-title":"Oncotarget"},{"key":"10.3168\/jds.2017-13707_bib57","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/physiolgenomics.00119.2013","article-title":"Ratio of lysine to methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells","volume":"46","author":"Nan","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2017-13707_bib58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biocel.2015.08.004","article-title":"LAT1 is the transport competent unit of the LAT1\/CD98 heterodimeric amino acid transporter","volume":"67","author":"Napolitano","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbf.1003","article-title":"Glutamine and glutamate\u2014their central role in cell metabolism and function","volume":"21","author":"Newsholme","year":"2003","journal-title":"Cell Biochem. Funct."},{"key":"10.3168\/jds.2017-13707_bib60","doi-asserted-by":"crossref","first-page":"e111556","DOI":"10.1371\/journal.pone.0111556","article-title":"DNA methylation and transcription in a distal region upstream from the bovine AlphaS1 casein gene after once or twice daily milking","volume":"9","author":"Nguyen","year":"2014","journal-title":"PLoS One"},{"key":"10.3168\/jds.2017-13707_bib61","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"key":"10.3168\/jds.2017-13707_bib62","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2017-13707_bib63","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"O'Reilly","year":"2006","journal-title":"Cancer Res."},{"key":"10.3168\/jds.2017-13707_bib64","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3168\/jds.2015-10157","article-title":"Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine","volume":"99","author":"Osorio","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib65","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s00424-003-1062-7","article-title":"The ancillary proteins of HATs: SLC3 family of amino acid transporters","volume":"447","author":"Palacin","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.3168\/jds.2017-13707_bib66","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/jcb.21904","article-title":"Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells","volume":"105","author":"Prizant","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.3168\/jds.2017-13707_bib67","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.bbrc.2003.07.015","article-title":"mTOR-mediated regulation of translation factors by amino acids","volume":"313","author":"Proud","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2017-13707_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3126\/jfstn.v8i0.11720","article-title":"Histamine in foods: Its safety and human health implications","volume":"8","author":"Rai","year":"2014","journal-title":"Journal of Food Science and Technology Nepal"},{"key":"10.3168\/jds.2017-13707_bib69","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14107","article-title":"SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1","volume":"519","author":"Rebsamen","year":"2015","journal-title":"Nature"},{"key":"10.3168\/jds.2017-13707_bib70","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: From protein synthesis to cell size","volume":"31","author":"Ruvinsky","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.3168\/jds.2017-13707_bib71","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"10.3168\/jds.2017-13707_bib72","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jds.2017-13707_bib73","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.3168\/jds.2017-13707_bib74","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1128\/MCB.21.24.8671-8683.2001","article-title":"Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation","volume":"21","author":"Tang","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.3168\/jds.2017-13707_bib75","first-page":"2162","article-title":"Effects of glycine on proliferation and apoptosis of mammary epithelial cells of dairy cows","volume":"26","author":"Tang","year":"2014","journal-title":"Chinese J. Anim. Nutr."},{"key":"10.3168\/jds.2017-13707_bib76","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3945\/jn.109.114033","article-title":"Nutritional stimulation of milk protein yield of cows is associated with changes in phosphorylation of mammary eukaryotic initiation factor 2 and ribosomal s6 kinase 1","volume":"140","author":"Toerien","year":"2010","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2017-13707_bib77","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.onc.1210693","article-title":"Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR","volume":"27","author":"Veverka","year":"2008","journal-title":"Oncogene"},{"key":"10.3168\/jds.2017-13707_bib78","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.3168\/jds.2009-2750","article-title":"Effects of dietary supplementation of methionine and lysine on milk production and nitrogen utilization in dairy cows","volume":"93","author":"Wang","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib79","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1007\/s11033-012-1561-8","article-title":"Reconstruction of metabolic network in the bovine mammary gland tissue","volume":"39","author":"Wang","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.3168\/jds.2017-13707_bib80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2017.02.084","article-title":"The effects of reduced dietary protein level on amino acid transporters and mTOR signaling pathway in pigs","volume":"485","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2017-13707_bib81","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.3168\/jds.2016-11823","article-title":"Short communication: Arginase inhibition reduces the synthesis of casein in bovine mammary epithelial cells","volume":"100","author":"Wang","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib82","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.1257132","article-title":"Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1","volume":"347","author":"Wang","year":"2015","journal-title":"Science"},{"key":"10.3168\/jds.2017-13707_bib83","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1021\/ac0713510","article-title":"Visualization of GC\/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models","volume":"80","author":"Wiklund","year":"2008","journal-title":"Anal. Chem."},{"key":"10.3168\/jds.2017-13707_bib84","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3168\/jds.S0022-0302(77)84118-0","article-title":"Valine, leucine, and isoleucine metabolism by lactating bovine mammary tissue","volume":"60","author":"Wohlt","year":"1977","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13707_bib85","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nprot.2011.319","article-title":"Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst","volume":"6","author":"Xia","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.3168\/jds.2017-13707_bib86","doi-asserted-by":"crossref","first-page":"e28174","DOI":"10.4161\/trla.28174","article-title":"Signaling crosstalk between the mTOR complexes","volume":"2","author":"Xie","year":"2014","journal-title":"Translation"},{"key":"10.3168\/jds.2017-13707_bib87","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1073\/pnas.0602282103","article-title":"TSC1\/TSC2 and Rheb have different effects on TORC1 and TORC2 activity","volume":"103","author":"Yang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2017-13707_bib88","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40104-016-0139-z","article-title":"Novel metabolic and physiological functions of branched chain amino acids: A review","volume":"8","author":"Zhang","year":"2017","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.3168\/jds.2017-13707_bib89","doi-asserted-by":"crossref","first-page":"E1636","DOI":"10.3390\/ijms17101636","article-title":"Recent advances in understanding amino acid sensing mechanisms that regulate mTORC1","volume":"17","author":"Zheng","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2017-13707_bib90","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/jpn.12246","article-title":"Effects of phenylalanine and threonine oligopeptides on milk protein synthesis in cultured bovine mammary epithelial cells","volume":"99","author":"Zhou","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218302558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218302558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218302558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:11:13Z","timestamp":1731103873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218302558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0022030218302558"],"URL":"https:\/\/doi.org\/10.3168\/jds.2017-13707","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2017-13707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}