{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:24:29Z","timestamp":1791599069724,"version":"4.3.4"},"reference-count":81,"publisher":"American Dairy Science Association","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.3168\/jds.2024-25790","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T19:06:27Z","timestamp":1736190387000},"page":"7662-7674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation\u2014Lights and shadows"],"prefix":"10.3168","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-1911","authenticated-orcid":false,"given":"Erminio","family":"Trevisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-7536","authenticated-orcid":false,"given":"Luca","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-7821","authenticated-orcid":false,"given":"Fiorenzo","family":"Piccioli-Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-0022","authenticated-orcid":false,"given":"Matteo","family":"Mezzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-6571","authenticated-orcid":false,"given":"Andrea","family":"Minuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2024-25790_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3168\/jds.S0022-0302(82)82146-2","article-title":"Primary ketosis in the high-producing dairy cow: Clinical and subclinical disorders, treatment, prevention, and outlook","volume":"65","author":"Baird","year":"1982","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/CDLI.11.3.463-472.2004","article-title":"Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection","volume":"11","author":"Bannerman","year":"2004","journal-title":"Clin. Vaccine Immunol."},{"key":"10.3168\/jds.2024-25790_bib3","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3168\/jds.S0022-0302(80)83111-0","article-title":"Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis","volume":"63","author":"Bauman","year":"1980","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib4","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2527\/1995.7392804x","article-title":"Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation","volume":"73","author":"Bell","year":"1995","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2024-25790_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cvfa.2013.04.004","article-title":"Use of the liver activity index and other metabolic variables in the assessment of metabolic health in dairy herds","volume":"29","author":"Bertoni","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2024-25790_bib6","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.3168\/jds.2008-0995","article-title":"Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows","volume":"91","author":"Bertoni","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib7","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3168\/jds.2006-445","article-title":"Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows","volume":"90","author":"Bionaz","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbi.2006.09.004","article-title":"Conceptual development of the immune system as a sixth sense","volume":"21","author":"Blalock","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.3168\/jds.2024-25790_bib9","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.3168\/jds.S0022-0302(04)73446-3","article-title":"Invited Review: Pathology, etiology, prevention, and treatment of fatty liver in dairy cows","volume":"87","author":"Bobe","year":"2004","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3945\/jn.109.108233","article-title":"Daily injection of tumor necrosis factor-\u03b1 increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle","volume":"139","author":"Bradford","year":"2009","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2024-25790_bib11","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.3168\/jds.2015-9683","article-title":"Invited review: Inflammation during the transition to lactation: New adventures with an old flame","volume":"98","author":"Bradford","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib12","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.3168\/jds.2013-7809","article-title":"Relationships between fertility and postpartum changes in body condition and body weight in lactating dairy cows","volume":"97","author":"Carvalho","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib13","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.3168\/jds.2020-19944","article-title":"Albumin-to-globulin ratio before dry-off as a possible index of inflammatory status and performance in the subsequent lactation in dairy cows","volume":"104","author":"Cattaneo","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jpn.13777","article-title":"Drying-off dairy cows without antibiotic therapy and orally supplemented with lyophilized Aloe arborescens: Effects on rumen activity, immunometabolic profile, and milk yield","volume":"107","author":"Cattaneo","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2024-25790_bib15","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.jprot.2012.04.004","article-title":"Acute phase proteins in ruminants","volume":"75","author":"Ceciliani","year":"2012","journal-title":"J. Proteomics"},{"key":"10.3168\/jds.2024-25790_bib16","doi-asserted-by":"crossref","first-page":"9514","DOI":"10.3168\/jds.2023-23409","article-title":"Lipolysis inhibition as a treatment of clinical ketosis in dairy cows: A randomized clinical trial","volume":"106","author":"Chirivi","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib17","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.3168\/jds.2017-13340","article-title":"Symposium review: Modulating adipose tissue lipolysis and remodeling to improve immune function during the transition period and early lactation of dairy cows","volume":"101","author":"Contreras","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1467538","article-title":"The regulation of inflammation by innate and adaptive lymphocytes","volume":"2018","author":"Cronkite","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.3168\/jds.2024-25790_bib19","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.3168\/jds.2017-14318","article-title":"Short communication: Effects of body fat mobilization on macrophage infiltration in adipose tissue of early lactation dairy cows","volume":"101","author":"De Koster","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.rvsc.2015.11.004","article-title":"Alterations in innate immunity reactants and carbohydrate and lipid metabolism precede occurrence of metritis in transition dairy cows","volume":"104","author":"Dervishi","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2024-25790_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1095\/biolreprod64.1.242","article-title":"Pregnancy stimulates secretion of adrenocorticotropin and nitric oxide from peripheral bovine lymphocytes","volume":"64","author":"Dixit","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.3168\/jds.2024-25790_bib22","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3168\/jds.S0022-0302(99)75474-3","article-title":"Biology of dairy cows during the transition period: The final frontier?","volume":"82","author":"Drackley","year":"1999","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib23","doi-asserted-by":"crossref","first-page":"00007","DOI":"10.3389\/fimmu.2015.00007","article-title":"The contribution of the maternal immune system to the establishment of pregnancy in cattle","volume":"6","author":"Fair","year":"2015","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2024-25790_bib24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.3168\/jds.2024-25790_bib25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12275-020-9182-8","article-title":"Autophagy of bovine mammary epithelial cell induced by intracellular Staphylococcus aureus","volume":"58","author":"Geng","year":"2020","journal-title":"J. Microbiol."},{"key":"10.3168\/jds.2024-25790_bib26","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3168\/jds.S0022-0302(97)76055-7","article-title":"Physiological changes at parturition and their relationship to metabolic disorders","volume":"80","author":"Goff","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib27","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.3168\/jds.2011-4251","article-title":"Endocrine changes and liver mRNA abundance of somatotropic axis and insulin system constituents during negative energy balance at different stages of lactation in dairy cows","volume":"94","author":"Gross","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib28","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.3168\/jds.S0022-0302(93)77729-2","article-title":"Etiology of lipid-related metabolic disorders in periparturient dairy cows","volume":"76","author":"Grummer","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib29","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.2527\/1995.7392820x","article-title":"Impact of changes in organic nutrient metabolism on feeding the transition dairy cow","volume":"73","author":"Grummer","year":"1995","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2024-25790_bib30","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.3168\/jds.2021-21220","article-title":"Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows","volume":"105","author":"H\u00e4ussler","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-1097(00)00455-9","article-title":"Demonstration of intracellular Staphylococcus aureus in bovine mastitis alveolar cells and macrophages isolated from naturally infected cow milk","volume":"193","author":"H\u00e9bert","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"10.3168\/jds.2024-25790_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1359-6101(98)00022-7","article-title":"Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation","volume":"10","author":"Heemskerk","year":"1999","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.3168\/jds.2024-25790_bib33","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3168\/jds.2014-8494","article-title":"Grazing dairy cows had decreased interferon-\u03b3, tumor necrosis factor, and interleukin-17, and increased expression of interleukin-10 during the first week after calving","volume":"98","author":"Heiser","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib34","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and performance\u2014A critical evaluation of traditional dogmas","volume":"104","author":"Horst","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib35","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1292\/jvms.66.1403","article-title":"Changes in interleukin-6 concentration in peripheral blood of pre- and post-partum dairy cattle and its relationship to postpartum reproductive diseases","volume":"66","author":"Ishikawa","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"10.3168\/jds.2024-25790_bib36","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.theriogenology.2013.01.018","article-title":"Determination of anti-inflammatory cytokine in periparturient cows for prediction of postpartum reproductive diseases","volume":"79","author":"Islam","year":"2013","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2024-25790_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.vetimm.2015.04.003","article-title":"Assessment of immune response in periparturient dairy cows using ex vivo whole blood stimulation assay with lipopolysaccharides and carrageenan skin test","volume":"165","author":"Jahan","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2024-25790_bib38","doi-asserted-by":"crossref","first-page":"8069","DOI":"10.3168\/jds.2021-21669","article-title":"Prepartum dietary energy intake alters hepatic expression of genes related to peroxisome proliferator-activated receptor and inflammation in peripartal dairy cows","volume":"105","author":"Janovick","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib39","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1210\/js.2019-00053","article-title":"Neuroendocrine regulation of brain cytokines after psychological stress","volume":"3","author":"Johnson","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.3168\/jds.2024-25790_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cimid.2013.10.007","article-title":"Adiponectin links adipose tissue function and monocyte inflammatory responses during bovine metabolic stress","volume":"37","author":"Kabara","year":"2014","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.3168\/jds.2024-25790_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.622468","article-title":"The role of the adipokine leptin in immune cell function in health and disease","volume":"11","author":"Kiernan","year":"2021","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2024-25790_bib42","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0093-691X(98)00029-6","article-title":"Release of proinflammatory cytokines related to luteolysis and the periparturient acute phase response in prostaglandin-induced parturition in cows","volume":"49","author":"Koets","year":"1998","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2024-25790_bib43","doi-asserted-by":"crossref","first-page":"s65","DOI":"10.1017\/S1751731119003124","article-title":"Review: Pro-inflammatory cytokines and hypothalamic inflammation: implications for insufficient feed intake of transition dairy cows","volume":"14","author":"Kuhla","year":"2020","journal-title":"Animal"},{"key":"10.3168\/jds.2024-25790_bib44","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.3390\/ijms20225638","article-title":"The novel perspectives of adipokines on brain health","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2024-25790_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/01652176.1988.9694158","article-title":"Pathophysiological effects of endotoxins in ruminants","volume":"10","author":"Lohuis","year":"1988","journal-title":"Vet. Q."},{"key":"10.3168\/jds.2024-25790_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11259-012-9545-7","article-title":"Effect of progesterone on Th1\/Th2\/Th17 and regulatory T cell-related genes in peripheral blood mononuclear cells during pregnancy in cows","volume":"37","author":"Maeda","year":"2013","journal-title":"Vet. Res. Commun."},{"key":"10.3168\/jds.2024-25790_bib47","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.3168\/jds.2024-25790_bib48","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.3168\/jds.2019-16497","article-title":"The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation","volume":"102","author":"Mezzetti","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/1828051X.2019.1691472","article-title":"Inflammatory status and metabolic changes at dry-off in high-yield dairy cows","volume":"19","author":"Mezzetti","year":"2020","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2024-25790_bib50","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10142-019-00720-0","article-title":"Evaluation of circulating leukocyte transcriptome and its relationship with immune function and blood markers in dairy cows during the transition period","volume":"20","author":"Minuti","year":"2020","journal-title":"Funct. Integr. Genomics"},{"key":"10.3168\/jds.2024-25790_bib51","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1600-0897.2010.00836.x","article-title":"Review Article: The immune system in pregnancy: A unique complexity","volume":"63","author":"Mor","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.3168\/jds.2024-25790_bib52","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3168\/jds.2023-24488","article-title":"Intramammary lipopolysaccharide challenge in early- versus mid-lactation dairy cattle: Immune, production, and metabolic responses","volume":"107","author":"Opgenorth","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib53","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.3168\/jds.2023-24350","article-title":"Intravenous lipopolysaccharide challenge in early- versus mid-lactation dairy cattle. I: The immune and inflammatory responses","volume":"107","author":"Opgenorth","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib54","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.3168\/jds.2023-24351","article-title":"Intravenous lipopolysaccharide challenge in early- versus mid-lactation dairy cattle. II: The production and metabolic responses","volume":"107","author":"Opgenorth","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib55","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1097\/01.CCM.0000186370.78639.23","article-title":"Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock","volume":"33","author":"Oppert","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.3168\/jds.2024-25790_bib56","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jinf.2006.06.010","article-title":"Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis","volume":"54","author":"Oviedo-Boyso","year":"2007","journal-title":"J. Infect."},{"key":"10.3168\/jds.2024-25790_bib57","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.3168\/jds.2023-24630","article-title":"Unraveling metabolic stress response in dairy cows: Genetic control of plasma biomarkers throughout lactation and the transition period","volume":"107","author":"Passamonti","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib58","doi-asserted-by":"crossref","DOI":"10.4137\/BBI.S5850","article-title":"Expression of metabolic, tissue remodeling, oxidative stress, and inflammatory pathways in mammary tissue during involution in lactating dairy cows","volume":"4","author":"Piantoni","year":"2010","journal-title":"Bioinform. Biol. Insights"},{"key":"10.3168\/jds.2024-25790_bib59","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.3168\/jds.2018-14591","article-title":"Changes in biomarkers of nutrient metabolism, inflammation, and oxidative stress in dairy cows during the transition into the early dry period","volume":"101","author":"Putman","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib60","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1051\/vetres:2006007","article-title":"Innate immunity of the bovine mammary gland","volume":"37","author":"Rainard","year":"2006","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2024-25790_bib61","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3168\/jds.2023-23904","article-title":"Invited review: Ketone biology\u2014The shifting paradigm of ketones and ketosis in the dairy cow","volume":"107","author":"Rico","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib62","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/jpn.12263","article-title":"Molecular insights into the mechanisms of liver-associated diseases in early-lactating dairy cows: Hypothetical role of endoplasmic reticulum stress","volume":"99","author":"Ringseis","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2024-25790_bib63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CDLI.7.2.161-167.2000","article-title":"Differential induction of complement fragment C5a and inflammatory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus","volume":"7","author":"Riollet","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.3168\/jds.2024-25790_bib64","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S8756-3282(01)00468-9","article-title":"The effect of 17\u03b2-estradiol on production of cytokines in cultures of peripheral blood","volume":"29","author":"Rogers","year":"2001","journal-title":"Bone"},{"key":"10.3168\/jds.2024-25790_bib65","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3168\/jds.2022-22068","article-title":"Invited review: Muscle protein breakdown and its assessment in periparturient dairy cows","volume":"106","author":"Sadri","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib66","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.3168\/jds.2021-20776","article-title":"Graduate Student Literature Review: Systemic mediators of inflammation during mastitis and the search for mechanisms underlying impaired lactation","volume":"105","author":"Shangraw","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib67","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3168\/jds.S0022-0302(56)94765-8","article-title":"Ketosis in dairy cattle. A review","volume":"39","author":"Shaw","year":"1956","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib68","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1097\/j.pain.0000000000002892","article-title":"Local analgesia of electroacupuncture is mediated by the recruitment of neutrophils and released \u03b2-endorphins","volume":"164","author":"Shi","year":"2023","journal-title":"Pain"},{"key":"10.3168\/jds.2024-25790_bib69","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.3168\/jds.S0022-0302(91)78568-8","article-title":"Suppression of milk production during endotoxin-induced mastitis","volume":"74","author":"Shuster","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib70","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.4081\/ijas.2015.3862","article-title":"Pro-inflammatory cytokine profile in dairy cows: Consequences for new lactation","volume":"14","author":"Trevisi","year":"2015","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2024-25790_bib71","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.rvsc.2017.12.001","article-title":"Assessment of the innate immune response in the periparturient cow","volume":"116","author":"Trevisi","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2024-25790_bib72","doi-asserted-by":"crossref","first-page":"230","DOI":"10.14310\/horm.2002.1202","article-title":"Pre- and early post-partum adiponectin and interleukin-1beta levels in women with and without gestational diabetes","volume":"7","author":"Vitoratos","year":"2008","journal-title":"Hormones (Athens)"},{"key":"10.3168\/jds.2024-25790_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.643206","article-title":"Bovine immunology: Implications for dairy cattle","volume":"12","author":"Vlasova","year":"2021","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2024-25790_bib74","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.3168\/jds.S0022-0302(03)73949-6","article-title":"Effect of lipopolysaccharide on indices of peripheral and hepatic metabolism in lactating cows","volume":"86","author":"Waldron","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib75","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","article-title":"T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2024-25790_bib76","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol. Today"},{"key":"10.3168\/jds.2024-25790_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tvjl.2011.09.013","article-title":"The innate immune response of the bovine mammary gland to bacterial infection","volume":"192","author":"Wellnitz","year":"2012","journal-title":"Vet. J."},{"key":"10.3168\/jds.2024-25790_bib78","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.prevetmed.2018.12.014","article-title":"Predictive models for early lactation diseases in transition dairy cattle at dry-off","volume":"163","author":"Wisnieski","year":"2019","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2024-25790_bib79","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.3168\/jds.2021-21225","article-title":"Symposium review: Mechanistic insights into adipose tissue inflammation and oxidative stress in periparturient dairy cows","volume":"105","author":"Zachut","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25790_bib80","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.rvsc.2016.06.012","article-title":"Dairy cows affected by ketosis show alterations in innate immunity and lipid and carbohydrate metabolism during the dry off period and postpartum","volume":"107","author":"Zhang","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2024-25790_bib81","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.3168\/jds.2019-16377","article-title":"Invited review: Accelerating mammary gland involution after drying-off in dairy cattle","volume":"102","author":"Zhao","year":"2019","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030224014449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030224014449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T15:53:05Z","timestamp":1750607585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030224014449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":81,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022030224014449"],"URL":"https:\/\/doi.org\/10.3168\/jds.2024-25790","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation\u2014Lights and shadows","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2024-25790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s).","name":"copyright","label":"Copyright"}]}}