{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:50:19Z","timestamp":1789771819687,"version":"4.0.1"},"reference-count":34,"publisher":"American Dairy Science Association","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.3168\/jds.2022-22666","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T19:40:35Z","timestamp":1687290035000},"page":"5788-5804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Targeted reproductive management for lactating Holstein cows: Reducing the reliance on exogenous reproductive hormones"],"prefix":"10.3168","volume":"106","author":[{"given":"Tomas D.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Factor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Montevecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segundo","family":"Casaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria R.","family":"Merenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica G.","family":"Prim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klibs N.","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael S.","family":"Bisinotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo C.","family":"Chebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2022-22666_bib1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3168\/jds.2011-4653","article-title":"Effects of management and health on the use of activity monitoring for estrus detection in dairy cows","volume":"95","author":"Aungier","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.theriogenology.2012.10.001","article-title":"Double-Ovsynch in high-producing dairy cows: effects on progesterone concentrations and ovulation to GnRH treatments","volume":"79","author":"Ayres","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2022-22666_bib3","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.3168\/jds.2020-19705","article-title":"Association of estrous expression detected by an automated activity monitoring system within 40 days in milk and reproductive performance of lactating Holstein cows","volume":"104","author":"Borchardt","year":"2021","journal-title":"J. Dairy Sci."},{"issue":"Suppl 1","key":"10.3168\/jds.2022-22666_bib4","article-title":"Review: Genetic selection of high-yielding dairy cattle toward sustainable farming systems in a rapidly changing world","volume":"15","author":"Brito","year":"2021","journal-title":"Animal"},{"key":"10.3168\/jds.2022-22666_bib5","doi-asserted-by":"crossref","first-page":"10754","DOI":"10.3168\/jds.2020-18207","article-title":"Associations between genomic merit for daughter pregnancy rate of Holstein cows and metabolites postpartum and estrus characteristics","volume":"103","author":"Chebel","year":"2020","journal-title":"J. Dairy Sci."},{"issue":"Suppl. 1","key":"10.3168\/jds.2022-22666_bib6","first-page":"101","article-title":"Genetic analysis of estrus expression in dairy cows","volume":"105","author":"Chinchilla-Vargas","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib7","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.3168\/jds.2011-4214","article-title":"Effects of sex-sorting and sperm dosage on conception rates of Holstein heifers: Is comparable fertility of sex-sorted and conventional semen plausible?","volume":"94","author":"DeJarnette","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3168\/jds.2016-12256","article-title":"Performance of automated activity monitoring systems used in combination with timed artificial insemination compared to timed artificial insemination only in early lactation in dairy cows","volume":"101","author":"Denis-Robichaud","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1051\/rnd:2000112","article-title":"Expression and detection of oestrus in cattle","volume":"40","author":"Diskin","year":"2000","journal-title":"Reprod. Nutr. Dev."},{"key":"10.3168\/jds.2022-22666_bib10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.3168\/jds.2015-9914","article-title":"A comparison of timed artificial insemination and automated activity monitoring with hormone intervention in 3 commercial dairy herds","volume":"99","author":"Dolecheck","year":"2016","journal-title":"J. Dairy Sci."},{"issue":"Suppl 1","key":"10.3168\/jds.2022-22666_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1017\/S1751731114000299","article-title":"Expression and detection of estrus in dairy cows: The role of new technologies","volume":"8","author":"Fricke","year":"2014","journal-title":"Animal"},{"key":"10.3168\/jds.2022-22666_bib12","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.3168\/jds.2021-21431","article-title":"Symposium review: The implications of spontaneous versus synchronized ovulations on the reproductive performance of lactating dairy cows","volume":"105","author":"Fricke","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib13","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.3168\/jds.2012-5982","article-title":"Economic comparison of reproductive programs for dairy herds using estrus detection, timed artificial insemination, or a combination","volume":"96","author":"Galv\u00e3o","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib14","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.3168\/jds.2011-5260","article-title":"Presynchronization with Double-Ovsynch improves fertility at first postpartum artificial insemination in lactating dairy cows","volume":"95","author":"Herlihy","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.anireprosci.2003.10.009","article-title":"Relationship between level of milk production and estrous behavior of lactating dairy cows","volume":"81","author":"Lopez","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2022-22666_bib16","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.3168\/jds.2019-17892","article-title":"Effect of estrous detection strategy on pregnancy outcomes of lactating Holstein cows receiving artificial insemination and embryo transfer","volume":"103","author":"Marques","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib17","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.3168\/jds.2020-19076","article-title":"Effects of metritis treatment strategies on health, behavior, reproductive, and productive responses of Holstein cows","volume":"104","author":"Merenda","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.theriogenology.2016.08.025","article-title":"Automated activity monitoring and visual observation of estrus in a herd of loose housed Hereford cattle: Diagnostic accuracy and time to ovulation","volume":"87","author":"Nelson","year":"2017","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2022-22666_bib19","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.3168\/jds.2011-5264","article-title":"Reproductive performance with an automated activity monitoring system versus a synchronized breeding program","volume":"95","author":"Neves","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib20","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2022-22666_bib21","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.3168\/jds.2015-10169","article-title":"Consumers' attitudes about milk quality and fertilization methods in dairy cows in Germany","volume":"99","author":"Pieper","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96834-2","article-title":"The reproductive success of bovine sperm after sex-sorting: a meta-analysis","volume":"11","author":"Reese","year":"2021","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2022-22666_bib23","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.3168\/jds.2022-22082","article-title":"Effect of a targeted reproductive management program designed to prioritize insemination at detected estrus and optimize time to insemination on the reproductive performance of lactating dairy cows","volume":"105","author":"Rial","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib24","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.3168\/jds.2011-4921","article-title":"Effects of presynchronization and length of proestrus on fertility of grazing dairy cows subjected to a 5-day timed artificial insemination protocol","volume":"95","author":"Ribeiro","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib25","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3168\/jds.2009-2870","article-title":"Effect of reducing the period of follicle dominance in a timed artificial insemination protocol on reproduction of dairy cows","volume":"93","author":"Santos","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.anireprosci.2008.01.014","article-title":"Risk factors for resumption of postpartum estrous cycles and embryonic survival in lactating dairy cows","volume":"110","author":"Santos","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2022-22666_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.theriogenology.2008.03.014","article-title":"A new presynchronization system (Double-Ovsynch) increases fertility at first postpartum timed AI in lactating dairy cows","volume":"70","author":"Souza","year":"2008","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2022-22666_bib28","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3168\/jds.2017-13425","article-title":"Reproductive performance and herd exit dynamics of lactating dairy cows managed for first service with the Presynch-Ovsynch or Double-Ovsynch protocol and different duration of the voluntary waiting period","volume":"101","author":"Stangaferro","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib29","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.3168\/jds.2020-19578","article-title":"Factors associated with estrous expression and subsequent fertility in lactating dairy cows using automated activity monitoring","volume":"104","author":"Tippenhauer","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib30","author":"USDA"},{"key":"10.3168\/jds.2022-22666_bib31","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.3168\/jds.2012-5639","article-title":"Assessment of an accelerometer system for detection of estrus and treatment with gonadotropin-releasing hormone at the time of insemination in lactating dairy cows","volume":"95","author":"Valenza","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1439-0531.2008.01263.x","article-title":"The effect of a chronic stressor, lameness, on detailed sexual behaviour and hormonal profiles in milk and plasma of dairy cattle","volume":"45","author":"Walker","year":"2010","journal-title":"Reprod. Domest. Anim."},{"key":"10.3168\/jds.2022-22666_bib33","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.3168\/jds.2008-1048","article-title":"Lameness, activity time-budgets, and estrus expression in dairy cattle","volume":"91","author":"Walker","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22666_bib34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.theriogenology.2013.09.017","article-title":"The cow as an induced ovulator: Timed AI after synchronization of ovulation","volume":"81","author":"Wiltbank","year":"2014","journal-title":"Theriogenology"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223003557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223003557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223003557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:39:00Z","timestamp":1731101940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223003557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0022030223003557"],"URL":"https:\/\/doi.org\/10.3168\/jds.2022-22666","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted reproductive management for lactating Holstein cows: Reducing the reliance on exogenous reproductive hormones","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2022-22666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023","name":"copyright","label":"Copyright"}]}}