{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:01:08Z","timestamp":1768482068155,"version":"3.49.0"},"reference-count":57,"publisher":"American Dairy Science Association","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.3168\/jds.2019-16335","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T21:44:44Z","timestamp":1567719884000},"page":"10316-10328","source":"Crossref","is-referenced-by-count":17,"title":["Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle II: Postpartum uterine health, ketosis, and milk production"],"prefix":"10.3168","volume":"102","author":[{"given":"M.","family":"Zinicola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.S.","family":"Bicalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Santin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.C.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.S.","family":"Bisinotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-1981","authenticated-orcid":false,"given":"R.C.","family":"Bicalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2019-16335_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.nu.13.070193.002253","article-title":"Effects of exogenous bovine somatotropin on lactation","volume":"13","author":"Bauman","year":"1993","journal-title":"Annu. Rev. Nutr."},{"key":"10.3168\/jds.2019-16335_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1026336505343","article-title":"Adaptations of glucose metabolism during pregnancy and lactation","volume":"2","author":"Bell","year":"1997","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.3168\/jds.2019-16335_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S8756-3282(03)00086-3","article-title":"Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease","volume":"33","author":"Bendre","year":"2003","journal-title":"Bone"},{"key":"10.3168\/jds.2019-16335_bib4","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.3168\/jds.2013-7832","article-title":"Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle","volume":"97","author":"Bicalho","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.vetmic.2011.11.034","article-title":"Association between virulence factors of Escherichia coli, Fusobacterium necrophorum, and Arcanobacterium pyogenes and uterine diseases of dairy cows","volume":"157","author":"Bicalho","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2019-16335_bib6","first-page":"10304","volume":"102","author":"Bicalho","year":"2019","journal-title":"Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle I: Production and functional characterization of rbIL-8 in vitro and in vivo."},{"key":"10.3168\/jds.2019-16335_bib7","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1091\/mbc.12.5.1445","article-title":"Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium","volume":"12","author":"Brantley","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.3168\/jds.2019-16335_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(01)00599-2","article-title":"IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development","volume":"107","author":"Cao","year":"2001","journal-title":"Cell"},{"key":"10.3168\/jds.2019-16335_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2119\/2005-00029.Saltiel","article-title":"Insulin signaling and the regulation of glucose transport","volume":"10","author":"Chang","year":"2004","journal-title":"Mol. Med."},{"key":"10.3168\/jds.2019-16335_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00024382-199810000-00004","article-title":"Proliferative effects of CXC chemokines in rat hepatocytes in vitro and in vivo","volume":"10","author":"Colletti","year":"1998","journal-title":"Shock"},{"key":"10.3168\/jds.2019-16335_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cvfa.2013.04.002","article-title":"Insulin resistance in dairy cows","volume":"29","author":"De Koster","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2019-16335_bib12","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3168\/jds.S0022-0302(99)75474-3","article-title":"ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: the final frontier?","volume":"82","author":"Drackley","year":"1999","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib13","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3168\/jds.S0022-0302(89)79081-0","article-title":"A body condition scoring chart for Holstein dairy cows","volume":"72","author":"Edmonson","year":"1989","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1055\/s-0030-1261872","article-title":"Insulin resistance and increased lipolysis in bone marrow derived adipocytes stimulated with agonists of Toll-like receptors","volume":"42","author":"Franchini","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"10.3168\/jds.2019-16335_bib16","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.3168\/jds.S0022-0302(03)74003-X","article-title":"Fertility of dairy cows after resynchronization of ovulation at three intervals following first timed insemination","volume":"86","author":"Fricke","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/me.2002-0131","article-title":"Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3\u2013L1 adipocytes","volume":"17","author":"Fujishiro","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.3168\/jds.2019-16335_bib18","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3168\/jds.2009-2551","article-title":"Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows","volume":"93","author":"Galvao","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib19","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.theriogenology.2005.04.022","article-title":"Prevalence of endometritis and its effects on reproductive performance of dairy cows","volume":"64","author":"Gilbert","year":"2005","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2019-16335_bib20","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3168\/jds.S0022-0302(97)76055-7","article-title":"Physiological changes at parturition and their relationship to metabolic disorders","volume":"80","author":"Goff","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib21","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3168\/jds.S0022-0302(00)74989-7","article-title":"Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation","volume":"83","author":"Greenfield","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetimm.2006.03.022","article-title":"Neutrophil function and energy status in Holstein cows with uterine health disorders","volume":"113","author":"Hammon","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2019-16335_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4142\/jvs.2005.6.1.53","article-title":"Risk factors for retained placenta and the effect of retained placenta on the occurrence of postpartum diseases and subsequent reproductive performance in dairy cows","volume":"6","author":"Han","year":"2005","journal-title":"J. Vet. Sci."},{"key":"10.3168\/jds.2019-16335_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.soard.2010.05.013","article-title":"Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity","volume":"7","author":"Hardy","year":"2011","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.3168\/jds.2019-16335_bib25","series-title":"Encyclopedia of Immunology","author":"Hiemstra","year":"1998"},{"key":"10.3168\/jds.2019-16335_bib26","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1096\/fasebj.13.12.1565","article-title":"Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines","volume":"13","author":"Hogaboam","year":"1999","journal-title":"FASEB J."},{"key":"10.3168\/jds.2019-16335_bib27","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1840701","article-title":"Structure and functional expression of a human interleukin-8 receptor","volume":"253","author":"Holmes","year":"1991","journal-title":"Science"},{"key":"10.3168\/jds.2019-16335_bib28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/cbin.10294","article-title":"IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor","volume":"38","author":"Hou","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.3168\/jds.2019-16335_bib29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1439-0450.1989.tb00657.x","article-title":"Bovine uterine defense-mechanisms - A review","volume":"36","author":"Hussain","year":"1989","journal-title":"J. Vet. Med. B Infect. Dis. Vet. Public Health"},{"key":"10.3168\/jds.2019-16335_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1447-0756.1988.tb00122.x","article-title":"The role of human neutrophil elastase in the premature rupture of membranes","volume":"14","author":"Kanayama","year":"1988","journal-title":"Asia Oceania J. Obstet. Gynaecol."},{"key":"10.3168\/jds.2019-16335_bib31","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3168\/jds.S0022-0302(89)79223-7","article-title":"Periparturient hypocalcemia in cows - Effects on peripheral blood neutrophil and lymphocyte function","volume":"72","author":"Kehrli","year":"1989","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3168\/jds.S0022-0302(02)74107-6","article-title":"Decreased neutrophil function as a cause of retained placenta in dairy cattle","volume":"85","author":"Kimura","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-9255-6-25","article-title":"Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway","volume":"6","author":"Kobashi","year":"2009","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.3168\/jds.2019-16335_bib34","doi-asserted-by":"crossref","first-page":"31372","DOI":"10.1074\/jbc.271.49.31372","article-title":"Expression of a constitutively active Akt Ser\/Thr kinase in 3T3\u2013L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation","volume":"271","author":"Kohn","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2019-16335_bib35","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1074\/jbc.C800207200","article-title":"CXCL8\/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3\/Bcl10\/Malt1) complex","volume":"284","author":"Martin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2019-16335_bib36","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.3168\/jds.2016-11295","article-title":"Increasing palmitic acid intake enhances milk production and prevents glucose-stimulated fatty acid disappearance without modifying systemic glucose tolerance in mid-lactation dairy cows","volume":"99","author":"Mathews","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0022-2275(20)38845-3","article-title":"Adaptations in lipid metabolism of bovine adipose tissue in lactogenesis and lactation","volume":"27","author":"McNamara","year":"1986","journal-title":"J. Lipid Res."},{"key":"10.3168\/jds.2019-16335_bib38","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1128\/IAI.71.4.1643-1649.2003","article-title":"Effect of interleukin-8 and granulocyte colony-stimulating factor on priming and activation of bovine neutrophils","volume":"71","author":"Mitchell","year":"2003","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2019-16335_bib39","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3168\/jds.S0022-0302(01)74600-0","article-title":"Effects of presynchronization and bovine somatotropin on pregnancy rates to a timed artificial insemination protocol in lactating dairy cows","volume":"84","author":"Moreira","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib40","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2019-16335_bib41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0165-6147(02)02064-3","article-title":"Chemokines, chemokine receptors and small-molecule antagonists: Recent developments","volume":"23","author":"Onuffer","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.3168\/jds.2019-16335_bib42","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1128\/IAI.70.11.6294-6301.2002","article-title":"Tumor necrosis factor alpha-induced interleukin-8 production via NF-B and phosphatidylinositol 3-kinase\/Akt pathways inhibits cell apoptosis in human hepatocytes","volume":"70","author":"Osawa","year":"2002","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2019-16335_bib43","series-title":"Proc. Dairy Cattle Reprod. Council Conv., Omaha, NE","first-page":"39","article-title":"Economics of postpartum uterine health","author":"Overton","year":"2008"},{"key":"10.3168\/jds.2019-16335_bib44","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0093-691X(95)00279-H","article-title":"Synchronization of ovulation in dairy cows using PGF2alpha and GnRH","volume":"44","author":"Pursley","year":"1995","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2019-16335_bib45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1515\/jpme.1998.26.6.437","article-title":"The importance of extracellular matrix in the induction of preterm delivery","volume":"26","author":"Rath","year":"1998","journal-title":"J. Perinat. Med."},{"key":"10.3168\/jds.2019-16335_bib46","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3168\/jds.S0022-0302(03)73704-7","article-title":"Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation","volume":"86","author":"Reynolds","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-16335_bib47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1677\/JOE-07-0068","article-title":"Effect of nutrition on the GH responsiveness of liver and adipose tissue in dairy cows","volume":"195","author":"Rhoads","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.3168\/jds.2019-16335_bib48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cytogfr.2006.09.008","article-title":"Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions","volume":"17","author":"Rico-Bautista","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.3168\/jds.2019-16335_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1469780","article-title":"Neutrophils: Their role in innate and adaptive immunity","volume":"2016","author":"Rosales","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.3168\/jds.2019-16335_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086211","article-title":"Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots","volume":"9","author":"Saremi","year":"2014","journal-title":"PLoS One"},{"key":"10.3168\/jds.2019-16335_bib51","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/physiolgenomics.00115.2013","article-title":"Prepartal dietary energy alters transcriptional adaptations of the liver and subcutaneous adipose tissue of dairy cows during the transition period","volume":"46","author":"Selim","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2019-16335_bib52","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2019-16335_bib53","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2460\/ajvr.1996.57.11.1569","article-title":"Bacterial growth, inflammatory cytokine production, and neutrophil recruitment during coliform mastitis in cows within ten days after calving, compared with cows at midlactation","volume":"57","author":"Shuster","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2019-16335_bib54","doi-asserted-by":"crossref","first-page":"46171","DOI":"10.1074\/jbc.M308545200","article-title":"Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells","volume":"278","author":"Srivastava","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2019-16335_bib55","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.4049\/jimmunol.173.5.3243","article-title":"The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression","volume":"173","author":"Stevenson","year":"2004","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2019-16335_bib56","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","article-title":"The functional role of the ELR motif in CXC chemokine-mediated angiogenesis","volume":"270","author":"Strieter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2019-16335_bib57","series-title":"Methods of Enzymatic Analysis","first-page":"1836","article-title":"D-(-)-3-hydroxybutyrate","author":"Williamson","year":"1974"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030219307751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030219307751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030219307751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:36:51Z","timestamp":1731101811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030219307751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0022030219307751"],"URL":"https:\/\/doi.org\/10.3168\/jds.2019-16335","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}