{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:40:10Z","timestamp":1792528810894,"version":"4.5.0"},"reference-count":117,"publisher":"American Dairy Science Association","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"Horizon 2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["101034319"],"award-info":[{"award-number":["101034319"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"H2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.3168\/jds.2025-28054","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:37:42Z","timestamp":1777941462000},"page":"8866-8888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large-scale monitoring of milk infrared-predicted blood biomarkers of stress resilience: Effects of breed and dairy systems and their interactions"],"prefix":"10.3168","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-0385","authenticated-orcid":false,"given":"Diana","family":"Giannuzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7110-9641","authenticated-orcid":false,"given":"Marco Aurelio","family":"Ramirez Mauricio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-1784","authenticated-orcid":false,"given":"Lucio Flavio Macedo","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-1911","authenticated-orcid":false,"given":"Erminio","family":"Trevisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Nocetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-5105","authenticated-orcid":false,"given":"Luigi","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-9826","authenticated-orcid":false,"given":"Sara","family":"Pegolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-5622","authenticated-orcid":false,"given":"Enrico","family":"Sturaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8947","authenticated-orcid":false,"given":"Stefano","family":"Schiavon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-720X","authenticated-orcid":false,"given":"Alessio","family":"Cecchinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2025-28054_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1120073","article-title":"Differences across herds with different dairy breeds in daily milk yield based proxies for resilience","volume":"14","author":"Adriaens","year":"2023","journal-title":"Front. Genet."},{"key":"10.3168\/jds.2025-28054_bib2","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.3168\/jds.2019-17952","article-title":"Mid-infrared spectroscopic analysis of raw milk to predict the blood nonesterified fatty acid concentrations in dairy cows","volume":"103","author":"Aernouts","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib3","first-page":"183","article-title":"Parmigiano Reggiano cheese: General and metabolic\/nutritional aspects from tradition to recent evidences","volume":"17","author":"Arsenio","year":"2015","journal-title":"Prog. Nutr."},{"key":"10.3168\/jds.2025-28054_bib4","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2004.06.030","article-title":"Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development","volume":"37","author":"Aviram","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.3168\/jds.2025-28054_bib5","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3390\/antiox10121918","article-title":"Oxidative stress in dairy cows: Insights into the mechanistic mode of actions and mitigating strategies","volume":"10","author":"Ayemele","year":"2021","journal-title":"Antioxidants"},{"key":"10.3168\/jds.2025-28054_bib6","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.3168\/jds.2021-21049","article-title":"Emphasis on resilience in dairy cattle breeding: Possibilities and consequences","volume":"105","author":"Bengtsson","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib7","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3168\/jds.2013-7163","article-title":"A field study to determine the prevalence, dairy herd management systems, and fresh cow clinical conditions associated with ketosis in western European dairy herds","volume":"97","author":"Berge","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fgene.2018.00692","article-title":"Opportunities to improve resilience in animal breeding programs","volume":"9","author":"Berghof","year":"2019","journal-title":"Front. Genet."},{"key":"10.3168\/jds.2025-28054_bib9","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3168\/jds.S0022-0302(05)72878-2","article-title":"Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows","volume":"88","author":"Bernabucci","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib10","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2527\/jas.2012-5862","article-title":"Cell Biology Symposium: Genetics of feed efficiency in dairy and beef cattle","volume":"91","author":"Berry","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1017\/S1751731119003318","article-title":"Comparative selection signature analyses identify genomic footprints in Reggiana cattle, the traditional breed of the Parmigiano-Reggiano cheese production system","volume":"14","author":"Bertolini","year":"2020","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cvfa.2013.04.004","article-title":"Use of the liver activity index and other metabolic variables in the assessment of metabolic health in dairy herds","volume":"29","author":"Bertoni","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2025-28054_bib13","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.3168\/jds.2008-0995","article-title":"Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows","volume":"91","author":"Bertoni","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib14","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3168\/jds.2006-445","article-title":"Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows","volume":"90","author":"Bionaz","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib15","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1017\/S1751731117001227","article-title":"Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds","volume":"11","author":"Bobbo","year":"2017","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1017\/S1751731112000018","article-title":"New phenotypes for new breeding goals in dairy cattle","volume":"6","author":"Boichard","year":"2012","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib17","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3168\/jds.2016-11837","article-title":"Standardization of milk infrared spectra for the retroactive application of calibration models","volume":"100","author":"Bonfatti","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib18","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.3168\/jds.2015-9683","article-title":"Invited review: Inflammation during the transition to lactation: New adventures with an old flame","volume":"98","author":"Bradford","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib19","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.2527\/jas.2015-9022","article-title":"Pattern of \u03b3-glutamyl transferase activity in cow milk throughout lactation and relationships with metabolic conditions and milk composition","volume":"93","author":"Calamari","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/1828051X.2023.2196995","article-title":"Metabolic and inflammatory responses reveal different adaptation to the transition period challenges in Holstein, Brown Swiss, and Simmental dairy cows","volume":"22","author":"Catellani","year":"2023","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib21","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.3168\/jds.2022-22684","article-title":"Metabolic and physiological adaptations to first and second lactation in Holstein dairy cows","volume":"106","author":"Cattaneo","year":"2023","journal-title":"J. Dairy Sci."},{"issue":"S1","key":"10.3168\/jds.2025-28054_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/jpn.13607","article-title":"Immune-metabolic-inflammatory markers in Holstein cows exposed to a nutritional and environmental stressing challenge","volume":"105","author":"Cavallini","year":"2021","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2025-28054_bib23","doi-asserted-by":"crossref","first-page":"11108","DOI":"10.3168\/jds.2018-14907","article-title":"Genetic variation in serum protein pattern and blood \u03b2-hydroxybutyrate and their relationships with udder health traits, protein profile, and cheese-making properties in Holstein cows","volume":"101","author":"Cecchinato","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib24","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3168\/jds.2024-25461","article-title":"Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management","volume":"108","author":"Cecchinato","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1071\/RD10268","article-title":"Relationship between late embryonic mortality and the increase in plasma advanced oxidised protein products (AOPP) in dairy cows","volume":"23","author":"Celi","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"10.3168\/jds.2025-28054_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.21451\/1984-3143-AR2019-0057","article-title":"Inflammation: Friend or foe of bovine reproduction?","volume":"16","author":"Chastant","year":"2019","journal-title":"Anim. Reprod."},{"key":"10.3168\/jds.2025-28054_bib27","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.3168\/jds.2024-24706","article-title":"Effects of parity and week after calving on the metabolic, redox, and immune status of dairy cows","volume":"107","author":"Corset","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib28","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.3168\/jds.2010-3687","article-title":"Short communication: Reference values for blood parameters in Holstein dairy cows: Effects of parity, stage of lactation, and season of production","volume":"94","author":"Cozzi","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.rvsc.2017.11.020","article-title":"What we have lost: Mastitis resistance in Holstein Friesians and in a local cattle breed","volume":"116","author":"Curone","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2025-28054_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S0022029921000650","article-title":"Comparison of metabolic, oxidative and inflammatory status of Simmental \u00d7 Holstein crossbred with parental breeds during the peripartal and early lactation periods","volume":"88","author":"De Matteis","year":"2021","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2025-28054_bib31","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.3168\/jds.2016-12186","article-title":"Flow cytometric assessment of myeloperoxidase in bovine blood neutrophils and monocytes","volume":"100","author":"Depreester","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib32","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1159\/000480529","article-title":"Elevated apoptosis in the liver of dairy cows with ketosis","volume":"43","author":"Du","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.3168\/jds.2025-28054_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.24099\/vet.arhiv.160126c","article-title":"Biomarkers of ketosis in dairy cows at postparturient period: Acute phase proteins and pro-inflammatory cytokines","volume":"87","author":"El-Deeb","year":"2017","journal-title":"Vet. Arh."},{"key":"10.3168\/jds.2025-28054_bib34","series-title":"Textbook of Veterinary Physiological Chemistry. 3rd ed.","author":"Engelking","year":"2015"},{"key":"10.3168\/jds.2025-28054_bib35","doi-asserted-by":"crossref","first-page":"e746","DOI":"10.1111\/jpn.12829","article-title":"Performance, body fat reserves and plasma metabolites in Brown Swiss dairy cows: Indoor feeding versus pasture-based feeding","volume":"102","author":"Frey","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2025-28054_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0167-9473(01)00065-2","article-title":"Stochastic gradient boosting","volume":"38","author":"Friedman","year":"2002","journal-title":"Comput. Stat. Data Anal."},{"key":"10.3168\/jds.2025-28054_bib37","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3168\/jds.2006-204","article-title":"Comparing local and commercial breeds on functional traits and profitability: The case of Reggiana dairy cattle","volume":"90","author":"Gandini","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib38","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3168\/jds.2022-22454","article-title":"Prediction of detailed blood metabolic profile using milk infrared spectra and machine learning methods in dairy cattle","volume":"106","author":"Giannuzzi","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib39","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3168\/jds.2023-23546","article-title":"Observational study on the associations between milk yield, composition, and coagulation properties with blood biomarkers of health in Holstein cows","volume":"107","author":"Giannuzzi","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib40","doi-asserted-by":"crossref","first-page":"16314","DOI":"10.1038\/s41598-021-95538-x","article-title":"Associations between ultrasound measurements and hematochemical parameters for the assessment of liver metabolic status in Holstein-Friesian cows","volume":"11","author":"Giannuzzi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2025-28054_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1017\/S1751731118001751","article-title":"Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach","volume":"13","author":"GplusE Consortium","year":"2019","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib42","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3168\/jds.2021-20783","article-title":"Changes in plasma electrolytes, minerals, and hepatic markers of health across the transition period in dairy cows divergent in genetic merit for fertility traits and postpartum anovulatory intervals","volume":"105","author":"Grala","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/af\/vfad014","article-title":"Dairy cow physiology and production limits","volume":"13","author":"Gross","year":"2023","journal-title":"Anim. Front."},{"issue":"Suppl. 1","key":"10.3168\/jds.2025-28054_bib44","first-page":"s753s81","article-title":"Review: Metabolic challenges in lactating dairy cows and their assessment via established and novel indicators in milk","volume":"13","author":"Gross","year":"2019","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib45","series-title":"The Elements of Statistical Learning. 2nd ed.","author":"Hastie","year":"2009"},{"key":"10.3168\/jds.2025-28054_bib46","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and performance-A critical evaluation of traditional dogmas","volume":"104","author":"Horst","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib47","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.3168\/jds.2022-21996","article-title":"Metabolome profiling of plasma reveals different metabolic responses to acute cold challenge between Inner-Mongolia Sanhe and Holstein cattle","volume":"105","author":"Hu","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib48","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.3168\/jds.2015-9522","article-title":"Long-term reticuloruminal pH dynamics and markers of liver health in early-lactating cows of various parities fed diets differing in grain processing","volume":"98","author":"Humer","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib49","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3168\/jds.2017-13191","article-title":"Invited review: Practical feeding management recommendations to mitigate the risk of subacute ruminal acidosis in dairy cattle","volume":"101","author":"Humer","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12011-011-9226-3","article-title":"Variations in copper concentration and ceruloplasmin activity of dairy cows in relation to lactation stages with regard to ceruloplasmin to copper ratios","volume":"146","author":"Hussein","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.3168\/jds.2025-28054_bib51","series-title":"Guidelines for Milk Analysis (Section 12).","author":"ICAR (International Committee for Animal Recording)","year":"2020"},{"key":"10.3168\/jds.2025-28054_bib52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.anifeedsci.2005.08.003","article-title":"Feeding- and management-related diseases in the transition cow: Physiological adaptations around calving and strategies to reduce feeding-related diseases","volume":"126","author":"Ingvartsen","year":"2006","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.3168\/jds.2025-28054_bib53","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1017\/S175173111200170X","article-title":"Nutrition, immune function and health of dairy cattle","volume":"7","author":"Ingvartsen","year":"2013","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.22358\/jafs\/155410\/2022","article-title":"The effects of heat stress in Jersey, Hungarian Simmental and Holstein-Friesian cows","volume":"32","author":"Jurkovich","year":"2023","journal-title":"J. Anim. Feed Sci."},{"key":"10.3168\/jds.2025-28054_bib55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1262\/jrd.2015-141","article-title":"Influence of hepatic load from far-off dry period to early postpartum period on the first postpartum ovulation and accompanying subsequent fertility in dairy cows","volume":"62","author":"Kawashima","year":"2016","journal-title":"J. Reprod. Dev."},{"key":"10.3168\/jds.2025-28054_bib56","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1017\/S1751731119002659","article-title":"Between- and within-herd variation in blood and milk biomarkers in Holstein cows in early lactation","volume":"14","author":"Krogh","year":"2020","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib57","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5713\/ajas.20.0018","article-title":"Metabolic profile according to the parity and stage of lactation of high-performance Holstein-Friesian cows","volume":"34","author":"Kuczy\u0144ska","year":"2021","journal-title":"Anim. Biosci."},{"key":"10.3168\/jds.2025-28054_bib58","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.3168\/jds.S0022-0302(06)72510-3","article-title":"Heat stress elicits different responses in peripheral blood mononuclear cells from Brown Swiss and Holstein cows","volume":"89","author":"Lacetera","year":"2006","journal-title":"J. Dairy Sci."},{"issue":"S","key":"10.3168\/jds.2025-28054_bib59","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1262\/jrd.1056S29","article-title":"Monitoring metabolic health of dairy cattle in the transition period","volume":"56","author":"LeBlanc","year":"2010","journal-title":"J. Reprod. Dev."},{"key":"10.3168\/jds.2025-28054_bib60","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3168\/jds.S0022-0302(06)72195-6","article-title":"Major advances in disease prevention in dairy cattle","volume":"89","author":"LeBlanc","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/vetsci12060545","article-title":"Effects of zinc (Zn) from different sources on production performance, health status, antioxidant properties and immune regulation of dairy cows in early lactation","volume":"12","author":"Li","year":"2025","journal-title":"Vet. Sci."},{"key":"10.3168\/jds.2025-28054_bib62","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/antiox13010132","article-title":"The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: The new progress","volume":"13","author":"Lin","year":"2024","journal-title":"Antioxidants"},{"key":"10.3168\/jds.2025-28054_bib63","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.3168\/jds.2021-21166","article-title":"Effect of Holstein genotype on immune response to an intramammary Escherichia coli challenge","volume":"105","author":"Lippolis","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib64","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1038\/s41598-022-06507-x","article-title":"Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (1H-NMR)","volume":"12","author":"Lisuzzo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2025-28054_bib65","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4103\/1947-2714.103310","article-title":"Antioxidant and anti-inflammatory role of paraoxonase 1: Implication in arteriosclerosis diseases","volume":"4","author":"Litvinov","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"key":"10.3168\/jds.2025-28054_bib66","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/af\/vfac061","article-title":"Immunometabolism in livestock: Triggers and physiological role of transcription regulators, nutrients, and microbiota","volume":"12","author":"Loor","year":"2022","journal-title":"Anim. Front."},{"key":"10.3168\/jds.2025-28054_bib67","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.3168\/jds.2019-16323","article-title":"Immunometabolic status and productive performance differences between periparturient Simmental and Holstein dairy cows in response to pegbovigrastim","volume":"102","author":"Lopreiato","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib68","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3168\/jds.2018-15103","article-title":"Metabolic profiling of early-lactation dairy cows using milk mid-infrared spectra","volume":"102","author":"Luke","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib69","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.3168\/jds.2024-24680","article-title":"Time profiles of energy balance in dairy cows in association with metabolic status, inflammatory status, and disease","volume":"107","author":"Ma","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib70","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3168\/jds.2022-23035","article-title":"Uncovering genetic parameters and environmental influences on fertility, milk production, and quality in autochthonous Reggiana cattle","volume":"107","author":"Mancin","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib71","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.3168\/jds.2020-19538","article-title":"Prolonged, low-grade inflammation in the first week of lactation: Associations with mineral, protein, and energy balance markers, and milk yield, in a clinically healthy Jersey cow cohort","volume":"104","author":"Martins","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib72","series-title":"The Multiple Roles of Grassland in the European Bioeconomy, Proc. 26th General Meeting of the European Grassland Federation, Trondheim, Norway.","first-page":"376","article-title":"Comparison of pasture based feeding systems and a total mixed ration feeding system on dairy cow milk production","author":"McAuliffe","year":"2016"},{"key":"10.3168\/jds.2025-28054_bib73","series-title":"Veterinary Laboratory Medicine: Interpretation & Diagnosis. 3rd ed.","author":"Meyer","year":"2004"},{"key":"10.3168\/jds.2025-28054_bib74","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1093\/jas\/skaa134","article-title":"Interaction between inflammation and metabolism in periparturient dairy cows","volume":"98","author":"Mezzetti","year":"2020","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib75","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.3168\/jds.2019-16497","article-title":"The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation","volume":"102","author":"Mezzetti","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib76","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.3168\/jds.2017-12968","article-title":"A 100-year review: Identification and genetic selection of economically important traits in dairy cattle","volume":"100","author":"Miglior","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib77","doi-asserted-by":"crossref","first-page":"520","DOI":"10.15232\/pas.2016-01602","article-title":"Review: The link between feeding dairy cows and Parmigiano-Reggiano cheese production area","volume":"33","author":"Mordenti","year":"2017","journal-title":"Prof. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib78","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.rvsc.2017.06.012","article-title":"Reference intervals for hematological and biochemical parameters, acute phase proteins and markers of oxidation in Holstein dairy cows around 3 and 30 days after calving","volume":"114","author":"Moretti","year":"2017","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2025-28054_bib79","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.3168\/jds.2020-19776","article-title":"Invited review: A 2020 perspective on pasture-based dairy systems and products","volume":"104","author":"Moscovici Joubran","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib80","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12711-024-00903-9","article-title":"Genomic prediction of blood biomarkers of metabolic disorders in Holstein cattle using parametric and nonparametric models","volume":"56","author":"Mota","year":"2024","journal-title":"Genet. Sel. Evol."},{"key":"10.3168\/jds.2025-28054_bib81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12711-023-00795-1","article-title":"Integrating on-farm and genomic information improves the predictive ability of milk infrared prediction of blood indicators of metabolic disorders in dairy cows","volume":"55","author":"Mota","year":"2023","journal-title":"Genet. Sel. Evol."},{"key":"10.3168\/jds.2025-28054_bib82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnbot.2013.00021","article-title":"Gradient boosting machines, a tutorial","volume":"7","author":"Natekin","year":"2013","journal-title":"Front. Neurorobot."},{"key":"10.3168\/jds.2025-28054_bib83","author":"Orlandini"},{"key":"10.3168\/jds.2025-28054_bib84","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.3168\/jds.2017-13054","article-title":"A 100-Year Review: Metabolic health indicators and management of dairy cattle","volume":"100","author":"Overton","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib85","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.3168\/jds.2023-24630","article-title":"Unraveling metabolic stress response in dairy cows: Genetic control of plasma biomarkers throughout lactation and the transition period","volume":"107","author":"Passamonti","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib86","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.3168\/jds.2021-21582","article-title":"Associations between ultrasound hepatic measurements, body measures, and milk production traits in Holstein cows","volume":"105","author":"Piazza","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib87","first-page":"151","article-title":"Fertility and longevity in the Reggiana cattle breed","volume":"2","author":"Pizzi","year":"2003","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib88","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3168\/jds.2019-17290","article-title":"Exploration of variance, autocorrelation, and skewness of deviations from lactation curves as resilience indicators for breeding","volume":"103","author":"Poppe","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib89","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3390\/ani11061714","article-title":"Changes of plasma analytes reflecting metabolic adaptation to the different stages of the lactation cycle in healthy multiparous Holstein dairy cows raised in high-welfare conditions","volume":"11","author":"Premi","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2025-28054_bib90","unstructured":"R Core Team. 2025. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"10.3168\/jds.2025-28054_bib91","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.3168\/jds.2024-25466","article-title":"Leveraging milk mid-infrared spectroscopy to authenticate animal welfare, farming practices, and dairy systems of Parmigiano Reggiano cheese","volume":"108","author":"Ramirez Mauricio","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib92","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3168\/jds.2025-27207","article-title":"Impact of farming systems and welfare indicators on enteric methane emissions calculated from infrared-predicted milk fatty acids in Parmigiano Reggiano Consortium farms","volume":"109","author":"Ramirez Mauricio","year":"2026","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2026.101830","article-title":"Field application of milk infrared-based equations to predict blood energy metabolites and minerals: Effects of cattle breed and dairy system interactions","volume":"20","author":"Ramirez Mauricio","year":"2026","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib94","series-title":"Explaining Health Across the Sciences","article-title":"Biological health and homeodynamic space","author":"Rattan","year":"2020"},{"key":"10.3168\/jds.2025-28054_bib95","doi-asserted-by":"crossref","first-page":"s350","DOI":"10.1017\/S1751731118002471","article-title":"Review: New considerations to refine breeding objectives of dairy cows for increasing robustness and sustainability of grass-based milk production systems","volume":"12","author":"Roche","year":"2018","journal-title":"Animal"},{"key":"10.3168\/jds.2025-28054_bib96","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S0022029919000141","article-title":"Breeding for organic dairy farming: What types of cows are needed?","volume":"86","author":"Rodr\u00edguez-Berm\u00fadez","year":"2019","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2025-28054_bib97","doi-asserted-by":"crossref","first-page":"8224","DOI":"10.3168\/jds.2017-14254","article-title":"Prepartal standing behavior as a parameter for early detection of postpartal subclinical ketosis associated with inflammation and liver function biomarkers in peripartal dairy cows","volume":"101","author":"Rodriguez-Jimenez","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib98","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0167-5877(86)90025-5","article-title":"Susceptibility to disease in the dairy cow and its relationship with occurrences of other diseases in the current or preceding lactation","volume":"4","author":"Rowlands","year":"1986","journal-title":"Prev. Vet. Med."},{"key":"10.3168\/jds.2025-28054_bib99","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1292\/jvms.67.813","article-title":"Changes of serum alkaline phosphatase activity in dry and lactational cows","volume":"67","author":"Sato","year":"2005","journal-title":"J. Vet. Med. Sci."},{"key":"10.3168\/jds.2025-28054_bib100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3168\/jds.S0022-0302(81)82529-5","article-title":"Effects of age, temperature-season, and breed on blood characteristics of dairy cattle","volume":"64","author":"Shaffer","year":"1981","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib101","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0165-9936(89)85073-3","article-title":"A program for calculating Mahalanobis distances using principal component analysis","volume":"8","author":"Shah","year":"1989","journal-title":"Trends Analyt. Chem."},{"key":"10.3168\/jds.2025-28054_bib102","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12711-025-00983-1","article-title":"Estimating the genetic parameters of resilience toward known and unknown disturbances in sheep using wool fibre diameter and body weight variability","volume":"57","author":"Smith","year":"2025","journal-title":"Genet. Sel. Evol."},{"key":"10.3168\/jds.2025-28054_bib103","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S1466252309990016","article-title":"Metabolic factors affecting the inflammatory response of periparturient dairy cows","volume":"10","author":"Sordillo","year":"2009","journal-title":"Anim. Health Res. Rev."},{"key":"10.3168\/jds.2025-28054_bib104","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.3168\/jds.2016-10907","article-title":"Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part I. metabolic and digestive disorders","volume":"99","author":"Stangaferro","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib105","first-page":"67","article-title":"Activities of AST, ALT and GGT in clinically healthy dairy cows during lactation and in the dry period","volume":"75","author":"Stojevi\u0107","year":"2005","journal-title":"Vet. Arh."},{"key":"10.3168\/jds.2025-28054_bib106","doi-asserted-by":"crossref","first-page":"26197","DOI":"10.1038\/s41598-024-78087-x","article-title":"Effects of intensive and conventional farming on oxidative stress and meat quality biomarkers in Holstein and Simmental cattle","volume":"14","author":"Tatar","year":"2024","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2025-28054_bib107","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.3168\/jds.2017-13647","article-title":"Diagnosing pregnancy status using infrared spectra and milk composition in dairy cows","volume":"101","author":"Toledo-Alvarado","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib108","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.3168\/jds.2024-25790","article-title":"International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation: Lights and shadows","volume":"108","author":"Trevisi","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2025-28054_bib109","first-page":"43","article-title":"Variation factors of paraoxonase in blood and in HDL lipoproteins in dairy cow","volume":"14","author":"Trevisi","year":"2012","journal-title":"Prog. Nutr."},{"key":"10.3168\/jds.2025-28054_bib110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.rvsc.2017.12.001","article-title":"Assessment of the innate immune response in the periparturient cow","volume":"116","author":"Trevisi","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.3168\/jds.2025-28054_bib111","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.nutres.2015.06.013","article-title":"Advanced oxidation protein products are more related to metabolic syndrome components than biomarkers of lipid peroxidation","volume":"35","author":"Venturini","year":"2015","journal-title":"Nutr. Res."},{"key":"10.3168\/jds.2025-28054_bib112","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3390\/ani12081008","article-title":"Effects of parity and stage of lactation on trend and variability of metabolic markers in dairy cows","volume":"12","author":"Walter","year":"2022","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2025-28054_bib113","series-title":"Bovine Medicine: Diseases and Husbandry of Cattle","first-page":"804","article-title":"Metabolic profiles","author":"Whitaker","year":"2004"},{"key":"10.3168\/jds.2025-28054_bib114","first-page":"155","article-title":"Factors influencing the activity of liver enzymes of clinically healthy dairy cows under field conditions","volume":"82","author":"Wille","year":"2010","journal-title":"Zuchtungskunde"},{"key":"10.3168\/jds.2025-28054_bib115","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.14202\/vetworld.2020.2780-2786","article-title":"Effect of parity on metabolic and oxidative stress profiles in Holstein dairy cows","volume":"13","author":"Yehia","year":"2020","journal-title":"Vet. World"},{"key":"10.3168\/jds.2025-28054_bib116","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1080\/1828051X.2021.1953410","article-title":"Effects of cattle breed and production system on veterinary diagnoses and administrated veterinary medicine in alpine dairy farms","volume":"20","author":"Zanon","year":"2021","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2025-28054_bib117","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.3168\/jds.2023-24156","article-title":"Systemic inflammation in early lactation and its relation to the cows' oxidative and metabolic status, productive and reproductive performance as well as activity","volume":"107","author":"Zhang","year":"2024","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226017406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226017406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:10:01Z","timestamp":1792527001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030226017406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":117,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0022030226017406"],"URL":"https:\/\/doi.org\/10.3168\/jds.2025-28054","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Large-scale monitoring of milk infrared-predicted blood biomarkers of stress resilience: Effects of breed and dairy systems and their interactions","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2025-28054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s).","name":"copyright","label":"Copyright"}]}}