{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:06:28Z","timestamp":1776492388783,"version":"3.51.2"},"reference-count":101,"publisher":"American Dairy Science Association","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.3168\/jds.2023-24578","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:18:31Z","timestamp":1717154311000},"page":"8432-8451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration"],"prefix":"10.3168","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8792-1374","authenticated-orcid":false,"given":"T.L.","family":"Reeder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-1724","authenticated-orcid":false,"given":"D.S.","family":"Zarlenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-0536","authenticated-orcid":false,"given":"A.L.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-0140","authenticated-orcid":false,"given":"R.M.","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2023-24578_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.molcel.2012.11.002","article-title":"Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals","volume":"49","author":"Albeck","year":"2013","journal-title":"Mol. Cell"},{"key":"10.3168\/jds.2023-24578_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/BF03546843","article-title":"Pathology of bovine laminitis especially as regards vascular lesions","volume":"21","author":"Andersson","year":"1980","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2023-24578_bib3","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/emboj\/19.9.2056","article-title":"Cell cycle dependent variations in c-Jun and junB phosphorylation. A role in the control of cyclin D1 expression","volume":"19","author":"Bakiri","year":"2000","journal-title":"EMBO J."},{"key":"10.3168\/jds.2023-24578_bib4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Perspective Article: Growth factors and cytokines in wounding","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"10.3168\/jds.2023-24578_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024194","article-title":"The receptor tyrosine kinase FGFR2\/KGFR controls early differentiation of human keratinocyte","volume":"6","author":"Belleudi","year":"2011","journal-title":"PLoS One"},{"key":"10.3168\/jds.2023-24578_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/cmi.2016.11","article-title":"Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals","volume":"14","author":"Bezbradica","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.3168\/jds.2023-24578_bib7","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1101\/gad.1477606","article-title":"Canonical notch signaling functions as a commitment switch in the epidermal lineage","volume":"20","author":"Blanpain","year":"2006","journal-title":"Genes Dev."},{"key":"10.3168\/jds.2023-24578_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-mediated inflammation in normal and diabetic wounds","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2023-24578_bib9","first-page":"3199","article-title":"Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts","volume":"9","author":"Brauchle","year":"1994","journal-title":"Oncogene"},{"key":"10.3168\/jds.2023-24578_bib10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQUE guidelines: Minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.3168\/jds.2023-24578_bib11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ncb1420","article-title":"P63 regulates an adhesion programme and cell survival in epithelial cells","volume":"8","author":"Carroll","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrc4000","article-title":"MEK1 and MEK2 inhibitors and cancer therapy: The long and winding road","volume":"15","author":"Caunt","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.3168\/jds.2023-24578_bib13","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1016\/S0021-9258(17)34123-6","article-title":"Regulation of keratinocyte growth factor gene expression by interleukin 1","volume":"269","author":"Chedid","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2023-24578_bib14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm1603","article-title":"Identification of a key pathway required for the sterile inflammatory response triggered by dying cells","volume":"13","author":"Chen","year":"2007","journal-title":"Nat. Med."},{"key":"10.3168\/jds.2023-24578_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature05574","article-title":"A single type of progenitor cell maintains normal epidermis","volume":"446","author":"Clayton","year":"2007","journal-title":"Nature"},{"key":"10.3168\/jds.2023-24578_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086660","article-title":"The monocyte to macrophage transition in the sterile murine wound","volume":"9","author":"Crane","year":"2014","journal-title":"PLoS One"},{"key":"10.3168\/jds.2023-24578_bib17","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/sj.onc.1205038","article-title":"The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation","volume":"21","author":"Crish","year":"2002","journal-title":"Oncogene"},{"key":"10.3168\/jds.2023-24578_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.jid.5700019","article-title":"The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vitro involucrin expression","volume":"126","author":"Crish","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12918-015-0187-6","article-title":"Regulation of ERK-MAPK signaling in human epidermis","volume":"9","author":"Cursons","year":"2015","journal-title":"BMC Syst. Biol."},{"key":"10.3168\/jds.2023-24578_bib20","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.4049\/jimmunol.1801258","article-title":"Histone methylation directs myeloid TLR4 expression and regulated wound healing following cutaneous tissue injury","volume":"202","author":"Davis","year":"2019","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2023-24578_bib21","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.149.5.1117","article-title":"Downregulation of 14-3-3\u03b3 prevents clonal evolution and leads to immortalization of primary keratinocytes","volume":"149","author":"Dellambra","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib22","first-page":"1283","article-title":"Keratinocyte growth factor receptor ligands induce transforming growth factor signaling pathway in cultured epidermal keratinocytes","volume":"5","author":"Dlugosz","year":"1994","journal-title":"Cell Growth Differ."},{"key":"10.3168\/jds.2023-24578_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/537028","article-title":"AP1 transcription factors in epidermal differentiation and skin cancer","volume":"2013","author":"Eckert","year":"2013","journal-title":"J. Skin Cancer"},{"key":"10.3168\/jds.2023-24578_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.22723.x","article-title":"Regulation of involucrin gene expression","volume":"123","author":"Eckert","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib25","doi-asserted-by":"crossref","first-page":"24387","DOI":"10.1074\/jbc.273.38.24387","article-title":"Regulation of involucrin promotor activity by protein kinase C, RAS, MEKK1, MEK3, p38\/RK, AP1 signal transduction pathway","volume":"273","author":"Efimova","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2023-24578_bib26","unstructured":"Eggers, T., C. K. W. Muellimng, C. H. Lischer, and R. D. Budras. 2002. Morphological aspects on wound healing of Rusterholtz ulcer in the bovine hoof. Pages 203\u2013205 in Proc. XI International Symposium on Disorders of the Ruminant Digit and III International Conference on Bovine Lameness. Parma, Italy."},{"key":"10.3168\/jds.2023-24578_bib27","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.jid.5700701","article-title":"Inflammation in wound repair: Molecular and cellular mechanisms","volume":"127","author":"Eming","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib28","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1194\/jlr.R700013-JLR200","article-title":"Thematic review series: Skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis","volume":"48","author":"Feingold","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.3168\/jds.2023-24578_bib29","first-page":"1619","article-title":"Altered expression of keratinocyte growth factor and its receptor in psoriasis","volume":"151","author":"Finch","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.3168\/jds.2023-24578_bib30","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1126\/science.2475908","article-title":"Human KGF is FGF-related with properties of a paracrine effector of epithelial growth","volume":"245","author":"Finch","year":"1989","journal-title":"Science"},{"key":"10.3168\/jds.2023-24578_bib31","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.0022-202X.2004.22319.x","article-title":"Regulation of MAPK activation, AP-1 transcription factor expression and keratinocyte differentiation in wounded fetal skin","volume":"122","author":"Gangnuss","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib32","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.semcdb.2011.09.008","article-title":"14-3-3 proteins as signaling integration points for cell cycle control and apoptosis","volume":"22","author":"Gardino","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.3168\/jds.2023-24578_bib33","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2017.03.042","article-title":"Stem cell lineage infidelity drives wound repair and cancer","volume":"169","author":"Ge","year":"2017","journal-title":"Cell"},{"key":"10.3168\/jds.2023-24578_bib34","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1016\/S0021-9258(17)32127-0","article-title":"Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes","volume":"269","author":"Hashimoto","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2023-24578_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0022029902005885","article-title":"Basement membrane integrity and keratinization in healthy and ulcerated bovine hoof tissue","volume":"70","author":"Hendry","year":"2003","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2023-24578_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1017\/S0022029901005052","article-title":"Synthesis and distribution of cytokeratins in healthy and ulcerated bovine claw epidermis","volume":"68","author":"Hendry","year":"2001","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2023-24578_bib37","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1073\/pnas.050586197","article-title":"Identification of CDK4 as a target of c-Myc","volume":"97","author":"Hermeking","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2023-24578_bib38","first-page":"155","article-title":"Quantities and types of ceramides and their relationships to physical properties of the horn covering the claws of clinically normal cows and cows with subclinical laminitis","volume":"69","author":"Higuchi","year":"2005","journal-title":"Can. J. Vet. Res."},{"key":"10.3168\/jds.2023-24578_bib39","doi-asserted-by":"crossref","first-page":"17796","DOI":"10.1073\/pnas.2006965117","article-title":"Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis","volume":"117","author":"Hiratsuka","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2023-24578_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05178","article-title":"Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin","volume":"4","author":"Hiratsuka","year":"2015","journal-title":"eLife"},{"key":"10.3168\/jds.2023-24578_bib41","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2014.02.057","article-title":"Transit-amplifying cells orchestrate stem cell activity and tissue regeneration","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"10.3168\/jds.2023-24578_bib42","doi-asserted-by":"crossref","first-page":"50024","DOI":"10.1074\/jbc.M308617200","article-title":"The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway","volume":"278","author":"Iavarone","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2023-24578_bib43","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1096\/fasebj.12.11.959","article-title":"Wounded reepitheloialization activates a growth factor-responsive enhancer in migrating keratinocytes","volume":"12","author":"Jaakkola","year":"1998","journal-title":"FASEB J."},{"key":"10.3168\/jds.2023-24578_bib44","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1073\/pnas.0601886103","article-title":"Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence","volume":"103","author":"Jensen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2023-24578_bib45","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1073\/pnas.90.14.6786","article-title":"Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16","volume":"90","author":"Jiang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2023-24578_bib46","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.immuni.2019.06.015","article-title":"The histone methyltransferase Setdb2 modulates macrophage phenotype and uric acid production in diabetic wound repair","volume":"51","author":"Kimball","year":"2019","journal-title":"Immunity"},{"key":"10.3168\/jds.2023-24578_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tvjl.2006.09.007","article-title":"Effects of housing, parturition and diet change on the biochemistry and biomechanics of the support structures of the hoof of dairy heifers","volume":"174","author":"Knott","year":"2007","journal-title":"Vet. J."},{"key":"10.3168\/jds.2023-24578_bib48","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1046\/j.1523-1747.2001.01249.x","article-title":"Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes","volume":"116","author":"Komine","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib49","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.0902485","article-title":"Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death","volume":"184","author":"Kono","year":"2010","journal-title":"J. Immunol."},{"key":"10.3168\/jds.2023-24578_bib50","first-page":"5015","article-title":"Existence of different Fos\/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: Differential role of Fos proteins","volume":"12","author":"Kovary","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.3168\/jds.2023-24578_bib51","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1084\/jem.164.6.2095","article-title":"Human keratinocytes contain mRNA indistinguishable from monocyte IL-1 alpha and beta mRNA. Keratinocyte epidermal cell derived thymocyte activating factor is identical to interleukin 1","volume":"164","author":"Kupper","year":"1986","journal-title":"J. Exp. Med."},{"key":"10.3168\/jds.2023-24578_bib52","first-page":"145","article-title":"MYC target transcriptomes","volume":"302","author":"Lee","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.3168\/jds.2023-24578_bib53","first-page":"694","article-title":"Suspensory structures and supporting tissues of the third phalynx of cows and their relevance to the development of sole ulcers (Rusterhulz ulcers)","volume":"151","author":"Lischer","year":"2002","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2023-24578_bib54","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jcp.21056","article-title":"AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells","volume":"212","author":"Lotti","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.3168\/jds.2023-24578_bib55","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0960-9822(00)00451-6","article-title":"Stimulation of human epidermal differentiation by Delta-Notch signaling at the boundaries of stem-cell clusters","volume":"10","author":"Lowell","year":"2000","journal-title":"Curr. Biol."},{"key":"10.3168\/jds.2023-24578_bib56","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1101\/gad.349662.122","article-title":"KLF5 governs sphingolipid metabolism and barrier function of the skin","volume":"36","author":"Lyu","year":"2022","journal-title":"Genes Dev."},{"key":"10.3168\/jds.2023-24578_bib57","first-page":"361","article-title":"Transcriptional control of K5, K6, K14 keratin genes by AP-1 and NF-kappaB family members","volume":"6","author":"Ma","year":"1997","journal-title":"Gene Expr."},{"key":"10.3168\/jds.2023-24578_bib58","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1523-1747.2000.00987.x","article-title":"Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced keratinocyte growth factor expression in resting fibroblasts","volume":"114","author":"Maas-Szabowski","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib59","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1242\/jcs.00474","article-title":"Epidermal tissue regeneration and stomal interaction in HaCaT cells is initiated by TGF-\u03b1","volume":"116","author":"Maas-Szabowski","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.3168\/jds.2023-24578_bib60","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/emboj\/16.9.2365","article-title":"The coupling of \u03b16\u03b24 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation","volume":"16","author":"Mainiero","year":"1997","journal-title":"EMBO J."},{"key":"10.3168\/jds.2023-24578_bib61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1476-4598-5-31","article-title":"Down-regulation of c-Myc following MEK\/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors","volume":"5","author":"Marampon","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.3168\/jds.2023-24578_bib62","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.182.5.1369","article-title":"Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin","volume":"182","author":"Marchese","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.3168\/jds.2023-24578_bib63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature11393","article-title":"Distinct contribution of stem and progenitor cells to epidermal maintenance","volume":"489","author":"Mascr\u00e9","year":"2012","journal-title":"Nature"},{"key":"10.3168\/jds.2023-24578_bib64","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.0022-202X.2004.23558.x","article-title":"Fos and Jun proteins are specifically expressed during differentiation of human keratinocytes","volume":"124","author":"Mehic","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib65","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1101\/gad.1038103","article-title":"Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development","volume":"17","author":"Mill","year":"2003","journal-title":"Genes Dev."},{"key":"10.3168\/jds.2023-24578_bib66","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.3168\/jds.2009-2097","article-title":"Age, segment and horn disease affect expression of cytokines, growth factors and receptors in the epidermis and dermis of the bovine claw","volume":"92","author":"Mills","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2023-24578_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mc.20160","article-title":"Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes","volume":"45","author":"Mizuno","year":"2006","journal-title":"Mol. Carcinog."},{"key":"10.3168\/jds.2023-24578_bib68","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ncb822","article-title":"Molecular interpretation of ERK signal duration by immediate early gene products","volume":"4","author":"Murphy","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib69","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/vr.138.24.586","article-title":"Epidemiology of lameness in dairy cattle: Description and analysis of foot lesions","volume":"138","author":"Murray","year":"1996","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2023-24578_bib70","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jcp.21233","article-title":"An intermediary role of proHB-EGF shedding in growth factor induced c-Myc expression","volume":"214","author":"Nanba","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.3168\/jds.2023-24578_bib71","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/emmm.201201839","article-title":"Actin filament dynamics impacts keratinocyte stem cell maintenance","volume":"5","author":"Nanba","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.3168\/jds.2023-24578_bib72","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1\u03b2 in monocytes and macrophages","volume":"113","author":"Netea","year":"2009","journal-title":"Blood"},{"key":"10.3168\/jds.2023-24578_bib73","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1038\/sj.jid.5700864","article-title":"Biphasic regulation of AP-1 subunits during epidermal wound healing","volume":"127","author":"Neub","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib74","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1038\/jid.2014.44","article-title":"Regulation of the dynamic chromatin architecture of the epidermal differentiation complex is mediated by a c-Jun\/AP-1-modulated enhancer","volume":"134","author":"Oh","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib75","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1093\/emboj\/19.12.2969","article-title":"Jun B suppresses cell proliferation by transcriptional activation of p16INK4a expression","volume":"19","author":"Passegu\u00e9","year":"2000","journal-title":"EMBO J."},{"key":"10.3168\/jds.2023-24578_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2023-24578_bib77","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparisons and statistical analysis of relative expression results in real time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2023-24578_bib78","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/B:BILE.0000019559.84305.47","article-title":"Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations","volume":"26","author":"Pfaffl","year":"2004","journal-title":"Biotechnol. Lett."},{"key":"10.3168\/jds.2023-24578_bib79","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/emboj\/20.13.3427","article-title":"Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation","volume":"20","author":"Rangarajan","year":"2001","journal-title":"EMBO J."},{"key":"10.3168\/jds.2023-24578_bib80","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.031427","article-title":"KGF and EGF signaling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin","volume":"136","author":"Richardson","year":"2009","journal-title":"Development"},{"key":"10.3168\/jds.2023-24578_bib81","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1038\/onc.2010.315","article-title":"AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation","volume":"29","author":"Rorke","year":"2010","journal-title":"Oncogene"},{"key":"10.3168\/jds.2023-24578_bib82","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1073\/pnas.86.3.802","article-title":"Purification and characterization of a newly identified growth factor specific for epithelial cells","volume":"86","author":"Rubin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.3168\/jds.2023-24578_bib83","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2007.02.045","article-title":"P63 is essential for the proliferative potential of stem cells in stratified epithelium","volume":"129","author":"Senoo","year":"2007","journal-title":"Cell"},{"key":"10.3168\/jds.2023-24578_bib84","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.0906-6705.2005.00317.x","article-title":"Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes","volume":"14","author":"Shi","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib85","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20182402","article-title":"Functional interactions between Mi-2\u03b2 and AP1 complexes control response and recovery from skin barrier disruption","volume":"217","author":"Shibata","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.3168\/jds.2023-24578_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100235","article-title":"Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases","volume":"63","author":"Suzuki","year":"2022","journal-title":"J. Lipid Res."},{"key":"10.3168\/jds.2023-24578_bib87","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tvjl.2015.05.023","article-title":"Treponema DNA in bovine nonhealing versus common sole ulcers and white line disease","volume":"205","author":"Sykora","year":"2015","journal-title":"Vet. J."},{"key":"10.3168\/jds.2023-24578_bib88","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1053\/tvjl.2001.0651","article-title":"Biomechanical and histological changes in the support structures of bovine hooves around the time of first calving","volume":"163","author":"Tarlton","year":"2002","journal-title":"Vet. J."},{"key":"10.3168\/jds.2023-24578_bib89","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1939-1676.2006.tb01789.x","article-title":"Review of Pododermatitis circumscripta (ulceration of the sole) in dairy cows","volume":"20","author":"van Amstel","year":"2006","journal-title":"J. Vet. Intern. Med."},{"key":"10.3168\/jds.2023-24578_bib90","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200804030","article-title":"Ap-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis","volume":"183","author":"Wang","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib91","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/jid.2012.358","article-title":"Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development","volume":"133","author":"Wang","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.3168\/jds.2023-24578_bib92","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ceb.2008.01.010","article-title":"Epidermal notch signalling: Differentiation, cancer and adhesion","volume":"20","author":"Watt","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib93","doi-asserted-by":"crossref","first-page":"12614","DOI":"10.1074\/jbc.270.21.12614","article-title":"Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promotor activity","volume":"270","author":"Welter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2023-24578_bib94","first-page":"2681","article-title":"Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation","volume":"11","author":"Welter","year":"1995","journal-title":"Oncogene"},{"key":"10.3168\/jds.2023-24578_bib95","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0962-8924(01)01955-9","article-title":"Paracrine regulation of keratinocyte proliferation and differentiation","volume":"11","author":"Werner","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.3168\/jds.2023-24578_bib96","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature09793","article-title":"Asymmetric cell divisions promote notch-dependent epidermal differentiation","volume":"470","author":"Williams","year":"2011","journal-title":"Nature"},{"key":"10.3168\/jds.2023-24578_bib97","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3168\/jds.2011-4489","article-title":"Mechanical properties of the bovine claw horn during lactation","volume":"95","author":"Winkler","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2023-24578_bib98","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1524-475X.2002.10902.x","article-title":"Transcription factor activation in response to cutaneous injury: Role of AP-1 in re-epithelialization","volume":"10","author":"Yates","year":"2002","journal-title":"Wound Repair Regen."},{"key":"10.3168\/jds.2023-24578_bib99","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin diseases and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"},{"key":"10.3168\/jds.2023-24578_bib100","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S1534-5807(03)00161-8","article-title":"c-Jun regulates eye lid closure and skin tumor development through EGFR signaling","volume":"4","author":"Zenz","year":"2003","journal-title":"Dev. Cell"},{"key":"10.3168\/jds.2023-24578_bib101","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1073\/pnas.96.12.6728","article-title":"Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro","volume":"96","author":"Zhu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030224008439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030224008439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030224008439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:51:47Z","timestamp":1731102707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030224008439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":101,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0022030224008439"],"URL":"https:\/\/doi.org\/10.3168\/jds.2023-24578","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2023-24578","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}]}}