{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:38:03Z","timestamp":1790307483524,"version":"4.1.0"},"reference-count":34,"publisher":"American Dairy Science Association","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000094","name":"OMAFRA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008986","name":"University of Guelph","doi-asserted-by":"publisher","award":["4385"],"award-info":[{"award-number":["4385"]}],"id":[{"id":"10.13039\/100008986","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.3168\/jds.2025-26910","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:29:51Z","timestamp":1761089391000},"page":"572-583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inflammatory and metabolic markers in postpartum dairy cows developing chronic reproductive tract disease: A case-control study"],"prefix":"10.3168","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-8081","authenticated-orcid":false,"given":"T.C.","family":"Bruinj\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-2133","authenticated-orcid":false,"given":"O.","family":"Bogado Pascottini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-7704","authenticated-orcid":false,"given":"S.J.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2025-26910_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.theriogenology.2020.06.005","article-title":"Metabolic markers for purulent vaginal discharge and subclinical endometritis in dairy cows","volume":"155","author":"Bogado Pascottini","year":"2020","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2025-26910_bib2","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-22-0452","article-title":"Genesis of clinical and subclinical endometritis in dairy cows","volume":"166","author":"Bogado Pascottini","year":"2023","journal-title":"Reproduction"},{"key":"10.3168\/jds.2025-26910_bib3","first-page":"1","article-title":"Dynamics of uterine microbiota in postpartum dairy cows with clinical or subclinical endometritis","volume":"10","author":"Bogado Pascottini","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2025-26910_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/ani15050633","article-title":"Invited Review: Inflammation and health in the transition period influence reproductive function in dairy cows","volume":"15","author":"Bruinj\u00e9","year":"2025","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2025-26910_bib5","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.3168\/jds.2023-23268","article-title":"Postpartum health is associated with detection of estrus by activity monitors and reproductive performance in dairy cows","volume":"106","author":"Bruinj\u00e9","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib6","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3168\/jds.2011-4602","article-title":"Effect of endocervical inflammation on days to conception in dairy cows","volume":"95","author":"Deguillaume","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib7","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.3168\/jds.2020-19211","article-title":"Prevalence, risk factors, and effects on fertility of cytological endometritis at the time of insemination in Norwegian Red cows","volume":"104","author":"Diaz-Lundahl","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0093-691X(00)00410-6","article-title":"Relationship between intra-uterine bacterial contamination, endotoxin levels and the development of endometritis in postpartum cows with dystocia or retained placenta","volume":"54","author":"Dohmen","year":"2000","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2025-26910_bib9","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib10","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.3168\/jds.2010-3428","article-title":"Definitions and diagnosis of postpartum endometritis in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib11","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3168\/jds.S0022-0302(94)77212-X","article-title":"Principal descriptors of body condition score in Holstein cows","volume":"77","author":"Ferguson","year":"1994","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib12","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3168\/jds.2009-2551","article-title":"Association between uterine disease and indicators of neutrophil and systemic energy status in lactating Holstein cows","volume":"93","author":"Galv\u00e3o","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib13","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.3168\/jds.2016-11373","article-title":"Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F2\u03b1 treatment","volume":"100","author":"Giuliodori","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3168\/jds.2012-5682","article-title":"Clinical endometritis in an Argentinean herd of dairy cows: Risk factors and reproductive efficiency","volume":"96","author":"Giuliodori","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib15","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.3168\/jds.2022-23070","article-title":"Association of dry matter intake, milk yield, and days to first ovulation with cytological endometritis in Holstein cows","volume":"106","author":"Guadagnin","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib16","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and performance\u2014A critical evaluation of traditional dogmas","volume":"104","author":"Horst","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3168\/jds.2008-1526","article-title":"Short communication: Haptoglobin as an early indicator of metritis","volume":"92","author":"Huzzey","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12964","article-title":"Calcium signalling and related ion channels in neutrophil recruitment and function","volume":"48","author":"Immler","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.3168\/jds.2025-26910_bib19","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.3168\/jds.S0022-0302(06)72335-9","article-title":"Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle","volume":"89","author":"Kimura","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib20","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/asj.12219","article-title":"Evaluation of vaginal discharge with the Metricheck device and the relationship to reproductive performance in postpartum dairy cows","volume":"85","author":"Lambertz","year":"2014","journal-title":"Anim. Sci. J."},{"key":"10.3168\/jds.2025-26910_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1439-0531.2012.02109.x","article-title":"Interactions of metabolism, inflammation, and reproductive tract health in the postpartum period in dairy cattle","volume":"47","author":"LeBlanc","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"10.3168\/jds.2025-26910_bib22","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.3168\/jds.2022-22471","article-title":"Viability and function dynamics of circulating versus endometrial polymorphonuclear leukocytes in postpartum dairy cows with subclinical or clinical endometritis","volume":"106","author":"Lietaer","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3168\/jds.2013-7408","article-title":"Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows","volume":"97","author":"Martinez","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cvfa.2023.02.009","article-title":"Considerations in the diagnosis and treatment of early lactation calcium disturbances","volume":"39","author":"McArt","year":"2023","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2025-26910_bib25","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.3168\/jds.2019-18048","article-title":"Prevalence of endometritis diagnosed by vaginal discharge scoring or uterine cytology in dairy cows and herds","volume":"103","author":"McDougall","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib26","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/jvim.14592","article-title":"Explanation and elaboration document for the STROBE-Vet Statement: Strengthening the reporting of observational studies in epidemiology\u2014Veterinary extension","volume":"30","author":"O'Connor","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"10.3168\/jds.2025-26910_bib27","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.3168\/jds.2024-24897","article-title":"The economic impact of purulent vaginal discharge in dairy herds within a single lactation","volume":"108","author":"Ojeda-Rojas","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib28","doi-asserted-by":"crossref","DOI":"10.3168\/jds.2021-20642","article-title":"Assessment of the main pathogens associated with clinical and subclinical endometritis in cows by culture and MALDI-TOF mass spectrometry identification","author":"Paiano","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib29","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3168\/jds.2024-25300","article-title":"Acute phase responses in clinically healthy multiparous Holsteins with and without calcium dysregulation during the early postpartum period","volume":"108","author":"Seminara","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-26910_bib30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-animal-020518-115227","article-title":"Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle","volume":"7","author":"Sheldon","year":"2019","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.3168\/jds.2025-26910_bib31","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2025-26910_bib32","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0093-691X(97)00098-8","article-title":"A lameness scoring system that uses posture and gait to predict dairy cattle reproductive performance","volume":"47","author":"Sprecher","year":"1997","journal-title":"Theriogenology"},{"key":"10.3168\/jds.2025-26910_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/vr.157.7.202","article-title":"Association between clinical hypocalcaemia and postpartum endometritis","volume":"157","author":"Whiteford","year":"2005","journal-title":"Vet. Rec."},{"key":"10.3168\/jds.2025-26910_bib34","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3168\/jds.2013-7322","article-title":"Associations of cytological endometritis with energy metabolism and inflammation during the periparturient period and early lactation in dairy cows","volume":"97","author":"Yasui","year":"2014","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022500829X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002203022500829X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:34:00Z","timestamp":1773902040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002203022500829X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S002203022500829X"],"URL":"https:\/\/doi.org\/10.3168\/jds.2025-26910","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory and metabolic markers in postpartum dairy cows developing chronic reproductive tract disease: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2025-26910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s).","name":"copyright","label":"Copyright"}]}}