{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:51:29Z","timestamp":1774435889514,"version":"3.50.1"},"reference-count":56,"publisher":"American Dairy Science Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.3168\/jds.2021-20584","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T17:26:05Z","timestamp":1637342765000},"page":"1573-1588","source":"Crossref","is-referenced-by-count":5,"title":["Randomized clinical trial to evaluate the effects of a prepartum cholecalciferol injection on postpartum serum calcium dynamics and health and performance in early-lactation multiparous dairy cows"],"prefix":"10.3168","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5508","authenticated-orcid":false,"given":"P.L.","family":"Venjakob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bauerfeind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7983-4603","authenticated-orcid":false,"given":"R.","family":"Staufenbiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-5024","authenticated-orcid":false,"given":"M.R.","family":"Wilkens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-2188","authenticated-orcid":false,"given":"C.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-7083","authenticated-orcid":false,"given":"W.","family":"Heuwieser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-5777","authenticated-orcid":false,"given":"S.","family":"Borchardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-20584_bib1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1001\/jama.2010.310","article-title":"Stopping randomized trials early for benefit and estimation of treatment effects","volume":"303","author":"Bassler","year":"2010","journal-title":"JAMA"},{"key":"10.3168\/jds.2021-20584_bib2","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/0024-3205(73)90120-3","article-title":"l\u03b1,25-dihydroxyvitamin D3 receptor: Competitive binding of vitamin D analogs","volume":"13","author":"Brumbaugh","year":"1973","journal-title":"Life Sci."},{"key":"10.3168\/jds.2021-20584_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.theriogenology.2017.01.039","article-title":"Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows","volume":"94","author":"Caixeta","year":"2017","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-20584_bib4","doi-asserted-by":"crossref","first-page":"E384","DOI":"10.1152\/ajpendo.1980.238.4.E384","article-title":"Effects of vitamin D metabolites on bovine parathyroid hormone release in vitro","volume":"238","author":"Chertow","year":"1980","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.3168\/jds.2021-20584_bib5","series-title":"Evaluation of Detection Capability for Clinical Laboratory Measurement Procedures: Approved Guideline","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2012"},{"key":"10.3168\/jds.2021-20584_bib6","series-title":"Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats","author":"Constable","year":"2016"},{"key":"10.3168\/jds.2021-20584_bib7","series-title":"Veterinary Epidemiologic Research","author":"Dohoo","year":"2009"},{"key":"10.3168\/jds.2021-20584_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/03014223.2013.772527","article-title":"Reference concentrations of cholecalciferol in animals: A basis for establishing non-target exposure","volume":"40","author":"Fairweather","year":"2013","journal-title":"N. Z. J. Zool."},{"key":"10.3168\/jds.2021-20584_bib9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0749-0720(15)30108-0","article-title":"Pathophysiology of calcium and phosphorus disorders","volume":"16","author":"Goff","year":"2000","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-20584_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tvjl.2007.12.020","article-title":"The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows","volume":"176","author":"Goff","year":"2008","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-20584_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cvfa.2014.04.003","article-title":"Calcium and magnesium disorders","volume":"30","author":"Goff","year":"2014","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-20584_bib12","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3168\/jds.2013-7467","article-title":"Diet-induced pseudohypoparathyroidism: A hypocalcemia and milk fever risk factor","volume":"97","author":"Goff","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib13","first-page":"664","article-title":"Prophylaxe der Geb\u00e4rparese der Milchkuh durch Verabreichen hoher Dosen Vitamin D3 [Prevention against milk fever in dairy cows by administering high doses of Vitamin D3]","volume":"32","author":"G\u00fcrtler","year":"1977","journal-title":"Monatsh. Veterinarmed."},{"issue":"Suppl. 1","key":"10.3168\/jds.2021-20584_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1017\/S0022029920000424","article-title":"A review of vitamin D and its importance to the health of dairy cattle","volume":"87","author":"Hodnik","year":"2020","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2021-20584_bib15","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3168\/jds.S0022-0302(94)77140-X","article-title":"Calcium and vitamin D metabolism in the dairy cow","volume":"77","author":"Horst","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib16","first-page":"35","article-title":"Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis","volume":"97","author":"Horst","year":"2003","journal-title":"Acta Vet. Scand. Suppl."},{"key":"10.3168\/jds.2021-20584_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0305-0491(82)90064-5","article-title":"Comparison of plasma concentrations of vitamin D and its metabolites in young and aged domestic animals","volume":"73","author":"Horst","year":"1982","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.3168\/jds.2021-20584_bib18","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.3168\/jds.2020-18268","article-title":"Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib19","first-page":"431","article-title":"Milk fever in dairy cows. VIII","volume":"60","author":"Julien","year":"1977","journal-title":"Effect of injected vitamin D3 and calcium and phosphorus intake on incidence"},{"key":"10.3168\/jds.2021-20584_bib20","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.3168\/jds.S0022-0302(06)72335-9","article-title":"Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle","volume":"89","author":"Kimura","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0309-1651(77)90015-7","article-title":"A possible effect of vitamin D metabolites on cell adhesion","volume":"1","author":"Levene","year":"1977","journal-title":"Cell Biol. Int. Rep."},{"key":"10.3168\/jds.2021-20584_bib22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3168\/jds.S0022-0302(82)82263-7","article-title":"Vitamin D3 toxicity in dairy cows","volume":"65","author":"Littledike","year":"1982","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cvfa.2014.07.007","article-title":"Calcium and magnesium physiology and nutrition in relation to the prevention of milk fever and tetany (dietary management of macrominerals in preventing disease)","volume":"30","author":"Mart\u00edn-Tereso","year":"2014","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-20584_bib24","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.3168\/jds.2012-5812","article-title":"Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease","volume":"95","author":"Martinez","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib25","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.3168\/jds.2017-13740","article-title":"Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses","volume":"101","author":"Martinez","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib26","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.3168\/jds.2017-13739","article-title":"Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Lactation performance and energy metabolism","volume":"101","author":"Martinez","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib27","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.3168\/jds.2015-10529","article-title":"Effects of oral calcium supplementation on productive and reproductive performance in Holstein cows","volume":"99","author":"Martinez","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib28","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3168\/jds.2019-17191","article-title":"Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows","volume":"103","author":"McArt","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib29","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.3168\/jds.2017-14143","article-title":"Intramammary 25-hydroxyvitamin D3 treatment modulates innate immune responses to endotoxin-induced mastitis","volume":"101","author":"Merriman","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib30","doi-asserted-by":"crossref","first-page":"9321","DOI":"10.3168\/jds.2018-14587","article-title":"Epidemiology of subclinical hypocalcemia in early-lactation Holstein dairy cows: The temporal associations of plasma calcium concentration in the first 4 days in milk with disease and milk production","volume":"101","author":"Neves","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib31","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2021-20584_bib32","doi-asserted-by":"crossref","DOI":"10.1071\/AN14344","article-title":"Effects of 25-hydroxyvitamin D3 on localisation and extent of gastrointestinal calcium absorption in dairy cattle","volume":"54","author":"Oehlschlaeger","year":"2014","journal-title":"Anim. Prod. Sci."},{"key":"10.3168\/jds.2021-20584_bib33","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3168\/jds.2019-16999","article-title":"Feeding supplemental 25-hydroxyvitamin D3 increases serum mineral concentrations and alters mammary immunity of lactating dairy cows","volume":"103","author":"Poindexter","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib34","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.3168\/jds.2011-4937","article-title":"Metabolic parameters in transition cows as indicators for early-lactation culling risk","volume":"95","author":"Roberts","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib35","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.3168\/jds.2017-13737","article-title":"Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Vitamin D, mineral, and bone metabolism","volume":"101","author":"Rodney","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib36","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.3168\/jds.2020-19344","article-title":"Association of subclinical hypocalcemia dynamics with dry matter intake, milk yield, and blood minerals during the periparturient period","volume":"104","author":"Seely","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tvjl.2010.04.007","article-title":"Metabolic predictors of post-partum disease and culling risk in dairy cattle","volume":"188","author":"Seifi","year":"2011","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-20584_bib38","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.3168\/jds.2020-19389","article-title":"Controlled trial of the effect of negative dietary cation-anion difference on postpartum health of dairy cows","volume":"104","author":"Serrenho","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib39","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.3168\/jds.2020-19371","article-title":"Graduate Student Literature Review: What do we know about the effects of clinical and subclinical hypocalcemia on health and performance of dairy cows?","volume":"104","author":"Serrenho","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0039-128X(96)00186-9","article-title":"Inhibition of membrane L-type calcium channel activity and intracellular calcium concentration by 24R,25-dihydroxyvitamin D3 in vascular smooth muscle","volume":"61","author":"Shan","year":"1996","journal-title":"Steroids"},{"key":"10.3168\/jds.2021-20584_bib41","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-20584_bib42","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0003-9861(71)90163-9","article-title":"Bone mineral mobilization activity of 1,25-dihydroxycholecalciferol, a metabolite of vitamin D","volume":"146","author":"Tanaka","year":"1971","journal-title":"Arch. Biochem. Biophys."},{"key":"10.3168\/jds.2021-20584_bib43","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3168\/jds.2007-0750","article-title":"Blood mineral, hormone, and osteocalcin responses of multiparous Jersey cows to an oral dose of 25-hydroxyvitamin D3 or vitamin D3 before parturition","volume":"91","author":"Taylor","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib44","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.3168\/jds.S0022-0302(05)72965-9","article-title":"Feeding behavior identifies dairy cows at risk for metritis","volume":"88","author":"Urton","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib45","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.3168\/jds.2016-12494","article-title":"Hypocalcemia-cow-level prevalence and preventive strategies in German dairy herds","volume":"100","author":"Venjakob","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib46","doi-asserted-by":"crossref","first-page":"9396","DOI":"10.3168\/jds.2017-14202","article-title":"Association of postpartum hypocalcemia with early-lactation milk yield, reproductive performance, and culling in dairy cows","volume":"101","author":"Venjakob","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib47","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.3168\/jds.2019-16721","article-title":"Serum calcium dynamics within the first 3 days in milk and the associated risk of acute puerperal metritis","volume":"102","author":"Venjakob","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib48","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.3168\/jds.2016-11867","article-title":"Association among gestation length and health, production, and reproduction in Holstein cows and implications for their offspring","volume":"100","author":"Vieira-Neto","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib49","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3168\/jds.2016-12506","article-title":"Use of calcitriol to maintain postpartum blood calcium and improve immune function in dairy cows","volume":"100","author":"Vieira-Neto","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3168\/jds.2020-18448","article-title":"Effects of injectable calcitriol on mineral metabolism and postpartum health and performance in dairy cows","volume":"104","author":"Vieira-Neto","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0169-6009(90)90023-9","article-title":"The mechanisms of vitamin D toxicity","volume":"11","author":"Vieth","year":"1990","journal-title":"Bone Miner."},{"key":"10.3168\/jds.2021-20584_bib52","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2460\/ajvr.82.8.634","article-title":"Effects of calcium supplementation, incomplete milking, and vitamin D3 injection on serum total calcium concentration during the first 24 hours after parturition in dairy cows fed an anionic diet during late gestation","volume":"82","author":"Weber","year":"2021","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-20584_bib53","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.3168\/jds.2014-9188","article-title":"Effect of feeding 25-hydroxyvitamin D3 with a negative cation-anion difference diet on calcium and vitamin D status of periparturient cows and their calves","volume":"98","author":"Weiss","year":"2015","journal-title":"J. Dairy Sci."},{"issue":"Suppl. 1","key":"10.3168\/jds.2021-20584_bib54","doi-asserted-by":"crossref","first-page":"s29","DOI":"10.1017\/S1751731119003197","article-title":"Review: Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants","volume":"14","author":"Wilkens","year":"2020","journal-title":"Animal"},{"key":"10.3168\/jds.2021-20584_bib55","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.3168\/jds.2019-17268","article-title":"Symposium review: Transition cow calcium homeostasis\u2014Health effects of hypocalcemia and strategies for prevention","volume":"103","author":"Wilkens","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-20584_bib56","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3168\/jds.2011-4342","article-title":"Influence of the combination of 25-hydroxyvitamin D3 and a diet negative in cation-anion difference on peripartal calcium homeostasis of dairy cows","volume":"95","author":"Wilkens","year":"2012","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221010316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221010316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221010316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:22:27Z","timestamp":1731100947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221010316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0022030221010316"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-20584","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}