{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:38:48Z","timestamp":1790725128711,"version":"4.1.0"},"reference-count":111,"publisher":"American Dairy Science Association","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.3168\/jds.2022-22689","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T02:41:31Z","timestamp":1677033691000},"page":"2890-2903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of hindgut acidosis on production, metabolism, and inflammatory biomarkers in feed-restricted lactating dairy cows"],"prefix":"10.3168","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-5310","authenticated-orcid":false,"given":"M.A.","family":"Abeyta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.M.","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-5191","authenticated-orcid":false,"given":"E.J.","family":"Mayorga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caratzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3077-5996","authenticated-orcid":false,"given":"L.H.","family":"Baumgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2022-22689_bib1","article-title":"Effects of hindgut acidosis on inflammation, metabolism, and productivity in lactating dairy cows fed a high-fiber diet","volume":"106","author":"Abeyta","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3168\/jds.2022-22303","article-title":"Effects of hindgut acidosis on metabolism, inflammation, and production in dairy cows consuming a standard lactation diet","volume":"106","author":"Abeyta","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11306-010-0227-6","article-title":"Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows","volume":"6","author":"Ametaj","year":"2010","journal-title":"Metabolomics"},{"key":"10.3168\/jds.2022-22689_bib4","series-title":"Official Methods of Analysis","first-page":"23","article-title":"AOAC official method 972.16. Fat, lactose, protein, and solids in milk. Mid infrared spectroscopic method","volume":"Vol. 2","author":"AOAC International","year":"1995"},{"key":"10.3168\/jds.2022-22689_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096864","article-title":"Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals","volume":"9","author":"Bala","year":"2014","journal-title":"PLoS One"},{"key":"10.3168\/jds.2022-22689_bib6","doi-asserted-by":"crossref","first-page":"10353","DOI":"10.3168\/jds.2017-13242","article-title":"A 100-year review: Regulation of nutrient partitioning to support lactation","volume":"100","author":"Baumgard","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib7","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3168\/jds.2006-445","article-title":"Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows","volume":"90","author":"Bionaz","year":"2007","journal-title":"J. Dairy Sci."},{"issue":"E-Suppl. 1","key":"10.3168\/jds.2022-22689_bib8","first-page":"845","article-title":"Cattle differ in ability to adapt to small intestinal digestion of starch","volume":"93","author":"Bissell","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib9","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/129.7.1340","article-title":"Food deprivation and refeeding influence growth, nutrient retention and functional recovery of rats","volume":"129","author":"Boza","year":"1999","journal-title":"J. Nutr."},{"issue":"Suppl. 2","key":"10.3168\/jds.2022-22689_bib10","first-page":"99","article-title":"Evaluation of sample preparation methods for the determination of fecal pH in dairy cows","volume":"100","author":"Branstad","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0301-6226(86)90012-6","article-title":"Hormonal regulation of metabolism in ruminants; a review","volume":"14","author":"Brockman","year":"1986","journal-title":"Livest. Prod. Sci."},{"key":"10.3168\/jds.2022-22689_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111012","article-title":"Prophylactic and therapeutic supplementation using fructo-oligosaccaride improves the intestinal homeostasis after mucositis induced by 5-fluorouracil","volume":"133","author":"Carvalho","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.3168\/jds.2022-22689_bib13","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.jprot.2012.04.004","article-title":"Acute phase proteins in ruminants","volume":"75","author":"Ceciliani","year":"2012","journal-title":"J. Proteomics"},{"key":"10.3168\/jds.2022-22689_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","article-title":"Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model","volume":"30","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"10.3168\/jds.2022-22689_bib15","first-page":"234","article-title":"Metabolic characteristics of pig colonocytes after adaptation to a high fiber diet","volume":"123","author":"Darcy-Vrillon","year":"1993","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2022-22689_bib16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3168\/jds.S0022-0302(85)80829-8","article-title":"Glucagon, insulin, growth hormone, and some blood metabolites during energy restriction ketonemia of lactating cows","volume":"68","author":"de Boer","year":"1985","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib17","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3168\/jds.2018-15148","article-title":"Postruminal infusion of calcium gluconate increases milk fat production and alters fecal volatile fatty acid profile in lactating dairy cows","volume":"102","author":"Doelman","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib18","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1039\/C5FO01217A","article-title":"Milk with and without lactoferrin can influence intestinal damage in a pig model of malnutrition","volume":"7","author":"Garas","year":"2016","journal-title":"Food Funct."},{"key":"10.3168\/jds.2022-22689_bib19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10350-007-0213-x","article-title":"Prebiotic and synbiotic fructooligosaccharide administration fails to reduce the severity of experimental colitis in rats","volume":"50","author":"Geier","year":"2007","journal-title":"Dis. Colon Rectum"},{"key":"10.3168\/jds.2022-22689_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3177\/jnsv.64.357","article-title":"The impact of fructo-oligosaccharides on gut permeability and inflammatory responses in the cecal mucosa quite differs between rats fed semi-purified and non-purified diets","volume":"64","author":"Genda","year":"2018","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.3168\/jds.2022-22689_bib21","doi-asserted-by":"crossref","first-page":"e486","DOI":"10.1111\/jpn.12712","article-title":"Reduced fasting periods increase intestinal permeability in chickens","volume":"102","author":"Gilani","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"issue":"Suppl. 1","key":"10.3168\/jds.2022-22689_bib22","first-page":"253","article-title":"Hyperinflamed cows at dry-off also have an exaggerated inflammatory response and decreased milk production in the next lactation","volume":"105","author":"Goetz","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib23","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/ndt\/gfy238","article-title":"Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression","volume":"34","author":"Gonzalez","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.3168\/jds.2022-22689_bib24","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3945\/jn.110.125948","article-title":"Effects of fructo-oligosaccharide on DSS-induced colitis differ in mice fed nonpurified and purified diets","volume":"140","author":"Goto","year":"2010","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2022-22689_bib25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3168\/jds.S0022-0302(05)72807-1","article-title":"Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response","volume":"88","author":"Gozho","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47851-9","article-title":"Hyperosmolar environment and intestinal epithelial cells: Impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro","volume":"9","author":"Grauso","year":"2019","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2022-22689_bib27","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3168\/jds.S0022-0302(07)71621-1","article-title":"Effects of low rumen-degradable protein or abomasal fructan infusion on diet digestibility and urinary nitrogen excretion in lactating dairy cows","volume":"90","author":"Gressley","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2527\/jas.2010-3460","article-title":"Ruminant nutrition symposium: Productivity, digestion, and health responses to hindgut acidosis in ruminants","volume":"89","author":"Gressley","year":"2011","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.3168\/jds.2022-22689_bib30","first-page":"4000","article-title":"Sodium butyrate protects the intestinal barrier function in peritonitic mice","volume":"8","author":"Han","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.3168\/jds.2022-22689_bib31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/bj3380569","article-title":"Mitochondrial 3-hydroxy-3-methylglutaryl-coa synthase: A control enzyme in ketogenesis","volume":"338","author":"Hegardt","year":"1999","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2022-22689_bib32","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/bj1300785","article-title":"Ketogenesis from butyrate and acetate by the caecum and the colon of rabbits","volume":"130","author":"Henning","year":"1972","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2022-22689_bib33","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.3168\/jds.2017-13842","article-title":"Infusion of butyrate affects plasma glucose, butyrate, and \u03b2-hydroxybutyrate but not plasma insulin in lactating dairy cows","volume":"101","author":"Herrick","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib34","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and performance\u2014A critical evaluation of traditional dogmas","volume":"104","author":"Horst","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib35","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.3168\/jds.2020-18860","article-title":"Evaluating effects of zinc hydroxychloride on biomarkers of inflammation and intestinal integrity during feed restriction","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"issue":"Suppl. 1","key":"10.3168\/jds.2022-22689_bib36","first-page":"231","article-title":"Effects of LPS administration and subsequent nutrient restriction on systemic inflammation and hepatic steatosis in lactating dairy cows","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib37","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.3168\/jds.2020-18686","article-title":"Evaluating acute inflammation\u2019s effects on hepatic triglyceride content in experimentally induced hyperlipidemic dairy cows in late lactation","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib38","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3168\/jds.S0022-0302(78)83742-4","article-title":"Insulin secretion in lactating cows: Responses to glucose infused intravenously in normal, ketonemic, and starved animals","volume":"61","author":"Hove","year":"1978","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1939-165X.2006.tb00112.x","article-title":"Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period","volume":"35","author":"Humblet","year":"2006","journal-title":"Vet. Clin. Pathol."},{"key":"10.3168\/jds.2022-22689_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4141\/cjas89-025","article-title":"Hepatic urea synthesis and site and rate of urea removal from blood of beef steers fed alfalfa hay or a high concentrate diet","volume":"69","author":"Huntington","year":"1989","journal-title":"Can. J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib41","series-title":"Feed Efficiency in Swine","first-page":"211","article-title":"Fueling the immune response: What\u2019s the cost?","author":"Johnson","year":"2012"},{"key":"10.3168\/jds.2022-22689_bib42","doi-asserted-by":"crossref","first-page":"G405","DOI":"10.1152\/ajpgi.2001.281.2.G405","article-title":"Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease","volume":"281","author":"J\u00f8rgensen","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.3168\/jds.2022-22689_bib43","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3168\/jds.2008-1656","article-title":"Alfalfa pellet-induced subacute ruminal acidosis in dairy cows increases bacterial endotoxin in the rumen without causing inflammation","volume":"92","author":"Khafipour","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib44","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3168\/jds.2008-1389","article-title":"A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation","volume":"92","author":"Khafipour","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib45","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.3168\/jds.S0022-0302(98)75889-8","article-title":"Glucose metabolism and milk yield of cows infused abomasally or ruminally with starch","volume":"81","author":"Knowlton","year":"1998","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"10.3168\/jds.2022-22689_bib47","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.3168\/jds.2016-12349","article-title":"Intentionally induced intestinal barrier dysfunction causes inflammation, affects metabolism, and reduces productivity in lactating Holstein cows","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib48","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3168\/jds.2016-12001","article-title":"Glucose requirements of an activated immune system in lactating Holstein cows","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib49","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.3168\/jds.2017-13229","article-title":"Characterizing effects of feed restriction and glucagon-like peptide 2 administration on biomarkers of inflammation and intestinal morphology","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib50","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.3168\/jds.2021-21355","article-title":"Effects of high-grain diet feeding on mucosa-associated bacterial community and gene expression of tight junction proteins and inflammatory cytokines in the small intestine of dairy cattle","volume":"105","author":"Lai","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2249.2005.02853.x","article-title":"One-hit, two-hit \u2026 is there really any benefit?","volume":"141","author":"Lang","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.3168\/jds.2022-22689_bib52","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3168\/jds.S0022-0302(06)72195-6","article-title":"Major advances in disease prevention in dairy cattle","volume":"89","author":"LeBlanc","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib53","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1439-0396.1995.tb00401.x","article-title":"A portal-vein-catheterization technique in pigs and sheep, and postprandial changes of pO2, pCO2, pH, urea, ammonia, and creatinine and proteins in portal and arterial blood measured in pigs","volume":"73","author":"Leeuwen","year":"1995","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2022-22689_bib54","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.3168\/jds.S0022-0302(97)76250-7","article-title":"Effects of a duodenal glucose infusion on the relationship between plasma concentrations of glucose and insulin in dairy cows","volume":"80","author":"Lemosquet","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib55","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3168\/jds.2011-4447","article-title":"Effects of subacute ruminal acidosis challenges on fermentation and endotoxins in the rumen and hindgut of dairy cows","volume":"95","author":"Li","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib56","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.2527\/jas.2010-3348","article-title":"Effects of abomasal oligofructose on blood and feces of Holstein steers","volume":"89","author":"Mainardi","year":"2011","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1746-6148-8-237","article-title":"The diversity of the fecal bacterial community and its relationship with the concentration of volatile fatty acids in the feces during subacute rumen acidosis in dairy cows","volume":"8","author":"Mao","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2022-22689_bib58","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skab163","article-title":"Effects of continuously infusing glucose or casein into the terminal ileum on biomarkers of metabolism, inflammation, and intestinal morphology in growing pigs","volume":"99","author":"Mayorga","year":"2021","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib59","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.theriogenology.2020.05.023","article-title":"Biology of heat stress; the nexus between intestinal hyperpermeability and swine reproduction","volume":"154","author":"Mayorga","year":"2020","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2022-22689_bib60","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.3168\/jds.2020-18151","article-title":"Energetic metabolism, milk production, and inflammatory response of transition dairy cows fed rumen-protected glucose","volume":"103","author":"McCarthy","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib61","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/1828051X.2019.1691472","article-title":"Inflammatory status and metabolic changes at dry-off in high-yield dairy cows","volume":"19","author":"Mezzetti","year":"2020","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib62","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1079\/BJN2003867","article-title":"Restoration of the integrity of rat caeco-colonic mucosa by resistant starch, but not by fructo-oligosaccharides, in dextran sulfate sodium-induced experimental colitis","volume":"90","author":"Moreau","year":"2003","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2022-22689_bib63","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.3168\/jds.S0022-0302(05)73058-7","article-title":"Prediction of manure and nutrient excretion from dairy cattle","volume":"88","author":"Nennich","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib64","doi-asserted-by":"crossref","first-page":"E27","DOI":"10.3168\/jds.S0022-0302(04)70058-2","article-title":"Investigation strategies for laminitis problem herds","volume":"87","author":"Nordlund","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib65","series-title":"Nutrient Requirements of Dairy Cattle","author":"NRC","year":"2001"},{"key":"10.3168\/jds.2022-22689_bib66","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.2527\/jas.2013-6759","article-title":"Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs","volume":"91","author":"Pearce","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib67","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/jas\/skx049","article-title":"Effect of ruminal acidosis and short-term low feed intake on indicators of gastrointestinal barrier function in Holstein steers","volume":"96","author":"Pederzolli","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzaa031","article-title":"Choice of laboratory rodent diet may confound data interpretation and reproducibility","volume":"4","author":"Pellizzon","year":"2020","journal-title":"Curr. Dev. Nutr."},{"key":"10.3168\/jds.2022-22689_bib69","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj0510251","article-title":"The metabolism of short-chain fatty acids in the sheep. I. Fatty acid utilization and ketone body production by rumen epithelium and other tissues","volume":"51","author":"Pennington","year":"1952","journal-title":"Biochem. J."},{"key":"10.3168\/jds.2022-22689_bib70","doi-asserted-by":"crossref","DOI":"10.3168\/jds.2022-22376","article-title":"Evaluation of feed restriction and abomasal infusion of resistant starch as models to induce intestinal barrier dysfunction in healthy lactating cows","volume":"106","author":"Piantoni","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib71","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.3168\/jds.2021-20878","article-title":"Simulation of feed restriction and fasting: Effects on animal recovery and gastrointestinal permeability in unweaned Angus-Holstein calves","volume":"105","author":"Pisoni","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib72","doi-asserted-by":"crossref","first-page":"s399","DOI":"10.1017\/S1751731118001921","article-title":"Review: Enhancing gastrointestinal health in dairy cows","volume":"12","author":"Plaizier","year":"2018","journal-title":"Animal"},{"key":"10.3168\/jds.2022-22689_bib73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2007.12.016","article-title":"Subacute ruminal acidosis in dairy cows: The physiological causes, incidence and consequences","volume":"176","author":"Plaizier","year":"2008","journal-title":"Vet. J."},{"key":"10.3168\/jds.2022-22689_bib74","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"issue":"E-suppl. 2","key":"10.3168\/jds.2022-22689_bib75","doi-asserted-by":"crossref","first-page":"E74","DOI":"10.2527\/animalsci2002.80E-Suppl_2E74x","article-title":"Economics of visceral energy metabolism in ruminants: Toll keeping or internal revenue service?","volume":"80","author":"Reynolds","year":"2002","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib76","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1079\/BJN19880126","article-title":"Partition of portal-drained visceral net flux in beef steers","volume":"60","author":"Reynolds","year":"1988","journal-title":"Br. J. Nutr."},{"key":"10.3168\/jds.2022-22689_bib77","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3168\/jds.2009-2469","article-title":"Effects of heat stress and nutrition on lactating Holstein cows: II. Aspects of hepatic growth hormone responsiveness","volume":"93","author":"Rhoads","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib78","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gut.39.3.416","article-title":"Intestinal paracellular permeability during malnutrition in guinea pigs: Effect of high dietary zinc","volume":"39","author":"Rodriguez","year":"1996","journal-title":"Gut"},{"issue":"Suppl. 1","key":"10.3168\/jds.2022-22689_bib79","first-page":"402","article-title":"Relationships between fecal pH and milk production, metabolism, and acute phase protein response in periparturient dairy cows","volume":"102","author":"Rodriguez-Jimenez","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib80","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0016-5085(82)80339-9","article-title":"Utilization of nutrients by isolated epithelial cells of the rat colon","volume":"83","author":"Roediger","year":"1982","journal-title":"Gastroenterology"},{"key":"10.3168\/jds.2022-22689_bib81","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2019.02.021","article-title":"Stress and inflammation\u2014The need to address the gap in the transition between acute and chronic stress effects","volume":"105","author":"Rohleder","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.3168\/jds.2022-22689_bib82","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.3168\/jds.2012-5558","article-title":"Effect of abomasal infusion of oligofructose on portal-drained visceral ammonia and urea-nitrogen fluxes in lactating Holstein cows","volume":"95","author":"R\u00f8jen","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib83","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.3168\/jds.2012-5403","article-title":"A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows","volume":"95","author":"Saleem","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib84","article-title":"Targeting the hindgut to improve health and performance in cattle","volume":"10","author":"Sanz-Fernandez","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2022-22689_bib85","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0027-5107(01)00301-3","article-title":"DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis","volume":"500","author":"Souliotis","year":"2002","journal-title":"Mutat. Res."},{"key":"10.3168\/jds.2022-22689_bib86","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.3168\/jds.2015-10351","article-title":"Development and physiology of the rumen and the lower gut: Targets for improving gut health","volume":"99","author":"Steele","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1079\/NRR200498","article-title":"Urea nitrogen salvage mechanisms and their relevance to ruminants, non-ruminants and man","volume":"18","author":"Stewart","year":"2005","journal-title":"Nutr. Res. Rev."},{"key":"10.3168\/jds.2022-22689_bib88","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3168\/jds.S0022-0302(04)70057-0","article-title":"Nutritional approaches to minimize subacute ruminal acidosis and laminitis in dairy cattle","volume":"87","author":"Stone","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib89","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12917-014-0235-2","article-title":"A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats","volume":"10","author":"Tao","year":"2014","journal-title":"BMC Vet. Res."},{"key":"10.3168\/jds.2022-22689_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01764","article-title":"Microbiome-metabolome responses to a high-grain diet associated with the hind-gut health of goats","volume":"8","author":"Tao","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2022-22689_bib91","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/jn\/133.7.2313","article-title":"Dietary fructo-oligosaccharides dose-dependently increase translocation of salmonella in rats","volume":"133","author":"Ten Bruggencate","year":"2003","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2022-22689_bib92","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.rvsc.2011.11.008","article-title":"Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows","volume":"93","author":"Trevisi","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2022-22689_bib93","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.rvsc.2017.12.001","article-title":"Assessment of the innate immune response in the periparturient cow","volume":"116","author":"Trevisi","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2022-22689_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ruminants2010001","article-title":"Nutritional and physiological constraints contributing to limitations in small intestinal starch digestion and glucose absorption in ruminants","volume":"2","author":"Trotta","year":"2022","journal-title":"Ruminants"},{"key":"10.3168\/jds.2022-22689_bib95","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.3168\/jds.2021-20323","article-title":"Abomasal infusion of corn starch and \u03b2-hydroxybutyrate in early-lactation Holstein-Friesian dairy cows to induce hindgut and metabolic acidosis","volume":"104","author":"van Gastelen","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib96","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.3168\/jds.2020-19300","article-title":"Abomasal infusion of ground corn and ammonium chloride in early-lactating Holstein-Friesian dairy cows to induce hindgut and metabolic acidosis","volume":"104","author":"van Gastelen","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib97","series-title":"Nutritional Ecology of the Ruminant","first-page":"253","article-title":"Microbes in the gut","author":"Van Soest","year":"1982"},{"key":"10.3168\/jds.2022-22689_bib98","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/j.1572-0241.2001.03802.x","article-title":"Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat","volume":"96","author":"Videla","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.3168\/jds.2022-22689_bib99","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.3168\/jds.2020-18738","article-title":"Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability, and expression of key tight junction proteins in dairy goats","volume":"104","author":"Wang","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2022-22689_bib100","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gut.42.3.396","article-title":"Gut barrier function in malnourished patients","volume":"42","author":"Welsh","year":"1998","journal-title":"Gut"},{"key":"10.3168\/jds.2022-22689_bib101","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jas\/sky082","article-title":"Postruminal digestion of starch infused into the abomasum of heifers with or without exogenous amylase administration","volume":"96","author":"Westreicher-Kristen","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib102","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0140-6736(71)90667-2","article-title":"Transport of urea and ammonia production in the human colon","volume":"298","author":"Wolpert","year":"1971","journal-title":"Lancet"},{"key":"10.3168\/jds.2022-22689_bib103","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1762","article-title":"Epithelial, metabolic and innate immunity transcriptomic signatures differentiating the rumen from other sheep and mammalian gastrointestinal tract tissues","volume":"4","author":"Xiang","year":"2016","journal-title":"PeerJ"},{"key":"10.3168\/jds.2022-22689_bib104","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1017\/S1751731112000754","article-title":"Transfer of blood urea nitrogen to cecal microbial nitrogen is increased by mannitol feeding in growing rabbits fed timothy hay diet","volume":"6","author":"Xiao","year":"2012","journal-title":"Animal"},{"key":"10.3168\/jds.2022-22689_bib105","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/00071669608417922","article-title":"Effects of fasting and refeeding on structures of the intestinal villi and epithelial cells in White Leghorn hens","volume":"37","author":"Yamauchi","year":"1996","journal-title":"Br. Poult. Sci."},{"key":"10.3168\/jds.2022-22689_bib106","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/jren.2001.24359","article-title":"Fermentable carbohydrate and digestive nitrogen excretion","volume":"11","author":"Younes","year":"2001","journal-title":"J. Ren. Nutr."},{"key":"10.3168\/jds.2022-22689_bib107","series-title":"Dairy Cow Monitoring in Relation to Fertility Performance. Scoring Cards","author":"Zaaijer","year":"2001"},{"key":"10.3168\/jds.2022-22689_bib108","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.rvsc.2012.02.004","article-title":"Interplay between rumen digestive disorders and diet-induced inflammation and dairy cattle","volume":"93","author":"Zebeli","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2022-22689_bib109","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11306-017-1204-0","article-title":"Comparative metabolome analysis of ruminal changes in Holstein dairy cows fed low- or high-concentrate diets","volume":"13","author":"Zhang","year":"2017","journal-title":"Metabolomics"},{"key":"10.3168\/jds.2022-22689_bib110","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.2527\/jas.2012-5669","article-title":"Short-term feed restriction impairs the absorptive function of the reticulo-rumen and total tract barrier function in beef cattle","volume":"91","author":"Zhang","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2022-22689_bib111","first-page":"359","article-title":"Impact of lactic acid fermentation in the large intestine on acute lactic acidosis in cattle","volume":"107","author":"Zust","year":"2000","journal-title":"Dtsch. Tierarztl. Wochenschr."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223000747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030223000747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223000747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:35:00Z","timestamp":1731101700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030223000747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":111,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0022030223000747"],"URL":"https:\/\/doi.org\/10.3168\/jds.2022-22689","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of hindgut acidosis on production, metabolism, and inflammatory biomarkers in feed-restricted lactating dairy cows","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2022-22689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}]}}