{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:43:46Z","timestamp":1777981426938,"version":"3.51.4"},"reference-count":50,"publisher":"American Dairy Science Association","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.3168\/jds.2018-14540","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T04:12:20Z","timestamp":1525320740000},"page":"7425-7436","source":"Crossref","is-referenced-by-count":47,"title":["Antimicrobial resistance in non-aureus staphylococci isolated from milk is associated with systemic but not intramammary administration of antimicrobials in dairy cattle"],"prefix":"10.3168","volume":"101","author":[{"given":"Diego B.","family":"Nobrega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"De Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman W.","family":"Barkema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2018-14540_bib1","doi-asserted-by":"crossref","first-page":"e00117-e17","DOI":"10.1128\/mSphere.00117-17","article-title":"Novel beta-Lactamase blaARL in Staphylococcus arlettae.","volume":"2","author":"Andreis","year":"2017","journal-title":"MSphere"},{"key":"10.3168\/jds.2018-14540_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.micpath.2014.06.005","article-title":"Molecular basis of antimicrobial drug resistance in Staphylococcus aureus isolates recovered from young healthy carriers in Spain","volume":"74","author":"Argudin","year":"2014","journal-title":"Microb. Pathog."},{"key":"10.3168\/jds.2018-14540_bib3","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.3168\/jds.2015-9377","article-title":"Invited review: Changes in the dairy industry affecting dairy cattle health and welfare","volume":"98","author":"Barkema","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.3168\/jds.2018-14540_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3164.2009.00856.x","article-title":"New concepts in antimicrobial susceptibility testing: The mutant prevention concentration and mutant selection window approach","volume":"20","author":"Blondeau","year":"2009","journal-title":"Vet. Dermatol."},{"key":"10.3168\/jds.2018-14540_bib6","series-title":"Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard\u2013Fourth edition","year":"2013"},{"key":"10.3168\/jds.2018-14540_bib7","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2016"},{"key":"10.3168\/jds.2018-14540_bib8","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.3168\/jds.2016-12478","article-title":"Prevalence of non-aureus staphylococci species causing intramammary infections in Canadian dairy herds","volume":"100","author":"Condas","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v034.i02","article-title":"Beta regression in R","volume":"34","author":"Cribari-Neto","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.3168\/jds.2018-14540_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.3168\/jds.2018-14540_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3168\/jds.2016-11476","article-title":"Coagulase-negative Staphylococcus species in bulk milk: Prevalence, distribution, and associated subgroup- and species-specific risk factors","volume":"100","author":"De Visscher","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.vetmic.2014.06.011","article-title":"Further evidence for the existence of environmental and host-associated species of coagulase-negative staphylococci in dairy cattle","volume":"172","author":"De Visscher","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2018-14540_bib13","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.3168\/jds.S0022-0302(02)74340-3","article-title":"Efficacy of systemic ceftiofur as a therapy for severe clinical mastitis in dairy cattle","volume":"85","author":"Erskine","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib14","year":"2017","journal-title":"Breakpoint tables for interpretation of MICs and zone diameters, version 7.1"},{"key":"10.3168\/jds.2018-14540_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/AAC.01310-13","article-title":"ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes","volume":"58","author":"Gupta","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.3168\/jds.2018-14540_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2460\/ajvr.70.2.198","article-title":"A metagenomic approach for determining prevalence of tetracycline resistance genes in the fecal flora of conventionally raised feedlot steers and feedlot steers raised without antimicrobials","volume":"70","author":"Harvey","year":"2009","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2018-14540_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.prevetmed.2004.04.001","article-title":"Veterinary antimicrobial-usage statistics based on standardized measures of dosage","volume":"64","author":"Jensen","year":"2004","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2018-14540_bib18","doi-asserted-by":"crossref","first-page":"D566","DOI":"10.1093\/nar\/gkw1004","article-title":"CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database","volume":"45","author":"Jia","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2018-14540_bib19","doi-asserted-by":"crossref","first-page":"e0173510","DOI":"10.1371\/journal.pone.0173510","article-title":"Fecal carriage of extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae after urinary tract infection\u2013A three year prospective cohort study","volume":"12","author":"Jorgensen","year":"2017","journal-title":"PLoS One"},{"key":"10.3168\/jds.2018-14540_bib20","first-page":"182","article-title":"Resistance of staphylococci to penicillin-G and cloxacillin","volume":"9","author":"Kimberlin","year":"1978","journal-title":"Pahlavi Med. J."},{"key":"10.3168\/jds.2018-14540_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/rda.13032","article-title":"Mastitis treatment-reduction in antibiotic usage in dairy cows","volume":"52","author":"Kromker","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"10.3168\/jds.2018-14540_bib22","doi-asserted-by":"crossref","first-page":"D574","DOI":"10.1093\/nar\/gkw1009","article-title":"MEGARes: An antimicrobial resistance database for high throughput sequencing","volume":"45","author":"Lakin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2018-14540_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13620-017-0085-x","article-title":"The RESET Mindset Model applied on decreasing antibiotic usage in dairy cattle in the Netherlands","volume":"70","author":"Lam","year":"2017","journal-title":"Ir. Vet. J."},{"key":"10.3168\/jds.2018-14540_bib24","doi-asserted-by":"crossref","first-page":"e01388-17","DOI":"10.1128\/AAC.01388-17","article-title":"Colocation of the multiresistance gene cfr and the fosfomycin resistance gene fosD on a novel plasmid in Staphylococcus arlettae from a chicken farm","volume":"61","author":"Liu","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.3168\/jds.2018-14540_bib25","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1128\/JCM.00941-10","article-title":"CTX-M1 ESBL-producing Klebsiella pneumoniae ssp. pneumoniae isolated from cases of bovine mastitis","volume":"48","author":"Locatelli","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.3168\/jds.2018-14540_bib26","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1073\/pnas.1120238109","article-title":"In-feed antibiotic effects on the swine intestinal microbiome","volume":"109","author":"Looft","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2018-14540_bib27","series-title":"Laboratory Handbook on Bovine Mastitis","year":"1999"},{"key":"10.3168\/jds.2018-14540_bib28","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.3389\/fmicb.2016.01990","article-title":"Comprehensive phylogenetic analysis of bovine non-aureus staphylococci species based on whole-genome sequencing","volume":"7","author":"Naushad","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2018-14540_bib29","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3168\/jds.S0022-0302(69)86632-4","article-title":"Control of mastitis in the dairy herd by hygiene and management","volume":"52","author":"Neave","year":"1969","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib30","doi-asserted-by":"crossref","first-page":"9736","DOI":"10.3168\/jds.2017-13116","article-title":"Comparison of treatment records and inventory of empty drug containers to quantify antimicrobial usage in dairy herds","volume":"100","author":"Nobrega","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fmicb.2018.00256","article-title":"Prevalence and genetic basis of antimicrobial resistance in non-aureus staphylococci isolated from Canadian dairy herds","volume":"9","author":"Nobrega","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2018-14540_bib32","author":"O\u2019Neill","year":"2016","journal-title":"Tackling drug-resistant infections globally: Final report and recommendations. The review on antimicrobial resistance"},{"key":"10.3168\/jds.2018-14540_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cvfa.2012.03.005","article-title":"Antimicrobial resistance of mastitis pathogens","volume":"28","author":"Oliver","year":"2012","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2018-14540_bib34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3168\/jds.S0022-0302(07)72626-7","article-title":"Treatment practices and quantification of antimicrobial drug usage in conventional and organic dairy farms in Wisconsin","volume":"90","author":"Pol","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib35","series-title":"R: A language and environment for statistical computing","year":"2017"},{"key":"10.3168\/jds.2018-14540_bib36","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3168\/jds.2010-3180","article-title":"The National Cohort of Dairy Farms\u2013a data collection platform for mastitis research in Canada","volume":"94","author":"Reyher","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib37","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1128\/AAC.45.12.3422-3426.2001","article-title":"Staphylococcus aureus mutants isolated via exposure to nonfluorinated quinolones: detection of known and unique mutations","volume":"45","author":"Roychoudhury","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.3168\/jds.2018-14540_bib38","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3168\/jds.2011-4527","article-title":"Antimicrobial use on Canadian dairy farms","volume":"95","author":"Saini","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib39","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.3168\/jds.2011-5065","article-title":"Herd-level association between antimicrobial use and antimicrobial resistance in bovine mastitis Staphylococcus aureus isolates on Canadian dairy farms","volume":"95","author":"Saini","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib40","doi-asserted-by":"crossref","first-page":"fiw001","DOI":"10.1093\/femsec\/fiw001","article-title":"The fate of antibiotic resistance genes and class 1 integrons following the application of swine and dairy manure to soils","volume":"92","author":"Sandberg","year":"2016","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.3168\/jds.2018-14540_bib41","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.3168\/jds.2015-9963","article-title":"Effect of different scenarios for selective dry-cow therapy on udder health, antimicrobial usage, and economics","volume":"99","author":"Scherpenzeel","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib42","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.3168\/jds.2013-6713","article-title":"Noninferiority trial comparing a first-generation cephalosporin with a third-generation cephalosporin in the treatment of nonsevere clinical mastitis in dairy cows","volume":"96","author":"Schukken","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib43","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.3168\/jds.2017-13365","article-title":"Antimicrobial consumption on dairy herds and its association with antimicrobial inhibition zone diameters of non-aureus staphylococci and Staphylococcus aureus isolated from subclinical mastitis","volume":"101","author":"Stevens","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-14540_bib44","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2542-5196(17)30141-9","article-title":"Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planet Health"},{"key":"10.3168\/jds.2018-14540_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.vetmic.2006.01.013","article-title":"Pheno- and genotyping of Staphylococcus epidermidis isolated from bovine milk and human skin","volume":"115","author":"Thorberg","year":"2006","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2018-14540_bib46","first-page":"41","article-title":"Antibiotic resistance of Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis","volume":"50","author":"Turutoglu","year":"2006","journal-title":"Bull. Vet. Inst. Pulawy."},{"key":"10.3168\/jds.2018-14540_bib47","series-title":"Modern Applied Statistics with S","author":"Venables","year":"2002"},{"key":"10.3168\/jds.2018-14540_bib48","year":"2016","journal-title":"Critically important antimicrobials for human medicine\u20135th revision. World Health Organization, Geneva, Switzerland"},{"key":"10.3168\/jds.2018-14540_bib49","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.3168\/jds.2018-14540_bib50","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1128\/AAC.00670-13","article-title":"Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota","volume":"57","author":"Zhang","year":"2013","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218304120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218304120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218304120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:18:08Z","timestamp":1731100688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218304120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0022030218304120"],"URL":"https:\/\/doi.org\/10.3168\/jds.2018-14540","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}