{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:53:48Z","timestamp":1769972028943,"version":"3.49.0"},"reference-count":72,"publisher":"American Dairy Science Association","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003385","name":"Georg-August-Universit\u00e4t G\u00f6ttingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["448536632"],"award-info":[{"award-number":["448536632"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.3168\/jds.2024-25978","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T16:44:53Z","timestamp":1744303493000},"page":"6114-6129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic insights: Disentangling milk yield and reproduction performance in first-lactation German Holsteins"],"prefix":"10.3168","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0069-5320","authenticated-orcid":false,"given":"Leopold","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-7148","authenticated-orcid":false,"given":"Johannes","family":"Heise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-1160","authenticated-orcid":false,"given":"J\u00f6rn","family":"Bennewitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Thaller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-464X","authenticated-orcid":false,"given":"Jens","family":"Tetens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2024-25978_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3168\/jds.2012-5632","article-title":"The relationship between fertility and lactation characteristics in Holstein cows on United Kingdom commercial dairy farms","volume":"96","author":"Albarr\u00e1n-Portillo","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib2","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.3168\/jds.2022-21780","article-title":"Genome-wide association study for selected cheese-making properties in dual-purpose Belgian Blue cows","volume":"105","author":"Atashi","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib3","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.3168\/jds.2021-20382","article-title":"Residual energy intake, energy balance, and liability to diseases: Genetic parameters and relationships in German Holstein dairy cows","volume":"104","author":"Becker","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-animal-021815-111406","article-title":"Milk Production and Fertility in Cattle","volume":"4","author":"Berry","year":"2016","journal-title":"Annu. Rev. Anim. Biosci."},{"issue":"Suppl. 1","key":"10.3168\/jds.2024-25978_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/S1751731114000743","article-title":"Genetics and genomics of reproductive performance in dairy and beef cattle","volume":"8","author":"Berry","year":"2014","journal-title":"Animal"},{"key":"10.3168\/jds.2024-25978_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12864-022-08555-z","article-title":"Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes","volume":"23","author":"Chen","year":"2022","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2024-25978_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/1471-2164-12-408","article-title":"Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows","volume":"12","author":"Cole","year":"2011","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2024-25978_bib8","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.3168\/jds.2015-10264","article-title":"Use of early lactation milk recording data to predict the calving to conception interval in dairy herds","volume":"99","author":"Cook","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/genetics\/35.2.212","article-title":"Heritability of threshold characters","volume":"35","author":"Dempster","year":"1950","journal-title":"Genetics"},{"key":"10.3168\/jds.2024-25978_bib10","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"10.3168\/jds.2024-25978_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/jbg.12238","article-title":"Genome-wide association study for milk somatic cell score in Holstein cattle using copy number variation as markers","volume":"134","author":"Dur\u00e1n Aguilar","year":"2017","journal-title":"J. Anim. Breed. Genet."},{"key":"10.3168\/jds.2024-25978_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S1751731114002614","article-title":"Invited review: Overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits","volume":"9","author":"Egger-Danner","year":"2015","journal-title":"Animal"},{"key":"10.3168\/jds.2024-25978_bib13","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.3168\/jds.2016-11333","article-title":"Economic opportunities for using sexed semen and semen of beef bulls in dairy herds","volume":"100","author":"Ettema","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/jbg.12274","article-title":"Genetic relationships among female fertility disorders, female fertility traits and productivity of Holstein dairy cows in the early lactation period","volume":"134","author":"Gernand","year":"2017","journal-title":"J. Anim. Breed. Genet."},{"key":"10.3168\/jds.2024-25978_bib15","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.3168\/jds.2012-5922","article-title":"Metritis in dairy cows: Risk factors and reproductive performance","volume":"96","author":"Giuliodori","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jbg.12365","article-title":"Unravelling the genetic loci for growth and carcass traits in Chinese Bamaxiang pigs based on a 1.4 million SNP array","volume":"136","author":"Gong","year":"2019","journal-title":"J. Anim. Breed. Genet."},{"key":"10.3168\/jds.2024-25978_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13028-014-0085-8","article-title":"A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle","volume":"56","author":"Grossi","year":"2014","journal-title":"Acta Vet. Scand."},{"key":"10.3168\/jds.2024-25978_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3168\/jds.2021-20588","article-title":"Genetic parameters and association of national evaluations with breeding values for health traits in US organic Holstein cows","volume":"105","author":"Hardie","year":"2022","journal-title":"J. Dairy Sci."},{"issue":"D1","key":"10.3168\/jds.2024-25978_bib19","doi-asserted-by":"crossref","first-page":"D891","DOI":"10.1093\/nar\/gkad1049","article-title":"Ensembl 2024","volume":"52","author":"Harrison","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2024-25978_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3168\/jds.2008-1646","article-title":"Invited review: Genomic selection in dairy cattle: Progress and challenges","volume":"92","author":"Hayes","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib21","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3168\/jds.2009-2879","article-title":"Genetic analysis of fertility-related diseases and disorders in Norwegian Red cows","volume":"93","author":"Heringstad","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04398-z","article-title":"Elucidating the genetic architecture of reproductive ageing in the Japanese population","volume":"9","author":"Horikoshi","year":"2018","journal-title":"Nat. Commun."},{"issue":"D1","key":"10.3168\/jds.2024-25978_bib23","doi-asserted-by":"crossref","first-page":"D956","DOI":"10.1093\/nar\/gkab1116","article-title":"Bringing the Animal QTLdb and CorrDB into the future: Meeting new challenges and providing updated services","volume":"50","author":"Hu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2024-25978_bib24","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1186\/1471-2164-11-724","article-title":"Accounting for multiple comparisons in a genome-wide association study (GWAS)","volume":"11","author":"Johnson","year":"2010","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2024-25978_bib25","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.3168\/jds.2011-5127","article-title":"Health recording in Canadian Holsteins: data and genetic parameters","volume":"95","author":"Koeck","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3168\/jds.2007-0170","article-title":"Exploration of relationships between claw disorders and milk yield in Holstein cows via recursive linear and threshold models","volume":"91","author":"K\u00f6nig","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajhg.2011.02.002","article-title":"Estimating missing heritability for disease from genome-wide association studies","volume":"88","author":"Lee","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2024-25978_bib28","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/bioinformatics\/bts474","article-title":"Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood","volume":"28","author":"Lee","year":"2012","journal-title":"Bioinformatics"},{"key":"10.3168\/jds.2024-25978_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009331","article-title":"A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle","volume":"17","author":"Lee","year":"2021","journal-title":"PLoS Genet."},{"key":"10.3168\/jds.2024-25978_bib30","first-page":"41","article-title":"A deregression method for single-step genomic model using all genotype data","volume":"56","author":"Liu","year":"2021","journal-title":"Interbull Bull."},{"key":"10.3168\/jds.2024-25978_bib31","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3168\/jds.S0022-0302(01)70158-0","article-title":"Reproductive loss in high-producing dairy cattle: Where will it end?","volume":"84","author":"Lucy","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib32","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.3168\/jds.2016-12249","article-title":"Derivation and genome-wide association study of a principal component-based measure of heat tolerance in dairy cattle","volume":"100","author":"Macciotta","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199931","article-title":"A system-based analysis of the genetic determinism of udder conformation and health phenotypes across three French dairy cattle breeds","volume":"13","author":"Marete","year":"2018","journal-title":"PLoS One"},{"key":"10.3168\/jds.2024-25978_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaaa082","article-title":"Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium","volume":"27","author":"Marla","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.3168\/jds.2024-25978_bib35","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.3168\/jds.2023-23668","article-title":"A comprehensive meta-analysis of genetic parameters for resilience and productivity indicator traits in Holstein cattle","volume":"107","author":"Maskal","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3168\/jds.2021-20685","article-title":"Genomic loci and genetic parameters for uterine diseases in first-parity Holstein cows and associations with milk production and fertility","volume":"105","author":"May","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1262\/jrd.17091","article-title":"Reproduction performance and management of dairy cattle","volume":"52","author":"McDougall","year":"2006","journal-title":"J. Reprod. Dev."},{"key":"10.3168\/jds.2024-25978_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tvjl.2007.12.032","article-title":"Prevalence and risk factors for dystocia in dairy cattle: A review","volume":"176","author":"Mee","year":"2008","journal-title":"Vet. J."},{"key":"10.3168\/jds.2024-25978_bib39","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.ajhg.2022.09.011","article-title":"Liability-scale heritability estimation for biobank studies of low-prevalence disease","volume":"109","author":"Ojavee","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2024-25978_bib40","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.3168\/jds.2021-20227","article-title":"Estimated genetic parameters for all genetically evaluated traits in Canadian Holsteins","volume":"104","author":"Oliveira","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib41","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.3168\/jds.2023-23699","article-title":"Archetypal clustering reveals physiological mechanisms linking milk yield and fertility in dairy cattle","volume":"107","author":"Ooi","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/cdd.2017.170","article-title":"Anti-apoptotic BCL-2 family members in development","volume":"25","author":"Opferman","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.3168\/jds.2024-25978_bib43","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.3168\/jds.2017-13054","article-title":"A 100-Year Review: Metabolic health indicators and management of dairy cattle","volume":"100","author":"Overton","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64575-3","article-title":"Structural equation modeling for investigating multi-trait genetic architecture of udder health in dairy cattle","volume":"10","author":"Pegolo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2024-25978_bib45","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.3168\/jds.2016-10854","article-title":"Invited review: Opportunities for genetic improvement of metabolic diseases","volume":"99","author":"Pryce","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0301-6226(03)00145-3","article-title":"Fertility in the high-producing dairy cow","volume":"86","author":"Pryce","year":"2004","journal-title":"Livest. Prod. Sci."},{"key":"10.3168\/jds.2024-25978_bib47","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2024-25978_bib48","series-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"10.3168\/jds.2024-25978_bib49","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.3168\/jds.2017-13796","article-title":"Effect of milk production on reproductive performance in dairy herds","volume":"101","author":"Rearte","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1017\/S002202991100080X","article-title":"Polymorphisms in genes in the SREBP1 signalling pathway and SCD are associated with milk fatty acid composition in Holstein cattle","volume":"79","author":"Rincon","year":"2012","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2024-25978_bib51","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/ajmg.a.34345","article-title":"Microdeletion of Xq28 involving the AFF2 (FMR2) gene in two unrelated males with developmental delay","volume":"155","author":"Sahoo","year":"2011","journal-title":"Am. J. Med. Genet. A."},{"key":"10.3168\/jds.2024-25978_bib52","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12864-023-09438-7","article-title":"X-linked genes influence various complex traits in dairy cattle","volume":"24","author":"Sanchez","year":"2023","journal-title":"BMC Genomics"},{"key":"10.3168\/jds.2024-25978_bib53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3168\/jds.2022-22363","article-title":"Genetic analysis of production traits and body size measurements and their relationships with metabolic diseases in German Holstein cattle","volume":"106","author":"Schmidtmann","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib54","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.3168\/jds.2012-5466","article-title":"Reliability of genomic prediction for German Holsteins using imputed genotypes from low-density chips","volume":"95","author":"Segelke","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2156-13-108","article-title":"Genetic effects and correlations between production and fertility traits and their dependency on the lactation-stage in Holstein Friesians","volume":"13","author":"Strucken","year":"2012","journal-title":"BMC Genet."},{"key":"10.3168\/jds.2024-25978_bib56","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/age.13099","article-title":"Genome-wide association study and inbreeding depression on body size traits in Qira black sheep (Ovis aries)","volume":"52","author":"Tao","year":"2021","journal-title":"Anim. Genet."},{"key":"10.3168\/jds.2024-25978_bib57","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.2527\/2003.8181911x","article-title":"Effects of DGAT1 variants on milk production traits in German cattle breeds","volume":"81","author":"Thaller","year":"2003","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2024-25978_bib58","doi-asserted-by":"crossref","first-page":"10272","DOI":"10.3168\/jds.2017-13399","article-title":"A 100-Year Review: Historical development of female reproductive physiology in dairy cattle","volume":"100","author":"Thatcher","year":"2017","journal-title":"J. Dairy Sci."},{"issue":"D1","key":"10.3168\/jds.2024-25978_bib59","doi-asserted-by":"crossref","first-page":"D939","DOI":"10.1093\/nar\/gkaa980","article-title":"Genenames.org: the HGNC and VGNC resources in 2021","volume":"49","author":"Tweedie","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.3168\/jds.2024-25978_bib60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/bdrb.20264","article-title":"Zinc and reproduction: Effects of zinc deficiency on prenatal and early postnatal development","volume":"89","author":"Uriu-Adams","year":"2010","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.3168\/jds.2024-25978_bib61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0301-6226(97)00058-4","article-title":"Accounting for herd, year and season effects in genetic evaluations of dairy cattle: A review","volume":"51","author":"van Bebber","year":"1997","journal-title":"Livest. Prod. Sci."},{"key":"10.3168\/jds.2024-25978_bib62","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jbg.12419","article-title":"Significance testing and genomic inflation factor using high-density genotypes or whole-genome sequence data","volume":"136","author":"van den Berg","year":"2019","journal-title":"J. Anim. Breed. Genet."},{"key":"10.3168\/jds.2024-25978_bib63","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3168\/jds.2008-1514","article-title":"Invited review: reliability of genomic predictions for North American Holstein bulls","volume":"92","author":"VanRaden","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2024-25978_bib64","author":"VIT (Vereinigte Informationssysteme Tierhaltung w.V.)"},{"key":"10.3168\/jds.2024-25978_bib65","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.anireprosci.2010.12.001","article-title":"A review of the causes of poor fertility in high milk producing dairy cows","volume":"123","author":"Walsh","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.3168\/jds.2024-25978_bib66","series-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.3168\/jds.2024-25978_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-09788-9","article-title":"Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle","volume":"7","author":"Xiang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2024-25978_bib68","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/s41467-021-21001-0","article-title":"Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations","volume":"12","author":"Xiang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.3168\/jds.2024-25978_bib69","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"Yang","year":"2010","journal-title":"Nat. Genet."},{"key":"10.3168\/jds.2024-25978_bib70","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.3168\/jds.2024-25978_bib71","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/ejhg.2011.39","article-title":"Genomic inflation factors under polygenic inheritance","volume":"19","author":"Yang","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.3168\/jds.2024-25978_bib72","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng.2876","article-title":"Advantages and pitfalls in the application of mixed-model association methods","volume":"46","author":"Yang","year":"2014","journal-title":"Nat. Genet."}],"updated-by":[{"DOI":"10.3168\/jds.2026-109-2-2067","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225002000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225002000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:22:09Z","timestamp":1769916129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030225002000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0022030225002000"],"URL":"https:\/\/doi.org\/10.3168\/jds.2024-25978","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic insights: Disentangling milk yield and reproduction performance in first-lactation German Holsteins","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2024-25978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s).","name":"copyright","label":"Copyright"}]}}