{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:31:30Z","timestamp":1790703090549,"version":"4.1.0"},"reference-count":35,"publisher":"American Dairy Science Association","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.3168\/jds.2018-15034","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T09:26:18Z","timestamp":1537435578000},"page":"11321-11329","source":"Crossref","is-referenced-by-count":18,"title":["Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro"],"prefix":"10.3168","volume":"101","author":[{"given":"Denisa","family":"Dan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert M.","family":"Bruckmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Wellnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2018-15034_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1017\/S0022029910000786","article-title":"Natural variation in biomarkers indicating mastitis in healthy cows","volume":"78","author":"Akerstedt","year":"2011","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2018-15034_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/CDLI.11.3.463-472.2004","article-title":"Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection","volume":"11","author":"Bannerman","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.3168\/jds.2018-15034_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/vr.163.17.506","article-title":"Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis","volume":"163","author":"Banting","year":"2008","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2018-15034_bib4","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0006-2952(01)00610-4","article-title":"Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers","volume":"61","author":"Bizzarri","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.3168\/jds.2018-15034_bib5","first-page":"374","article-title":"Escherichia coli endotoxin-induced mastitis in dairy cows: Changes and importance of insulin-like growth factor I and oxytocin","volume":"48","author":"Bruckmaier","year":"1993","journal-title":"Milchwissenschaft"},{"key":"10.3168\/jds.2018-15034_bib6","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.2527\/jas2017.1845","article-title":"Pathogen-specific immune response and changes in the blood-milk barrier of the bovine mammary gland","volume":"95","author":"Bruckmaier","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2018-15034_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0749-0720(02)00073-7","article-title":"Immunity and mastitis. Some new ideas for an old disease","volume":"19","author":"Burton","year":"2003","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2018-15034_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2885.2012.01396.x","article-title":"Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows","volume":"36","author":"Donalisio","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2018-15034_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/vr.148.2.35","article-title":"Acute phase proteins in serum and milk from dairy cows with clinical mastitis","volume":"148","author":"Eckersall","year":"2001","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2018-15034_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-213X-5-27","article-title":"Selection of reference genes for quantitative real-time PCR in bovine preimplantation embryos","volume":"5","author":"Goossens","year":"2005","journal-title":"BMC Dev. Biol."},{"key":"10.3168\/jds.2018-15034_bib11","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.3168\/jds.2007-0752","article-title":"Staphylococcus aureus and Escherichia coli cause deviating expression profiles of cytokines and lactoferrin messenger ribonucleic acid in mammary epithelial cells","volume":"91","author":"Griesbeck-Zilch","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib12","first-page":"551","article-title":"Effects of ketoprofen on cellular immune responses in mice","volume":"47","author":"Hamdani","year":"2015","journal-title":"Pak. J. Zool."},{"key":"10.3168\/jds.2018-15034_bib13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/j.1875-9114.1986.tb03459.x","article-title":"Ketoprofen: A review of its pharmacologic and clinical properties","volume":"6","author":"Kantor","year":"1986","journal-title":"Pharmacotherapy"},{"key":"10.3168\/jds.2018-15034_bib14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.3168\/jds.2016-11708","article-title":"Antimicrobial treatment of clinical mastitis in the eastern United States: The influence of dairy farmers' mastitis management and treatment behavior and attitudes","volume":"100","author":"Kayitsinga","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3168\/jds.2012-5410","article-title":"Concomitant lipopolysaccharide-induced transfer of blood-derived components including immunoglobulins into milk","volume":"96","author":"Lehmann","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1093-3263(01)00135-8","article-title":"Differential binding mode of diverse cyclooxygenase inhibitors","volume":"20","author":"Llorens","year":"2002","journal-title":"J. Mol. Graph. Model."},{"key":"10.3168\/jds.2018-15034_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.1980.sp013494","article-title":"Local production of prostaglandins in relation to mammary function at the onset of lactation in the goat","volume":"309","author":"Maule Walker","year":"1980","journal-title":"J. Physiol."},{"key":"10.3168\/jds.2018-15034_bib18","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.3168\/jds.2009-2284","article-title":"Effect of treatment with the nonsteroidal anti-inflammatory meloxicam on milk production, somatic cell count, probability of re-treatment, and culling of dairy cows with mild clinical mastitis","volume":"92","author":"McDougall","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.domaniend.2009.10.001","article-title":"Adipose tissue depots of Holstein cows are immune responsive: Inflammatory gene expression in vitro","volume":"38","author":"Mukesh","year":"2010","journal-title":"Domest. Anim. Endocrinol."},{"issue":"Suppl. 4","key":"10.3168\/jds.2018-15034_bib20","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1186\/2046-0481-62-S4-S15","article-title":"Nutrition and udder health in dairy cows: A review","volume":"62","author":"O'Rourke","year":"2009","journal-title":"Ir. Vet. J."},{"key":"10.3168\/jds.2018-15034_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3168\/jds.S0022-0302(03)73632-7","article-title":"Gene expression of immunologically important factors in blood cells, milk cells, and mammary tissue of cows","volume":"86","author":"Pfaffl","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vetimm.2016.01.007","article-title":"Immunomodulatory properties of gamithromycin and ketoprofen in lipopolysaccharide-challenged calves with emphasis on the acute-phase response","volume":"171","author":"Plessers","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2018-15034_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1051\/vetres:2006007","article-title":"Innate immunity of the bovine mammary gland","volume":"37","author":"Rainard","year":"2006","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2018-15034_bib24","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.3168\/jds.2018-15034_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1017\/S0022029905001317","article-title":"Distribution of leucocyte populations, and milk composition, in milk fractions of healthy quarters in dairy cows","volume":"72","author":"Sarikaya","year":"2005","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2018-15034_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.domaniend.2003.09.003","article-title":"Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis","volume":"26","author":"Schmitz","year":"2004","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.3168\/jds.2018-15034_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0034-5288(94)90197-X","article-title":"Anti-inflammatory ketoprofen in the treatment of field cases of bovine mastitis","volume":"56","author":"Shpigel","year":"1994","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2018-15034_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1020347818725","article-title":"Mammary gland immunity and mastitis susceptibility","volume":"7","author":"Sordillo","year":"2002","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.3168\/jds.2018-15034_bib29","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.3168\/jds.S0022-0302(94)77301-X","article-title":"Effect of milking frequency and somatotropin on the activity of plasminogen activator, plasminogen, and plasmin in bovine milk","volume":"77","author":"Stelwagen","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0022-3565(25)23646-1","article-title":"Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats","volume":"248","author":"Vannier","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.3168\/jds.2018-15034_bib31","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.3168\/jds.2010-3931","article-title":"Lipopolysaccharide and lipoteichoic acid induce different immune responses in the bovine mammary gland","volume":"94","author":"Wellnitz","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.vetimm.2004.04.019","article-title":"Cryopreserved bovine mammary cells to model epithelial response to infection","volume":"101","author":"Wellnitz","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2018-15034_bib33","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.3168\/jds.2016-10927","article-title":"Short communication: Differential loss of bovine mammary epithelial barrier integrity in response to lipopolysaccharide and lipoteichoic acid","volume":"99","author":"Wellnitz","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib34","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.3168\/jds.2011-5064","article-title":"The effects of experimentally induced Escherichia coli mastitis and flunixin meglumine administration on activity measures, feed intake, and milk parameters","volume":"95","author":"Yeiser","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15034_bib35","doi-asserted-by":"crossref","first-page":"e87374","DOI":"10.1371\/journal.pone.0087374","article-title":"The inflammatory response of primary bovine mammary epithelial cells to Staphylococcus aureus strains is linked to the bacterial phenotype","volume":"9","author":"Zbinden","year":"2014","journal-title":"PLoS One"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218308658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030218308658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218308658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:25:32Z","timestamp":1751934332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030218308658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0022030218308658"],"URL":"https:\/\/doi.org\/10.3168\/jds.2018-15034","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}