{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:27:42Z","timestamp":1790004462543,"version":"4.0.1"},"reference-count":36,"publisher":"American Dairy Science Association","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.3168\/jds.2019-17594","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T20:35:15Z","timestamp":1585341315000},"page":"4919-4928","source":"Crossref","is-referenced-by-count":50,"title":["Purification and characterization of angiotensin-I-converting enzyme inhibitory peptides isolated from whey proteins of milk fermented with Lactobacillus plantarum QS670"],"prefix":"10.3168","volume":"103","author":[{"given":"Yanan","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-4274","authenticated-orcid":false,"given":"Weihan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-7384","authenticated-orcid":false,"given":"Quan","family":"Shuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2019-17594_bib1","doi-asserted-by":"crossref","first-page":"E164","DOI":"10.3390\/biom9050164","article-title":"Encapsulation of antihypertensive peptides from whey proteins and their releasing in gastrointestinal conditions","volume":"9","author":"Alvarado","year":"2019","journal-title":"Biomolecules"},{"key":"10.3168\/jds.2019-17594_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.foodres.2010.02.013","article-title":"Three novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) using digestive proteases","volume":"43","author":"Balti","year":"2010","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2019-17594_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jprot.2013.06.023","article-title":"Peptides with angiotensin I converting enzyme (ACE) inhibitory activity generated from porcine skeletal muscle proteins by the action of meat-borne Lactobacillus.","volume":"89","author":"Castellano","year":"2013","journal-title":"J. Proteomics"},{"key":"10.3168\/jds.2019-17594_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/1541-4337.12017","article-title":"Identification of bioactive peptides from cereal storage proteins and their potential role in prevention of chronic diseases","volume":"12","author":"Cavazos","year":"2013","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.3168\/jds.2019-17594_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.fm.2014.03.005","article-title":"Impact of microbial cultures on proteolysis and release of bioactive peptides in fermented milk","volume":"42","author":"Chaves-L\u00f3pez","year":"2014","journal-title":"Food Microbiol."},{"key":"10.3168\/jds.2019-17594_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0021-9258(19)86187-2","article-title":"Binding of peptide substrates and inhibitors of angiotensin-converting enzyme","volume":"255","author":"Cheung","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2019-17594_bib7","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem. Pharmacol."},{"key":"10.3168\/jds.2019-17594_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/0974-8520.175534","article-title":"Antihypertensive peptides from curd","volume":"36","author":"Dabarera","year":"2015","journal-title":"Ayu"},{"key":"10.3168\/jds.2019-17594_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lwt.2018.03.026","article-title":"Novel angiotensin I-converting enzyme inhibitory peptides from soybean protein isolates fermented by Pediococcus pentosaceus SDL1409","volume":"93","author":"Daliri","year":"2018","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2019-17594_bib10","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1021\/bi00439a001","article-title":"Angiotensin-converting enzyme: New concepts concerning its biological role","volume":"28","author":"Ehlers","year":"1989","journal-title":"Biochemistry"},{"key":"10.3168\/jds.2019-17594_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.foodchem.2014.03.117","article-title":"Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion","volume":"161","author":"Escudero","year":"2014","journal-title":"Food Chem."},{"key":"10.3168\/jds.2019-17594_bib12","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1002\/jcb.27203","article-title":"Generation of tolerogenic dendritic cells using Lactobacillus rhamnosus and Lactobacillus delbrueckii as tolerogenic probiotics","volume":"119","author":"Esmaeili","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.3168\/jds.2019-17594_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.foodres.2019.05.009","article-title":"Peptide profile of Camembert-type cheese: Effect of heat treatment and adjunct culture Lactobacillus rhamnosus GG","volume":"123","author":"Galli","year":"2019","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2019-17594_bib14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.foodres.2009.12.012","article-title":"Impact of processing on stability of angiotensin I-converting enzyme (ACE) inhibitory peptides obtained from tuna cooking juice","volume":"43","author":"Hwang","year":"2010","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2019-17594_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2016.12.002","article-title":"Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk","volume":"8","author":"Ibrahim","year":"2017","journal-title":"J. Adv. Res."},{"key":"10.3168\/jds.2019-17594_bib16","first-page":"441","article-title":"Animal and plant proteins as precursors of peptides with ACE inhibitory activity\u2014An in silico strategy of protein evaluation","volume":"47","author":"Iwaniak","year":"2009","journal-title":"Food Technol. Biotechnol."},{"key":"10.3168\/jds.2019-17594_bib17","first-page":"118","article-title":"BIOPEP-PBIL tool for the analysis of the structure of biologically active motifs derived from food proteins","volume":"49","author":"Iwaniak","year":"2011","journal-title":"Food Technol. Biotechnol."},{"key":"10.3168\/jds.2019-17594_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phrs.2018.07.006","article-title":"The anti-inflammatory peptide Ac-SDKP: Synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases","volume":"134","author":"Kumar","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.3168\/jds.2019-17594_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/1082013205056781","article-title":"Mung-bean protein hydrolysates obtained with Alcalase exhibit angiotensin I-converting enzyme inhibitory activity","volume":"11","author":"Li","year":"2005","journal-title":"Food Sci. Technol. Int."},{"key":"10.3168\/jds.2019-17594_bib20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.lwt.2018.08.045","article-title":"Optimization of ACE inhibitory peptides from black soybean by microwave-assisted enzymatic method and study on its stability","volume":"98","author":"Li","year":"2018","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2019-17594_bib21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s10068-014-0138-9","article-title":"Identification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide (ACEIP) from silkworm pupa","volume":"23","author":"Li","year":"2014","journal-title":"Food Sci. Biotechnol."},{"key":"10.3168\/jds.2019-17594_bib22","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1128\/AEM.69.9.5297-5305.2003","article-title":"Angiotensin I-converting-enzyme-inhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species","volume":"69","author":"Minervini","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.3168\/jds.2019-17594_bib23","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3168\/jds.S0022-0302(95)76745-5","article-title":"Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme","volume":"78","author":"Nakamura","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17594_bib24","series-title":"Methods of Peptide Synthesis","first-page":"317","article-title":"Solid phase peptide synthesis","author":"Schroder","year":"1965"},{"key":"10.3168\/jds.2019-17594_bib25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ajcn\/77.2.326","article-title":"A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects","volume":"77","author":"Seppo","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2019-17594_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/19476337.2019.1575909","article-title":"Effect of processing conditions and simulated gastrointestinal digestion on the activity of angiotensin I-converting enzyme (ACE) inhibitory peptide derived from duck meat hydrolysate","volume":"17","author":"Shi","year":"2019","journal-title":"CYTA J. Food"},{"key":"10.3168\/jds.2019-17594_bib27","first-page":"181","article-title":"Antihypertensive effects of yogurt fermented with Lactobacillus plantarum QS670 in spontaneously hypertensive rats. Food","volume":"38","author":"Shuang","year":"2017","journal-title":"Res. Developm."},{"key":"10.3168\/jds.2019-17594_bib28","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.foodres.2018.11.019","article-title":"Antioxidant peptides (<3 kDa) identified on hard cow milk cheese with rennet from different origin","volume":"120","author":"Tim\u00f3n","year":"2019","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2019-17594_bib29","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.procbio.2005.12.026","article-title":"Antihypertensive peptides and \u03b3-aminobutyric acid from prozyme 6 facilitated lactic acid bacteria fermentation of soymilk","volume":"41","author":"Tsai","year":"2006","journal-title":"Process Biochem."},{"key":"10.3168\/jds.2019-17594_bib30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/intimm\/dxy035","article-title":"Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice","volume":"30","author":"Usui","year":"2018","journal-title":"Int. Immunol."},{"key":"10.3168\/jds.2019-17594_bib31","first-page":"170","article-title":"Structural characterization and structure-activity relationship of ACE inhibitory peptides from peanut","volume":"34","author":"Wang","year":"2013","journal-title":"Food. Sci. (China)"},{"key":"10.3168\/jds.2019-17594_bib32","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.3168\/jds.2018-15901","article-title":"Angiotensin-converting enzyme inhibitory peptides from Lactobacillus delbrueckii QS306 fermented milk","volume":"102","author":"Wu","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17594_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12934-015-0394-2","article-title":"Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide","volume":"14","author":"Yang","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.3168\/jds.2019-17594_bib34","doi-asserted-by":"crossref","first-page":"E411","DOI":"10.3390\/md16110411","article-title":"Identification and molecular docking study of a novel angiotensin-I converting enzyme inhibitory peptide derived from enzymatic hydrolysates of Cyclina sinensis","volume":"16","author":"Yu","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.3168\/jds.2019-17594_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14631-2","article-title":"Impact of hypertension versus diabetes on cardiovascular and all-cause mortality in Iranian older adults: Results of 14 years of follow-up","volume":"7","author":"Zafari","year":"2017","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2019-17594_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.foodres.2019.03.035","article-title":"Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba): Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs)","volume":"121","author":"Zhao","year":"2019","journal-title":"Food Res. Int."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220302289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220302289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220302289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:46:15Z","timestamp":1731102375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220302289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0022030220302289"],"URL":"https:\/\/doi.org\/10.3168\/jds.2019-17594","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}