{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:45:26Z","timestamp":1790963126341,"version":"4.1.0"},"reference-count":39,"publisher":"American Dairy Science Association","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21A235"],"award-info":[{"award-number":["21A235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072931"],"award-info":[{"award-number":["32072931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32125038"],"award-info":[{"award-number":["32125038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A2062"],"award-info":[{"award-number":["U20A2062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003352","name":"Beijing University of Agriculture","doi-asserted-by":"publisher","award":["BUAPSP202206"],"award-info":[{"award-number":["BUAPSP202206"]}],"id":[{"id":"10.13039\/501100003352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.3168\/jds.2022-22114","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:47:27Z","timestamp":1670374047000},"page":"1315-1329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1\u03b1-NF\u03baB pathway in bovine mammary epithelial cells"],"prefix":"10.3168","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-8264","authenticated-orcid":false,"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baogen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3440-2190","authenticated-orcid":false,"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-4856","authenticated-orcid":false,"given":"Qianming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-4365","authenticated-orcid":false,"given":"Juan J.","family":"Loor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-1439","authenticated-orcid":false,"given":"Chuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2022-22114_bib1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/cvr\/cvq080","article-title":"The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells","volume":"87","author":"\u00c1lvarez-Guardia","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.3168\/jds.2022-22114_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7517219","article-title":"Oleanolic acid decreases IL-1\u03b2-induced activation of fibroblast-like synoviocytes via the SIRT3-NF-\u03baB axis in osteoarthritis","volume":"2020","author":"Bao","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.3168\/jds.2022-22114_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0739-7240(00)00079-5","article-title":"Tumor necrosis factor-\u03b1 and nitrite\/nitrate responses during acute mastitis induced by Escherichia coli infection and endotoxin in dairy cows","volume":"19","author":"Blum","year":"2000","journal-title":"Domest. Anim. Endocrinol."},{"issue":"Suppl 1","key":"10.3168\/jds.2022-22114_bib4","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.3168\/jds.2006-696","article-title":"Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period","volume":"90","author":"Burvenich","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22114_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2022.01.005","article-title":"Sirtuin 3: Emerging therapeutic target for cardiovascular diseases","volume":"180","author":"Cao","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2022-22114_bib6","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.carres.2003.07.010","article-title":"Structure of bacterial lipopolysaccharides","volume":"338","author":"Caroff","year":"2003","journal-title":"Carbohydr. Res."},{"key":"10.3168\/jds.2022-22114_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107206","article-title":"Physcion 8-O-\u03b2-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-\u03baB P65 nuclear expression","volume":"90","author":"Chen","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.3168\/jds.2022-22114_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bbrc.2012.11.066","article-title":"SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-\u03baB","volume":"430","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.3168\/jds.2022-22114_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3168\/jds.2010-4074","article-title":"Invited review: Mastitis in dairy heifers: Nature of the disease, potential impact, prevention, and control","volume":"95","author":"De Vliegher","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22114_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.119.315767","article-title":"Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress","volume":"126","author":"Dikalova","year":"2020","journal-title":"Circ. Res."},{"key":"10.3168\/jds.2022-22114_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/path.5282","article-title":"PGC-1\u03b1 deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI","volume":"249","author":"Fontecha-Barriuso","year":"2019","journal-title":"J. Pathol."},{"key":"10.3168\/jds.2022-22114_bib12","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1111\/jcmm.13617","article-title":"NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis","volume":"22","author":"Gao","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.3168\/jds.2022-22114_bib13","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3168\/jds.S0022-0302(04)73276-2","article-title":"Somatic cell count distributions during lactation predict clinical mastitis","volume":"87","author":"Green","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22114_bib14","doi-asserted-by":"crossref","first-page":"878","DOI":"10.5713\/ajas.16.0515","article-title":"Mammary alveolar cell as in vitro evaluation system for casein gene expression involved in glucose level","volume":"30","author":"Heo","year":"2017","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"10.3168\/jds.2022-22114_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"10.3168\/jds.2022-22114_bib16","article-title":"Overview of research development on the role of NF-\u03baB signaling in mastitis","volume":"10","author":"Khan","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2022-22114_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094558","article-title":"Role of PGC-1\u03b1 in the mitochondrial NAD(+) pool in metabolic diseases","volume":"22","author":"Koh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2022-22114_bib18","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.freeradbiomed.2011.05.028","article-title":"SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells","volume":"51","author":"Koyama","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2022-22114_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120722","article-title":"SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury","volume":"4","author":"Kurundkar","year":"2019","journal-title":"JCI Insight"},{"key":"10.3168\/jds.2022-22114_bib20","author":"Liu"},{"key":"10.3168\/jds.2022-22114_bib21","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.3168\/jds.2021-20536","article-title":"Sirtuin 3 inhibits nuclear factor-\u03baB signaling activated by a fatty acid challenge in bovine mammary epithelial cells","volume":"104","author":"Liu","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22114_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1897820","article-title":"Caffeic acid prevented LPS-induced injury of primary bovine mammary epithelial cells through inhibiting NF-\u03baB and MAPK activation","volume":"2019","author":"Liu","year":"2019","journal-title":"Mediators Inflamm."},{"key":"10.3168\/jds.2022-22114_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13567-021-00973-3","article-title":"Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-\u03baB and Nrf2 signaling pathways to restore mitochondrial dynamics and ROS generation","volume":"52","author":"Liu","year":"2021","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2022-22114_bib24","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.bbadis.2017.12.027","article-title":"Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation","volume":"1864","author":"Liu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.3168\/jds.2022-22114_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10911-011-9232-2","article-title":"Functional adaptations of the transcriptome to mastitis-causing pathogens: The mammary gland and beyond","volume":"16","author":"Loor","year":"2011","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.3168\/jds.2022-22114_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.18632\/aging.100544","article-title":"The sirtuins, oxidative stress and aging: An emerging link","volume":"5","author":"Merksamer","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"10.3168\/jds.2022-22114_bib27","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-\u03baB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.3168\/jds.2022-22114_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41392-020-0114-1","article-title":"SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation","volume":"5","author":"Palomer","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.3168\/jds.2022-22114_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/path.5166","article-title":"Obesity causes PGC-1alpha deficiency in the pancreas leading to marked IL-6 upregulation via NF-\u03baB in acute pancreatitis","volume":"247","author":"P\u00e9rez","year":"2019","journal-title":"J. Pathol."},{"key":"10.3168\/jds.2022-22114_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/ijms21020402","article-title":"Sirtuin 3 activation by honokiol decreases unilateral ureteral obstruction-induced renal inflammation and fibrosis via regulation of mitochondrial dynamics and the renal NF-\u03baB-TGF-\u03b21\/Smad signaling pathway","volume":"21","author":"Quan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2022-22114_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1452696","article-title":"PGC-1\u03b1, inflammation, and oxidative stress: An integrative view in metabolism","volume":"2020","author":"Rius-P\u00e9rez","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.3168\/jds.2022-22114_bib32","first-page":"5244","article-title":"Sodium propionate and sodium butyrate effects on histone deacetylase (HDAC) activity, histone acetylation, and inflammatory gene expression in bovine mammary epithelial cells","volume":"96","author":"Silva","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22114_bib33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The Role of Sirtuins in Antioxidant and Redox Signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.3168\/jds.2022-22114_bib34","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.3168\/jds.2020-18189","article-title":"Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide, by inactivating NF-kappaB signaling","volume":"103","author":"Sun","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22114_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molimm.2015.01.026","article-title":"Bovine recombinant lipopolysaccharide binding protein (BRLBP) regulated apoptosis and inflammation response in lipopolysaccharide-challenged bovine mammary epithelial cells (BMEC)","volume":"65","author":"Sun","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.3168\/jds.2022-22114_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.micpath.2017.03.030","article-title":"Sodium acetate inhibits Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-\u03baB activation","volume":"107","author":"Wei","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.3168\/jds.2022-22114_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.577062","article-title":"\u03b1-Cyperone confers antidepressant-like effects in mice via neuroplasticity enhancement by SIRT3\/ROS mediated NLRP3 inflammasome deactivation","volume":"11","author":"Xia","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.3168\/jds.2022-22114_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/ars.2017.7172","article-title":"Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 signaling","volume":"30","author":"Zeng","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.3168\/jds.2022-22114_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3168\/jds.2020-18246","article-title":"Acetate regulates milk fat synthesis through the mammalian target of rapamycin\/eukaryotic initiation factor 4E signaling pathway in bovine mammary epithelial cells","volume":"104","author":"Zhao","year":"2021","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022200707X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022200707X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203022200707X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:22:13Z","timestamp":1771262533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203022200707X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S002203022200707X"],"URL":"https:\/\/doi.org\/10.3168\/jds.2022-22114","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1\u03b1-NF\u03baB pathway in bovine mammary epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2022-22114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}