{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:39:42Z","timestamp":1790725182782,"version":"4.1.0"},"reference-count":80,"publisher":"American Dairy Science Association","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"NIFA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.3168\/jds.2021-21227","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T21:21:16Z","timestamp":1646947276000},"page":"4611-4623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Lipopolysaccharide challenge following intravenous amino acid infusion in postpartum dairy cows: II. Clinical and inflammatory responses"],"prefix":"10.3168","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-9436","authenticated-orcid":false,"given":"T.L.","family":"Chandler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Westhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-824X","authenticated-orcid":false,"given":"A.S.","family":"Sipka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-4916","authenticated-orcid":false,"given":"T.R.","family":"Overton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-1154","authenticated-orcid":false,"given":"S.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-21227_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0034-5288(18)30989-5","article-title":"Endotoxin concentrations in the blood following intravenous injection and effect on prostaglandin F2\u03b1 release, calcium and bile acids in goats","volume":"48","author":"Aiumlamai","year":"1990","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2021-21227_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/01652176.1994.9694410","article-title":"Concentrations of serum amyloid-a (SAA) and haptoglobin (HP) as parameters of inflammatory diseases in cattle","volume":"16","author":"Alsemgeest","year":"1994","journal-title":"Vet. Q."},{"issue":"Suppl. 1","key":"10.3168\/jds.2021-21227_bib3","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1186\/1751-0147-44-S1-S141","article-title":"Bovine endotoxicosis\u2014Some aspects of relevance to production diseases. A review","volume":"44","author":"Andersen","year":"2003","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2021-21227_bib4","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.3168\/jds.2008-1016","article-title":"Modifying the acute phase response of jersey calves by supplementing milk replacer with omega-3 fatty acids from fish oil","volume":"91","author":"Ballou","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib5","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.4049\/jimmunol.1102157","article-title":"TLR4-mediated AKT activation is MyD88\/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages","volume":"188","author":"Bauerfeld","year":"2012","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21227_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1017\/S0029665100000148","article-title":"Protein nutrition in late pregnancy, maternal protein reserves and lactation performance in dairy cows","volume":"59","author":"Bell","year":"2000","journal-title":"Proc. Nutr. Soc."},{"key":"10.3168\/jds.2021-21227_bib7","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3168\/jds.2006-445","article-title":"Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows","volume":"90","author":"Bionaz","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib8","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.2527\/jas.2008-0926","article-title":"Behavior of dairy calves after a low dose of bacterial endotoxin","volume":"86","author":"Borderas","year":"2008","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21227_bib9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3945\/jn.109.108233","article-title":"Daily injection of tumor necrosis factor-\u03b1 increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle","volume":"139","author":"Bradford","year":"2009","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2021-21227_bib10","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.3168\/jds.2015-9683","article-title":"Invited review: Inflammation during the transition to lactation: New adventures with an old flame","volume":"98","author":"Bradford","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib11","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.3168\/jds.2015-10621","article-title":"Physiologic, health, and production responses of dairy cows supplemented with an immunomodulatory feed ingredient during the transition period","volume":"99","author":"Brand\u00e3o","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib12","series-title":"Present Knowledge in Nutrition","first-page":"625","article-title":"Nutrient regulation of the immune response","volume":"Vol. 1","author":"Calder","year":"2020"},{"key":"10.3168\/jds.2021-21227_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1753425908099170","article-title":"Profile of the bovine acute-phase response following an intravenous bolus-dose lipopolysaccharide challenge","volume":"15","author":"Carroll","year":"2009","journal-title":"Innate Immun."},{"key":"10.3168\/jds.2021-21227_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(89)80476-4","article-title":"Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes","volume":"242","author":"Castell","year":"1989","journal-title":"FEBS Lett."},{"key":"10.3168\/jds.2021-21227_bib15","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.3168\/jds.2021-21226","article-title":"Lipopolysaccharide challenge following intravenous amino acid infusion in postpartum dairy cows: I. Production, metabolic, and hormonal responses","volume":"105","author":"Chandler","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.2042-3306.1991.tb02706.x","article-title":"Effects of slow infusion of a low dosage of endotoxin on systemic haemodynamics in conscious horses","volume":"23","author":"Clark","year":"1991","journal-title":"Equine Vet. J."},{"issue":"Suppl. 7","key":"10.3168\/jds.2021-21227_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.2042-3306.1989.tb05652.x","article-title":"The effects of slow infusion of a low dosage of endotoxin in healthy horses","volume":"21","author":"Clark","year":"1989","journal-title":"Equine Vet. J. Suppl."},{"key":"10.3168\/jds.2021-21227_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.2460\/ajvr.1991.52.07.990","article-title":"Respiratory, renal, hematologic, and serum biochemical effects of hypertonic saline solution in endotoxemic calves","volume":"52","author":"Constable","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-21227_bib19","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: The master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21227_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/cc1822","article-title":"Clinical review: Myocardial depression in sepsis and septic shock","volume":"6","author":"Court","year":"2002","journal-title":"Crit. Care"},{"key":"10.3168\/jds.2021-21227_bib21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jaci.2005.04.036","article-title":"Mechanisms of nutrient modulation of the immune response","volume":"115","author":"Cunningham-Rundles","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.3168\/jds.2021-21227_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.shk.0000074789.29800.a5","article-title":"Modulation of endotoxin-induced endothelial function by calcium\/calmodulin-dependent protein kinase","volume":"20","author":"Cuschieri","year":"2003","journal-title":"Shock"},{"key":"10.3168\/jds.2021-21227_bib23","first-page":"485","article-title":"Effect of Salmonella typhimurium endotoxin on PGF-2 alpha release and fetal death in the mare","volume":"35","author":"Daels","year":"1987","journal-title":"J. Repro. Fert."},{"key":"10.3168\/jds.2021-21227_bib24","series-title":"Pathology of Septic Shock","first-page":"134","article-title":"Cytokines as mediators in the pathogenesis of septic shock","author":"Dinarello","year":"1996"},{"key":"10.3168\/jds.2021-21227_bib25","series-title":"Fever: Basic Mechanisms and Management","first-page":"23","article-title":"Endogenous pyrogens. The role of cytokines in the pathogenesis of fever","author":"Dinarello","year":"1999"},{"key":"10.3168\/jds.2021-21227_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/PSY.0b013e318245d762","article-title":"Associations of in vivo \u03b2-adrenergic receptor sensitivity with inflammatory markers in healthy subjects","volume":"74","author":"Euteneuer","year":"2012","journal-title":"Psychosom. Med."},{"key":"10.3168\/jds.2021-21227_bib27","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.3168\/jds.2015-10086","article-title":"Short communication: Amino acid supplementation and stage of lactation alter apparent utilization of nutrients by blood neutrophils from lactating dairy cows in vitro","volume":"99","author":"Garcia","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib28","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.4049\/jimmunol.1000296","article-title":"A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation","volume":"185","author":"Haidinger","year":"2010","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21227_bib29","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.3168\/jds.2017-13899","article-title":"Effect of chromium on bioenergetics and leukocyte dynamics following immunoactivation in lactating Holstein cows","volume":"101","author":"Horst","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib30","doi-asserted-by":"crossref","first-page":"11681","DOI":"10.3168\/jds.2019-17037","article-title":"Effects of dietary zinc source on the metabolic and immunological response to lipopolysaccharide in lactating Holstein dairy cows","volume":"102","author":"Horst","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib31","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.3168\/jds.2020-18268","article-title":"Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1017\/S0031182001007922","article-title":"The expression of immunity to Teladorsagia circumcincta in ewes and its relationship to protein nutrition depend on body protein reserves","volume":"122","author":"Houdijk","year":"2001","journal-title":"Parasitology"},{"key":"10.3168\/jds.2021-21227_bib33","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1073\/pnas.97.13.7078","article-title":"Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice","volume":"97","author":"Ing","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl. 1","key":"10.3168\/jds.2021-21227_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1017\/S175173111200170X","article-title":"Nutrition, immune function and health of dairy cattle","volume":"7","author":"Ingvartsen","year":"2013","journal-title":"Animal"},{"key":"10.3168\/jds.2021-21227_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.3168\/jds.2021-21227_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1051\/vetres:2004062","article-title":"Dose dependency and individual variability in selected clinical, haematological and blood biochemical responses after systemic lipopolysaccharide challenge in cattle","volume":"36","author":"Jacobsen","year":"2005","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2021-21227_bib37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijpara.2011.01.011","article-title":"Dissecting the impact of protein versus energy host nutrition on the expression of immunity to gastrointestinal parasites during lactation","volume":"41","author":"Jones","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.3168\/jds.2021-21227_bib38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1353\/pbm.1993.0004","article-title":"Regulation of the acute phase response by cytokines","volume":"36","author":"Kushner","year":"1993","journal-title":"Perspect. Biol. Med."},{"key":"10.3168\/jds.2021-21227_bib39","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3168\/jds.2016-12001","article-title":"Glucose requirements of an activated immune system in lactating Holstein cows","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib40","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/00003246-199909000-00039","article-title":"Effects of inhaled nitric oxide on pulmonary hemodynamics in a porcine model of endotoxin shock","volume":"27","author":"Lambermont","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.3168\/jds.2021-21227_bib41","first-page":"2097","article-title":"Effect of experimentally increased protein supply to postpartum dairy cows on plasma protein synthesis, rumen tissue proliferation, and immune homeostasis","volume":"95","author":"Larsen","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2021-21227_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00075198-200102000-00001","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.3168\/jds.2021-21227_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01652176.1988.9694157","article-title":"Pathophysiological effects of endotoxins in ruminants","volume":"10","author":"Lohuis","year":"1988","journal-title":"Vet. Q."},{"key":"10.3168\/jds.2021-21227_bib44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s40104-020-00501-x","article-title":"Role of nutraceuticals during the transition period of dairy cows: A review","volume":"11","author":"Lopreiato","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.3168\/jds.2021-21227_bib45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1439-0442.1988.tb00097.x","article-title":"Local and general effects of Salmonella typhimurium endotoxin in calves","volume":"35","author":"Luthman","year":"1988","journal-title":"Zentralbl. Veterin\u00e4rmed. A"},{"key":"10.3168\/jds.2021-21227_bib46","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.4049\/jimmunol.146.9.3032","article-title":"Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines","volume":"146","author":"Mackiewicz","year":"1991","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21227_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00360-016-0969-1","article-title":"Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum","volume":"186","author":"Mann","year":"2016","journal-title":"J. Comp. Physiol. B"},{"key":"10.3168\/jds.2021-21227_bib48","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3168\/jds.2014-9024","article-title":"Dry period plane of energy: Effects on feed intake, energy balance, milk production, and composition in transition dairy cows","volume":"98","author":"Mann","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib49","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.3168\/jds.2018-14549","article-title":"Nutrient-sensing kinase signaling in bovine immune cells is altered during the postpartum nutrient deficit: A possible role in transition cow inflammatory response","volume":"101","author":"Mann","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib50","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.4049\/jimmunol.0903790","article-title":"Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain","volume":"185","author":"Medina","year":"2010","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21227_bib51","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3168\/jds.S0022-0302(95)76730-3","article-title":"Free amino acids in plasma and muscle of high yielding dairy cows in early lactation","volume":"78","author":"Meijer","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib52","series-title":"Nutritional Requirements of Dairy Cattle","author":"NRC (National Research Council)","year":"1971"},{"key":"10.3168\/jds.2021-21227_bib53","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cvfa.2013.04.003","article-title":"Using nonesterified fatty acids and B-hydroxybutyrate concentrations during the transition period for herd-level monitoring of increased risk of disease and decreased reproductive and milking performance","volume":"29","author":"Ospina","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-21227_bib54","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1172\/JCI112135","article-title":"A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance","volume":"76","author":"Parrillo","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.3168\/jds.2021-21227_bib55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3389\/fphar.2020.00481","article-title":"Impact of TNF-\u03b1 inhibitors on body weight and BMI: A systematic review and meta-analysis","volume":"11","author":"Patsalos","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.3168\/jds.2021-21227_bib56","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2249.1991.tb05666.x","article-title":"Acute-phase protein synthesis in human hepatoma cells: Differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6","volume":"83","author":"Raynes","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"10.3168\/jds.2021-21227_bib57","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.3168\/jds.2019-17307","article-title":"The effect of ex vivo lipopolysaccharide stimulation and nutrient availability on transition cow innate immune cell AKT\/mTOR pathway responsiveness","volume":"103","author":"Sipka","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib58","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3168\/jdsc.2021-0191","article-title":"Development of a bead-based multiplex assay to quantify bovine IL-10, TNF-\u03b1, and IFN-\u03b3 concentrations in plasma and cell culture supernatant","volume":"3","author":"Sipka","year":"2022","journal-title":"JDS Commun."},{"key":"10.3168\/jds.2021-21227_bib59","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1084\/jem.154.4.1212","article-title":"Role of prostaglandin E in the biphasic fever response to endotoxin","volume":"154","author":"Skarnes","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.3168\/jds.2021-21227_bib60","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.3168\/jds.2015-10354","article-title":"Nutritional strategies to optimize dairy cattle immunity","volume":"99","author":"Sordillo","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib61","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1071\/AN14503","article-title":"The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows","volume":"54","author":"Sordillo","year":"2014","journal-title":"Anim. Prod. Sci."},{"key":"10.3168\/jds.2021-21227_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0165-2427(95)05465-0","article-title":"Enhanced production of bovine tumor necrosis factor-\u03b1 during the periparturient period","volume":"49","author":"Sordillo","year":"1995","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21227_bib63","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1371\/journal.pbio.0040284","article-title":"Cellular and molecular bases of the initiation of fever","volume":"4","author":"Steiner","year":"2006","journal-title":"PLoS Biol."},{"key":"10.3168\/jds.2021-21227_bib64","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/infdis\/jis527","article-title":"Protein energy malnutrition decreases immunity and increases susceptibility to influenza infection in mice","volume":"207","author":"Taylor","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.3168\/jds.2021-21227_bib65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3168\/jds.2008-1345","article-title":"Dietary calcium has little effect on mineral balance and bone mineral metabolism through twenty weeks of lactation in Holstein cows","volume":"92","author":"Taylor","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib66","first-page":"135","article-title":"Metabolic response of calves following acute experimental endotoxemia","volume":"4","author":"Tennant","year":"1973","journal-title":"Ann. Rech. Vet."},{"key":"10.3168\/jds.2021-21227_bib67","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.3168\/jds.2015-9378","article-title":"The Cornell Net Carbohydrate and Protein System: Updates to the model and evaluation of version 6.5","volume":"98","author":"Van Amburgh","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib68","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.3168\/jds.2011-4771","article-title":"Protein and fat mobilization and associations with serum \u03b2-hydroxybutyrate concentrations in dairy cows","volume":"95","author":"van der Drift","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib69","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.nut.2018.10.024","article-title":"Protein malnutrition impairs the immune control of Trichinella spiralis infection","volume":"60","author":"Vila","year":"2019","journal-title":"Nutrition"},{"key":"10.3168\/jds.2021-21227_bib70","doi-asserted-by":"crossref","first-page":"e00017","DOI":"10.1128\/mSphere.00046-17","article-title":"Protein malnutrition modified innate immunity and gene expression by intestinal epithelial cells and human rotavirus infection in neonatal gnotobiotic pigs","volume":"2","author":"Vlasova","year":"2017","journal-title":"MSphere"},{"key":"10.3168\/jds.2021-21227_bib71","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2460\/ajvr.2004.65.64","article-title":"Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis","volume":"65","author":"Wagner","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-21227_bib72","series-title":"Proc. Florida Ruminant Nutrition Symposium, Gainesville, FL","first-page":"1","article-title":"Nutritional strategies to enhance immunity during the transition period of dairy cows","author":"Waldron","year":"2007"},{"key":"10.3168\/jds.2021-21227_bib73","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.3168\/jds.S0022-0302(03)73949-6","article-title":"Effect of lipopolysaccharide on indices of peripheral and hepatic metabolism in lactating cows","volume":"86","author":"Waldron","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00064.2009","article-title":"Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows","volume":"39","author":"Wathes","year":"2009","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2021-21227_bib75","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.immuni.2008.08.012","article-title":"The TSC-mTOR signaling pathway regulates the innate inflammatory response","volume":"29","author":"Weichhart","year":"2008","journal-title":"Immunity"},{"key":"10.3168\/jds.2021-21227_bib76","series-title":"Large Animal Internal Medicine","first-page":"32","article-title":"Alterations in body temperature","author":"White","year":"2008"},{"key":"10.3168\/jds.2021-21227_bib77","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3168\/jds.2013-7322","article-title":"Associations of cytological endometritis with energy metabolism and inflammation during the periparturient period and early lactation in dairy cows","volume":"97","author":"Yasui","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21227_bib78","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mehy.2018.07.014","article-title":"Proposed mechanisms of relative bradycardia","volume":"119","author":"Ye","year":"2018","journal-title":"Med. Hypotheses"},{"key":"10.3168\/jds.2021-21227_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080316","article-title":"TNF\u03b1 altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows","volume":"8","author":"Yuan","year":"2013","journal-title":"PLoS One"},{"key":"10.3168\/jds.2021-21227_bib80","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3168\/jds.2013-7222","article-title":"Induced hyperketonemia affects the mammary immune response during lipopolysaccharide challenge in dairy cows","volume":"97","author":"Zarrin","year":"2014","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030222001461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030222001461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030222001461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:51:11Z","timestamp":1731102671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030222001461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0022030222001461"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-21227","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide challenge following intravenous amino acid infusion in postpartum dairy cows: II. Clinical and inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-21227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-21226","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}