{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:53:36Z","timestamp":1792641216278,"version":"4.5.0"},"reference-count":50,"publisher":"American Dairy Science Association","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":447,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005012","name":"\u00d6sterreichische Agentur f\u00fcr Internationale Mobilit\u00e4t und Kooperation in Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["LS12-010"],"award-info":[{"award-number":["LS12-010"]}],"id":[{"id":"10.13039\/501100005012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","award":["LS12-010"],"award-info":[{"award-number":["LS12-010"]}],"id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","award":["LS12-010"],"award-info":[{"award-number":["LS12-010"]}],"id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.3168\/jds.2020-19496","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T04:08:28Z","timestamp":1614658108000},"page":"5417-5431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of an intramammary lipopolysaccharide challenge on the hindgut microbial composition and fermentation of dairy cattle experiencing intermittent subacute ruminal acidosis"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-8261","authenticated-orcid":false,"given":"R.M.","family":"Petri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0117-681X","authenticated-orcid":false,"given":"S.","family":"Aditya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-0353","authenticated-orcid":false,"given":"E.","family":"Humer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-9004","authenticated-orcid":false,"given":"Q.","family":"Zebeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2020-19496_bib1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3168\/jds.2016-11796","article-title":"Intramammary infusion of Escherichia coli lipopolysaccharide negatively affects feed intake, chewing, and clinical variables, but some effects are stronger in cows experiencing subacute rumen acidosis","volume":"100","author":"Aditya","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1017\/S1751731117002191","article-title":"Metabolic and stress responses in dairy cows fed a concentrate-rich diet and submitted to intramammary lipopolysaccharide challenge","volume":"12","author":"Aditya","year":"2018","journal-title":"Animal"},{"key":"10.3168\/jds.2020-19496_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1461-0248.2006.00926.x","article-title":"Multivariate dispersion as a measure of beta diversity","volume":"9","author":"Anderson","year":"2006","journal-title":"Ecol. Lett."},{"key":"10.3168\/jds.2020-19496_bib4","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.2527\/jas.2010-3301","article-title":"Ruminant Nutrition Symposium: Role of fermentation acid absorption in the regulation of ruminal pH","volume":"89","author":"Aschenbach","year":"2011","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2020-19496_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-41017-3","article-title":"Characterization of the rumen and fecal microbiome in bloated and non-bloated cattle grazing alfalfa pastures and subjected to bloat prevention strategies","volume":"9","author":"Azad","year":"2019","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2020-19496_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.2276","article-title":"Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing","volume":"10","author":"Bokulich","year":"2013","journal-title":"Nat. Methods"},{"key":"10.3168\/jds.2020-19496_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.3168\/jds.2020-19496_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13028-015-0128-9","article-title":"Indicators of induced subacute ruminal acidosis (SARA) in Danish Holstein cows","volume":"57","author":"Danscher","year":"2015","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2020-19496_bib9","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.3168\/jds.2020-19496_bib10","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1126\/science.281.5383.1666","article-title":"Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle","volume":"281","author":"Diez-Gonzalez","year":"1998","journal-title":"Science"},{"key":"10.3168\/jds.2020-19496_bib11","article-title":"Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows","volume":"9","author":"Dong","year":"2014","journal-title":"PLoS One"},{"key":"10.3168\/jds.2020-19496_bib12","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"10.3168\/jds.2020-19496_bib13","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.3168\/jds.2007-0257","article-title":"Acidosis and Lipopolysaccharide from Escherichia coli B:055 cause hyperpermeability of rumen and colon tissues","volume":"90","author":"Emmanuel","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib14","series-title":"Empfehlungen zur Energie- und N\u00e4hrstoffversorgung der Milchk\u00fche und Aufzuchtrinder. GfE Handbook. Nr. 8","author":"GfE (Gesellschaft f\u00fcr Ern\u00e4hrungsphysiologie)","year":"2001"},{"key":"10.3168\/jds.2020-19496_bib15","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2527\/jas.2010-3460","article-title":"Productivity, digestion, and health responses to hindgut acidosis in ruminants1","volume":"89","author":"Gressley","year":"2011","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2020-19496_bib16","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2134\/jeq2008.0252","article-title":"Effects of dried distillers' grains with solubles (wheat-based) in feedlot cattle diets on feces and manure composition","volume":"38","author":"Hao","year":"2009","journal-title":"J. Environ. Qual."},{"key":"10.3168\/jds.2020-19496_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/702572","article-title":"Ruminal acidosis in feedlot: From aetiology to prevention","volume":"2014","author":"Hern\u00e1ndez","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.3168\/jds.2020-19496_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0034-5288(18)32532-3","article-title":"Factors influencing the outcome of Escherichia coli mastitis in the dairy cow","volume":"31","author":"Hill","year":"1981","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2020-19496_bib19","series-title":"Applied Statistics for the Behavioral Sciences","author":"Hinkle","year":"2003"},{"key":"10.3168\/jds.2020-19496_bib20","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.3168\/jds.2017-14051","article-title":"Graded substitution of grains with bakery by-products modulates ruminal fermentation, nutrient degradation, and microbial community composition in vitro","volume":"101","author":"Humer","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib21","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1017\/S1751731118000411","article-title":"Innate immunity and metabolomic responses in dairy cows challenged intramammarily with lipopolysaccharide after subacute ruminal acidosis","volume":"12","author":"Humer","year":"2018","journal-title":"Animal"},{"key":"10.3168\/jds.2020-19496_bib22","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3168\/jds.2017-13191","article-title":"Invited review: Practical feeding management recommendations to mitigate the risk of subacute ruminal acidosis in dairy cattle","volume":"101","author":"Humer","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/fpd.2011.0947","article-title":"Evaluation of a multiplex realtime polymerase chain reaction for the quantification of Escherichia coli O157 in cattle feces","volume":"9","author":"Jacob","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"key":"10.3168\/jds.2020-19496_bib24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1017\/S000711451400066X","article-title":"Intravenous lipopolysaccharide challenge alters ruminal bacterial microbiota and disrupts ruminal metabolism in dairy cattle","volume":"112","author":"Jing","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2020-19496_bib25","author":"Kassambara"},{"key":"10.3168\/jds.2020-19496_bib26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3168\/jds.2008-1389","article-title":"A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation","volume":"92","author":"Khafipour","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3168\/jds.2010-3435","article-title":"Population structure of rumen Escherichia coli associated with subacute ruminal acidosis (SARA) in dairy cattle","volume":"94","author":"Khafipour","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3168\/jds.2011-4447","article-title":"Effects of subacute ruminal acidosis challenges on fermentation and endotoxins in the rumen and hindgut in dairy cows","volume":"95","author":"Li","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib29","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: A new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.3168\/jds.2020-19496_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1746-6148-8-237","article-title":"The diversity of the fecal bacterial community and its relationship with the concentration of volatile fatty acids in the feces during subacute rumen acidosis in dairy cows","volume":"8","author":"Mao","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2020-19496_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3389\/fmicb.2016.00701","article-title":"Induction of subacute ruminal acidosis affects the ruminal microbiome and epithelium","volume":"7","author":"McCann","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2020-19496_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/jpn.12675","article-title":"Differences between pH of indwelling sensors and the pH of fluid and solid phase in the rumen of dairy cows fed varying concentrate levels","volume":"102","author":"Neubauer","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2020-19496_bib33","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.3168\/jds.2017-13565","article-title":"High-grain diets supplemented with phytogenic compounds or autolyzed yeast modulate ruminal bacterial community and fermentation in dry cows","volume":"101","author":"Neubauer","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib34","author":"Oksanen"},{"key":"10.3168\/jds.2020-19496_bib35","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","article-title":"The NIH human microbiome project","volume":"19","author":"Peterson","year":"2009","journal-title":"Genome Res."},{"key":"10.3168\/jds.2020-19496_bib36","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.3168\/jds.2018-15704","article-title":"Graded replacement of corn grain with molassed sugar beet pulp modulates the fecal microbial community and hindgut fermentation profile in lactating dairy cows","volume":"102","author":"Petri","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083424","article-title":"Characterization of the core rumen microbiome in cattle during transition from forage to concentrate as well as during and after an acidotic challenge","volume":"8","author":"Petri","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl 2","key":"10.3168\/jds.2020-19496_bib38","doi-asserted-by":"crossref","first-page":"s399","DOI":"10.1017\/S1751731118001921","article-title":"Review: Enhancing gastrointestinal health in dairy cows","volume":"12","author":"Plaizier","year":"2018","journal-title":"Animal"},{"key":"10.3168\/jds.2020-19496_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.anifeedsci.2011.12.004","article-title":"Subacute ruminal acidosis (SARA), endotoxins, and health consequences","volume":"172","author":"Plaizier","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.3168\/jds.2020-19496_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2007.12.016","article-title":"Subacute ruminal acidosis in dairy cows: The physiological causes, incidence and consequences","volume":"176","author":"Plaizier","year":"2008","journal-title":"Vet. J."},{"key":"10.3168\/jds.2020-19496_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00248-017-0940-z","article-title":"Changes in microbiota in rumen digesta and feces due to a grain-based subacute ruminal acidosis (SARA) challenge","volume":"74","author":"Plaizier","year":"2017","journal-title":"Microb. Ecol."},{"key":"10.3168\/jds.2020-19496_bib42","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2527\/jas.2015-9605","article-title":"Transient feeding of a concentrate-rich diet increases the severity of subacute ruminal acidosis in dairy cattle","volume":"94","author":"Pourazad","year":"2016","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2020-19496_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164192","article-title":"Evidence of in vivo absorption of lactate and modulation of short chain fatty acid absorption from the reticulorumen of non-lactating cattle fed high concentrate diets","volume":"11","author":"Qumar","year":"2016","journal-title":"PLoS One"},{"key":"10.3168\/jds.2020-19496_bib44","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.3168\/jds.2020-19496_bib45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2460\/ajvr.1993.54.01.80","article-title":"Cytokine production during endotoxin-induced mastitis in lactating dairy cows","volume":"54","author":"Shuster","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2020-19496_bib46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12917-014-0235-2","article-title":"A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats","volume":"10","author":"Tao","year":"2014","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2020-19496_bib47","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fmicb.2016.00274","article-title":"Epimural indicator phylotypes of transiently-induced subacute ruminal acidosis in dairy cattle","volume":"7","author":"Wetzels","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2020-19496_bib48","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.3168\/jds.2007-0572","article-title":"Modeling the adequacy of dietary fiber in dairy cows based on the responses of ruminal pH and milk fat production to composition of the diet","volume":"91","author":"Zebeli","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19496_bib49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.rvsc.2012.02.004","article-title":"Interplay between rumen digestive disorders and diet-induced inflammation in dairy cattle","volume":"93","author":"Zebeli","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2020-19496_bib50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Zhang","year":"2000","journal-title":"J. Comput. Biol."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221002174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221002174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221002174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:01:29Z","timestamp":1731103289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221002174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0022030221002174"],"URL":"https:\/\/doi.org\/10.3168\/jds.2020-19496","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of an intramammary lipopolysaccharide challenge on the hindgut microbial composition and fermentation of dairy cattle experiencing intermittent subacute ruminal acidosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2020-19496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}