{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:18:33Z","timestamp":1787887113022,"version":"build-2784847793"},"reference-count":45,"publisher":"American Dairy Science Association","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":536,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.3168\/jds.2020-19267","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T06:27:25Z","timestamp":1606285645000},"page":"2384-2395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of raft microdomains in bovine mammary tissue during lactation: How they are modulated by fatty acid treatments"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-0297","authenticated-orcid":false,"given":"H.","family":"Taga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-7168","authenticated-orcid":false,"given":"M.P.","family":"Dallaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-2027","authenticated-orcid":false,"given":"R.","family":"Gervais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-4847","authenticated-orcid":false,"given":"L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-3279","authenticated-orcid":false,"given":"B.A.","family":"Corl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-0727","authenticated-orcid":false,"given":"P.Y.","family":"Chouinard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2020-19267_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/cells3010129","article-title":"Flotillins in receptor tyrosine kinase signaling and cancer","volume":"3","author":"Banning","year":"2014","journal-title":"Cells"},{"key":"10.3168\/jds.2020-19267_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/cancers12010154","article-title":"Targeting glucose transporters for breast cancer therapy: The effect of natural and synthetic compounds","volume":"12","author":"Barbosa","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.3168\/jds.2020-19267_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35025089","article-title":"CAP defines a second signalling pathway required for insulin-stimulated glucose transport","volume":"407","author":"Baumann","year":"2000","journal-title":"Nature"},{"key":"10.3168\/jds.2020-19267_bib4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3168\/jds.S0022-0302(03)73716-3","article-title":"Postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cows","volume":"86","author":"Bell","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib5","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1074\/jbc.M211566200","article-title":"Lipid raft-dependent and -independent signalling through HLA-DR molecules","volume":"278","author":"Bouillon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2020-19267_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tcb.2007.06.005","article-title":"The SPFH domain-containing proteins: More than lipid raft markers","volume":"17","author":"Browman","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.3168\/jds.2020-19267_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02533368","article-title":"Composition and synthesis of three higher ganglioside homologs in bovine mammary tissue","volume":"13","author":"Bushway","year":"1978","journal-title":"Lipids"},{"key":"10.3168\/jds.2020-19267_bib8","series-title":"Guide to the Care and Use of Experimental Animals","volume":"Vol. 1","author":"Canadian Council on Animal Care","year":"1993"},{"key":"10.3168\/jds.2020-19267_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0005-2760(93)90045-B","article-title":"Inhibition of fatty acid \u03946-and \u03945-desaturation by cyclopropene fatty acids in rat liver microsomes","volume":"1210","author":"Cao","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2020-19267_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1574-6968.2006.00545.x","article-title":"Rafting with cholera toxin: Endocytosis and trafficking from plasma membrane to ER","volume":"266","author":"Chinnapen","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"10.3168\/jds.2020-19267_bib11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2337\/diabetes.53.5.1261","article-title":"Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation","volume":"53","author":"Cohen","year":"2004","journal-title":"Diabetes"},{"key":"10.3168\/jds.2020-19267_bib12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1095\/biolreprod.104.030502","article-title":"Reorganization of lipid rafts during capacitation of human sperm","volume":"71","author":"Cross","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2020-19267_bib13","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.3168\/jds.2013-7853","article-title":"Effects of abomasal infusion of conjugated linoleic acids, Sterculia foetida oil and fish oil on production performance and the extent of fatty-acid \u03949 desaturation in dairy cows","volume":"97","author":"Dallaire","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib14","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.4161\/cc.7.14.6475","article-title":"Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase","volume":"7","author":"Di Vizio","year":"2008","journal-title":"Cell Cycle"},{"key":"10.3168\/jds.2020-19267_bib15","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/jn\/133.6.1913","article-title":"Dietary (n\u22123) polyunsaturated fatty acids remodel mouse T-cell lipid rafts","volume":"133","author":"Fan","year":"2003","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2020-19267_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1096\/fj.05-4661fje","article-title":"Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells","volume":"20","author":"Fecchi","year":"2006","journal-title":"FASEB J."},{"key":"10.3168\/jds.2020-19267_bib17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00395-014-0439-4","article-title":"Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells","volume":"109","author":"Fork","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.3168\/jds.2020-19267_bib18","series-title":"Advanced Dairy Chemistry, Volume 3: Lactose, Water, Salts and Minor Constituents","first-page":"1","article-title":"Lactose: Chemistry and properties","author":"Fox","year":"2009"},{"key":"10.3168\/jds.2020-19267_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.152.5.1079","article-title":"Caveolin-2 is targeted to lipid droplets, a new \u201cmembrane domain\u201d in the cell","volume":"152","author":"Fujimoto","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.3168\/jds.2020-19267_bib20","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.3168\/jds.2008-1238","article-title":"Effects of intravenous infusion of conjugated diene 18:3 isomers on milk fat synthesis in lactating dairy cows","volume":"91","author":"Gervais","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib21","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.3168\/jds.2009-2281","article-title":"Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows","volume":"92","author":"Gervais","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejcb.2004.12.002","article-title":"Intracellular origin and secretion of milk fat globules","volume":"84","author":"Heid","year":"2005","journal-title":"Eur. J. Cell Biol."},{"key":"10.3168\/jds.2020-19267_bib23","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1091\/mbc.E16-06-0364","article-title":"The endoplasmic reticulum and casein-containing vesicles contribute to milk fat globule membrane","volume":"27","author":"Honvo-Hou\u00e9to","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.3168\/jds.2020-19267_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1152\/physiolgenomics.00244.2004","article-title":"Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice","volume":"21","author":"House","year":"2005","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2020-19267_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nutres.2010.02.003","article-title":"Conjugated linoleic acid alters caveolae phospholipid fatty acid composition and decreases caveolin-1 expression in MCF-7 breast cancer cells","volume":"30","author":"Huot","year":"2010","journal-title":"Nutr. Res."},{"key":"10.3168\/jds.2020-19267_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3168\/jds.2020-19267_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.anifeedsci.2004.12.016","article-title":"Effects of ruminal or duodenal supply of fish oil on milk fat secretion and profiles of trans-fatty acids and conjugated linoleic acid isomers in dairy cows fed maize silage","volume":"119","author":"Loor","year":"2005","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.3168\/jds.2020-19267_bib28","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1096\/fj.03-1430fje","article-title":"n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon","volume":"18","author":"Ma","year":"2004","journal-title":"FASEB J."},{"key":"10.3168\/jds.2020-19267_bib29","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3168\/jds.2007-0905","article-title":"Continuous lactation in dairy cows: Effect on milk production and mammary nutrient supply and extraction","volume":"91","author":"Madsen","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib30","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1091\/mbc.e07-09-0897","article-title":"Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro","volume":"19","author":"Martin","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.3168\/jds.2020-19267_bib31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj20031100","article-title":"Membrane and raft association of reggie-1\/flotillin-2: Role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression","volume":"378","author":"Neumann-Giesen","year":"2004","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2020-19267_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1051\/rnd:2002014","article-title":"Milk lipid and protein traffic in mammary epithelial cells: Joint and independent pathways","volume":"42","author":"Ollivier-Bousquet","year":"2002","journal-title":"Reprod. Nutr. Dev."},{"key":"10.3168\/jds.2020-19267_bib33","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1242\/jcs.092015","article-title":"The roles of flotillin microdomains\u2013endocytosis and beyond","volume":"124","author":"Otto","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.3168\/jds.2020-19267_bib34","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1194\/jlr.R200021-JLR200","article-title":"Lipid rafts: Bringing order to chaos","volume":"44","author":"Pike","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.3168\/jds.2020-19267_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1134\/S1990519X16030081","article-title":"Characteristics of morphological differences of detergent-resistant membrane domains isolated from different cells and investigated by atomic force microscopy","volume":"10","author":"Pleskova","year":"2016","journal-title":"Cell Tissue Biol."},{"key":"10.3168\/jds.2020-19267_bib36","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1074\/jbc.M701076200","article-title":"Requirement of oxidation-dependent CD40 homodimers for CD154\/CD40 bidirectional signalling","volume":"282","author":"Reyes-Moreno","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2020-19267_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MCO.0b013e3282f44c2c","article-title":"Update on lipid membrane microdomains","volume":"11","author":"Schmitz","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.3168\/jds.2020-19267_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jds.2020-19267_bib39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1600-0854.2009.01022.x","article-title":"Gangliosides and \u03b21-integrin are required for caveolae and membrane domains","volume":"11","author":"Singh","year":"2010","journal-title":"Traffic"},{"key":"10.3168\/jds.2020-19267_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/809259","article-title":"Novel insights into the role of caveolin-2 in cell-and tissue-specific signalling and function","volume":"2011","author":"Sowa","year":"2011","journal-title":"Biochem. Res. Int."},{"key":"10.3168\/jds.2020-19267_bib41","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/emboj.2008.156","article-title":"\u03946-Desaturase (FADS2) deficiency unveils the role of \u03c93-and \u03c96-polyunsaturated fatty acids","volume":"27","author":"Stoffel","year":"2008","journal-title":"EMBO J."},{"key":"10.3168\/jds.2020-19267_bib42","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.bbrc.2008.12.118","article-title":"Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells","volume":"379","author":"Vassilieva","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2020-19267_bib43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1479-5876-11-190","article-title":"Flotillin-2 is associated with breast cancer progression and poor survival outcomes","volume":"11","author":"Wang","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.3168\/jds.2020-19267_bib44","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.3168\/jds.2006-470","article-title":"Expression and regulation of glucose transporters in the bovine mammary gland","volume":"90","author":"Zhao","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19267_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.canlet.2018.01.028","article-title":"Inhibition of FASN and ER\u03b1 signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism","volume":"419","author":"Zielinska","year":"2018","journal-title":"Cancer Lett."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220309875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030220309875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220309875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:56:52Z","timestamp":1731103012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030220309875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0022030220309875"],"URL":"https:\/\/doi.org\/10.3168\/jds.2020-19267","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of raft microdomains in bovine mammary tissue during lactation: How they are modulated by fatty acid treatments","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2020-19267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}