{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:05:04Z","timestamp":1788055504169,"version":"build-2784847793"},"reference-count":45,"publisher":"American Dairy Science Association","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["202202067"],"award-info":[{"award-number":["202202067"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.3168\/jds.2025-27238","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:29:57Z","timestamp":1761089397000},"page":"13138-13152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of tea polyphenol-modified lactoferrin complexes and their antimicrobial activity against Escherichia coli"],"prefix":"10.3168","volume":"108","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4957-0138","authenticated-orcid":false,"given":"Qingle","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-9859","authenticated-orcid":false,"given":"Mao-Cheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-1194","authenticated-orcid":false,"given":"Yangchao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-7490","authenticated-orcid":false,"given":"Changhui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2025-27238_bib1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1007\/s12010-023-04579-7","article-title":"Assessment of broad-spectrum antimicrobial, antibiofilm, and anticancer potential of lactoferrin extracted from camel milk","volume":"196","author":"Alkhulaifi","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.3168\/jds.2025-27238_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.115383","article-title":"Effect of bioactive compounds in processed Camellia sinensis tea on the intestinal barrier","volume":"199","author":"Chen","year":"2025","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2025-27238_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141870","article-title":"Chitosan-alginate microcapsules: A strategy for improving stability and antibacterial potential of bovine lactoferrin","volume":"307","author":"Cots","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.3168\/jds.2025-27238_bib4","doi-asserted-by":"crossref","first-page":"8575","DOI":"10.1039\/D3FO00406F","article-title":"A multi-omics analysis strategy reveals the molecular mechanism of the inhibition of Escherichia coli O157:H7 by anthocyanins from Aronia melanocarpa and its application","volume":"14","author":"Deng","year":"2023","journal-title":"Food Funct."},{"key":"10.3168\/jds.2025-27238_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131307","article-title":"Complexation of ellagic acid with \u03b1-lactalbumin and its antioxidant property","volume":"372","author":"Diao","year":"2022","journal-title":"Food Chem."},{"key":"10.3168\/jds.2025-27238_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112265","article-title":"Enhanced cytotoxicity and antioxidant capacity of kaempferol complexed with \u03b1-lactalbumin","volume":"153","author":"Diao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.3168\/jds.2025-27238_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0924-8579(00)00317-4","article-title":"Activity of gatifloxacin and ciprofloxacin in combination with other antimicrobial agents","volume":"17","author":"Gradelski","year":"2001","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.3168\/jds.2025-27238_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2023.114540","article-title":"1H NMR\u2013based metabolomics reveals the antimicrobial action of oregano essential oil against Escherichia coli and Staphylococcus aureus in broth, milk, and beef","volume":"176","author":"Hao","year":"2023","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2025-27238_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2021.108533","article-title":"Antibacterial mechanism of linalool against L. monocytogenes, a metabolomic study","volume":"132","author":"He","year":"2022","journal-title":"Food Control"},{"key":"10.3168\/jds.2025-27238_bib10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3390\/antibiotics11070896","article-title":"Bactericidal activity of sodium bituminosulfonate against Staphylococcus aureus","volume":"11","author":"Heuser","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.3168\/jds.2025-27238_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105183","article-title":"Lactoferrin: Current situation and future prospects","volume":"62","author":"Hu","year":"2024","journal-title":"Food Biosci."},{"key":"10.3168\/jds.2025-27238_bib12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3906\/kim-1402-37","article-title":"Molecular docking analysis and molecular dynamics simulation study of ameltolide analogous as a sodium channel blocker","volume":"39","author":"Iman","year":"2015","journal-title":"Turk. J. Chem."},{"key":"10.3168\/jds.2025-27238_bib13","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/jam.13468","article-title":"Environmental Escherichia coli: Ecology and public health implications\u2014A review","volume":"123","author":"Jang","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"10.3168\/jds.2025-27238_bib14","doi-asserted-by":"crossref","first-page":"26710","DOI":"10.1039\/D1RA03256A","article-title":"Elucidation of molecular interactions of theaflavin monogallate with camel milk lactoferrin: Detailed spectroscopic and dynamic simulation studies","volume":"11","author":"Khan","year":"2021","journal-title":"RSC Advances"},{"key":"10.3168\/jds.2025-27238_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128145","article-title":"Protein-polyphenol functional ingredients: The foaming properties of lactoferrin are enhanced by forming complexes with procyanidin","volume":"339","author":"Li","year":"2021","journal-title":"Food Chem."},{"key":"10.3168\/jds.2025-27238_bib16","article-title":"The combination of allicin with domiphen is effective against microbial biofilm formation","volume":"15","author":"Li","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2025-27238_bib17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/C8FO02146E","article-title":"Fabrication and characterization of functional protein\u2013polysaccharide\u2013polyphenol complexes assembled from lactoferrin, hyaluronic acid and (\u2212)-epigallocatechin gallate","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"10.3168\/jds.2025-27238_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140835","article-title":"Non-covalent interaction between lactoferrin and theaflavin: Focused on the structural changes, binding mechanism, and functional properties","volume":"461","author":"Liu","year":"2024","journal-title":"Food Chem."},{"key":"10.3168\/jds.2025-27238_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2022.107895","article-title":"Deciphering the non-covalent binding patterns of three whey proteins with rosmarinic acid by multi-spectroscopic, molecular docking and molecular dynamics simulation approaches","volume":"132","author":"Lu","year":"2022","journal-title":"Food Hydrocoll."},{"key":"10.3168\/jds.2025-27238_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.fm.2014.03.006","article-title":"Quantitative analysis of the effect of specific tea compounds on germination and outgrowth of Bacillus subtilis spores at single cell resolution","volume":"45","author":"Pandey","year":"2015","journal-title":"Food Microbiol."},{"key":"10.3168\/jds.2025-27238_bib21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1080\/17460913.2024.2352263","article-title":"Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis","volume":"19","author":"Pandit","year":"2024","journal-title":"Future Microbiol."},{"key":"10.3168\/jds.2025-27238_bib22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/microorganisms11020344","article-title":"The diversity of Escherichia coli pathotypes and vaccination strategies against this versatile bacterial pathogen","volume":"11","author":"Pokharel","year":"2023","journal-title":"Microorganisms"},{"key":"10.3168\/jds.2025-27238_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00628-23","article-title":"Insights into the synergistic antibacterial activity of silver nitrate with potassium tellurite against Pseudomonas aeruginosa.","volume":"11","author":"Pormohammad","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.3168\/jds.2025-27238_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1139\/bcb-2020-0253","article-title":"Antibiofilm activity of lactoferrin-derived synthetic peptides against Pseudomonas aeruginosa PAO1","volume":"99","author":"Ramamourthy","year":"2021","journal-title":"Biochem. Cell Biol."},{"key":"10.3168\/jds.2025-27238_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/bcb-2024-0183","article-title":"Antibiofilm activities of lactoferricin-related Trp- and Arg-rich antimicrobial hexapeptides against pathogenic Staphylococcus aureus and Pseudomonas aeruginosa strains","volume":"103","author":"Ramamourthy","year":"2025","journal-title":"Biochem. Cell Biol."},{"key":"10.3168\/jds.2025-27238_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2022.101795","article-title":"Unravelling the comparative metabolite fingerprints and therapeutic effects of diverse teas","volume":"48","author":"Rana","year":"2022","journal-title":"Food Biosci."},{"key":"10.3168\/jds.2025-27238_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.538572","article-title":"Metabolomics study reveals inhibition and metabolic dysregulation in Staphylococcus aureus planktonic cells and biofilms induced by carnosol","volume":"11","author":"Shen","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.3168\/jds.2025-27238_bib28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.dib.2018.03.010","article-title":"Gene datasets associated with mouse cleft palate","volume":"18","author":"Suzuki","year":"2018","journal-title":"Data Brief"},{"key":"10.3168\/jds.2025-27238_bib29","doi-asserted-by":"crossref","DOI":"10.4274\/mjima.galenos.2021.2021.46","article-title":"Compounds and methods to re-sensitize antibiotic-resistant bacteria","author":"Swaminathan","year":"2021","journal-title":"Mediterranean Journal of Infection Microbes and Antimicrobials"},{"key":"10.3168\/jds.2025-27238_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246196","article-title":"Health functions and related molecular mechanisms of tea components: An update review","volume":"20","author":"Tang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2025-27238_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lwt.2018.12.049","article-title":"Nisin-based antimicrobial combination with cold plasma treatment inactivate Listeria monocytogenes on Granny Smith apples","volume":"104","author":"Ukuku","year":"2019","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2025-27238_bib32","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.3168\/jds.2023-24088","article-title":"Complexation of bovine lactoferrin with selected phenolic acids via noncovalent interactions: Binding mechanism and altered functionality","volume":"107","author":"Wang","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27238_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.103442","article-title":"Combined transcriptomics and metabolomics analysis reveals the antifungal activity and mechanism of Enterococcus faecium cell-free supernatant against Alternaria alternata","volume":"57","author":"Wang","year":"2024","journal-title":"Food Biosci."},{"key":"10.3168\/jds.2025-27238_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128048","article-title":"Effects of theaflavins on the structure and function of bovine lactoferrin","volume":"338","author":"Wang","year":"2021","journal-title":"Food Chem."},{"key":"10.3168\/jds.2025-27238_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/foods13121935","article-title":"Effect of milk protein\u2013polyphenol conjugate on the regulation of GLP-1 hormone","volume":"13","author":"Wazzan","year":"2024","journal-title":"Foods"},{"key":"10.3168\/jds.2025-27238_bib36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.foodhyd.2014.12.008","article-title":"Evaluation of structural and functional properties of protein\u2013EGCG complexes and their ability of stabilizing a model \u03b2-carotene emulsion","volume":"45","author":"Wei","year":"2015","journal-title":"Food Hydrocoll."},{"key":"10.3168\/jds.2025-27238_bib37","article-title":"Multi-omics joint analysis of molecular mechanisms of compound essential oils inhibiting spoilage yeast in paocai","volume":"14","author":"Wu","year":"2025","journal-title":"Foods"},{"key":"10.3168\/jds.2025-27238_bib38","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1039\/D1FO02153B","article-title":"Lactoferrin\u2013thymol complex for the disinfection of gram-positive Staphylococcus aureus and gram-negative Escherichia coli.","volume":"12","author":"Yan","year":"2021","journal-title":"Food Funct."},{"key":"10.3168\/jds.2025-27238_bib39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.aninu.2020.01.001","article-title":"Antioxidant mechanism of tea polyphenols and its impact on health benefits","volume":"6","author":"Yan","year":"2020","journal-title":"Anim. Nutr."},{"key":"10.3168\/jds.2025-27238_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.foodres.2014.06.001","article-title":"Molecular interaction between (\u2212)-epigallocatechin-3-gallate and bovine lactoferrin using multi-spectroscopic method and isothermal titration calorimetry","volume":"64","author":"Yang","year":"2014","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2025-27238_bib41","first-page":"2297","article-title":"Multispectral analysis of interaction between catechins and egg yolk immunoglobulin and the change of bacteriostasis","volume":"42","author":"Zhang","year":"2022","journal-title":"Guangpuxue Yu Guangpu Fenxi"},{"key":"10.3168\/jds.2025-27238_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2022.101601","article-title":"Complexation of chlorogenic acid enhances the antiproliferative effect of lactoferrin to colon cancer cells","volume":"46","author":"Zhang","year":"2022","journal-title":"Food Biosci."},{"key":"10.3168\/jds.2025-27238_bib43","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.foodchem.2019.04.116","article-title":"Gallic acid liposomes decorated with lactoferrin: Characterization, in vitro digestion and antibacterial activity","volume":"293","author":"Zhang","year":"2019","journal-title":"Food Chem."},{"key":"10.3168\/jds.2025-27238_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2023.109051","article-title":"In vitro and in silico studies of the structure and functional properties of the lactoferrin-chlorogenic acid complex","volume":"144","author":"Zhang","year":"2023","journal-title":"Food Hydrocoll."},{"key":"10.3168\/jds.2025-27238_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105741","article-title":"Prebiotic and modulatory evidence of lactoferrin on gut health and function","volume":"108","author":"Zhao","year":"2023","journal-title":"J. Funct. Foods"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225008446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225008446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:33:24Z","timestamp":1768401204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030225008446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0022030225008446"],"URL":"https:\/\/doi.org\/10.3168\/jds.2025-27238","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of tea polyphenol-modified lactoferrin complexes and their antimicrobial activity against Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2025-27238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s).","name":"copyright","label":"Copyright"}]}}