{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:59:22Z","timestamp":1790805562110,"version":"4.1.0"},"reference-count":45,"publisher":"American Dairy Science Association","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021532","name":"Alberta Milk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.3168\/jds.2026-28663","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:02:27Z","timestamp":1783119747000},"page":"10517-10530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dilution of colostrum replacer on IgG absorption, abomasal emptying rate, and gastrointestinal permeability in newborn Holstein calves"],"prefix":"10.3168","volume":"109","author":[{"given":"A.J.","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mergh Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2026-28663_bib1","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3168\/jds.2018-15847","article-title":"Effect of energy source in calf milk replacer on performance, digestibility, and gut permeability in rearing calves","volume":"102","author":"Amado","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib2","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.3168\/jds.2015-10457","article-title":"The effects of increasing amounts of milk replacer powder added to whole milk on feed intake and performance in dairy heifers","volume":"99","author":"Azevedo","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2527\/1991.69167x","article-title":"A simple, rapid and reliable method for selecting or assessing the numbers of replicates for animal experiments","volume":"69","author":"Berndtson","year":"1991","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jds.2026-28663_bib4","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3168\/jds.S0022-0302(85)81065-1","article-title":"Effect of colostral immunoglobulin G1 and immunoglobulin M concentrations on immunoglobulin absorption in calves","volume":"68","author":"Besser","year":"1985","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","article-title":"Intestinal permeability\u2014A new target for disease prevention and therapy","volume":"14","author":"Bischoff","year":"2014","journal-title":"BMC Gastroenterol."},{"key":"10.3168\/jds.2026-28663_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3168\/jds.2016-10949","article-title":"Invited review: Abomasal emptying in calves and its potential influence on gastrointestinal disease","volume":"100","author":"Burgstaller","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib7","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3168\/jds.2013-7007","article-title":"Colostrum replacer feeding regimen, addition of sodium bicarbonate, and milk replacer: The combined effects on absorptive efficiency of immunoglobulin G in neonatal calves","volume":"97","author":"Cabral","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib8","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.3168\/jds.2021-21768","article-title":"Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves","volume":"105","author":"Cangiano","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib9","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3168\/jds.2011-4627","article-title":"Technical note: Comparison of 3 methods for analyzing areas under the curve for glucose and nonesterified fatty acids concentrations following epinephrine challenge in dairy cows","volume":"94","author":"Cardoso","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib10","unstructured":"CCAC. 1993. Guide to the Care and Use of Experimental Animals. Vol. 1. E. D. Olfert, B. M. Cross, and A. A. McWilliams, ed. Canadian Council on Animal Care."},{"key":"10.3168\/jds.2026-28663_bib11","first-page":"407","article-title":"Evaluation of methods for dehydration of bovine colostrum for total replacement of normal colostrum in calves","volume":"34","author":"Chelack","year":"1993","journal-title":"Can. Vet. J."},{"key":"10.3168\/jds.2026-28663_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3168\/jds.2008-1462","article-title":"Comparative effects of two oral rehydration solutions on milk clotting, abomasal luminal pH, and abomasal emptying rate in suckling calves","volume":"92","author":"Constable","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib13","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.3168\/jds.2017-13397","article-title":"Effect of delaying colostrum feeding on passive transfer and intestinal bacterial colonization in neonatal male Holstein calves","volume":"101","author":"Fischer","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib14","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.3168\/jds.2025-27228","article-title":"Effects of feeding colostrum volume at 6%, 8%, 10%, or 12% of birth body weight on efficiency of immunoglobulin G absorption, gastric emptying, and postfeeding behavior in Holstein calves","volume":"108","author":"Frederick","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib15","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.3168\/jds.2014-8790","article-title":"Effect of colostrum heat treatment and bacterial population on immunoglobulin G absorption and health of neonatal calves","volume":"98","author":"Gelsinger","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib16","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3168\/jds.2014-8567","article-title":"Effect of supplementing pasteurized milk balancer products to heat-treated whole milk on the growth and health of dairy calves","volume":"98","author":"Glosson","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cvfa.2019.07.005","article-title":"Colostrum management for dairy calves","volume":"35","author":"Godden","year":"2019","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.3168\/jds.2026-28663_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0195-5616(99)50030-2","article-title":"Clinical laboratory evaluation of small intestinal function","volume":"29","author":"Hall","year":"1999","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.3168\/jds.2026-28663_bib19","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.3168\/jds.2007-0219","article-title":"Effects of feeding heat-treated colostrum on passive transfer of immune and nutritional parameters in neonatal dairy calves","volume":"90","author":"Johnson","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.15232\/S1080-7446(15)30245-X","article-title":"Review: A historical perspective of specific milk-replacer feeding programs in the United States and effects on eventual performance of Holstein dairy calves","volume":"29","author":"Kertz","year":"2013","journal-title":"Prof. Anim. Sci."},{"key":"10.3168\/jds.2026-28663_bib21","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.3168\/jds.2024-25807","article-title":"Controlled field study investigating effects of 2 methods of enriching moderate-quality maternal colostrum on transfer of passive immunity and well-being of neonatal dairy calves","volume":"108","author":"Knauer","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib22","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.3168\/jds.2019-17955","article-title":"Consensus recommendations on calf- and herd-level passive immunity in dairy calves in the United States","volume":"103","author":"Lombard","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib23","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.3168\/jds.2022-22518","article-title":"Effects of enriching IgG concentration in low- and medium-quality colostrum with colostrum replacer on IgG absorption in newborn Holstein calves","volume":"106","author":"Lopez","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib24","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.3168\/jds.2015-10826","article-title":"Effect of plane of milk replacer intake and age on glucose and insulin kinetics and abomasal emptying in female Holstein Friesian dairy calves fed twice daily","volume":"99","author":"MacPherson","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib25","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.3168\/jds.2021-21231","article-title":"Heat treatment of colostrum at 60\u00b0C decreases colostrum immunoglobulins but increases serum immunoglobulins and serum total protein: A meta-analysis","volume":"105","author":"Malik","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib26","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3168\/jds.2022-22155","article-title":"Gastrointestinal structure and function of preweaning dairy calves fed a whole milk powder or a milk replacer high in fat","volume":"106","author":"Mellors","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib27","first-page":"747","article-title":"Response of the small intestine to the application of a hypertonic solution","volume":"73","author":"Norris","year":"1973","journal-title":"Am. J. Pathol."},{"key":"10.3168\/jds.2026-28663_bib28","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3168\/jds.S0022-0302(03)73789-8","article-title":"Fractionized milk composition during removal of colostrum and mature milk","volume":"86","author":"Ontsouka","year":"2003","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib29","author":"PTC (Proficiency Testing Canada)"},{"key":"10.3168\/jds.2026-28663_bib30","doi-asserted-by":"crossref","first-page":"11016","DOI":"10.3168\/jds.2019-16682","article-title":"Effects of colostrum and milk replacer feeding rates on intake, growth, and digestibility in calves","volume":"102","author":"Quigley","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib31","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.3168\/jds.S0022-0302(98)75836-9","article-title":"Nutrient and immunity transfer from cow to calf pre- and postcalving","volume":"81","author":"Quigley","year":"1998","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib32","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3168\/jds.S0022-0302(02)74188-X","article-title":"Absorption of protein and IgG in calves fed a colostrum supplement or replacer","volume":"85","author":"Quigley","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib33","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.3168\/jds.2018-15542","article-title":"Effect of different heating times of high-, medium-, and low-quality colostrum on immunoglobulin G absorption in dairy calves","volume":"102","author":"Saldana","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib34","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2460\/ajvr.67.8.1377","article-title":"Effect of suckling isotonic or hypertonic solutions of sodium bicarbonate or glucose on abomasal emptying rate in calves","volume":"67","author":"Sen","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"10.3168\/jds.2026-28663_bib35","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.3168\/jds.2017-14008","article-title":"Preweaned heifer management on US dairy operations: Part II. Factors associated with colostrum quality and passive transfer status of dairy heifer calves","volume":"101","author":"Shivley","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1203\/00006450-198202000-00013","article-title":"Gastric emptying in prematures of isocaloric feedings with differing osmolalities","volume":"16","author":"Siegel","year":"1982","journal-title":"Pediatr. Res."},{"key":"10.3168\/jds.2026-28663_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156443","article-title":"A mechanistic model of intermittent gastric emptying and glucose-insulin dynamics following a meal containing milk components","volume":"11","author":"Stahel","year":"2016","journal-title":"PLoS One"},{"key":"10.3168\/jds.2026-28663_bib38","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.3168\/jds.S0022-0302(79)83472-4","article-title":"Colostral immunoglobulin transfer in calves I. Period of absorption","volume":"62","author":"Stott","year":"1979","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1749-6632.1966.tb50180.x","article-title":"Anomalous transport of electrolytes and sucrose through isolated frog skin induced by hypertonicity of the outside bathing solution","volume":"137","author":"Ussing","year":"1966","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.3168\/jds.2026-28663_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0033583500000718","article-title":"The interpretation of tracer fluxes in terms of membrane structure","volume":"1","author":"Ussing","year":"1969","journal-title":"Q. Rev. Biophys."},{"key":"10.3168\/jds.2026-28663_bib41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3168\/jds.2016-11213","article-title":"Systematic early obstetrical assistance at calving: I. Effects on dairy calf stillbirth, vigor, and passive immunity transfer","volume":"100","author":"Villettaz Robichaud","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1939-1676.2000.tb02278.x","article-title":"Passive transfer of colostral immunoglobulins in calves","volume":"14","author":"Weaver","year":"2000","journal-title":"J. Vet. Intern. Med."},{"key":"10.3168\/jds.2026-28663_bib43","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.3168\/jds.2020-19405","article-title":"Effects of energy source in milk replacer on glucose metabolism of neonatal dairy calves","volume":"104","author":"Welboren","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib44","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3168\/jds.2018-15265","article-title":"Hypertonic milk replacers increase gastrointestinal permeability in healthy dairy calves","volume":"102","author":"Wilms","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-28663_bib45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3168\/jds.2023-23368","article-title":"Postprandial metabolism and gut permeability in calves fed milk replacer with different macronutrient profiles or a whole milk powder","volume":"107","author":"Wilms","year":"2024","journal-title":"J. Dairy Sci."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226030742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226030742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:22:31Z","timestamp":1790803351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030226030742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0022030226030742"],"URL":"https:\/\/doi.org\/10.3168\/jds.2026-28663","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of dilution of colostrum replacer on IgG absorption, abomasal emptying rate, and gastrointestinal permeability in newborn Holstein calves","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2026-28663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors.","name":"copyright","label":"Copyright"}]}}