{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:00:02Z","timestamp":1790805602906,"version":"4.1.0"},"reference-count":36,"publisher":"American Dairy Science Association","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2024-68008-42644"],"award-info":[{"award-number":["2024-68008-42644"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["GEO00916"],"award-info":[{"award-number":["GEO00916"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030791","name":"Southeast Milk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.3168\/jds.2026-28261","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:19:39Z","timestamp":1780298379000},"page":"9886-9898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows"],"prefix":"10.3168","volume":"109","author":[{"given":"J.","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G.","family":"Savegnago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.N.","family":"Marins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Roper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.G.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.P.","family":"Kant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bohlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2026-28261_bib1","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.3168\/jds.2019-17966","article-title":"Effects of postpartum acetylsalicylic acid on metabolic status, health, and production in lactating dairy cattle","volume":"103","author":"Barragan","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib2","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.3168\/jds.2012-6425","article-title":"Measurement of fecal glucocorticoid metabolites and evaluation of udder characteristics to estimate stress after sudden dry-off in dairy cows with different milk yields","volume":"96","author":"Bertulat","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3168\/jds.2015-10048","article-title":"Hot topic: Early postpartum treatment of commercial dairy cows with nonsteroidal antiinflammatory drugs increases whole-lactation milk yield","volume":"99","author":"Carpenter","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib4","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.3168\/jds.2020-19944","article-title":"Plasma albumin-to-globulin ratio before dry-off as a possible index of inflammatory status and performance in the subsequent lactation in dairy cows","volume":"104","author":"Cattaneo","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib5","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jpn.13777","article-title":"Drying-off dairy cows without antibiotic therapy and orally supplemented with lyophilized Aloe arborescens: Effects on rumen activity, immunometabolic profile, and milk yield","volume":"107","author":"Cattaneo","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2026-28261_bib6","first-page":"E1","article-title":"Pharmacokinetics of intravenous and oral meloxicam in ruminant calves","volume":"10","author":"Coetzee","year":"2009","journal-title":"Vet. Ther."},{"key":"10.3168\/jds.2026-28261_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1439-0396.2012.01298.x","article-title":"Concentrations of haptoglobin in bovine plasma determined by ELISA or a colorimetric method based on peroxidase activity","volume":"97","author":"Cooke","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jds.2026-28261_bib8","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.3168\/jds.2018-15718","article-title":"Effect of dietary transition at dry off on the behavior and physiology of dairy cows","volume":"102","author":"Dancy","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib9","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/ar2336","article-title":"The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors","volume":"9","author":"de Rham","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.3168\/jds.2026-28261_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3390\/vetsci9110624","article-title":"Association of high somatic cell counts prior to dry off to the incidence of periparturient diseases in Holstein dairy cows","volume":"9","author":"Egyedy","year":"2022","journal-title":"Vet. Sci."},{"key":"10.3168\/jds.2026-28261_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-2427(00)00162-8","article-title":"Effects of human IL-8 isoforms on bovine neutrophil function in vitro","volume":"74","author":"Galligan","year":"2000","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jds.2026-28261_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.domaniend.2023.106790","article-title":"Hormonal and immunological responses of Holstein dairy cows from late lactation to the dry period and from the dry period to early lactation","volume":"83","author":"Gao","year":"2023","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.3168\/jds.2026-28261_bib13","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3168\/jds.2024-25279","article-title":"Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving","volume":"108","author":"Gao","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib14","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.3168\/jds.2025-26999","article-title":"Effects of different vaccination schedules prior to dry-off on systemic inflammation, immunity, and subsequent performance of dairy cows","volume":"109","author":"Gao","year":"2026","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib15","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3390\/ani10071119","article-title":"Immune responses and performance are influenced by respiratory vaccine antigen type and stress in beef calves","volume":"10","author":"Hudson","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.3168\/jds.2026-28261_bib16","doi-asserted-by":"crossref","first-page":"11425","DOI":"10.3168\/jds.2024-24913","article-title":"Prepartum anti-inflammatory therapies in Holstein dairy cows blocked by parity and body condition score group: Effects on metabolic stress, systemic inflammation, performance, and health","volume":"107","author":"Jimenez","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skad187","article-title":"Effect of withdrawing an immunomodulatory feed additive from lactating cow diets on peripheral blood mononuclear cell proliferation","volume":"101","author":"Marins","year":"2023","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2026-28261_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/1828051X.2019.1691472","article-title":"Inflammatory status and metabolic changes at dry-off in high-yield dairy cows","volume":"19","author":"Mezzetti","year":"2020","journal-title":"Ital. J. Anim. Sci."},{"key":"10.3168\/jds.2026-28261_bib19","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2460\/javma.1996.209.07.1291","article-title":"Effect of vaccination with an Escherichia coli bacterin-toxoid on milk production in dairy cattle","volume":"209","author":"Musser","year":"1996","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.3168\/jds.2026-28261_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.bjp.0706081","article-title":"TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation","volume":"144","author":"Norman","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.3168\/jds.2026-28261_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-59745-353-0_3","article-title":"Analysis of neutrophil chemotaxis","volume":"370","author":"Nuzzi","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.3168\/jds.2026-28261_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0168-1591(00)00159-3","article-title":"Effects of milking frequency on lying down and getting up behaviour in dairy cows","volume":"70","author":"\u00d6sterman","year":"2001","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.3168\/jds.2026-28261_bib23","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1038\/s41598-020-62103-x","article-title":"Effect of anti-inflammatory treatment on systemic inflammation, immune function, and endometrial health in postpartum dairy cows","volume":"10","author":"Pascottini","year":"2020","journal-title":"Sci. Rep."},{"key":"10.3168\/jds.2026-28261_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/bio.1170100105","article-title":"Comparison of MTT and ATP-based assays for the measurement of viable cell number","volume":"10","author":"Petty","year":"1995","journal-title":"J. Biolumin. Chemilumin."},{"key":"10.3168\/jds.2026-28261_bib25","doi-asserted-by":"crossref","DOI":"10.4137\/BBI.S5850","article-title":"Expression of metabolic, tissue remodeling, oxidative stress, and inflammatory pathways in mammary tissue during involution in lactating dairy cows","volume":"4","author":"Piantoni","year":"2010","journal-title":"Bioinform. Biol. Insights"},{"key":"10.3168\/jds.2026-28261_bib26","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.3168\/jds.2018-15158","article-title":"Oxylipid profiles of dairy cattle vary throughout the transition into early mammary gland involution","volume":"102","author":"Putman","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib27","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.3168\/jds.2018-14591","article-title":"Changes in biomarkers of nutrient metabolism, inflammation, and oxidative stress in dairy cows during the transition into the early dry period","volume":"101","author":"Putman","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib28","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.3168\/jds.2017-13588","article-title":"Effect of milk cessation method at dry-off on behavioral activity of dairy cows","volume":"101","author":"Rajala-Schultz","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3390\/vetsci6030073","article-title":"A comparative pharmacokinetic analysis of oral and subcutaneous meloxicam administered to postpartum dairy cows","volume":"6","author":"Shock","year":"2019","journal-title":"Vet. Sci."},{"key":"10.3168\/jds.2026-28261_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209236","article-title":"Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial","volume":"13","author":"Shock","year":"2018","journal-title":"PLoS One"},{"key":"10.3168\/jds.2026-28261_bib31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1051\/vetres:2007033","article-title":"Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma","volume":"38","author":"Sohn","year":"2007","journal-title":"Vet. Res."},{"key":"10.3168\/jds.2026-28261_bib32","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.3168\/jds.2018-14657","article-title":"Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows","volume":"101","author":"Swartz","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib33","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.3168\/jds.2024-25790","article-title":"International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation\u2014Lights and shadows","volume":"108","author":"Trevisi","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib34","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.3168\/jds.2008-1930","article-title":"Effect of milking frequency and feeding level before and after dry off on dairy cattle behavior and udder characteristics","volume":"92","author":"Tucker","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28261_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2020.105503","article-title":"Dry-off and dairy cow udder health and welfare: Effects of different milk cessation methods","volume":"262","author":"Vilar","year":"2020","journal-title":"Vet. J."},{"key":"10.3168\/jds.2026-28261_bib36","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.3168\/jds.2012-6501","article-title":"Gradual cessation of milking reduces milk leakage and motivation to be milked in dairy cows at dry-off","volume":"96","author":"Zobel","year":"2013","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226028882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226028882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:29:50Z","timestamp":1790803790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030226028882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0022030226028882"],"URL":"https:\/\/doi.org\/10.3168\/jds.2026-28261","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2026-28261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s).","name":"copyright","label":"Copyright"}]}}