{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:20:20Z","timestamp":1778055620416,"version":"3.51.4"},"reference-count":63,"publisher":"American Dairy Science Association","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2024BBF02018"],"award-info":[{"award-number":["2024BBF02018"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2024CX147"],"award-info":[{"award-number":["2024CX147"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["SY202303305"],"award-info":[{"award-number":["SY202303305"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801400"],"award-info":[{"award-number":["2023YFD1801400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20250156BS"],"award-info":[{"award-number":["JJKH20250156BS"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["323B200281"],"award-info":[{"award-number":["323B200281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32473105"],"award-info":[{"award-number":["32473105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302943"],"award-info":[{"award-number":["32302943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.3168\/jds.2025-27422","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:43:55Z","timestamp":1765611835000},"page":"2890-2903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excessive lipolysis and inflammatory response in adipose tissue are associated with elevated serum growth hormone in dairy cows with clinical ketosis"],"prefix":"10.3168","volume":"109","author":[{"given":"Xinxing","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3157-238X","authenticated-orcid":false,"given":"Chenyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-0972","authenticated-orcid":false,"given":"Zhiyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-7596","authenticated-orcid":false,"given":"Wenwen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-1508","authenticated-orcid":false,"given":"Lin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9392-715X","authenticated-orcid":false,"given":"Yuxiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-677X","authenticated-orcid":false,"given":"Xinwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-6998","authenticated-orcid":false,"given":"Xiliang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-6104","authenticated-orcid":false,"given":"Guowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2025-27422_bib1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1530\/EJE-11-1009","article-title":"GH activity and markers of inflammation: a crossover study in healthy volunteers treated with GH and a GH receptor antagonist","volume":"166","author":"Andreassen","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.3168\/jds.2025-27422_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fphar.2019.00133","article-title":"Blocking \u03b1(2)\u03b4-1 subunit reduces bladder hypersensitivity and inflammation in a cystitis mouse model by decreasing NF-\u03baB pathway activation","volume":"10","author":"Boudieu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.3168\/jds.2025-27422_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3945\/jn.109.108233","article-title":"Daily injection of tumor necrosis factor-\u03b1 increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle","volume":"139","author":"Bradford","year":"2009","journal-title":"J. Nutr."},{"key":"10.3168\/jds.2025-27422_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41392-024-01881-6","article-title":"DNA of neutrophil extracellular traps promote NF-\u03baB-dependent autoimmunity via cGAS\/TLR9 in chronic obstructive pulmonary disease","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.3168\/jds.2025-27422_bib5","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.3168\/jds.2023-23998","article-title":"Lipolysis inhibition as a treatment of clinical ketosis in dairy cows: effects on adipose tissue metabolic and immune responses","volume":"107","author":"Chirivi","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib6","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.3168\/jds.2015-9370","article-title":"Macrophage infiltration in the omental and subcutaneous adipose tissues of dairy cows with displaced abomasum","volume":"98","author":"Contreras","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cimid.2011.01.004","article-title":"Lipid mobilization and inflammatory responses during the transition period of dairy cows","volume":"34","author":"Contreras","year":"2011","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.3168\/jds.2025-27422_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40104-017-0174-4","article-title":"Adipose tissue lipolysis and remodeling during the transition period of dairy cows","volume":"8","author":"Contreras","year":"2017","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.3168\/jds.2025-27422_bib9","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1182\/blood-2003-09-3037","article-title":"Interruption of the NF-\u03baB pathway by Bay 11\u20137082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells","volume":"103","author":"Dai","year":"2004","journal-title":"Blood"},{"key":"10.3168\/jds.2025-27422_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110916","article-title":"Regulatory role of NF-\u03baB in growth plate chondrogenesis and its functional interaction with growth hormone","volume":"514","author":"De Luca","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.3168\/jds.2025-27422_bib11","doi-asserted-by":"crossref","first-page":"8426","DOI":"10.3168\/jds.2022-22009","article-title":"Tumor necrosis factor-\u03b1 promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes","volume":"105","author":"Du","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib12","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.3168\/jds.2017-13234","article-title":"High concentrations of fatty acids and \u03b2-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows","volume":"101","author":"Du","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3168\/jds.2008-1507","article-title":"Impact of hyperketonemia in early lactation dairy cows on health and production","volume":"92","author":"Duffield","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3168\/jds.S0022-0302(89)79081-0","article-title":"A body condition scoring chart for Holstein dairy cows","volume":"72","author":"Edmonson","year":"1989","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.24099\/vet.arhiv.160126c","article-title":"Biomarkers of ketosis in dairy cows at postparturient period: Acute phase proteins and pro-inflammatory cytokines","volume":"87","author":"El-Deeb","year":"2017","journal-title":"Vet. Arh."},{"key":"10.3168\/jds.2025-27422_bib16","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.3168\/jds.2020-19319","article-title":"Inhibition of cell death inducing DNA fragmentation factor-\u03b1-like effector c (CIDEC) by tumor necrosis factor-\u03b1 induces lipolysis and inflammation in calf adipocytes","volume":"104","author":"Fan","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib17","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.3168\/jds.2021-20892","article-title":"Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis","volume":"105","author":"Fang","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100440","article-title":"Inflammation promotes adipocyte lipolysis via IRE1 kinase","volume":"296","author":"Foley","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jds.2025-27422_bib19","author":"Gao"},{"key":"10.3168\/jds.2025-27422_bib20","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.2174\/138161212803530763","article-title":"NF-\u03baB as a target for modulating inflammatory responses","volume":"18","author":"Gasparini","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.3168\/jds.2025-27422_bib21","doi-asserted-by":"crossref","first-page":"E608","DOI":"10.1152\/ajpendo.00009.2005","article-title":"Metabolic and cellular plasticity in white adipose tissue I: Effects of beta3-adrenergic receptor activation","volume":"289","author":"Granneman","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.3168\/jds.2025-27422_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2337\/db09-0925","article-title":"Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: Dissociation of adipocyte hypertrophy from inflammation","volume":"59","author":"Han","year":"2010","journal-title":"Diabetes"},{"key":"10.3168\/jds.2025-27422_bib23","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.3168\/jds.2021-21220","article-title":"Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows","volume":"105","author":"H\u00e4ussler","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/15548627.2022.2080957","article-title":"The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy","volume":"19","author":"Hou","year":"2023","journal-title":"Autophagy"},{"key":"10.3168\/jds.2025-27422_bib25","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14373","article-title":"The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals","volume":"8","author":"H\u00f8yer","year":"2020","journal-title":"Physiol. Rep."},{"key":"10.3168\/jds.2025-27422_bib26","first-page":"117","article-title":"Lpcat3 deficiency promotes palmitic acid-induced 3T3\u2013L1 mature adipocyte inflammation through enhanced ROS generation","volume":"55","author":"Hu","year":"2022","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.3168\/jds.2025-27422_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: An overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.3168\/jds.2025-27422_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41574-019-0280-9","article-title":"The effects of growth hormone on adipose tissue: Old observations, new mechanisms","volume":"16","author":"Kopchick","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.3168\/jds.2025-27422_bib29","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1172\/JCI42845","article-title":"Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue","volume":"120","author":"Kosteli","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.3168\/jds.2025-27422_bib30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s13105-014-0321-8","article-title":"Growth hormone (GH) differentially regulates NF-\u03baB activity in preadipocytes and macrophages: implications for GH's role in adipose tissue homeostasis in obesity","volume":"70","author":"Kumar","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"10.3168\/jds.2025-27422_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21005\/asp.2019.18.4.02","article-title":"Hormonal changes in dairy cows during periparturient period","volume":"18","author":"Kurpi\u0144ska","year":"2020","journal-title":"Acta Sci. Pol. Zootech."},{"key":"10.3168\/jds.2025-27422_bib32","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3168\/jds.S0022-0302(03)73664-9","article-title":"Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows","volume":"86","author":"Kushibiki","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2460\/ajvr.1992.53.05.731","article-title":"Impact of bovine somatotropin administration beginning at day 70 of lactation on serum metabolites, milk constituents, and production in cows previously exposed to exogenous somatotropin","volume":"53","author":"Lean","year":"1992","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2025-27422_bib34","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1210\/en.2013-2086","article-title":"Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles","volume":"155","author":"List","year":"2014","journal-title":"Endocrinology"},{"key":"10.3168\/jds.2025-27422_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1152\/physiolgenomics.00188.2007","article-title":"Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows","volume":"32","author":"Loor","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.3168\/jds.2025-27422_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/jvetres-2016-0024","article-title":"Changes in circulating adiponectin and tumour necrosis factor-\u03b1 and their relationship with insulin resistance in periparturient dairy cows","volume":"60","author":"Mecitoglu","year":"2016","journal-title":"J. Vet. Res. (Pulawy)"},{"key":"10.3168\/jds.2025-27422_bib37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2478\/aoas-2022-0034","article-title":"Effects of higher plasma growth hormone levels on subclinical ketosis in postpartum Holstein cows","volume":"22","author":"Mohsin","year":"2022","journal-title":"Ann. Anim. Sci."},{"key":"10.3168\/jds.2025-27422_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40104-021-00549-3","article-title":"A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows","volume":"12","author":"Myers","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.3168\/jds.2025-27422_bib39","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2337\/diabetes.50.10.2301","article-title":"Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure","volume":"50","author":"Nielsen","year":"2001","journal-title":"Diabetes"},{"key":"10.3168\/jds.2025-27422_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.3168\/jds.2025-27422_bib41","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-\u03baB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.3168\/jds.2025-27422_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cells11071188","article-title":"Specific NLRP3 inflammasome assembling and regulation in neutrophils: Relevance in inflammatory and infectious diseases","volume":"11","author":"Paget","year":"2022","journal-title":"Cells"},{"key":"10.3168\/jds.2025-27422_bib43","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/en.2008-1199","article-title":"Age-related changes in body composition of bovine growth hormone transgenic mice","volume":"150","author":"Palmer","year":"2009","journal-title":"Endocrinology"},{"key":"10.3168\/jds.2025-27422_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1624770","article-title":"NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease","volume":"16","author":"Pinz\u00f3n-Fern\u00e1ndez","year":"2025","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2025-27422_bib45","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.3168\/jds.S0022-0302(03)74000-4","article-title":"Plasma hormones and expression of growth hormone receptor and insulin-like growth factor-I mRNA in hepatic tissue of periparturient dairy cows","volume":"86","author":"Radcliff","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-nutr-120524-013857","article-title":"Regulation of adipose tissue metabolism during fasting","volume":"45","author":"Ruppert","year":"2025","journal-title":"Annu. Rev. Nutr."},{"key":"10.3168\/jds.2025-27422_bib47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1083\/jcb.201409063","article-title":"The cell biology of fat expansion","volume":"208","author":"Rutkowski","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.3168\/jds.2025-27422_bib48","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41574-019-0230-6","article-title":"The endocrine function of adipose tissues in health and cardiometabolic disease","volume":"15","author":"Scheja","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.3168\/jds.2025-27422_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aninu.2025.04.009","article-title":"Ruminal microbiota-derived inosine alleviates metabolic disorders in dairy cows supplemented with grape seed extract","volume":"23","author":"Shao","year":"2025","journal-title":"Anim. Nutr."},{"key":"10.3168\/jds.2025-27422_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/JOE-18-0282","article-title":"Growth hormone controls lipolysis by regulation of FSP27 expression","volume":"239","author":"Sharma","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.3168\/jds.2025-27422_bib51","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1152\/ajpendo.00129.2018","article-title":"Growth hormone acts along the PPAR\u03b3-FSP27 axis to stimulate lipolysis in human adipocytes","volume":"316","author":"Sharma","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.3168\/jds.2025-27422_bib52","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.3168\/jds.2019-16706","article-title":"Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows","volume":"102","author":"Shen","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cyto.2007.11.007","article-title":"Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB","volume":"41","author":"Sodhi","year":"2008","journal-title":"Cytokine"},{"key":"10.3168\/jds.2025-27422_bib54","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1159\/000490866","article-title":"Effects of the TLR4\/Myd88\/NF-\u03baB signaling pathway on NLRP3 inflammasome in coronary microembolization-induced myocardial injury","volume":"47","author":"Su","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.3168\/jds.2025-27422_bib55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3168\/jds.2014-8362","article-title":"Risk factors for subclinical and clinical ketosis and association with production parameters in dairy cows in the Netherlands","volume":"98","author":"Vanholder","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib56","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/aro2.80","article-title":"Hepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review","volume":"3","author":"Wang","year":"2025","journal-title":"Anim. Res. One Health"},{"key":"10.3168\/jds.2025-27422_bib57","doi-asserted-by":"crossref","first-page":"9165","DOI":"10.3892\/mmr.2017.7710","article-title":"Ginsenoside Rb1 inhibits free fatty acids-induced oxidative stress and inflammation in 3T3\u2013L1 adipocytes","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.3168\/jds.2025-27422_bib58","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/jas\/skz132","article-title":"Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation","volume":"97","author":"Xu","year":"2019","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2025-27422_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13724","article-title":"Inflammation-mediated metabolic regulation in adipose tissue","volume":"25","author":"Xu","year":"2024","journal-title":"Obes. Rev."},{"key":"10.3168\/jds.2025-27422_bib60","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/acs.jproteome.9b00706","article-title":"Metabolomics of milk reflects a negative energy balance in cows","volume":"19","author":"Xu","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.3168\/jds.2025-27422_bib61","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.3168\/jds.2021-21287","article-title":"Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues","volume":"105","author":"Yu","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-27422_bib62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fimmu.2018.00467","article-title":"Perilipin 1 mediates lipid metabolism homeostasis and inhibits inflammatory cytokine synthesis in bovine adipocytes","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.3168\/jds.2025-27422_bib63","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3390\/antiox13050614","article-title":"Multi-omics reveals disrupted immunometabolic homeostasis and oxidative stress in adipose tissue of dairy cows with subclinical ketosis: A sphingolipid-centric perspective","volume":"13","author":"Zhao","year":"2024","journal-title":"Antioxidants"}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225010252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030225010252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:59:22Z","timestamp":1778054362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030225010252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0022030225010252"],"URL":"https:\/\/doi.org\/10.3168\/jds.2025-27422","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive lipolysis and inflammatory response in adipose tissue are associated with elevated serum growth hormone in dairy cows with clinical ketosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2025-27422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s).","name":"copyright","label":"Copyright"}]}}