{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:56:54Z","timestamp":1790672214770,"version":"4.1.0"},"reference-count":36,"publisher":"American Dairy Science Association","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.3168\/jds.2021-20122","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T07:37:09Z","timestamp":1617349029000},"page":"8243-8255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Role of long polar fimbriae type 1 and 2 in pathogenesis of mammary pathogenic Escherichia coli"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8157-7623","authenticated-orcid":false,"given":"Mingxu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8841","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-9085","authenticated-orcid":false,"given":"Miaomiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-1238","authenticated-orcid":false,"given":"Fang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-6251","authenticated-orcid":false,"given":"Yue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-6709","authenticated-orcid":false,"given":"Bihua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-2182","authenticated-orcid":false,"given":"Jinqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-0670","authenticated-orcid":false,"given":"Guoqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-9286","authenticated-orcid":false,"given":"Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-20122_bib1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1128\/jb.177.8.2087-2097.1995","article-title":"Identification and sequence analysis of lpfABCDE, a putative fimbrial operon of Salmonella typhimurium.","volume":"177","author":"B\u00e4umler","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.3168\/jds.2021-20122_bib2","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1128\/AEM.03315-14","article-title":"Prevalence of carriage of Shiga toxin-producing Escherichia coli serotypes O157:H7, O26:H11, O103:H2, O111:H8, and O145:H28 among slaughtered adult cattle in France","volume":"81","author":"Bibbal","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib3","doi-asserted-by":"crossref","first-page":"e00717","DOI":"10.1128\/mBio.00717-17","article-title":"Enteroaggregative Escherichia coli adherence fimbriae drive inflammatory cell recruitment via interactions with epithelial MUC1","volume":"8","author":"Boll","year":"2017","journal-title":"MBio"},{"key":"10.3168\/jds.2021-20122_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.fm.2019.03.024","article-title":"Curli fimbriae confer shiga toxin-producing Escherichia coli a competitive trait in mixed biofilms","volume":"82","author":"Carter","year":"2019","journal-title":"Food Microbiol."},{"key":"10.3168\/jds.2021-20122_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI44632","article-title":"Crohn disease\u2013associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae","volume":"121","author":"Chassaing","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.3168\/jds.2021-20122_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/srep44655","article-title":"Enterohemorrhagic Escherichia coli pathogenesis: Role of long polar fimbriae in Peyer's patches interactions","volume":"7","author":"Cordonnier","year":"2017","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2021-20122_bib7","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2021-20122_bib8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1039\/C9SM02038A","article-title":"Biofilms at interfaces: microbial distribution in floating films","volume":"16","author":"Desai","year":"2020","journal-title":"Soft Matter"},{"key":"10.3168\/jds.2021-20122_bib9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.vetmic.2012.03.033","article-title":"Phylogroup and lpfA influence epithelial invasion by mastitis associated Escherichia coli.","volume":"159","author":"Dogan","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.vetmic.2013.04.030","article-title":"Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E. coli.","volume":"166","author":"Duan","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.vetmic.2012.05.015","article-title":"The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro","volume":"160","author":"Duan","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib12","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1348-0421.2011.00387.x","article-title":"Biological and virulence characteristics of the YqhC mutant of Salmonella.","volume":"55","author":"Eakley","year":"2011","journal-title":"Microbiol. Immunol."},{"key":"10.3168\/jds.2021-20122_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetimm.2012.09.017","article-title":"The long polar fimbriae of STEC O157:H7 induce expression of pro-inflammatory markers by intestinal epithelial cells","volume":"152","author":"Farfan","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-20122_bib14","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/IAI.05317-11","article-title":"Long polar fimbriae of enterohemorrhagic Escherichia coli O157:H7 bind to extracellular matrix proteins","volume":"79","author":"Farfan","year":"2011","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2021-20122_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.2001.02361.x","article-title":"Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation","volume":"40","author":"Frend\u00e9us","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib16","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.3168\/jds.2016-12334","article-title":"Incidence of clinical mastitis and distribution of pathogens on large Chinese dairy farms","volume":"100","author":"Gao","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20122_bib17","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1111\/j.1462-5822.2007.00999.x","article-title":"Toll-like receptor 4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitis","volume":"9","author":"Gonen","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib18","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1128\/IAI.71.7.4052-4058.2003","article-title":"A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression","volume":"71","author":"Haraga","year":"2003","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2021-20122_bib19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2958.2001.02205.x","article-title":"Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells","volume":"39","author":"Hedlund","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib20","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1124\/mol.105.019695","article-title":"A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling","volume":"69","author":"Ii","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.3168\/jds.2021-20122_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01487","article-title":"The effect of lipopolysaccharide-induced experimental bovine mastitis on clinical parameters, inflammatory markers, and the metabolome: A kinetic approach","volume":"9","author":"Johnzon","year":"2018","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2021-20122_bib22","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1128\/IAI.72.10.6168-6171.2004","article-title":"Long polar fimbriae contribute to colonization by Escherichia coli O157:H7 in vivo","volume":"72","author":"Jordan","year":"2004","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2021-20122_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01017","article-title":"Everything you always wanted to know about Salmonella type 1 fimbriae, but were afraid to ask","volume":"10","author":"Kolenda","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2021-20122_bib24","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1128\/iai.58.6.1995-1998.1990","article-title":"Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae","volume":"58","author":"Krogfelt","year":"1990","journal-title":"Infect. Immun."},{"key":"10.3168\/jds.2021-20122_bib25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2021-20122_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141845","article-title":"The role of long polar fimbriae in Escherichia coli O104:H4 adhesion and colonization","volume":"10","author":"Ross","year":"2015","journal-title":"PLoS One"},{"key":"10.3168\/jds.2021-20122_bib27","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.3168\/jds.2021-20122_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vetimm.2011.08.022","article-title":"Host-response patterns of intramammary infections in dairy cows","volume":"144","author":"Schukken","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-20122_bib29","first-page":"333","article-title":"Characterization of the second long polar (LP) fimbriae of Escherichia coli O157:H7 and distribution of LP fimbriae in other pathogenic E. coli strains","volume":"238","author":"Torres","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.3168\/jds.2021-20122_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fcimb.2014.00185","article-title":"Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157:H7","volume":"4","author":"Vergara","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"Suppl 1","key":"10.3168\/jds.2021-20122_bib31","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1086\/318849","article-title":"The role of P fimbriae for colonization and host response induction in the human urinary tract","volume":"183","author":"Wullt","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.3168\/jds.2021-20122_bib32","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2353\/ajpath.2007.070220","article-title":"Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination","volume":"171","author":"Ye","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.3168\/jds.2021-20122_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-291X(02)02431-2","article-title":"IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells","volume":"298","author":"Yoo","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2021-20122_bib34","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1007\/s00253-019-10014-x","article-title":"Long polar fimbriae contribute to pathogenic Escherichia coli infection to host cells","volume":"103","author":"Zhou","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.3168\/jds.2021-20122_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1297-9716-44-30","article-title":"Both flagella and F4 fimbriae from F4ac+ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro","volume":"44","author":"Zhou","year":"2013","journal-title":"Vet. Res. (Faisalabad)"},{"key":"10.3168\/jds.2021-20122_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.vetmic.2013.10.014","article-title":"Flagellin and F4 fimbriae have opposite effects on biofilm formation and quorum sensing in F4ac+ enterotoxigenic Escherichia coli.","volume":"168","author":"Zhou","year":"2014","journal-title":"Vet. Microbiol."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221004884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221004884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221004884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:02:14Z","timestamp":1731103334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221004884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0022030221004884"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-20122","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of long polar fimbriae type 1 and 2 in pathogenesis of mammary pathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-20122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}