{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:46:30Z","timestamp":1788367590488,"version":"build-2803163510"},"reference-count":78,"publisher":"American Dairy Science Association","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003524","name":"Ministry of Business, Innovation and Employment","doi-asserted-by":"publisher","award":["1302"],"award-info":[{"award-number":["1302"]}],"id":[{"id":"10.13039\/501100003524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.3168\/jds.2021-21742","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T15:20:05Z","timestamp":1673882405000},"page":"2651-2666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of nonsteroidal anti-inflammatory drugs on the inflammatory response of bovine endometrial epithelial cells in vitro"],"prefix":"10.3168","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6137-2006","authenticated-orcid":false,"given":"M.A.","family":"Crookenden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-8661","authenticated-orcid":false,"given":"A.V.R.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-8675","authenticated-orcid":false,"given":"C.R.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-8758","authenticated-orcid":false,"given":"J.T.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-7176","authenticated-orcid":false,"given":"M.D.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4912-4069","authenticated-orcid":false,"given":"C.V.C.","family":"Phyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-9253","authenticated-orcid":false,"given":"J.R.","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-6132","authenticated-orcid":false,"given":"A.","family":"Heiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2021-21742_bib1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.repbio.2018.10.001","article-title":"Eicosanoid pathway expression in bovine endometrial epithelial and stromal cells in response to lipopolysaccharide, interleukin 1 beta, and tumor necrosis factor alpha","volume":"18","author":"Almughlliq","year":"2018","journal-title":"Reprod. Biol."},{"key":"10.3168\/jds.2021-21742_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2885.2001.00358.x","article-title":"Flunixin meglumine accelerates uterine involution and shortens the calving-to-first-oestrus interval in cows with puerperal metritis","volume":"24","author":"Amiridis","year":"2001","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21742_bib3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.theriogenology.2007.12.005","article-title":"A comparison of diagnostic techniques for postpartum endometritis in dairy cattle","volume":"69","author":"Barlund","year":"2008","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jacl.2012.04.077","article-title":"Fatty acids in cardiovascular health and disease: A comprehensive update","volume":"6","author":"Baum","year":"2012","journal-title":"J. Clin. Lipidol."},{"key":"10.3168\/jds.2021-21742_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.3168\/jds.2021-21742_bib6","doi-asserted-by":"crossref","DOI":"10.4172\/2153-2435.1000560","article-title":"In vivo studies for drug development via oral delivery: Challenges, animal models, and techniques","volume":"8","author":"Brake","year":"2017","journal-title":"Pharm. Anal. Acta"},{"key":"10.3168\/jds.2021-21742_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2460\/ajvr.2003.64.211","article-title":"Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B","volume":"64","author":"Bryant","year":"2003","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-21742_bib8","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.3168\/jds.2019-16630","article-title":"Meloxicam affects the inflammatory responses of bovine mammary epithelial cells","volume":"102","author":"Caldeira","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib9","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.jprot.2012.04.004","article-title":"Acute phase proteins in ruminants","volume":"75","author":"Ceciliani","year":"2012","journal-title":"J. Proteomics"},{"key":"10.3168\/jds.2021-21742_bib10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2174\/1389203720666190405101138","article-title":"The immune functions of \u03b11 acid glycoprotein","volume":"20","author":"Ceciliani","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.3168\/jds.2021-21742_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetimm.2012.09.042","article-title":"Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. coli stimulation","volume":"151","author":"Chapwanya","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21742_bib12","author":"Crookenden"},{"key":"10.3168\/jds.2021-21742_bib13","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/mnfr.201000621","article-title":"Response of a Lactobacillus plantarum human isolate to tannic acid challenge assessed by proteomic analyses","volume":"55","author":"Curiel","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.3168\/jds.2021-21742_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1477-7827-6-53","article-title":"Toll-like receptor and antimicrobial peptide expression in the bovine endometrium","volume":"6","author":"Davies","year":"2008","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.3168\/jds.2021-21742_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/01.AOG.0000230214.26638.0c","article-title":"Primary dysmenorrhea: Advances in pathogenesis and management","volume":"108","author":"Dawood","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"10.3168\/jds.2021-21742_bib16","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.3168\/jds.2013-7450","article-title":"Invited review: Systematic review of diagnostic tests for reproductive-tract infection and inflammation in dairy cows","volume":"97","author":"de Boer","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib17","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2460\/ajvr.1996.57.07.1031","article-title":"Ketoprofen concentrations in plasma and milk after intravenous administration in dairy cattle","volume":"57","author":"De Graves","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2021-21742_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2885.2012.01396.x","article-title":"Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows","volume":"36","author":"Donalisio","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21742_bib19","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3168\/jds.S0022-0302(01)74644-9","article-title":"Evaluation of a systemic antibiotic treatment of toxic puerperal metritis in dairy cows","volume":"84","author":"Drillich","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib20","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3168\/jds.S0022-0302(06)72216-0","article-title":"Acute phase proteins in bovine milk in an experimental model of Staphylococcus aureus subclinical mastitis","volume":"89","author":"Eckersall","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1071\/RD09120","article-title":"Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis","volume":"22","author":"Fischer","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"10.3168\/jds.2021-21742_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0167-4838(00)00153-9","article-title":"Alpha-1-acid glycoprotein","volume":"1482","author":"Fournier","year":"2000","journal-title":"Biochim. Biophys. Acta Protein Struct. Mol. Enzymol."},{"key":"10.3168\/jds.2021-21742_bib23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1124\/dmd.118.085506","article-title":"Role of ABCG2 in secretion into milk of the anti-inflammatory flunixin and its main metabolite: In vitro-in vivo correlation in mice and cows","volume":"47","author":"Garcia-Mateos","year":"2019","journal-title":"Drug Metab. Dispos."},{"key":"10.3168\/jds.2021-21742_bib24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1071\/AN16028","article-title":"Effects of a single injection of flunixin meglumine or carprofen postpartum on haematological parameters, productive performance and fertility of dairy cattle","volume":"58","author":"Giammarco","year":"2018","journal-title":"Anim. Prod. Sci."},{"key":"10.3168\/jds.2021-21742_bib25","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ygyno.2006.05.043","article-title":"Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF\/VEGFR2(KDR) pathway and prognosis","volume":"103","author":"Giatromanolaki","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.3168\/jds.2021-21742_bib26","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.theriogenology.2005.04.022","article-title":"Prevalence of endometritis and its effects on reproductive performance of dairy cows","volume":"64","author":"Gilbert","year":"2005","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib27","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2460\/javma.1975.167.10.945","article-title":"Pharmacokinetics and dosage of aspirin in cattle","volume":"167","author":"Gingerich","year":"1975","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2021-21742_bib28","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1080\/14767058.2017.1311318","article-title":"Intrauterine infection, immune system, and premature birth","volume":"31","author":"Helmo","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.3168\/jds.2021-21742_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1751-0147-54-45","article-title":"Treatment of dairy cows with PGF2\u03b1 or NSAID, in combination with antibiotics, in cases of postpartum uterine inflammation","volume":"54","author":"Jeremejeva","year":"2012","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2021-21742_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.theriogenology.2003.03.001","article-title":"Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows","volume":"62","author":"Kasimanickam","year":"2004","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib31","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13676","article-title":"Regulation of inflammatory mediator expression in bovine endometrial cells: Effects of lipopolysaccharide, interleukin 1 beta, and tumor necrosis factor alpha","volume":"6","author":"Koh","year":"2018","journal-title":"Physiol. Rep."},{"issue":"1 C-Reactive Pr","key":"10.3168\/jds.2021-21742_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.1982.tb22124.x","article-title":"The phenomenon of the acute phase response","volume":"389","author":"Kushner","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.3168\/jds.2021-21742_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.2042-3306.1995.tb03073.x","article-title":"Comparison of the anti-inflammatory actions of flunixin and ketoprofen in horses applying PK\/PD modelling","volume":"27","author":"Landoni","year":"1995","journal-title":"Equine Vet. J."},{"key":"10.3168\/jds.2021-21742_bib34","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3168\/jds.S0022-0302(02)74302-6","article-title":"Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows","volume":"85","author":"LeBlanc","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41401-018-0014-x","article-title":"Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolism","volume":"40","author":"Liu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.3168\/jds.2021-21742_bib36","series-title":"Predictmeans: Calculate predicted means for linear models. R A Lang. Environ. Stat. Comput","author":"Luo","year":"2014"},{"key":"10.3168\/jds.2021-21742_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vetimm.2012.11.015","article-title":"In vitro studies on the influence of dexamethasone and meloxicam on bovine WC1+ \u03b3\u03b4 T cells","volume":"151","author":"Ma\u015blanka","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21742_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-2427(01)00380-4","article-title":"Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrum","volume":"83","author":"McDonald","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21742_bib39","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.3168\/jds.2019-18048","article-title":"Prevalence of endometritis diagnosed by vaginal discharge scoring or uterine cytology in dairy cows and herds","volume":"103","author":"McDougall","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.theriogenology.2010.12.024","article-title":"Relationships between cytology, bacteriology, and vaginal discharge scores and reproductive performance in dairy cattle","volume":"76","author":"McDougall","year":"2011","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2885.2011.01331.x","article-title":"Pharmacokinetics of oral meloxicam in ruminant and preruminant calves","volume":"35","author":"Mosher","year":"2012","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21742_bib42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3168\/jds.2016-11747","article-title":"The effects of periparturient administration of flunixin meglumine on the health and production of dairy cattle","volume":"100","author":"Newby","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2885.1995.tb00589.x","article-title":"Pharmacokinetics of flunixin and its effect on prostaglandin F2\u03b1 metabolite concentrations after oral and intravenous administration in heifers","volume":"18","author":"Odensvik","year":"1995","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21742_bib44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2217\/pgs.10.181","article-title":"Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients","volume":"12","author":"Oh","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.3168\/jds.2021-21742_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-62103-x","article-title":"Effect of anti-inflammatory treatment on systemic inflammation, immune function, and endometrial health in postpartum dairy cows","volume":"10","author":"Pascottini","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2021-21742_bib46","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.3168\/jds.2020-19125","article-title":"The economic cost of metritis in dairy herds","volume":"104","author":"P\u00e9rez-B\u00e1ez","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1051\/vetres:2004002","article-title":"Application of acute phase protein measurements in veterinary clinical chemistry","volume":"35","author":"Petersen","year":"2004","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2021-21742_bib48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.anireprosci.2010.07.006","article-title":"Subclinical endometritis and its impact on reproductive performance in grazing dairy cattle in Argentina","volume":"122","author":"Pl\u00f6ntzke","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2021-21742_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vetimm.2008.05.010","article-title":"Alpha1-acid glycoprotein is contained in bovine neutrophil granules and released after activation","volume":"125","author":"Rahman","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2021-21742_bib50","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/ijms18040742","article-title":"Possible roles of CC- and CXC-chemokines in regulating bovine endometrial function during early pregnancy","volume":"18","author":"Sakumoto","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2021-21742_bib51","first-page":"671","article-title":"Comparison of serum acute phase proteins and inflammatory cytokines between healthy and subclinically endometritic postpartum buffaloes","volume":"31","author":"Salah","year":"2021","journal-title":"J. Anim. Plant Sci."},{"key":"10.3168\/jds.2021-21742_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S0022029921000078","article-title":"Evaluation of different acute-phase proteins for herd health diagnostics in early postpartum Holstein Friesian dairy cows","volume":"88","author":"Schmitt","year":"2021","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2021-21742_bib53","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1095\/biolreprod.109.077370","article-title":"Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle","volume":"81","author":"Sheldon","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2021-21742_bib54","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/vr.148.6.172","article-title":"Acute phase protein responses to uterine bacterial contamination in cattle after calving","volume":"148","author":"Sheldon","year":"2001","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2021-21742_bib55","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.4049\/jimmunol.171.4.1647","article-title":"Cutting edge: SR-PSOX\/CXC chemokine ligand 16 mediates bacterial phagocytosis by APCs through its chemokine domain","volume":"171","author":"Shimaoka","year":"2003","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2021-21742_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209236","article-title":"Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial","volume":"13","author":"Shock","year":"2018","journal-title":"PLoS One"},{"key":"10.3168\/jds.2021-21742_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2885.2004.00633.x","article-title":"Influence of marbofloxacin on the pharmacokinetics and pharmacodynamics of tolfenamic acid in calves","volume":"28","author":"Sidhu","year":"2005","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.3168\/jds.2021-21742_bib58","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3168\/jds.2007-0900","article-title":"cDNA microarray analysis reveals that antioxidant and immune genes are upregulated during involution of the bovine mammary gland","volume":"91","author":"Singh","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib59","doi-asserted-by":"crossref","first-page":"10742","DOI":"10.3168\/jds.2020-18818","article-title":"Nonsteroidal anti-inflammatory drugs affect the mammary epithelial barrier during inflammation","volume":"103","author":"Sintes","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/13506120009146815","article-title":"Serum amyloid A: From fibril to function. Current status","volume":"7","author":"Sipe","year":"2000","journal-title":"Amyloid"},{"key":"10.3168\/jds.2021-21742_bib61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.chembiol.2017.02.003","article-title":"Non-steroidal anti-inflammatory drugs are caspase inhibitors","volume":"24","author":"Smith","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.3168\/jds.2021-21742_bib62","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/geno.1993.1209","article-title":"A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)","volume":"16","author":"Steel","year":"1993","journal-title":"Genomics"},{"key":"10.3168\/jds.2021-21742_bib63","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/JLB.3A0720-422R","article-title":"Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils","volume":"109","author":"Sumanth","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.3168\/jds.2021-21742_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114696","article-title":"The involvement of lipid raft pathway in suppression of TGF\u03b2-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells","volume":"380","author":"Sun","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.3168\/jds.2021-21742_bib65","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3168\/jds.2008-1382","article-title":"Transcriptome profiling of Streptococcus uberis-induced mastitis reveals fundamental differences between immune gene expression in the mammary gland and in a primary cell culture model","volume":"92","author":"Swanson","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215332","article-title":"Endometrial immune dysfunction in recurrent pregnancy loss","volume":"20","author":"Ticconi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2021-21742_bib67","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/intimm\/dxm083","article-title":"CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes","volume":"19","author":"Tohyama","year":"2007","journal-title":"Int. Immunol."},{"key":"10.3168\/jds.2021-21742_bib68","article-title":"Outcomes from experimental testing of nonsteroidal anti-inflammatory drug (NSAID) administration during the transition period of dairy cows","volume":"10","author":"Trimboli","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2021-21742_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.605773","article-title":"Pre- and post-partum concentrations of interleukin 1\u03b1, interleukin 8, and \u03b11-acid glycoprotein in vaginal fornix and endometrium of dairy cows with clinical cervicitis","volume":"7","author":"Vallejo-Timar\u00e1n","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.3168\/jds.2021-21742_bib70","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.3168\/jds.2020-18692","article-title":"Incidence, clinical patterns, and risk factors of postpartum uterine diseases in dairy cows from high-altitude tropical herds","volume":"104","author":"Vallejo-Timaran","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2021-21742_bib71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1152\/physiolgenomics.00098.2014","article-title":"Modulation of the immune system during postpartum uterine inflammation","volume":"47","author":"Walker","year":"2015","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2021-21742_bib72","series-title":"lmPerm: permutation tests for linear models. R A Lang. Environ. Stat. Comput","author":"Wheeler","year":"2010"},{"key":"10.3168\/jds.2021-21742_bib73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/rda.12205","article-title":"Drivers of post-partum uterine disease in dairy cattle","volume":"48","author":"Williams","year":"2013","journal-title":"Reprod. Domest. Anim."},{"key":"10.3168\/jds.2021-21742_bib74","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.theriogenology.2007.04.056","article-title":"The relationship between uterine pathogen growth density and ovarian function in the postpartum dairy cow","volume":"68","author":"Williams","year":"2007","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib75","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.theriogenology.2004.03.017","article-title":"Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle","volume":"63","author":"Williams","year":"2005","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2021-21742_bib76","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1933719111415546","article-title":"Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis","volume":"19","author":"Zelenko","year":"2012","journal-title":"Reprod. Sci."},{"key":"10.3168\/jds.2021-21742_bib77","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3892\/mmr.2021.12276","article-title":"Hypoxia-induced lactate dehydrogenase A protects cells from apoptosis in endometriosis","volume":"24","author":"Zheng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.3168\/jds.2021-21742_bib78","article-title":"Chemokines as the modulators of endometrial epithelial cells remodelling","volume":"9","author":"Z\u0142otkowska","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223000103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:51:39Z","timestamp":1777413099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0022030223000103"],"URL":"https:\/\/doi.org\/10.3168\/jds.2021-21742","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of nonsteroidal anti-inflammatory drugs on the inflammatory response of bovine endometrial epithelial cells in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2021-21742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}]}}