{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:04:28Z","timestamp":1792746268096,"version":"4.5.0"},"reference-count":38,"publisher":"American Dairy Science Association","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.3168\/jds.2018-15445","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T05:00:10Z","timestamp":1550120410000},"page":"3431-3438","source":"Crossref","is-referenced-by-count":23,"title":["Acute pain responses in dairy calves undergoing cornual nerve blocks with or without topical anesthetic"],"prefix":"10.3168","volume":"102","author":[{"given":"Reyna E.","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.J.","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra B.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2018-15445_bib1","article-title":"Topical lidocaine-prilocaine cream versus lidocaine infiltration for pain relief during repair of perineal tears after vaginal delivery: Randomized clinical trial","author":"Abbas","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.3168\/jds.2018-15445_bib2","first-page":"588","article-title":"The effects of an oral distraction on cattle during a painful procedure","volume":"54","author":"Aitken","year":"2013","journal-title":"Can. Vet. J."},{"key":"10.3168\/jds.2018-15445_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/bja\/64.2.173","article-title":"Depth and duration of skin analgesia to needle insertion after topical application of EMLA cream","volume":"64","author":"Bjerring","year":"1990","journal-title":"Br. J. Anaesth."},{"key":"10.3168\/jds.2018-15445_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2165\/00003495-199346010-00008","article-title":"Eutectic lidocaine\/prilocaine cream","volume":"46","author":"Buckley","year":"1993","journal-title":"Drugs"},{"key":"10.3168\/jds.2018-15445_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1037\/0278-6133.18.6.591","article-title":"Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations","volume":"18","author":"Cohen","year":"1999","journal-title":"Health Psychol."},{"key":"10.3168\/jds.2018-15445_bib6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/vaa.12177","article-title":"The use of eutectic mixture of lidocaine and prilocaine in mice (Mus musculus) for tail vein injections","volume":"41","author":"David","year":"2014","journal-title":"Vet. Anaesth. Analg."},{"key":"10.3168\/jds.2018-15445_bib7","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1038\/s41598-018-27669-7","article-title":"Approach-aversion in calves following injections","volume":"8","author":"Ede","year":"2018","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2018-15445_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2885.2005.00657.x","article-title":"Comparison of topical lidocaine\/prilocaine anesthetic cream and local infiltration of 2% lidocaine for episioplasty in mares","volume":"28","author":"Erkert","year":"2005","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2018-15445_bib9","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3168\/jds.2012-5954","article-title":"The effect of a topical anesthetic on the sensitivity of calf dehorning wounds","volume":"96","author":"Espinoza","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15445_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1467-2995.2012.00717.x","article-title":"Onset, duration and efficacy of four methods of local anesthesia of the horn bud in calves","volume":"39","author":"Fierheller","year":"2012","journal-title":"Vet. Anaesth. Analg."},{"key":"10.3168\/jds.2018-15445_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1258\/002367790780890121","article-title":"The use of lignocaine-prilocaine local anaesthetic cream for pain-free venepuncture in laboratory animals","volume":"24","author":"Flecknell","year":"1990","journal-title":"Lab. Anim."},{"key":"10.3168\/jds.2018-15445_bib12","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/2041-210X.12584","article-title":"BORIS: A free, versatile open-source event-logging software for video\/audio coding and live observations","volume":"7","author":"Friard","year":"2016","journal-title":"Methods Ecol. Evol."},{"key":"10.3168\/jds.2018-15445_bib13","first-page":"1019","article-title":"Topical anesthetics update: EMLA and beyond","volume":"27","author":"Friedman","year":"2001","journal-title":"Dermatol. Surg."},{"key":"10.3168\/jds.2018-15445_bib14","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1016\/j.vaccine.2012.03.085","article-title":"Immunization site pain: Case definition and guidelines for collection, analysis, and presentation of immunization safety data","volume":"30","author":"Gidudu","year":"2012","journal-title":"Vaccine"},{"key":"10.3168\/jds.2018-15445_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.applanim.2017.10.001","article-title":"Evaluation of visible eye white and maximum eye temperature as non-invasive indicators of stress in dairy cows","volume":"198","author":"G\u00f3mez","year":"2018","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.3168\/jds.2018-15445_bib16","doi-asserted-by":"crossref","first-page":"e44437","DOI":"10.1371\/journal.pone.0044437","article-title":"Evaluation of EMLA cream for preventing pain during tattooing of rabbits: Changes in physiological, behavioural and facial expression responses","volume":"7","author":"Keating","year":"2012","journal-title":"PLoS One"},{"key":"10.3168\/jds.2018-15445_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1017\/S1751731113002140","article-title":"Welfare implication of measuring heart rate and heart rate variability in dairy cattle: Literature review and conclusions for future research","volume":"8","author":"Kov\u00e1cs","year":"2014","journal-title":"Animal"},{"key":"10.3168\/jds.2018-15445_bib18","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.2527\/jas.2012-5984","article-title":"Topical anesthesia mitigates the pain of castration in beef calves","volume":"91","author":"Lomax","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2018-15445_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/15374416.2013.843464","article-title":"Low vagal tone magnifies the association between psychosocial stress exposure and internalizing psychopathology in adolescents","volume":"44","author":"McLaughlin","year":"2015","journal-title":"J. Clin. Child Adolesc. Psychol."},{"key":"10.3168\/jds.2018-15445_bib20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2044.2006.04901.x","article-title":"Mechanisms influencing the vasoactive effects of lidocaine in human skin","volume":"62","author":"Newton","year":"2007","journal-title":"Anaesthesia"},{"key":"10.3168\/jds.2018-15445_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00006565-199102000-00004","article-title":"Comparison of topical mixture of lidocaine and prilocaine (EMLA) versus 1% lidocaine infiltration on wound healing","volume":"7","author":"Nykanen","year":"1991","journal-title":"Pediatr. Emerg. Care"},{"key":"10.3168\/jds.2018-15445_bib22","author":"Pinheiro"},{"key":"10.3168\/jds.2018-15445_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0736-4679(91)90414-B","article-title":"Damage to tissue defenses by EMLA cream","volume":"9","author":"Powell","year":"1991","journal-title":"J. Emerg. Med."},{"key":"10.3168\/jds.2018-15445_bib24","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"10.3168\/jds.2018-15445_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1525-1470.1998.1998015309.x","article-title":"EMLA cream provides rapid pain relief for the curettage of molluscum contagiosum in children with atopic dermatitis without causing serious application-site reactions","volume":"15","author":"R\u00f6nnerf\u00e4lt","year":"1998","journal-title":"Pediatr. Dermatol."},{"key":"10.3168\/jds.2018-15445_bib26","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1097\/AJP.0000000000000281","article-title":"Pharmacological and combined interventions to reduce vaccine injection pain in children and adults: Systematic review and meta-analysis","volume":"31","author":"Shah","year":"2015","journal-title":"Clin. J. Pain"},{"key":"10.3168\/jds.2018-15445_bib27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.physbeh.2007.11.044","article-title":"Eye temperature and heart rate variability of calves disbudded with or without local anaesthetic","volume":"93","author":"Stewart","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.3168\/jds.2018-15445_bib28","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3168\/jds.2008-1578","article-title":"Effects of local anesthetic and a nonsteroidal antiinflammatory drug on pain responses of dairy calves to hot-iron dehorning","volume":"92","author":"Stewart","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15445_bib29","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.3168\/jds.2010-3114","article-title":"Noninvasive assessment of autonomic activity for evaluation of pain in calves, using surgical castration as a model","volume":"93","author":"Stewart","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2018-15445_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cvfa.2012.11.001","article-title":"Bovine dehorning: Assessing pain and providing analgesic management","volume":"29","author":"Stock","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2018-15445_bib31","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1503\/cmaj.150391","article-title":"Reducing pain during vaccine injections: Clinical practice guideline","volume":"187","author":"Taddio","year":"2015","journal-title":"CMAJ"},{"key":"10.3168\/jds.2018-15445_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cmpb.2013.07.024","article-title":"Kubios HRV\u2014Heart rate variability analysis software","volume":"113","author":"Tarvainen","year":"2014","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.3168\/jds.2018-15445_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3959(02)00007-6","article-title":"Cognitive modulation of pain: How do attention and emotion influence pain processing?","volume":"95","author":"Villemure","year":"2002","journal-title":"Pain"},{"key":"10.3168\/jds.2018-15445_bib34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.physbeh.2007.01.007","article-title":"Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals\u2014A review","volume":"92","author":"von Borell","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.3168\/jds.2018-15445_bib35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.applanim.2006.04.013","article-title":"Identifying and preventing pain in animals","volume":"100","author":"Weary","year":"2006","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.3168\/jds.2018-15445_bib36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/00365598909180341","article-title":"Repeated application of EMLA cream 5% for the alleviation of cannulation pain in haemodialysis","volume":"23","author":"Wehle","year":"1989","journal-title":"Scand. J. Urol. Nephrol."},{"key":"10.3168\/jds.2018-15445_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.physbeh.2013.05.013","article-title":"An assessment of the aversive nature of an animal management procedure (clipping) using behavioral and physiological measures","volume":"118","author":"Yarnell","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.3168\/jds.2018-15445_bib38","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1129729818768182","article-title":"Evaluation of EMLA cream for relieving pain during needle insertion on totally implantable venous access device","volume":"19","author":"Yin","year":"2018","journal-title":"J. Vasc. Access"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203021930147X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203021930147X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203021930147X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:26:01Z","timestamp":1731101161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203021930147X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S002203021930147X"],"URL":"https:\/\/doi.org\/10.3168\/jds.2018-15445","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}