{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:34:25Z","timestamp":1789155265798,"version":"build-2803163510"},"reference-count":48,"publisher":"American Dairy Science Association","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.3168\/jds.2020-18643","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T23:09:52Z","timestamp":1597878592000},"page":"9261-9276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["The association of cow-related factors assessed at metritis diagnosis with metritis cure risk, reproductive performance, milk yield, and culling for untreated and ceftiofur-treated dairy cows"],"prefix":"10.3168","volume":"103","author":[{"given":"V.S.","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Celestino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.B.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Ballou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.N.","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2020-18643_bib1","doi-asserted-by":"crossref","first-page":"8248","DOI":"10.3168\/jds.2018-14510","article-title":"Assessment of daily activity patterns and biomarkers of pain, inflammation, and stress in lactating dairy cows diagnosed with clinical metritis","volume":"101","author":"Barragan","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.vetmic.2011.11.034","article-title":"Association between virulence factors of Escherichia coli, Fusobacterium necrophorum, and Arcanobacterium pyogenes and uterine diseases of dairy cows","volume":"157","author":"Bicalho","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2020-18643_bib3","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.3168\/jds.2013-7832","article-title":"Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle","volume":"97","author":"Bicalho","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.theriogenology.2014.03.001","article-title":"Diagnosis of acute puerperal metritis by electronic nose device analysis of vaginal discharge in dairy cows","volume":"82","author":"Burfeind","year":"2014","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2460\/javma.2004.224.1634","article-title":"Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows","volume":"224","author":"Chenault","year":"2004","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2020-18643_bib6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/bmj.310.6977.452","article-title":"The number needed to treat: A clinically useful measure of treatment effect","volume":"310","author":"Cook","year":"1995","journal-title":"BMJ"},{"key":"10.3168\/jds.2020-18643_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1439-0396.2012.01298.x","article-title":"Concentrations of haptoglobin in bovine plasma determined by ELISA or a colorimetric method based on peroxidase activity","volume":"97","author":"Cooke","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2020-18643_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vetmic.2010.11.032","article-title":"IncN plasmids carrying bla CTX-M-1 in Escherichia coli isolates on a dairy farm","volume":"149","author":"Dolejska","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2020-18643_bib9","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.3168\/jds.2007-0052","article-title":"Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment","volume":"90","author":"Drillich","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib10","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3168\/jds.S0022-0302(89)79081-0","article-title":"A body condition scoring chart for Holstein dairy cows","volume":"72","author":"Edmonson","year":"1989","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib12","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.3168\/jds.2017-14296","article-title":"Metritis diagnosis and treatment practices in 45 dairy farms in California","volume":"101","author":"Espadamala","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib13","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.3168\/jds.2013-7088","article-title":"Sodium salicylate treatment in early lactation increases whole-lactation milk and milk fat yield in mature dairy cows","volume":"96","author":"Farney","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11250-010-9682-3","article-title":"Dystocia in Friesian cows and its effects on postpartum reproductive performance and milk production","volume":"43","author":"Gaafar","year":"2011","journal-title":"Trop. Anim. Health Prod."},{"key":"10.3168\/jds.2020-18643_bib15","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3168\/jds.2009-2551","article-title":"Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows","volume":"93","author":"Galv\u00e3o","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib16","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.3168\/jds.2012-5922","article-title":"Metritis in dairy cows: risk factors and reproductive performance","volume":"96","author":"Giuliodori","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2017.06.009","article-title":"Implementation of an algorithm for selection of antimicrobial therapy for diarrhoeic calves: Impact on antimicrobial treatment rates, health and faecal microbiota","volume":"226","author":"Gomez","year":"2017","journal-title":"Vet. J."},{"key":"10.3168\/jds.2020-18643_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-5877(00)00115-X","article-title":"Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests","volume":"45","author":"Greiner","year":"2000","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2020-18643_bib19","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.3168\/jds.2014-8462","article-title":"Invited review: Antibiotic treatment of metritis in dairy cows: A systematic approach","volume":"97","author":"Haimerl","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetimm.2006.03.022","article-title":"Neutrophil function and energy status in Holstein cows with uterine health disorders","volume":"113","author":"Hammon","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2020-18643_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3168\/jds.2008-1526","article-title":"Short communication: Haptoglobin as an early indicator of metritis","volume":"92","author":"Huzzey","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165740","article-title":"Uterine microbiota and immune parameters associated with fever in dairy cows with metritis","volume":"11","author":"Jeon","year":"2016","journal-title":"PLoS One"},{"key":"10.3168\/jds.2020-18643_bib23","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1128\/AEM.01753-15","article-title":"Uterine microbiota progression from calving until establishment of metritis in dairy cows","volume":"81","author":"Jeon","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.3168\/jds.2020-18643_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2307\/2986296","article-title":"An exploratory technique for investigating large quantities of categorical data","volume":"29","author":"Kass","year":"1980","journal-title":"Appl. Stat."},{"key":"10.3168\/jds.2020-18643_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2011.10.023","article-title":"Using non-steroidal anti-inflammatory drugs around calving: Maximizing comfort, productivity and fertility","volume":"192","author":"Laven","year":"2012","journal-title":"Vet. J."},{"key":"10.3168\/jds.2020-18643_bib26","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.theriogenology.2011.07.017","article-title":"Reproductive tract defense and disease in postpartum dairy cows","volume":"76","author":"LeBlanc","year":"2011","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib27","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.3168\/jds.2018-15383","article-title":"Economic comparison of systemic antimicrobial therapies for metritis in dairy cows","volume":"102","author":"Lima","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib28","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.3168\/jds.2013-7569","article-title":"Efficacy of ampicillin trihydrate or ceftiofur hydrochloride for treatment of metritis and subsequent fertility in dairy cows","volume":"97","author":"Lima","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib29","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.3168\/jds.2017-13812","article-title":"Changes in feeding, social, and lying behaviors in dairy cows with metritis following treatment with a nonsteroidal anti-inflammatory drug as adjunctive treatment to an antimicrobial","volume":"101","author":"Lomb","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1292\/jvms1939.44.15","article-title":"Quantitative determination of bovine serum haptoglobin and its elevation in some inflammatory diseases","volume":"44","author":"Makimura","year":"1982","journal-title":"Nippon Juigaku Zasshi"},{"key":"10.3168\/jds.2020-18643_bib31","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.3168\/jds.2011-5111","article-title":"Evaluation of two doses of ceftiofur crystalline free acid sterile suspension for treatment of metritis in lactating dairy cows","volume":"95","author":"McLaughlin","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.theriogenology.2012.11.029","article-title":"Evaluation of ceftiofur crystalline free acid sterile suspension for control of metritis in high-risk lactating dairy cows","volume":"79","author":"McLaughlin","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.vetimm.2014.12.016","article-title":"Elevated plasma haptoglobin concentrations following parturition are associated with elevated leukocyte responses and decreased subsequent reproductive efficiency in multiparous Holstein dairy cows","volume":"164","author":"Nightingale","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2020-18643_bib34","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2020-18643_bib35","article-title":"Using chitosan microparticles to treat metritis in lactating dairy cows","author":"Oliveira","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib36","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3168\/jds.2009-2277","article-title":"Evaluation of nonesterified fatty acids and beta-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib37","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.theriogenology.2015.10.038","article-title":"Effect of puerperal metritis on reproductive and productive performance in dairy cows in Argentina","volume":"85","author":"Piccardi","year":"2016","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib38","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.3168\/jds.2015-10775","article-title":"Randomized, controlled clinical trial on the efficacy of nonsteroidal antiinflammatory drugs for the treatment of acute puerperal metritis in dairy cows","volume":"99","author":"Pohl","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib39","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.3168\/jds.2014-9181","article-title":"The associations between postpartum serum haptoglobin concentration and metabolic status, calving difficulties, retained fetal membranes, and metritis","volume":"98","author":"Pohl","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib40","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.theriogenology.2013.01.016","article-title":"Comparison of two monitoring and treatment strategies for cows with acute puerperal metritis","volume":"79","author":"Sannmann","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib41","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2020-18643_bib42","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.3168\/jds.2016-11352","article-title":"Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part III. Metritis","volume":"99","author":"Stangaferro","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib43","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3168\/jds.2014-9296","article-title":"Assessment of visceral pain associated with metritis in dairy cows","volume":"98","author":"Stojkov","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1439-0442.2007.00850.x","article-title":"Effect of various degrees of dystocia in dairy cattle on calf viability, milk production, fertility and culling","volume":"54","author":"Tenhagen","year":"2007","journal-title":"J. Vet. Med. Ser. A Physiol. Pathol. Clin. Med."},{"key":"10.3168\/jds.2020-18643_bib45","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.3168\/jds.2017-13807","article-title":"Use of a culture-independent on-farm algorithm to guide the use of selective dry-cow antibiotic therapy","volume":"101","author":"Vasquez","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib46","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.3168\/jds.2012-6440","article-title":"Risk factors for postpartum problems in dairy cows: Explanatory and predictive modeling","volume":"97","author":"Vergara","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib47","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.3168\/jds.2016-10872","article-title":"Vulvovaginal laceration as a risk factor for uterine disease in postpartum dairy cows","volume":"99","author":"Vieira-Neto","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-18643_bib48","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3168\/jds.2010-3697","article-title":"Short communication: Metritis affects milk production and cull rate of Holstein multiparous and primiparous dairy cows differently","volume":"94","author":"Wittrock","year":"2011","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220306299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220306299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220306299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:31:13Z","timestamp":1762198273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220306299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0022030220306299"],"URL":"https:\/\/doi.org\/10.3168\/jds.2020-18643","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of cow-related factors assessed at metritis diagnosis with metritis cure risk, reproductive performance, milk yield, and culling for untreated and ceftiofur-treated dairy cows","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2020-18643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}