{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:20:36Z","timestamp":1790749236139,"version":"4.1.0"},"reference-count":50,"publisher":"American Dairy Science Association","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.3168\/jds.2019-17952","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T18:03:12Z","timestamp":1588874592000},"page":"6422-6438","source":"Crossref","is-referenced-by-count":26,"title":["Mid-infrared spectroscopic analysis of raw milk to predict the blood nonesterified fatty acid concentrations in dairy cows"],"prefix":"10.3168","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-3019","authenticated-orcid":false,"given":"Ben","family":"Aernouts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9768-2308","authenticated-orcid":false,"given":"Ines","family":"Adriaens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-0088","authenticated-orcid":false,"given":"Jos\u00e9","family":"Diaz-Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-4301","authenticated-orcid":false,"given":"Wouter","family":"Saeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-4802","authenticated-orcid":false,"given":"P\u00e4ivi","family":"M\u00e4ntysaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-1120","authenticated-orcid":false,"given":"Tuomo","family":"Kokkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-882X","authenticated-orcid":false,"given":"Terhi","family":"Mehti\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4622","authenticated-orcid":false,"given":"Sari","family":"Kajava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-2629","authenticated-orcid":false,"given":"Paula","family":"Lidauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-9991","authenticated-orcid":false,"given":"Martin H.","family":"Lidauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-4801","authenticated-orcid":false,"given":"Matti","family":"Pastell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2019-17952_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/01652176.2005.9695192","article-title":"Non esterified fatty acids (NEFA) in dairy cattle. A review","volume":"27","author":"Adewuyi","year":"2005","journal-title":"Vet. Q."},{"key":"10.3168\/jds.2019-17952_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.aca.2011.04.018","article-title":"Mid-infrared spectrometry of milk for dairy metabolomics: a comparison of two sampling techniques and effect of homogenization","volume":"705","author":"Aernouts","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"10.3168\/jds.2019-17952_bib3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1366\/000370210791666200","article-title":"Predicting the fatty acid composition of milk: A comparison of two Fourier transform infrared sampling techniques","volume":"64","author":"Afseth","year":"2010","journal-title":"Appl. Spectrosc."},{"key":"10.3168\/jds.2019-17952_bib4","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1366\/0003702894202201","article-title":"Standard normal variate transformation and de-trending of near-infrared diffuse reflectance spectra","volume":"43","author":"Barnes","year":"1989","journal-title":"Appl. Spectrosc."},{"key":"10.3168\/jds.2019-17952_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/andp.18521620505","article-title":"Bestimmung der Absorption des rothen Lichts in farbigen Fl\u00fcssigkeiten","volume":"162","author":"Beer","year":"1852","journal-title":"Ann. Phys."},{"key":"10.3168\/jds.2019-17952_bib6","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.3168\/jds.2019-16937","article-title":"Prediction of blood metabolites from milk mid-infrared spectra in early-lactation cows","volume":"102","author":"Benedet","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib7","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3168\/jds.2011-4419","article-title":"Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation","volume":"95","author":"Bjerre-Harp\u00f8th","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1439-0442.2000.00266.x","article-title":"Twenty-four-hour patterns of hormones and metabolites in week 9 and 19 of lactation in high-yielding dairy cows fed triglycerides and free fatty acids","volume":"47","author":"Blum","year":"2000","journal-title":"J. Vet. Med. A Physiol. Pathol. Clin. Med."},{"key":"10.3168\/jds.2019-17952_bib9","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00216-007-1790-1","article-title":"Cross-validation of component models: A critical look at current methods","volume":"390","author":"Bro","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.3168\/jds.2019-17952_bib10","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1039\/C3AY41907J","article-title":"Principal component analysis","volume":"6","author":"Bro","year":"2014","journal-title":"Anal. Methods"},{"key":"10.3168\/jds.2019-17952_bib11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/cem.956","article-title":"A comparison of methods for testing differences in predictive ability","volume":"19","author":"Cederkvist","year":"2005","journal-title":"J. Chemometr."},{"key":"10.3168\/jds.2019-17952_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.chemolab.2004.12.011","article-title":"Performance of some variable selection methods when multicollinearity is present","volume":"78","author":"Chong","year":"2005","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.3168\/jds.2019-17952_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3168\/jds.2013-6799","article-title":"Invited review: Mid-infrared spectroscopy as phenotyping tool for milk traits","volume":"97","author":"De Marchi","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib14","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.3168\/jds.2016-12466","article-title":"Use of milk fatty acids to estimate plasma nonesterified fatty acid concentrations as an indicator of animal energy balance","volume":"100","author":"D\u00f3rea","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3168\/jds.S0022-0302(01)74511-0","article-title":"Ketone bodies in milk and blood of dairy cows: Relationship between concentrations and utilization for detection of subclinical ketosis","volume":"84","author":"Enjalbert","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib16","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.patrec.2005.10.010","article-title":"An Introduction to ROC analysis","volume":"27","author":"Fawcett","year":"2006","journal-title":"Pattern Recognit. Lett."},{"key":"10.3168\/jds.2019-17952_bib17","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.3168\/jds.2009-3015","article-title":"Day-to-day variation in milk yield and milk composition at the udder-quarter level","volume":"93","author":"Forsb\u00e4ck","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/ani9040176","article-title":"Variation of detailed protein composition of cow milk predicted from a large database of mid-infrared spectra","volume":"9","author":"Franzoi","year":"2019","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2019-17952_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1366\/0003702854248656","article-title":"Linearization and scatter-correction for near-infrared reflectance spectra of meat","volume":"39","author":"Geladi","year":"1985","journal-title":"Appl. Spectrosc."},{"key":"10.3168\/jds.2019-17952_bib20","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.3168\/jds.2015-10477","article-title":"Development of Fourier transform mid-infrared calibrations to predict acetone, \u03b2-hydroxybutyrate, and citrate contents in bovine milk through a European dairy network","volume":"99","author":"Grelet","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib21","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3168\/jds.2014-8764","article-title":"Standardization of milk mid-infrared spectra from a European dairy network","volume":"98","author":"Grelet","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1017\/S1751731118001751","article-title":"Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach","volume":"13","author":"Grelet","year":"2019","journal-title":"Animal"},{"key":"10.3168\/jds.2019-17952_bib23","series-title":"Section 12 - Guidelines for Milk Analysis","author":"ICAR","year":"2019"},{"key":"10.3168\/jds.2019-17952_bib24","series-title":"International Standard ISO 9622:2013\/IDF 141:2013","first-page":"14","article-title":"Milk and liquid milk products\u2013Guidelines for the application of mid-infrared spectrometry","author":"ISO\/IDF","year":"2013"},{"key":"10.3168\/jds.2019-17952_bib25","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.3168\/jds.2014-8039","article-title":"Milk fatty acids as possible biomarkers to early diagnose elevated concentrations of blood plasma nonesterified fatty acids in dairy cows","volume":"97","author":"Jorjong","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1255\/jnirs.882","article-title":"The importance of choosing the right validation strategy in inverse modelling","volume":"18","author":"Kemps","year":"2010","journal-title":"J. Near Infrared Spectrosc."},{"issue":"S","key":"10.3168\/jds.2019-17952_bib27","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1262\/jrd.1056S29","article-title":"Monitoring metabolic health of dairy cattle in the transition period","volume":"56","author":"LeBlanc","year":"2010","journal-title":"J. Reprod. Dev."},{"key":"10.3168\/jds.2019-17952_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tvjl.2009.10.003","article-title":"The effect of animal handling procedures on the blood non-esterified fatty acid and glucose concentrations of lactating dairy cows","volume":"187","author":"Leroy","year":"2011","journal-title":"Vet. J."},{"key":"10.3168\/jds.2019-17952_bib29","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1530\/rep.1.00735","article-title":"Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro","volume":"130","author":"Leroy","year":"2005","journal-title":"Reproduction"},{"key":"10.3168\/jds.2019-17952_bib30","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3168\/jds.2018-15103","article-title":"Metabolic profiling of early-lactation dairy cows using milk mid-infrared spectra","volume":"102","author":"Luke","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib31","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.3168\/jds.2018-15792","article-title":"Body and milk traits as indicators of dairy cow energy status in early lactation","volume":"102","author":"M\u00e4ntysaari","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib32","series-title":"Multivariate calibration by data compression","author":"Martens","year":"1987"},{"key":"10.3168\/jds.2019-17952_bib33","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1017\/S002202991000052X","article-title":"Effects of divergent Holstein-Friesian strain and diet on diurnal patterns of plasma metabolites and hormones","volume":"77","author":"Meier","year":"2010","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2019-17952_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1366\/0003702001949500","article-title":"Interval partial least-squares regression (iPLS): A comparative chemometric study with an example from near-infrared spectroscopy","volume":"54","author":"N\u00f8rgaard","year":"2000","journal-title":"Appl. Spectrosc."},{"key":"10.3168\/jds.2019-17952_bib35","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3168\/jds.2009-2852","article-title":"Associations of elevated nonesterified fatty acids and \u03b2-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition dairy cattle in the northeastern United States","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib36","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3168\/jds.2009-2277","article-title":"Evaluation of nonesterified fatty acids and \u03b2-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib37","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.3168\/jds.2009-2141","article-title":"Short communication: Effect of sampling time relative to the first daily feeding on interpretation of serum fatty acid and \u03b2-hydroxybutyrate concentrations in dairy cattle","volume":"93","author":"Quiroz-Rocha","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib38","series-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2017"},{"key":"10.3168\/jds.2019-17952_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: An open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.3168\/jds.2019-17952_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0022-4073(00)00021-2","article-title":"Baseline subtraction using robust local regression estimation","volume":"68","author":"Ruckstuhl","year":"2001","journal-title":"J. Quant. Spectrosc. Radiat. Transf."},{"key":"10.3168\/jds.2019-17952_bib41","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.3168\/jds.2009-2456","article-title":"Predicting bovine milk fat composition using infrared spectroscopy based on milk samples collected in winter and summer","volume":"92","author":"Rutten","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib42","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.3168\/jds.2011-5206","article-title":"Effects of abomasal infusion of tallow or camelina oil on responses to glucose and insulin in dairy cows during late pregnancy","volume":"95","author":"Salin","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib43","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/ac60214a047","article-title":"Smoothing and differentiation of data by simplified least squares procedures","volume":"36","author":"Savitzky","year":"1964","journal-title":"Anal. Chem."},{"key":"10.3168\/jds.2019-17952_bib44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3168\/jds.S0022-0302(06)72078-1","article-title":"In vitro effects of nonesterified fatty acids on bovine neutrophils oxidative burst and viability","volume":"89","author":"Scalia","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib45","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/00401706.1977.10489581","article-title":"Validation of regression models: Methods and examples","volume":"19","author":"Snee","year":"1977","journal-title":"Technometrics"},{"key":"10.3168\/jds.2019-17952_bib46","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.3168\/jds.2008-1734","article-title":"Potential estimation of major mineral contents in cow milk using mid-infrared spectrometry","volume":"92","author":"Soyeurt","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib47","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3168\/jds.2010-3408","article-title":"Mid-infrared prediction of bovine milk fatty acids across multiple breeds, production systems, and countries","volume":"94","author":"Soyeurt","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib48","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.3168\/jds.2008-1375","article-title":"Short communication: Elevated concentrations of oleic acid and long-chain fatty acids in milk fat of multiparous subclinical ketotic cows","volume":"91","author":"Van Haelst","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2019-17952_bib49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1255\/jnirs.271","article-title":"Variable selection in near infrared spectroscopy based on significance testing in partial least squares regression","volume":"8","author":"Westad","year":"2000","journal-title":"J. Near Infrared Spectrosc."},{"key":"10.3168\/jds.2019-17952_bib50","series-title":"Near-Infrared Technology in the Agricultural and Food Industries","author":"Williams","year":"2001"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220303519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220303519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220303519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T16:47:47Z","timestamp":1731084467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220303519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0022030220303519"],"URL":"https:\/\/doi.org\/10.3168\/jds.2019-17952","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/853127","asserted-by":"object"}]},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}