{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:28:36Z","timestamp":1782390516067,"version":"3.54.5"},"reference-count":39,"publisher":"American Dairy Science Association","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.3168\/jds.2017-13954","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T02:31:10Z","timestamp":1522290670000},"page":"5317-5328","source":"Crossref","is-referenced-by-count":23,"title":["Nuclear factor erythroid 2-related factor 2-antioxidant activation through the action of ataxia telangiectasia-mutated serine\/threonine kinase is essential to counteract oxidative stress in bovine mammary epithelial cells"],"prefix":"10.3168","volume":"101","author":[{"given":"Y.F.","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Loor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2017-13954_bib1","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1111\/febs.13901","article-title":"Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response","volume":"283","author":"Biagiotti","year":"2016","journal-title":"FEBS J."},{"key":"10.3168\/jds.2017-13954_bib2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1006\/jmbi.1999.3310","article-title":"Sequence and structure-based prediction of eukaryotic protein phosphorylation sites","volume":"294","author":"Blom","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.3168\/jds.2017-13954_bib3","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/pmic.200300771","article-title":"Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence","volume":"4","author":"Blom","year":"2004","journal-title":"Proteomics"},{"key":"10.3168\/jds.2017-13954_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/302223","article-title":"Multiple ATM-dependent pathways: An explanation for pleiotropy","volume":"64","author":"Brown","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2017-13954_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0891-5849(94)00198-S","article-title":"Superoxide and hydrogen peroxide in relation to mammalian cell proliferation","volume":"18","author":"Burdon","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2017-13954_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jnr.22577","article-title":"Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage","volume":"89","author":"Chen","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.3168\/jds.2017-13954_bib7","doi-asserted-by":"crossref","first-page":"10805","DOI":"10.1158\/0008-5472.CAN-06-1236","article-title":"Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase\/Sp1-mediated activation of two GC-rich promoter elements","volume":"66","author":"Dasari","year":"2006","journal-title":"Cancer Res."},{"key":"10.3168\/jds.2017-13954_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40104-016-0136-2","article-title":"Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats","volume":"8","author":"Deng","year":"2017","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.3168\/jds.2017-13954_bib9","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1073\/pnas.172398899","article-title":"Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants","volume":"99","author":"Dinkova-Kostova","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2017-13954_bib10","doi-asserted-by":"crossref","first-page":"13084","DOI":"10.1073\/pnas.93.23.13084","article-title":"Pleiotropic defects in ataxia-telangiectasia protein-deficient mice","volume":"93","author":"Elson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2017-13954_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3835(01)00695-4","article-title":"Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention","volume":"174","author":"Hayes","year":"2001","journal-title":"Cancer Lett."},{"key":"10.3168\/jds.2017-13954_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"10.3168\/jds.2017-13954_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12038-012-9218-2","article-title":"DNA damage by reactive species: Mechanisms, mutation and repair","volume":"37","author":"Jena","year":"2012","journal-title":"J. Biosci."},{"key":"10.3168\/jds.2017-13954_bib14","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/jid.2011.56","article-title":"Heme oxygenase-1 protects human melanocytes from H2O2-induced oxidative stress via the Nrf2-ARE pathway","volume":"131","author":"Jian","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2017-13954_bib15","doi-asserted-by":"crossref","first-page":"2572175","DOI":"10.1155\/2016\/2572175","article-title":"Protection of bovine mammary epithelial cells from hydrogen peroxide-induced oxidative cell damage by resveratrol","volume":"2016","author":"Jin","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.3168\/jds.2017-13954_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1196\/annals.1427.036","article-title":"The Nrf2-ARE pathway: An indicator and modulator of oxidative stress in neurodegeneration","volume":"1147","author":"Johnson","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.3168\/jds.2017-13954_bib17","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.3168\/jds.2017-13954_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.3168\/jds.2017-13954_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0192623309356453","article-title":"Oxidative stress and oxidative damage in carcinogenesis","volume":"38","author":"Klaunig","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.3168\/jds.2017-13954_bib20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1074\/mcp.M115.055723","article-title":"Reactive oxygen species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen","volume":"15","author":"Kozlov","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.3168\/jds.2017-13954_bib21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrm2514","article-title":"Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer","volume":"9","author":"Lavin","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jds.2017-13954_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1089\/ars.2007.1986","article-title":"Redox signaling, vascular function, and hypertension","volume":"10","author":"Lee","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.3168\/jds.2017-13954_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3168\/jds.2017-13954_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev-animal-031412-103728","article-title":"Systems physiology in dairy cattle: Nutritional genomics and beyond","volume":"2013","author":"Loor","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.3168\/jds.2017-13954_bib25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/med.21257","article-title":"Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents","volume":"32","author":"Magesh","year":"2012","journal-title":"Med. Res. Rev."},{"key":"10.3168\/jds.2017-13954_bib26","first-page":"2032","article-title":"Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase","volume":"7","author":"Matsuda","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.3168\/jds.2017-13954_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3168\/jds.2010-3366","article-title":"Selenomethionine increases proliferation and reduces apoptosis in bovine mammary epithelial cells under oxidative stress","volume":"94","author":"Miranda","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2017-13954_bib28","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1158\/0008-5472.CAN-04-1725","article-title":"Invasive potential induced under long-term oxidative stress in mammary epithelial cells","volume":"64","author":"Mori","year":"2004","journal-title":"Cancer Res."},{"key":"10.3168\/jds.2017-13954_bib29","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.275.18.13613","article-title":"Endothelial heme oxygenase-1 induction by hypoxia","volume":"275","author":"Motterlini","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2017-13954_bib30","doi-asserted-by":"crossref","first-page":"40666","DOI":"10.1074\/jbc.M203863200","article-title":"Induction of heme oxygenase 1 by nitrosative stress. A role for nitroxyl anion","volume":"277","author":"Naughton","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2017-13954_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","article-title":"Regulation of Nrf2\u2013An update","volume":"66","author":"Niture","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2017-13954_bib32","doi-asserted-by":"crossref","first-page":"pe18","DOI":"10.1126\/scisignal.2001961","article-title":"All stressed out without ATM kinase","volume":"4","author":"Perry","year":"2011","journal-title":"Sci. Signal."},{"key":"10.3168\/jds.2017-13954_bib33","doi-asserted-by":"crossref","first-page":"e63471","DOI":"10.1371\/journal.pone.0063471","article-title":"T helper 17-associated cytokines are produced during antigen-specific inflammation in the mammary gland","volume":"8","author":"Rainard","year":"2013","journal-title":"PLoS One"},{"key":"10.3168\/jds.2017-13954_bib34","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1471-4159.2009.06552.x","article-title":"Plumbagin, a novel Nrf2\/ARE activator, protects against cerebral ischemia","volume":"112","author":"Son","year":"2010","journal-title":"J. Neurochem."},{"key":"10.3168\/jds.2017-13954_bib35","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.freeradbiomed.2011.03.008","article-title":"Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2\/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs","volume":"50","author":"Tang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2017-13954_bib36","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fimmu.2014.00493","article-title":"Bovine mastitis: Frontiers in immunogenetics","volume":"5","author":"Thompson-Crispi","year":"2014","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2017-13954_bib37","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1128\/MCB.26.8.2887-2900.2006","article-title":"Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model","volume":"26","author":"Tong","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.3168\/jds.2017-13954_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.expneurol.2014.09.021","article-title":"Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity","volume":"263","author":"Tsou","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.3168\/jds.2017-13954_bib39","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/j.febslet.2005.04.058","article-title":"Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury","volume":"579","author":"Zhu","year":"2005","journal-title":"FEBS Lett."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218302881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218302881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218302881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:11:40Z","timestamp":1731103900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218302881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0022030218302881"],"URL":"https:\/\/doi.org\/10.3168\/jds.2017-13954","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}