{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:17:57Z","timestamp":1789532277881,"version":"build-2803163510"},"reference-count":41,"publisher":"American Dairy Science Association","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1604302-03"],"award-info":[{"award-number":["2018YFC1604302-03"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.3168\/jds.2021-20260","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T05:59:06Z","timestamp":1631771946000},"page":"12353-12364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of enzymatic hydrolysis on the allergenicity of natural cow milk based on a BALB\/c mouse model"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-7742","authenticated-orcid":false,"given":"Xiaona","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-1461","authenticated-orcid":false,"given":"Xiqing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-20260_bib1","doi-asserted-by":"crossref","first-page":"10858","DOI":"10.1021\/jf3031293","article-title":"Immunomodulatory potential of partially hydrolyzed \u03b2-lactoglobulin and large synthetic peptides","volume":"60","author":"Adel-Patient","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.3168\/jds.2021-20260_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jim.2012.04.007","article-title":"A shorter and more specific oral sensitization-based experimental model of food allergy in mice","volume":"381","author":"Bail\u00f3n","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"10.3168\/jds.2021-20260_bib3","first-page":"187","article-title":"Peptidic profile, molecular mass distribution and immunological properties of commercial hypoallergenic infant formulas","volume":"57","author":"Calvo","year":"2002","journal-title":"Milchwissenschaft"},{"key":"10.3168\/jds.2021-20260_bib4","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/S0002-8223(02)90351-2","article-title":"Food allergies in children affect nutrient intake and growth","volume":"102","author":"Christie","year":"2002","journal-title":"J. Am. Diet. Assoc."},{"key":"10.3168\/jds.2021-20260_bib5","first-page":"231","article-title":"Effects of enzymatic hydrolysis on the allergenicity of whey protein concentrates","volume":"13","author":"Duan","year":"2014","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.3168\/jds.2021-20260_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0308-8146(99)00199-5","article-title":"Effect of heat treatment on camel milk proteins with respect to antimicrobial factors: A comparison with cows' and buffalo milk proteins","volume":"68","author":"Elagamy","year":"2000","journal-title":"Food Chem."},{"key":"10.3168\/jds.2021-20260_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jaci.2006.05.012","article-title":"Apple allergy across Europe: How allergen sensitization profiles determine the clinical expression of allergies to plant foods","volume":"118","author":"Fern\u00e1ndez-Rivas","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.3168\/jds.2021-20260_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0378-4274(03)00026-2","article-title":"Animal models in food allergy: Assessment of allergenicity and preventive activity of infant formulas","volume":"140\u2013141","author":"Fritsch\u00e9","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.3168\/jds.2021-20260_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2222.2005.02415.x","article-title":"Evaluation of allergenicity of genetically modified soybean protein extract in a murine model of oral allergen-specific sensitization","volume":"36","author":"Gizzarelli","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.3168\/jds.2021-20260_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cellimm.2015.09.001","article-title":"Hydrolyzed whey protein prevents the development of food allergy to \u03b2-lactoglobulin in sensitized mice","volume":"298","author":"Gomes-Santos","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.3168\/jds.2021-20260_bib11","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1046\/j.1365-2222.2003.01790.x","article-title":"Oral administration of an edible-mushroom-derived protein inhibits the development of food-allergic reactions in mice","volume":"33","author":"Hsieh","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.3168\/jds.2021-20260_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000323940","article-title":"Regulatory T cells control type I food allergy to \u03b2-lactoglobulin in mice","volume":"156","author":"Kanjarawi","year":"2011","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.3168\/jds.2021-20260_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.intimp.2018.07.039","article-title":"Allergenicity assessment of Buchanania lanzan protein extract in Balb\/c mice","volume":"63","author":"Kumar","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.3168\/jds.2021-20260_bib14","first-page":"29","article-title":"Lessons from cases of mortality due to food allergy in Israel: Cow's milk protein should be considered a potentially fatal allergen","volume":"14","author":"Levy","year":"2012","journal-title":"Isr. Med. Assoc. J."},{"key":"10.3168\/jds.2021-20260_bib15","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/fsn3.2066","article-title":"Effects of enzymatic treatments on the hydrolysis and antigenicity reduction of natural cow milk","volume":"9","author":"Liang","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.3168\/jds.2021-20260_bib16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jaci.2010.11.009","article-title":"IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling","volume":"127","author":"Mathias","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.3168\/jds.2021-20260_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/pai.12887","article-title":"Ingestion of partially hydrolyzed whey protein suppresses epicutaneous sensitization to \u03b2-lactoglobulin in mice","volume":"29","author":"Matsubara","year":"2018","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.3168\/jds.2021-20260_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.fct.2016.10.010","article-title":"Characterization of the potential allergenicity of irradiated bovine \u03b1-lactalbumin in a BALB\/c mouse model","volume":"97","author":"Meng","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.3168\/jds.2021-20260_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000053832","article-title":"Sensitizing capacity and residual allergenicity of hydrolyzed cow's milk formulae: Results from a murine model","volume":"125","author":"Niggemann","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.3168\/jds.2021-20260_bib20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jaci.2016.06.003","article-title":"Regulatory T cells in allergic diseases","volume":"138","author":"Noval Rivas","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.3168\/jds.2021-20260_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tifs.2014.04.001","article-title":"ISO 14470:2011 and EU legislative background on food irradiation technology: The Italian attitude","volume":"38","author":"Parlato","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"10.3168\/jds.2021-20260_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3389\/fimmu.2014.00671","article-title":"CD4 T-cell subsets in malaria: TH1\/TH2 revisited","volume":"5","author":"Perez-Mazliah","year":"2015","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2021-20260_bib23","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/cea.12570","article-title":"Naturally occurring tolerance acquisition to foods in previously allergic children is characterized by antigen specificity and associated with increased subsets of regulatory T cells","volume":"45","author":"Qamar","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"10.3168\/jds.2021-20260_bib24","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1007\/s00253-014-5678-7","article-title":"Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice","volume":"98","author":"Ren","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.3168\/jds.2021-20260_bib25","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/eji.1830210729","article-title":"Differential regulation of antigen presentation in high- and low-IgE responder mice","volume":"21","author":"Rizzo","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.3168\/jds.2021-20260_bib26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1398-9995.2011.02724.x","article-title":"Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb\/c mouse model of egg allergy","volume":"67","author":"Rupa","year":"2012","journal-title":"Allergy"},{"key":"10.3168\/jds.2021-20260_bib27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1590\/S0100-879X2004000600005","article-title":"A model of chronic IgE-mediated food allergy in ovalbumin-sensitized mice","volume":"37","author":"Saldanha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.3168\/jds.2021-20260_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.alit.2016.08.006","article-title":"Food allergy: Past, present and future","volume":"65","author":"Sampson","year":"2016","journal-title":"Allergol. Int."},{"key":"10.3168\/jds.2021-20260_bib29","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1056\/NEJMcp012667","article-title":"Peanut allergy","volume":"346","author":"Sampson","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 79","key":"10.3168\/jds.2021-20260_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1398-9995.2005.00853.x","article-title":"Food allergy\u2014Accurately identifying clinical reactivity","volume":"60","author":"Sampson","year":"2005","journal-title":"Allergy"},{"key":"10.3168\/jds.2021-20260_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.idairyj.2013.10.010","article-title":"Effects of fermentation by Lactobacillus casei on the antigenicity and allergenicity of four bovine milk proteins","volume":"35","author":"Shi","year":"2014","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2021-20260_bib32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jaci.2010.11.044","article-title":"Epidemiology of food allergy","volume":"127","author":"Sicherer","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.3168\/jds.2021-20260_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jep.2015.08.038","article-title":"Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1\/type 2 helper T cells (Th1\/Th2) balance in a mouse model of food allergy","volume":"175","author":"Shin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.3168\/jds.2021-20260_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2014.12.027","article-title":"Th1\/Th2\/Th17\/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity","volume":"72","author":"Talaat","year":"2015","journal-title":"Cytokine"},{"key":"10.3168\/jds.2021-20260_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.fct.2017.11.026","article-title":"Caffeic acid-assisted cross-linking catalyzed by polyphenol oxidase decreases the allergenicity of ovalbumin in a Balb\/c mouse model","volume":"111","author":"Tong","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.3168\/jds.2021-20260_bib36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxlet.2011.01.010","article-title":"In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas","volume":"201","author":"van Esch","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.3168\/jds.2021-20260_bib37","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3109\/14767058.2015.1057811","article-title":"Th1, Th2, Th17 and Treg levels in umbilical cord blood in preeclampsia","volume":"29","author":"Vargas-Rojas","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.3168\/jds.2021-20260_bib38","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1398-9995.1998.tb03811.x","article-title":"Cow's milk allergens","volume":"53","author":"Wal","year":"1998","journal-title":"Allergy"},{"key":"10.3168\/jds.2021-20260_bib39","article-title":"Enzymatic hydrolysis of cow's whey milk proteins in the aspect of their utilization for the production of hypoallergenic formulas","volume":"14","author":"Wr\u00f3blewska","year":"2005","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"10.3168\/jds.2021-20260_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.yrtph.2015.04.021","article-title":"Allergenicity characteristics of germinated soybean proteins in a BALB\/c mouse model","volume":"72","author":"Yang","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.3168\/jds.2021-20260_bib41","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11947-016-1676-3","article-title":"Effects of enzymatic hydrolysis assisted by high hydrostatic pressure processing on the hydrolysis and allergenicity of proteins from ginkgo seeds","volume":"9","author":"Zhou","year":"2016","journal-title":"Food Bioprocess Technol."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022100881X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022100881X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203022100881X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:31:33Z","timestamp":1731101493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203022100881X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S002203022100881X"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-20260","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of enzymatic hydrolysis on the allergenicity of natural cow milk based on a BALB\/c mouse model","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-20260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}