{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:00:54Z","timestamp":1781002854616,"version":"3.54.1"},"reference-count":53,"publisher":"American Dairy Science Association","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.3168\/jds.2021-20262","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T05:59:01Z","timestamp":1631771941000},"page":"12887-12899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Integration of statistical inferences and machine learning algorithms for prediction of metritis cure in dairy cows"],"prefix":"10.3168","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-8501","authenticated-orcid":false,"given":"E.B.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-2269","authenticated-orcid":false,"given":"F.C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-4476","authenticated-orcid":false,"given":"K.N.","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-0261","authenticated-orcid":false,"given":"J.","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tagkopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-6797","authenticated-orcid":false,"given":"N.","family":"Silva-del-Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-8761","authenticated-orcid":false,"given":"R.V.V.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-8216","authenticated-orcid":false,"given":"V.S.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-6469","authenticated-orcid":false,"given":"F.S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-20262_bib1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.3168\/jds.2006-482","article-title":"Rectal temperature, calving-related factors, and the incidence of puerperal metritis in postpartum dairy cows","volume":"90","author":"Benzaquen","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"10.3168\/jds.2021-20262_bib3","series-title":"SIGMOD International Conference on Management of Data","first-page":"93","article-title":"LOF: Identifying density-based local outliers","author":"Breunig","year":"2000"},{"key":"10.3168\/jds.2021-20262_bib4","author":"CDC"},{"key":"10.3168\/jds.2021-20262_bib5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2460\/javma.2004.224.1634","article-title":"Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows","volume":"224","author":"Chenault","year":"2004","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2021-20262_bib6","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.3168\/jds.2019-18028","article-title":"Using chitosan microparticles to treat metritis in lactating dairy cows","volume":"103","author":"de Oliveira","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib7","author":"de Oliveira"},{"key":"10.3168\/jds.2021-20262_bib8","series-title":"Veterinary Epidemiological Research","author":"Dohoo","year":"2009"},{"key":"10.3168\/jds.2021-20262_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1023\/A:1007413511361","article-title":"On the optimality of the simple Bayesian classifier under zero-one loss","volume":"29","author":"Domingos","year":"1997","journal-title":"Mach. Learn."},{"key":"10.3168\/jds.2021-20262_bib10","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4137\/PMC.S14459","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. Medicin. Chem."},{"key":"10.3168\/jds.2021-20262_bib12","author":"FDA"},{"key":"10.3168\/jds.2021-20262_bib13","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3168\/jds.S0022-0302(94)77212-X","article-title":"Principal descriptors of body condition in Holstein dairy cattle","volume":"77","author":"Ferguson","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib14","first-page":"347","article-title":"Phases of glucose dyshomeostasis in endotoxicosis","volume":"5","author":"Filkins","year":"1978","journal-title":"Circ. Shock"},{"key":"10.3168\/jds.2021-20262_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11259-011-9479-5","article-title":"Cow-specific risk factors for retained placenta, metritis and clinical mastitis in Holstein cows","volume":"35","author":"Ghavi Hossein-Zadeh","year":"2011","journal-title":"Vet. Res. Commun."},{"key":"10.3168\/jds.2021-20262_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.compag.2010.09.001","article-title":"Detection of cows with insemination problems using selected classification models","volume":"74","author":"Grzesiak","year":"2010","journal-title":"Comput. Electron. Agric."},{"key":"10.3168\/jds.2021-20262_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep07060","article-title":"Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1","volume":"4","author":"Healy","year":"2014","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2021-20262_bib18","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.3168\/jds.2014-8984","article-title":"Machine learning algorithms for the prediction of conception success to a given insemination in lactating dairy cows","volume":"98","author":"Hempstalk","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib19","series-title":"Proc. 3rd International Conference on Document Analysis and Recognition","first-page":"278","article-title":"Random decision forest","author":"Ho","year":"1995"},{"key":"10.3168\/jds.2021-20262_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s40064-016-2941-7","article-title":"The distance function effect on k-nearest neighbor classification for medical datasets","volume":"5","author":"Hu","year":"2016","journal-title":"Springerplus"},{"issue":"Suppl. 13","key":"10.3168\/jds.2021-20262_bib21","article-title":"A machine learning approach for the identification of key markers involved in brain development from single-cell transcriptomic data","volume":"17","author":"Hu","year":"2016","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2021-20262_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-61126-8","article-title":"Automated prediction of mastitis infection patterns in dairy herds using machine learning","volume":"10","author":"Hyde","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2021-20262_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1090-0233(05)80007-3","article-title":"The costs of production diseases in dairy herds in England","volume":"154","author":"Kossaibati","year":"1997","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-20262_bib24","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3168\/jds.2016-12001","article-title":"Glucose requirements of an activated immune system in lactating Holstein cows","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib25","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3168\/jds.S0022-0302(02)74302-6","article-title":"Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows","volume":"85","author":"LeBlanc","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib26","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.3168\/jds.2013-7569","article-title":"Efficacy of ampicillin trihydrate or ceftiofur hydrochloride for treatment of metritis and subsequent fertility in dairy cows","volume":"97","author":"Lima","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib27","series-title":"Eighth IEEE International Conference on Data Mining","first-page":"413","article-title":"Isolation Forest","author":"Liu","year":"2008"},{"key":"10.3168\/jds.2021-20262_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.dss.2015.03.008","article-title":"Recommender system application developments: A survey","volume":"74","author":"Lu","year":"2015","journal-title":"Decis. Support Syst."},{"key":"10.3168\/jds.2021-20262_bib29","doi-asserted-by":"crossref","first-page":"9261","DOI":"10.3168\/jds.2020-18643","article-title":"The association of cow-related factors assessed at metritis diagnosis with metritis cure risk, reproductive performance, milk yield, and culling for untreated and ceftiofur-treated dairy cows","volume":"103","author":"Machado","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3168\/jds.S0022-0302(87)79990-1","article-title":"Periparturient traits in seven high dairy herds. Incidence rates, association with parity, and interrelationships among traits","volume":"70","author":"Markusfeld","year":"1987","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1146\/annurev.nutr.24.012003.132159","article-title":"Defective glucose homeostasis during infection","volume":"25","author":"McGuinness","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.3168\/jds.2021-20262_bib32","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.3168\/jds.2011-5111","article-title":"Evaluation of two doses of ceftiofur crystalline free acid sterile suspension for treatment of metritis in lactating dairy cows","volume":"95","author":"McLaughlin","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.3168\/jds.2020-19076","article-title":"Effects of metritis treatment strategies on health, behavior, reproductive, and productive responses of Holstein cows","volume":"104","author":"Merenda","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib34","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1186\/cc11444","article-title":"Effects of endotoxin on lactate metabolism in humans","volume":"16","author":"Michaeli","year":"2012","journal-title":"Crit. Care"},{"key":"10.3168\/jds.2021-20262_bib35","series-title":"Machine Learning","first-page":"111","article-title":"Artificial neural networks","author":"Mitchell","year":"1997"},{"key":"10.3168\/jds.2021-20262_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1109\/TMI.2009.2021941","article-title":"Comparison of AdaBoost and support vector machines for detecting Alzheimer's disease through automated hippocampal segmentation","volume":"29","author":"Morra","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.3168\/jds.2021-20262_bib37","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.3168\/jds.2018-15878","article-title":"Association of dry matter intake and energy balance prepartum and post-partum with health disorders post-partum: Part I. Calving disorders and metritis","volume":"102","author":"P\u00e9rez-B\u00e1ez","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib38","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0031-9384(96)00148-5","article-title":"Anorexia induced by chronic central administration of cytokines at estimated 583 pathophysiological concentrations","volume":"60","author":"Plata-Salam\u00e1n","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.3168\/jds.2021-20262_bib39","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.theriogenology.2013.01.016","article-title":"Comparison of two monitoring and treatment strategies for cows with acute puerperal metritis","volume":"79","author":"Sannmann","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-20262_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/127130","article-title":"Prediction of breeding values for dairy cattle using artificial neural networks and neuro-fuzzy systems","volume":"2012","author":"Shahinfar","year":"2012","journal-title":"Comput. Math. Methods Med."},{"key":"10.3168\/jds.2021-20262_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/vr.155.13.383","article-title":"Minimum inhibitory concentrations of some anti-microbial drugs against bacteria causing uterine infections in cattle","volume":"15","author":"Sheldon","year":"2004","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2021-20262_bib42","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1095\/biolreprod.109.077370","article-title":"Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle","volume":"81","author":"Sheldon","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2021-20262_bib43","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining post-partum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-20262_bib44","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.3168\/jds.2020-19430","article-title":"Economic comparison between ceftiofur-treated and nontreated dairy cows with metritis","volume":"104","author":"Silva","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest non-parametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"key":"10.3168\/jds.2021-20262_bib46","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3168\/jds.2014-9296","article-title":"Assessment of visceral pain associated with metritis in dairy cows","volume":"98","author":"Stojkov","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib47","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/bioinformatics\/17.6.520","article-title":"Missing value estimation methods for DNA microarrays","volume":"17","author":"Troyanskaya","year":"2001","journal-title":"Bioinformatics"},{"issue":"Suppl. 5","key":"10.3168\/jds.2021-20262_bib48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12918-018-0615-5","article-title":"Pipeline design to identify key features and classify the chemotherapy response on lung cancer patients using large-scale genetic data","volume":"12","author":"Vald\u00e9s","year":"2018","journal-title":"BMC Syst. Biol."},{"key":"10.3168\/jds.2021-20262_bib49","first-page":"1","article-title":"mice: Multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.3168\/jds.2021-20262_bib50","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.3168\/jds.2016-10872","article-title":"Vulvovaginal laceration as a risk factor for uterine disease in post-partum dairy cows","volume":"99","author":"Vieira-Neto","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib51","series-title":"Data Mining: Practical Machine Learning Tools and Techniques","author":"Witten","year":"2011"},{"key":"10.3168\/jds.2021-20262_bib52","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.3168\/jds.2018-15791","article-title":"Prediction of metabolic status of dairy cows in early lactation with on-farm cow data and machine learning algorithms","volume":"102","author":"Xu","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20262_bib53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.csbj.2018.02.001","article-title":"An artificial neural network integrated pipeline for biomarker discovery using Alzheimer's disease as a case study","volume":"16","author":"Zafeiris","year":"2018","journal-title":"Comput. Struct. Biotechnol. J."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221008821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221008821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221008821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:31:13Z","timestamp":1731101473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221008821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0022030221008821"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-20262","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of statistical inferences and machine learning algorithms for prediction of metritis cure in dairy cows","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-20262","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Dairy Science Association\u00ae.","name":"copyright","label":"Copyright"}]}}