{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:09Z","timestamp":1790633349331,"version":"4.1.0"},"reference-count":61,"publisher":"American Dairy Science Association","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.3168\/jds.2020-19867","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T08:06:31Z","timestamp":1619165191000},"page":"7711-7724","source":"Crossref","is-referenced-by-count":27,"title":["Preweaning nutrient supply alters serum metabolomics profiles related to protein and energy metabolism and hepatic function in Holstein heifer calves"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-3995","authenticated-orcid":false,"given":"L.N.","family":"Leal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-8042","authenticated-orcid":false,"given":"J.","family":"Doelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-7775","authenticated-orcid":false,"given":"B.R.","family":"Keppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-6205","authenticated-orcid":false,"given":"M.A.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-4629","authenticated-orcid":false,"given":"J.","family":"Mart\u00edn-Tereso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2020-19867_bib1","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.3168\/jds.S0022-0302(04)70061-2","article-title":"Rumen development, intestinal growth and hepatic metabolism in the pre- and postweaning ruminant","volume":"87","author":"Baldwin","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib2","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.3168\/jds.S0022-0302(97)76205-2","article-title":"Increased weight gain and effects on production parameters of Holstein heifer calves that were allowed to suckle from birth to six weeks of age","volume":"80","author":"Bar-Peled","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib3","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1017\/S0007114516004013","article-title":"Neonatal milk supplementation in lambs has persistent effects on growth and metabolic function that differ by sex and gestational age","volume":"116","author":"Berry","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2020-19867_bib4","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13296","article-title":"Neonatal high protein intake enhances neonatal growth without significant adverse renal effects in spontaneous IUGR piglets","volume":"5","author":"Boubred","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.3168\/jds.2020-19867_bib5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/cphy.c120027","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.3168\/jds.2020-19867_bib6","doi-asserted-by":"crossref","first-page":"G413","DOI":"10.1152\/ajpgi.00361.2016","article-title":"Gut-liver axis at the frontier of host-microbial interactions","volume":"312","author":"Brandl","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2020-19867_bib7","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.3168\/jds.2015-10372","article-title":"Effect of milk replacer program on calf performance and digestion of nutrients with age of the dairy calf","volume":"99","author":"Chapman","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib8","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1016\/j.febslet.2012.08.020","article-title":"Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine","volume":"586","author":"Davids","year":"2012","journal-title":"FEBS Lett."},{"key":"10.3168\/jds.2020-19867_bib9","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.3168\/jds.2010-3923","article-title":"Effect of intensified feeding of heifer calves on growth, pubertal age, calving age, milk yield, and economics","volume":"94","author":"Davis Rincker","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.clnu.2012.02.005","article-title":"Long term metabolic impact of high protein neonatal feeding: A preliminary study in male rat pups born with a low birth weight","volume":"31","author":"Delamaire","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.3168\/jds.2020-19867_bib11","first-page":"E608","article-title":"Leucine metabolism in human newborns","volume":"253","author":"Denne","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.3168\/jds.2020-19867_bib12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.11613\/BM.2017.039","article-title":"Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA(1c) measurement","volume":"27","author":"Desmons","year":"2017","journal-title":"Biochem. Med. (Zagreb)"},{"key":"10.3168\/jds.2020-19867_bib13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3168\/jds.S0022-0302(01)74541-9","article-title":"Composition of growth of Holstein calves fed milk replacer from birth to 105-kilogram body weight","volume":"84","author":"Diaz","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cvfa.2008.01.001","article-title":"Calf nutrition from birth to breeding","volume":"24","author":"Drackley","year":"2008","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2020-19867_bib15","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.3168\/jds.2014-9062","article-title":"Weaning age affects growth, feed intake, gastrointestinal development, and behavior in Holstein calves fed an elevated plane of nutrition during the preweaning stage","volume":"98","author":"Eckert","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib16","first-page":"115","article-title":"Equine fasting hyperbilirubinemia","volume":"37","author":"Engelking","year":"1993","journal-title":"Adv. Vet. Sci. Comp. Med."},{"key":"10.3168\/jds.2020-19867_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00125-002-1012-5","article-title":"Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life","volume":"46","author":"Eriksson","year":"2003","journal-title":"Diabetologia"},{"key":"10.3168\/jds.2020-19867_bib18","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/ac901536h","article-title":"Integrated, nontargeted ultrahigh performance liquid chromatography\/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems","volume":"81","author":"Evans","year":"2009","journal-title":"Anal. Chem."},{"key":"10.3168\/jds.2020-19867_bib19","first-page":"301","article-title":"Heifer calves reared on very high or normal levels of whole milk from birth to 6\u20138 weeks of age and their subsequent milk production","volume":"3","author":"Foldager","year":"1994","journal-title":"Proc. Soc. Nutr. Physiol."},{"key":"10.3168\/jds.2020-19867_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12917-017-1185-2","article-title":"Diurnal variation of NMR based blood metabolites in calves fed a high plane of milk replacer: A pilot study","volume":"13","author":"Ghaffari","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2020-19867_bib21","first-page":"153","article-title":"Studies on salivary lipase in young ruminants","volume":"32","author":"Grosskopf","year":"1965","journal-title":"Onderstepoort J. Vet. Res."},{"key":"10.3168\/jds.2020-19867_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1469-8137.2005.01632.x","article-title":"Plant metabolomics: From holistic hope, to hype, to hot topic","volume":"169","author":"Hall","year":"2006","journal-title":"New Phytol."},{"issue":"Suppl. 1","key":"10.3168\/jds.2020-19867_bib23","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003338","article-title":"Metabolic imprinting, programming and epigenetics\u2014A review of present priorities and future opportunities","volume":"104","author":"Hanley","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2020-19867_bib24","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.3168\/jds.2016-11239","article-title":"Effect of milk replacer program on calf performance and digestion of nutrients in dairy calves to 4 months of age","volume":"99","author":"Hill","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib25","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.3168\/jds.S0022-0302(02)74391-9","article-title":"Effects of ad libitum milk intake on dairy calves","volume":"85","author":"Jasper","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib26","doi-asserted-by":"crossref","first-page":"8446","DOI":"10.3168\/jds.2018-14559","article-title":"Different milk feeding intensities during the first 4 weeks of rearing dairy calves: Part 3: Plasma metabolomics analysis reveals long-term metabolic imprinting in Holstein heifers","volume":"101","author":"Ken\u00e9z","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib27","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbamcr.2011.01.008","article-title":"Control of intracellular heme levels: Heme transporters and heme oxygenases","volume":"1813","author":"Khan","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2020-19867_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3168\/jds.2015-9975","article-title":"Invited review: Transitioning from milk to solid feed in dairy heifers","volume":"99","author":"Khan","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib29","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.3168\/jds.2007-0104","article-title":"Structural growth, rumen development, and metabolic and immune responses of Holstein male calves fed milk through step-down and conventional methods","volume":"90","author":"Khan","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib30","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3168\/jds.S0022-0302(07)71571-0","article-title":"Pre- and postweaning performance of Holstein female calves fed milk through step-down and conventional methods","volume":"90","author":"Khan","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib31","author":"Leal"},{"key":"10.3168\/jds.2020-19867_bib32","author":"Leal"},{"key":"10.3168\/jds.2020-19867_bib33","first-page":"38","article-title":"Programming by early nutrition in man","volume":"156","author":"Lucas","year":"1991","journal-title":"Ciba Found. Symp."},{"key":"10.3168\/jds.2020-19867_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00726-015-2078-y","article-title":"Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs","volume":"48","author":"Manjar\u00edn","year":"2016","journal-title":"Amino Acids"},{"key":"10.3168\/jds.2020-19867_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/msb4100153","article-title":"A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model","volume":"3","author":"Martin","year":"2007","journal-title":"Mol. Syst. Biol."},{"key":"10.3168\/jds.2020-19867_bib36","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.3168\/jds.2016-12474","article-title":"From pre- to postweaning: Transformation of the young calf's gastrointestinal tract","volume":"100","author":"Meale","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41598-017-00223-7","article-title":"Weaning age influences the severity of gastrointestinal microbiome shifts in dairy calves","volume":"7","author":"Meale","year":"2017","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2020-19867_bib38","doi-asserted-by":"crossref","first-page":"U141","DOI":"10.1530\/eje.0.151u141","article-title":"The Avon Longitudinal Study of Parents and Children (ALSPAC)\u2014A resource for the study of the environmental determinants of childhood obesity","volume":"151","author":"Ness","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.3168\/jds.2020-19867_bib39","series-title":"Nutrient requirements of dairy cattle","author":"NRC (National Research Council)","year":"2001"},{"key":"10.3168\/jds.2020-19867_bib40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0167-7799(98)01214-1","article-title":"Systematic functional analysis of the yeast genome","volume":"16","author":"Oliver","year":"1998","journal-title":"Trends Biotechnol."},{"key":"10.3168\/jds.2020-19867_bib41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj0510251","article-title":"The metabolism of short-chain fatty acids in the sheep. 1. Fatty acid utilization and ketone body production by rumen epithelium and other tissues","volume":"51","author":"Pennington","year":"1952","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2020-19867_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF01115004","article-title":"The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids","volume":"6","author":"Preedy","year":"1986","journal-title":"Biosci. Rep."},{"key":"10.3168\/jds.2020-19867_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbalip.2014.04.008","article-title":"Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice","volume":"1851","author":"Qi","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.3168\/jds.2020-19867_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3168\/jds.S0022-0302(00)74850-8","article-title":"Effects of diet and injection of bovine somatotropin on prepubertal growth and first-lactation milk yields of Holstein cows","volume":"83","author":"Radcliff","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib45","doi-asserted-by":"crossref","first-page":"833","DOI":"10.15232\/pas.2016-01536","article-title":"Pre-and postweaning performance and health of dairy calves fed milk replacers with differing protein sources","volume":"32","author":"Raeth","year":"2016","journal-title":"Prof. Anim. Sci."},{"key":"10.3168\/jds.2020-19867_bib46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3168\/jds.2008-1470","article-title":"Impact of conventional or intensive milk replacer programs on Holstein heifer performance through six months of age and during first lactation","volume":"92","author":"Raeth-Knight","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib47","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0021859600066089","article-title":"Natural sucking performance and age at weaning in zebu cattle (Bos indicus)","volume":"96","author":"Reinhardt","year":"1981","journal-title":"J. Agric. Sci."},{"key":"10.3168\/jds.2020-19867_bib48","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3168\/jds.S0022-0302(76)84354-8","article-title":"Response to lactating dairy cows to abomasal infusion of amino acids","volume":"59","author":"Schwab","year":"1976","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu. Rev. Nutr."},{"key":"10.3168\/jds.2020-19867_bib50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/BF02530972","article-title":"Composition of bile acids in ruminants","volume":"3","author":"Sheriha","year":"1968","journal-title":"Lipids"},{"key":"10.3168\/jds.2020-19867_bib51","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3168\/jds.2011-4391","article-title":"Preweaning milk replacer intake and effects on long-term productivity of dairy calves","volume":"95","author":"Soberon","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib52","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.3168\/jds.2016-12310","article-title":"Abrupt weaning reduces postweaning growth and is associated with alterations in gastrointestinal markers of development in dairy calves fed an elevated plane of nutrition during the preweaning period","volume":"100","author":"Steele","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2020-19867_bib53","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/pr.2011.79","article-title":"Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways","volume":"71","author":"Suryawan","year":"2012","journal-title":"Pediatr. Res."},{"key":"10.3168\/jds.2020-19867_bib54","series-title":"Trace Elements in Human and Animal Nutrition","author":"Underwood","year":"1977"},{"key":"10.3168\/jds.2020-19867_bib55","author":"USDA"},{"key":"10.3168\/jds.2020-19867_bib56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0377-8401(93)90078-X","article-title":"The production and metabolism of volatile fatty acids by ruminants fed roughages: A review","volume":"43","author":"van Houtert","year":"1993","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.3168\/jds.2020-19867_bib57","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3923\/ijps.2005.442.448","article-title":"Evaluation of separate and combined effects of choline and betaine in diets for male broilers","volume":"4","author":"Waldroup","year":"2005","journal-title":"Int. J. Poult. Sci."},{"key":"10.3168\/jds.2020-19867_bib58","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3945\/ajcn.117.152702","article-title":"Odd-chain fatty acids as a biomarker for dietary fiber intake: A novel pathway for endogenous production from propionate","volume":"105","author":"Weitkunat","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2020-19867_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.01133","article-title":"Manipulating rumen microbiome and fermentation through interventions during early life: A review","volume":"6","author":"Y\u00e1\u00f1ez-Ruiz","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2020-19867_bib60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.livsci.2015.09.008","article-title":"Short- and medium-term changes in performance and metabolism of dairy calves offered different amounts of milk replacers","volume":"181","author":"Yunta","year":"2015","journal-title":"Livest. Sci."},{"key":"10.3168\/jds.2020-19867_bib61","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","article-title":"Choline: An essential nutrient for public health","volume":"67","author":"Zeisel","year":"2009","journal-title":"Nutr. Rev."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221005439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221005439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221005439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:07:40Z","timestamp":1731103660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221005439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0022030221005439"],"URL":"https:\/\/doi.org\/10.3168\/jds.2020-19867","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}