{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:01:35Z","timestamp":1787025695179,"version":"build-2736575974"},"reference-count":52,"publisher":"American Dairy Science Association","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.3168\/jds.2021-21004","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T12:27:17Z","timestamp":1637324837000},"page":"1603-1617","source":"Crossref","is-referenced-by-count":15,"title":["Effect of bupivacaine liposome suspension administered as a cornual nerve block on indicators of pain and distress during and after cautery dehorning in dairy calves"],"prefix":"10.3168","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-5011","authenticated-orcid":false,"given":"Miriam S.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-3657","authenticated-orcid":false,"given":"Michael D.","family":"Kleinhenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie V.","family":"Viscardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-2841","authenticated-orcid":false,"given":"Andrew K.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-6515","authenticated-orcid":false,"given":"Blaine T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-397X","authenticated-orcid":false,"given":"Shawnee R.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-0948","authenticated-orcid":false,"given":"Maria E.","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-3991","authenticated-orcid":false,"given":"Johann F.","family":"Coetzee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-21004_bib1","series-title":"Dehorning Guidelines","author":"AABP","year":"2019"},{"key":"10.3168\/jds.2021-21004_bib2","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.3168\/jds.2018-14987","article-title":"The effect of disbudding age on healing and pain sensitivity in dairy calves","volume":"101","author":"Adcock","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-60260-7","article-title":"Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding","volume":"10","author":"Adcock","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2021-21004_bib4","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.3168\/jds.2012-6251","article-title":"The effect of timing of oral meloxicam administration on physiological responses in calves after cautery dehorning with local anesthesia","volume":"96","author":"Allen","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib5","author":"AVMA"},{"key":"10.3168\/jds.2021-21004_bib6","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.3168\/jds.2018-15033","article-title":"A new method of administering local anesthesia for calf disbudding: Findings from a comparative on-farm study in New Zealand","volume":"102","author":"Bates","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/229255031502300206","article-title":"Buffered lidocaine and bupivacaine mixture-the ideal local anesthetic solution?","volume":"23","author":"Best","year":"2015","journal-title":"Plast. Surg. (Oakv.)"},{"key":"10.3168\/jds.2021-21004_bib8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.rvsc.2013.11.006","article-title":"Influence of environmental factors on infrared eye temperature measurements in cattle","volume":"96","author":"Church","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2021-21004_bib9","first-page":"E1","article-title":"Pharmacokinetics of intravenous and oral meloxicam in ruminant calves","volume":"10","author":"Coetzee","year":"2009","journal-title":"Vet. Ther."},{"key":"10.3168\/jds.2021-21004_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1746-6148-8-153","article-title":"Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia","volume":"8","author":"Coetzee","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2021-21004_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.livsci.2015.05.011","article-title":"Dehorning of cattle in the EU Member States: A quantitative survey of the current practices","volume":"179","author":"Cozzi","year":"2015","journal-title":"Livest. Sci."},{"key":"10.3168\/jds.2021-21004_bib12","series-title":"Guide for the Care and Use of Agricultural Animals in Research and Teaching","author":"FASS","year":"2020"},{"key":"10.3168\/jds.2021-21004_bib13","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3168\/jds.S0022-0302(00)75084-3","article-title":"Reducing pain after dehorning in dairy calves","volume":"83","author":"Faulkner","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib14","author":"FDA"},{"key":"10.3168\/jds.2021-21004_bib15","author":"FDA"},{"key":"10.3168\/jds.2021-21004_bib16","author":"FDA"},{"key":"10.3168\/jds.2021-21004_bib17","author":"FDA"},{"key":"10.3168\/jds.2021-21004_bib18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3168\/jds.2007-0631","article-title":"Survey of dairy management practices on one hundred thirteen north central and northeastern United States dairies","volume":"91","author":"Fulwider","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib19","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jvp.12042","article-title":"The pharmacokinetics and effects of meloxicam, gabapentin, and flunixin in postweaning dairy calves following dehorning with local anesthesia","volume":"36","author":"Glynn","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-1591(93)90094-6","article-title":"Behavioral agitation during handling of cattle is persistent over time","volume":"36","author":"Grandin","year":"1993","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.3168\/jds.2021-21004_bib21","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3168\/jds.2009-2813","article-title":"The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic","volume":"93","author":"Heinrich","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3168\/jds.2008-1424","article-title":"The impact of meloxicam on postsurgical stress associated with cautery dehorning","volume":"92","author":"Heinrich","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib23","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.2527\/jas.2008-1557","article-title":"Temperament traits of beef calves measured under field conditions and their relationships to performance","volume":"88","author":"Hoppe","year":"2010","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.prevetmed.2009.08.015","article-title":"Explaining mastitis incidence in Dutch dairy farming: The influence of farmers' attitudes and behaviour","volume":"92","author":"Jansen","year":"2009","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21004_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2460\/javma.258.2.197","article-title":"Current attitudes of veterinarians and producers regarding the use of local and systemic analgesia in beef and dairy cattle in the United States","volume":"258","author":"Johnstone","year":"2021","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2021-21004_bib26","first-page":"1993","article-title":"Effects of transdermal flunixin meglumine on pain biomarkers at dehorning in calves","volume":"95","author":"Kleinhenz","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.livsci.2018.03.016","article-title":"The impact of transdermal flunixin meglumine on biomarkers of pain in calves when administered at the time of surgical castration without local anesthesia","volume":"212","author":"Kleinhenz","year":"2018","journal-title":"Livest. Sci."},{"key":"10.3168\/jds.2021-21004_bib28","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/jas\/sky450","article-title":"Rapid Communication: Use of pressure mat gait analysis in measuring pain following normal parturition in dairy cows","volume":"97","author":"Kleinhenz","year":"2019","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1751-0813.1998.tb10160.x","article-title":"Effects of local anaesthesia of 4 to 8 hours duration on the acute cortisol response to scoop dehorning in calves","volume":"76","author":"McMeekan","year":"1998","journal-title":"Aust. Vet. J."},{"key":"10.3168\/jds.2021-21004_bib30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tvjl.2003.08.004","article-title":"Animal welfare implications of neonatal mortality and morbidity in farm animals","volume":"168","author":"Mellor","year":"2004","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-21004_bib31","author":"National Milk Producers Federation"},{"key":"10.3168\/jds.2021-21004_bib32","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.2527\/jas.2014-8796","article-title":"Measuring the efficacy of flunixin meglumine and meloxicam for lame sows using a GAITFour pressure mat and an embedded microcomputer-based force plate system","volume":"93","author":"Pairis-Garcia","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib33","series-title":"Veterinary Pharmacology and Therapeutics","author":"Riviere","year":"2018"},{"key":"10.3168\/jds.2021-21004_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/ani11010209","article-title":"Producer and veterinarian perspectives towards pain management practices in the US cattle industry","volume":"11","author":"Robles","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2021-21004_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13054-015-0961-2","article-title":"Burn wound healing and treatment: Review and advancements","volume":"19","author":"Rowan","year":"2015","journal-title":"Crit. Care"},{"key":"10.3168\/jds.2021-21004_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cvfa.2012.11.003","article-title":"Extralabel use of anesthetic and analgesic compounds in cattle","volume":"29","author":"Smith","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-21004_bib37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.tvjl.2004.02.005","article-title":"Dehorning and disbudding distress and its alleviation in calves","volume":"169","author":"Stafford","year":"2005","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-21004_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.applanim.2011.10.018","article-title":"Addressing the pain associated with disbudding and dehorning in cattle","volume":"135","author":"Stafford","year":"2011","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.3168\/jds.2021-21004_bib39","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.physbeh.2007.11.044","article-title":"Eye temperature and heart rate variability of calves disbudded with or without local anaesthetic","volume":"93","author":"Stewart","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.3168\/jds.2021-21004_bib40","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3168\/jds.2008-1578","article-title":"Effects of local anesthetic and a nonsteroidal antiinflammatory drug on pain responses of dairy calves to hot-iron dehorning","volume":"92","author":"Stewart","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cvfa.2012.11.001","article-title":"Bovine dehorning: Assessing pain and providing analgesic management","volume":"29","author":"Stock","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-21004_bib42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2527\/jas.2015-9510","article-title":"Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning","volume":"94","author":"Stock","year":"2016","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib43","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.3168\/jds.2014-8877","article-title":"The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves","volume":"98","author":"Stock","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2527\/jas.2012-5190","article-title":"Effect of castration and dehorning singularly or combined on the behavior and physiology of Holstein calves","volume":"91","author":"Sutherland","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21004_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1746-6148-8-48","article-title":"Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers","volume":"8","author":"Theurer","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2021-21004_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bpa.2014.02.001","article-title":"Liposomal bupivacaine and clinical outcomes","volume":"28","author":"Tong","year":"2014","journal-title":"Baillieres. Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.3168\/jds.2021-21004_bib47","author":"USDA-APHIS-NAHMS"},{"key":"10.3168\/jds.2021-21004_bib48","author":"USDA-APHIS-NAHMS"},{"key":"10.3168\/jds.2021-21004_bib49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1017\/S1466252318000075","article-title":"Effects of transportation on cattle health and production: A review","volume":"19","author":"Van Engen","year":"2018","journal-title":"Anim. Health Res. Rev."},{"key":"10.3168\/jds.2021-21004_bib50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tvjl.2007.02.002","article-title":"Pain mechanisms and their implication for the management of pain in farm and companion animals","volume":"174","author":"Vi\u00f1uela-Fern\u00e1ndez","year":"2007","journal-title":"Vet. J."},{"key":"10.3168\/jds.2021-21004_bib51","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.3168\/jds.2016-11270","article-title":"Practices for the disbudding and dehorning of dairy calves by veterinarians and dairy producers in Ontario, Canada","volume":"99","author":"Winder","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21004_bib52","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.3168\/jds.2017-14092","article-title":"Effects of local anesthetic or systemic analgesia on pain associated with cautery disbudding in calves: A systematic review and meta-analysis","volume":"101","author":"Winder","year":"2018","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221010420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030221010420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221010420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T16:22:26Z","timestamp":1731082946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030221010420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0022030221010420"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-21004","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}