{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:10:08Z","timestamp":1790493008515,"version":"4.1.0"},"reference-count":81,"publisher":"American Dairy Science Association","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"NIFA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.3168\/jds.2021-21276","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T21:41:38Z","timestamp":1647553298000},"page":"4301-4313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genome-wide association analysis for susceptibility to infection by Mycobacterium avium ssp. paratuberculosis in US Holsteins"],"prefix":"10.3168","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-3861","authenticated-orcid":false,"given":"B.W.","family":"Kirkpatrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Frie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.B.","family":"Sporer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-7124","authenticated-orcid":false,"given":"B.","family":"Lett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Coussens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-21276_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.20506\/rst.17.1.1092","article-title":"The major histocompatibility complex of ruminants","volume":"17","author":"Amills","year":"1998","journal-title":"Rev. Sci. Tech."},{"key":"10.3168\/jds.2021-21276_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.3168\/jds.2021-21276_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate \u2013 A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.3168\/jds.2021-21276_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/gb-2011-12-10-232","article-title":"Genome-wide association studies in plants: the missing heritability is in the field","volume":"12","author":"Brachi","year":"2011","journal-title":"Genome Biol."},{"key":"10.3168\/jds.2021-21276_bib5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ajhg.2018.07.015","article-title":"A one-penny imputed genome from next-generation reference panels","volume":"103","author":"Browning","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2021-21276_bib6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cvfa.2011.07.010","article-title":"State, federal, and industry efforts at paratuberculosis control","volume":"27","author":"Carter","year":"2011","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-21276_bib7","series-title":"Council on Dairy Cattle Breeding Activity Report. 2018 Oct 17\/Sep 18","volume":"Vol. 2021","author":"CDCB","year":"2018"},{"key":"10.3168\/jds.2021-21276_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"10.3168\/jds.2021-21276_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrg3114","article-title":"Human genetic susceptibility to infectious disease","volume":"13","author":"Chapman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.3168\/jds.2021-21276_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/1040841X.2011.638273","article-title":"Crohn's disease and the mycobacterioses: A quarter century later. Causation or simple association?","volume":"38","author":"Chiodini","year":"2012","journal-title":"Crit. Rev. Microbiol."},{"key":"10.3168\/jds.2021-21276_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-2052.2004.01138.x","article-title":"Evidence for quantitative trait loci affecting twinning rate in North American Holstein cattle","volume":"35","author":"Cruickshank","year":"2004","journal-title":"Anim. Genet."},{"key":"10.3168\/jds.2021-21276_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2460\/javma.2001.219.497","article-title":"Prevalence of antibodies against Mycobacterium avium subsp paratuberculosis among beef cow-calf herds","volume":"219","author":"Dargatz","year":"2001","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2021-21276_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: Generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLOS Comput. Biol."},{"key":"10.3168\/jds.2021-21276_bib14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fvets.2020.00108","article-title":"Mycobacterium avium subspecies paratuberculosis drives an innate Th17-like T cell response regardless of the presence of antigen-presenting cells","volume":"7","author":"DeKuiper","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.3168\/jds.2021-21276_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2019.109952","article-title":"Mycobacterium avium sp. paratuberculosis (MAP) induces IL-17a production in bovine peripheral blood mononuclear cells (PBMCs) and enhances IL-23R expression in vivo and in vitro","volume":"218","author":"DeKuiper","year":"2019","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21276_bib16","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.3168\/jds.2013-7059","article-title":"Increased blood-circulating interferon-gamma, interleukin-17, and osteopontin levels in bovine paratuberculosis","volume":"97","author":"Dudemaine","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib17","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1073\/pnas.0502402102","article-title":"Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2","volume":"102","author":"Eggler","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2021-21276_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/BJ20090471","article-title":"Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1","volume":"422","author":"Eggler","year":"2009","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2021-21276_bib19","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ng.3528","article-title":"Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci","volume":"48","author":"Ellinghaus","year":"2016","journal-title":"Nat. Genet."},{"key":"10.3168\/jds.2021-21276_bib20","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.3168\/jds.2011-4550","article-title":"Reduction in incidence of Johne's disease associated with implementation of a disease control program in Minnesota demonstration herds","volume":"95","author":"Espejo","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib21","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ejhg.2015.269","article-title":"The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants","volume":"24","author":"Fadista","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.3168\/jds.2021-21276_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.prevetmed.2008.08.001","article-title":"Decrease of Johne's disease prevalence and incidence in six Minnesota, USA, dairy cattle herds on a long-term management program","volume":"88","author":"Ferrouillet","year":"2009","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030545","article-title":"A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle","volume":"7","author":"Finlay","year":"2012","journal-title":"PLoS One"},{"key":"10.3168\/jds.2021-21276_bib24","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1186\/s12864-018-5385-3","article-title":"Genome-wide association study of Mycobacterium avium subspecies paratuberculosis infection in Chinese Holstein","volume":"19","author":"Gao","year":"2018","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2021-21276_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1297-9686-41-55","article-title":"Deregressing estimated breeding values and weighting information for genomic regression analyses","volume":"41","author":"Garrick","year":"2009","journal-title":"Genet. Sel. Evol."},{"issue":"D1","key":"10.3168\/jds.2021-21276_bib26","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: Enriching a GOld mine","volume":"49","author":"Gene Ontology","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2021-21276_bib27","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3168\/jds.S0022-0302(06)72249-4","article-title":"Genetic variation of Mycobacterium avium ssp. paratuberculosis infection in US Holsteins","volume":"89","author":"Gonda","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.prevetmed.2007.01.011","article-title":"Effect of Mycobacterium paratuberculosis infection on production, reproduction, and health traits in US Holsteins","volume":"80","author":"Gonda","year":"2007","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0167-5877(03)00083-7","article-title":"Development of the Dutch Johne's disease control program supported by a simulation model","volume":"60","author":"Groenendaal","year":"2003","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib30","first-page":"255","article-title":"Control of paratuberculosis in Iceland","volume":"44","author":"Gunnarsson","year":"2003","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2021-21276_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.14.3.489-512.2001","article-title":"Mycobacterium avium subsp. paratuberculosis in veterinary medicine","volume":"14","author":"Harris","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.3168\/jds.2021-21276_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-animal-020518-115024","article-title":"1000 Bull Genomes Project to map simple and complex genetic traits in cattle: Applications and outcomes","volume":"7","author":"Hayes","year":"2019","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.3168\/jds.2021-21276_bib33","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.3168\/jds.2008-1021","article-title":"Heritability estimates for antibody response to Mycobacterium avium subspecies paratuberculosis in German Holstein cattle","volume":"91","author":"Hinger","year":"2008","journal-title":"J. Dairy Sci."},{"issue":"D1","key":"10.3168\/jds.2021-21276_bib34","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2021-21276_bib35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0378-1135(00)00327-8","article-title":"Herd testing to control bovine Johne's disease","volume":"77","author":"Jubb","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2021-21276_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fmicb.2012.00215","article-title":"Infection of primary bovine macrophages with Mycobacterium avium subspecies paratuberculosis suppresses host cell apoptosis","volume":"3","author":"Kabara","year":"2012","journal-title":"Front. Microbiol."},{"issue":"D1","key":"10.3168\/jds.2021-21276_bib37","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2021-21276_bib38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/bib\/bbx085","article-title":"The BioCyc collection of microbial genomes and metabolic pathways","volume":"20","author":"Karp","year":"2019","journal-title":"Brief. Bioinform."},{"key":"10.3168\/jds.2021-21276_bib39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2121-11-63","article-title":"Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors","volume":"11","author":"Kelley","year":"2010","journal-title":"BMC Cell Biol."},{"key":"10.3168\/jds.2021-21276_bib40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0378-1135(00)00329-1","article-title":"Progress in national control and assurance programs for bovine Johne's disease in Australia","volume":"77","author":"Kennedy","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.3168\/jds.2021-21276_bib41","author":"Kirkpatrick"},{"key":"10.3168\/jds.2021-21276_bib42","author":"Kirkpatrick"},{"key":"10.3168\/jds.2021-21276_bib43","author":"Kirkpatrick"},{"key":"10.3168\/jds.2021-21276_bib44","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.3168\/jds.2018-15021","article-title":"Short communication: Heritability of susceptibility to infection by Mycobacterium avium ssp. paratuberculosis in Holstein cattle","volume":"101","author":"Kirkpatrick","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib45","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3168\/jds.S0022-0302(00)75164-2","article-title":"Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle","volume":"83","author":"Koets","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fpubh.2017.00208","article-title":"The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017","volume":"5","author":"Kuenstner","year":"2017","journal-title":"Front. Public Health"},{"key":"10.3168\/jds.2021-21276_bib47","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.3168\/jds.2011-4994","article-title":"Heritability estimates for Mycobacterium avium subspecies paratuberculosis status of German Holstein cows tested by fecal culture","volume":"95","author":"K\u00fcpper","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib48","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.3168\/jds.2021-21276_bib49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cvfa.2011.07.012","article-title":"Epidemiology and economics of paratuberculosis","volume":"27","author":"Lombard","year":"2011","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2021-21276_bib50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.prevetmed.2012.08.006","article-title":"Herd-level prevalence of Mycobacterium avium subsp. paratuberculosis infection in United States dairy herds in 2007","volume":"108","author":"Lombard","year":"2013","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib51","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrm2261","article-title":"The prolyl isomerase PIN1: A pivotal new twist in phosphorylation signalling and disease","volume":"8","author":"Lu","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jds.2021-21276_bib52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nm.2102","article-title":"Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes","volume":"16","author":"Manganaro","year":"2010","journal-title":"Nat. Med."},{"issue":"D1","key":"10.3168\/jds.2021-21276_bib53","doi-asserted-by":"crossref","first-page":"D613","DOI":"10.1093\/nar\/gkaa1024","article-title":"WikiPathways: Connecting communities","volume":"49","author":"Martens","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2021-21276_bib54","series-title":"Manual for BLUPF90 family programs","volume":"Vol. 2020","author":"Misztal","year":"2018"},{"issue":"Suppl","key":"10.3168\/jds.2021-21276_bib55","first-page":"S19","article-title":"Epidemiological situation and control strategies for paratuberculosis in Japan","volume":"60","author":"Momotani","year":"2012","journal-title":"Jpn. J. Vet. Res."},{"key":"10.3168\/jds.2021-21276_bib56","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.3168\/jds.S0022-0302(04)70029-6","article-title":"Genetic variation and heritability of the antibody response to Mycobacterium avium subspecies paratuberculosis in Danish Holstein cows","volume":"87","author":"Mortensen","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib57","author":"National Animal Health Monitoring System"},{"key":"10.3168\/jds.2021-21276_bib58","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2011.04.010","article-title":"A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens","volume":"9","author":"Ogawa","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.3168\/jds.2021-21276_bib59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0167-5877(99)00037-9","article-title":"Herd-level economic losses associated with Johne's disease on US dairy operations","volume":"40","author":"Ott","year":"1999","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib60","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.3168\/jds.2013-7543","article-title":"Genomic selection for producer-recorded health event data in US dairy cattle","volume":"97","author":"Parker Gaddis","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/gepi.20303","article-title":"Estimation of the multiple testing burden for genomewide association studies of nearly all common variants","volume":"32","author":"Pe'er","year":"2008","journal-title":"Genet. Epidemiol."},{"key":"10.3168\/jds.2021-21276_bib62","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/gut.2009.182170","article-title":"Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease","volume":"58","author":"Rovedatti","year":"2009","journal-title":"Gut"},{"key":"10.3168\/jds.2021-21276_bib63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S0022029916000807","article-title":"An across-breed genome wide association analysis of susceptibility to paratuberculosis in dairy cattle","volume":"84","author":"Sallam","year":"2017","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2021-21276_bib64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12711-020-00535-9","article-title":"Identification of the ABCC4, IER3, and CBFA2T2 candidate genes for resistance to paratuberculosis from sequence-based GWAS in Holstein and Normande dairy cattle","volume":"52","author":"Sanchez","year":"2020","journal-title":"Genet. Sel. Evol."},{"key":"10.3168\/jds.2021-21276_bib65","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/1471-2164-15-478","article-title":"A new approach for efficient genotype imputation using information from relatives","volume":"15","author":"Sargolzaei","year":"2014","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2021-21276_bib66","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ibd.20339","article-title":"Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD","volume":"14","author":"Seiderer","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.3168\/jds.2021-21276_bib67","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12859-017-1571-6","article-title":"Avoiding the pitfalls of gene set enrichment analysis with SetRank","volume":"18","author":"Simillion","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"10.3168\/jds.2021-21276_bib68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.prevetmed.2017.01.007","article-title":"Economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study","volume":"138","author":"Smith","year":"2017","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2021-21276_bib69","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.3168\/jds.2008-1832","article-title":"A longitudinal study on the impact of Johne's disease status on milk production in individual cows","volume":"92","author":"Smith","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib70","author":"Storey"},{"key":"10.3168\/jds.2021-21276_bib71","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1939-1676.2012.01019.x","article-title":"Paratuberculosis (Johne's disease) in cattle and other susceptible species","volume":"26","author":"Sweeney","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"10.3168\/jds.2021-21276_bib72","first-page":"243","article-title":"The National paratuberculosis program in Norway","volume":"44","author":"Tharaldsen","year":"2003","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2021-21276_bib73","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2164-15-559","article-title":"A genome-wide association study of immune response traits in Canadian Holstein cattle","volume":"15","author":"Thompson-Crispi","year":"2014","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2021-21276_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148731","article-title":"The Association of Mycobacterium avium subsp. paratuberculosis with inflammatory bowel disease","volume":"11","author":"Timms","year":"2016","journal-title":"PLoS One"},{"key":"10.3168\/jds.2021-21276_bib75","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3168\/jds.2010-3472","article-title":"Effect of herd prevalence on heritability estimates of antibody response to Mycobacterium avium subspecies paratuberculosis","volume":"94","author":"van Hulzen","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib76","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0016672312000274","article-title":"Genome-wide association mapping including phenotypes from relatives without genotypes","volume":"94","author":"Wang","year":"2012","journal-title":"Genet. Res."},{"key":"10.3168\/jds.2021-21276_bib77","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2460\/ajvr.2002.63.1207","article-title":"Evaluation of bacteriologic culture of pooled fecal samples for detection of Mycobacterium paratuberculosis","volume":"63","author":"Wells","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-21276_bib78","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1420-9101.2005.00917.x","article-title":"Combining probability from independent tests: The weighted Z-method is superior to Fisher's approach","volume":"18","author":"Whitlock","year":"2005","journal-title":"J. Evol. Biol."},{"key":"10.3168\/jds.2021-21276_bib79","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1126\/science.281.5379.998","article-title":"IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival","volume":"281","author":"Wu","year":"1998","journal-title":"Science"},{"key":"10.3168\/jds.2021-21276_bib80","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.3168\/jds.2013-7426","article-title":"Short communication: Heritability estimates for susceptibility to Mycobacterium avium subspecies paratuberculosis infection defined by ELISA and fecal culture test results in Jersey cattle","volume":"97","author":"Zare","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21276_bib81","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/23293","article-title":"A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation","volume":"400","author":"Zhu","year":"1999","journal-title":"Nature"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030222001709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030222001709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030222001709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:51:13Z","timestamp":1731102673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030222001709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0022030222001709"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-21276","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association analysis for susceptibility to infection by Mycobacterium avium ssp. paratuberculosis in US Holsteins","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-21276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}