{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:11:59Z","timestamp":1789071119220,"version":"build-2803163510"},"reference-count":104,"publisher":"American Dairy Science Association","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007513","name":"Dairy Management Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofdairyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dairy Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.3168\/jds.2026-29265","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:09:08Z","timestamp":1788970148000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whey protein phospholipid concentrate at the interface of function and health: Heat-induced protein interactions, bioactivity, and choline delivery"],"prefix":"10.3168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-6704","authenticated-orcid":false,"given":"Jerina","family":"Rugji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0143-1419","authenticated-orcid":false,"given":"Rebecca J.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2004-7231","authenticated-orcid":false,"given":"Mitchell T.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6874-0529","authenticated-orcid":false,"given":"Sheng-Luen","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia K.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-162X","authenticated-orcid":false,"given":"Yu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7862-1810","authenticated-orcid":false,"given":"Gulustan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jds.2026-29265_bib1","unstructured":"ADPI (2023). Infant Formula (IF) Grade Whey Protein Phospholipid Concentrate (WPPC) Standard (Access date: 06.16.2025)."},{"key":"10.3168\/jds.2026-29265_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jprot.2009.11.008","article-title":"Qualitative and quantitative profiling of the bovine milk fat globule membrane proteome","volume":"73","author":"Affolter","year":"2010","journal-title":"J. Proteomics"},{"key":"10.3168\/jds.2026-29265_bib3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3168\/jds.2015-9924","article-title":"Effect of heating strategies on whey protein denaturation\u2014Revisited by liquid chromatography quadrupole time-of-flight mass spectrometry","volume":"99","author":"Akkerman","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2021.105136","article-title":"Heat-induced changes in caseins and casein micelles, including interactions with denatured whey proteins","volume":"122","author":"Anema","year":"2021","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0005-2736(82)90328-5","article-title":"Differential scanning calorimetry of milk fat globule membranes","volume":"690","author":"Appell","year":"1982","journal-title":"Biochimica et Biophysica Acta (BBA)-. Biochim. Biophys. Acta Biomembr."},{"key":"10.3168\/jds.2026-29265_bib6","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202502683R","article-title":"Whey Protein Phospholipid Concentrate and Its Fractions as a Diet Intervention Enhance Bone Health and Alter the Gut Microbiome in Weanling Mice","volume":"39","author":"Armstrong","year":"2025","journal-title":"FASEB J."},{"key":"10.3168\/jds.2026-29265_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12937-025-01227-0","article-title":"Effect of egg consumption on circulating choline, betaine, and trimethylamine N-oxide in adults: A systematic review and meta-analysis of randomized controlled trials","volume":"24","author":"Aryaeian","year":"2025","journal-title":"Nutr. J."},{"key":"10.3168\/jds.2026-29265_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00394-021-02637-6","article-title":"Differential metabolism of choline supplements in adult volunteers","volume":"61","author":"B\u00f6ckmann","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.3168\/jds.2026-29265_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.nutres.2026.05.002","article-title":"Choline, a nexus for neurocognitive nutrients: A narrative review","volume":"151","author":"Boldon","year":"2026","journal-title":"Nutr. Res."},{"key":"10.3168\/jds.2026-29265_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s12035-026-05849-1","article-title":"Lipidomic analysis of human plasma and hippocampus across Alzheimer's progression and preclinical 5xFAD mouse model","volume":"63","author":"Castroflorio","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"10.3168\/jds.2026-29265_bib11","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/s41430-023-01336-1","article-title":"Dietary choline intake and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2017\u20132018","volume":"77","author":"Chai","year":"2023","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.3168\/jds.2026-29265_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ifset.2006.08.003","article-title":"Interactions of milk proteins during heat and high hydrostatic pressure treatments\u2014a review","volume":"8","author":"Considine","year":"2007","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"10.3168\/jds.2026-29265_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2527\/af.2014-0014","article-title":"Buttermilk: much more than a source of milk phospholipids","volume":"4","author":"Conway","year":"2014","journal-title":"Anim. Front."},{"key":"10.3168\/jds.2026-29265_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0022029900031940","article-title":"Effect of different heat treatments on the strong binding interactions between whey proteins and milk fat globules in whole milk","volume":"63","author":"Corredig","year":"1996","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2026-29265_bib15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3201\/eid2306.151603","article-title":"Outbreak-related disease burden associated with consumption of unpasteurized cow's milk and cheese, United States, 2009\u20132014","volume":"23","author":"Costard","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.3168\/jds.2026-29265_bib16","series-title":"Protein and fat globule modifications by heat treatment, homogenization and other technological means for high quality dairy products. IDF Seminar, Munich (Germany), 25\u201328 Aug 1992","article-title":"Interactions between milkfat and milk proteins. The effect of heat on the nature of the complexes formed","author":"Dalgleish","year":"1993"},{"key":"10.3168\/jds.2026-29265_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.focha.2022.100041","article-title":"A comprehensive review on heat treatments and related impact on the quality and microbial safety of milk and milk-based products","volume":"1","author":"Dash","year":"2022","journal-title":"Food Chemistry Advances"},{"key":"10.3168\/jds.2026-29265_bib18","first-page":"44","article-title":"The role of phospholipids in the stability of milk fat gobules","volume":"52","author":"Deeth","year":"1997","journal-title":"Aust. J. Dairy Technol."},{"key":"10.3168\/jds.2026-29265_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2021.105104","article-title":"Heat-induced inactivation of enzymes in milk and dairy products. A review","volume":"121","author":"Deeth","year":"2021","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib20","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.idairyj.2007.10.014","article-title":"Nutritional and technological aspects of milk fat globule membrane material","volume":"18","author":"Dewettinck","year":"2008","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2019.102040","article-title":"Effects of industrial heat treatments on bovine milk oxylipins and conventional markers of lipid oxidation","volume":"152","author":"Dias","year":"2020","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.3168\/jds.2026-29265_bib22","doi-asserted-by":"crossref","first-page":"10986","DOI":"10.3168\/jds.2020-18605","article-title":"Invited review: Heat stability of milk and concentrated milk: Past, present, and future research objectives","volume":"103","author":"Dumpler","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3168\/jdsc.2021-0076","article-title":"Direct ethanolic extraction of polar lipids and fractional crystallization from whey protein phospholipid concentrate","volume":"2","author":"Ferraris","year":"2021","journal-title":"JDS Commun."},{"key":"10.3168\/jds.2026-29265_bib24","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3945\/ajcn.2010.30064","article-title":"Dietary choline requirements of women: Effects of estrogen and genetic variation","volume":"92","author":"Fischer","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2026-29265_bib25","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/85.5.1275","article-title":"Sex and menopausal status influence human dietary requirements for the nutrient choline","volume":"85","author":"Fischer","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2026-29265_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.idairyj.2006.05.004","article-title":"Protein and lipid composition of bovine milk-fat-globule membrane","volume":"17","author":"Fong","year":"2007","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib27","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1021\/jf9032409","article-title":"Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins","volume":"58","author":"Gallier","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.3168\/jds.2026-29265_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1051\/dst:2008006","article-title":"Heat treatment of cream affects the physicochemical properties of sweet buttermilk","volume":"88","author":"Gassi","year":"2008","journal-title":"Dairy Sci. Technol."},{"key":"10.3168\/jds.2026-29265_bib29","author":"Greenwalt"},{"key":"10.3168\/jds.2026-29265_bib30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/10408398.2017.1386158","article-title":"Milk fat globule membrane glycoproteins: Valuable ingredients for lactic acid bacteria encapsulation?","volume":"59","author":"Guerin","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.3168\/jds.2026-29265_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3168\/jds.2024-25493","article-title":"Effects of high-temperature, short-time pasteurization on milk and whey during commercial whey protein concentrate production","volume":"108","author":"Haas","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.103857","article-title":"Comparison of glycation and glycosylation level between bovine milk-based and goat milk-based infant formula through label-free proteomics techniques","volume":"59","author":"Han","year":"2024","journal-title":"Food Biosci."},{"key":"10.3168\/jds.2026-29265_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2019.109887","article-title":"Microfiltration of raw milk for production of high-purity milk fat globule membrane material","volume":"276","author":"Hansen","year":"2020","journal-title":"J. Food Eng."},{"key":"10.3168\/jds.2026-29265_bib34","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3168\/jds.2019-18066","article-title":"Disulfide bond formation is not crucial for the heat-induced interaction between \u03b2-lactoglobulin and milk fat globule membrane proteins","volume":"103","author":"Hansen","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.idairyj.2017.12.015","article-title":"Placing pasteurisation before or after microfiltration impacts the protein composition of milk fat globule membrane material","volume":"81","author":"Hansen","year":"2018","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib36","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/jsfa.5720","article-title":"Food in an evolutionary context: insights from mother's milk","volume":"92","author":"Hinde","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"10.3168\/jds.2026-29265_bib37","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/jf960789q","article-title":"Heat-induced aggregation of \u03b2-lactoglobulin: role of the free thiol group and disulfide bonds","volume":"45","author":"Hoffmann","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"10.3168\/jds.2026-29265_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S0022029900030430","article-title":"Interactions between the bovine milk fat globule membrane and skim milk components on heating whole milk","volume":"59","author":"Houlihan","year":"1992","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2026-29265_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112580","article-title":"Effects of various thermal treatments on interfacial composition and physical properties of bovine milk fat globules","volume":"167","author":"Huang","year":"2023","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2026-29265_bib40","doi-asserted-by":"crossref","unstructured":"Huppertz, T. (2016). Heat stability of milk. Advanced dairy chemistry: volume 1B: proteins: applied aspects, 179\u2013196.","DOI":"10.1007\/978-1-4939-2800-2_7"},{"key":"10.3168\/jds.2026-29265_bib41","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1432-1033.1996.0628h.x","article-title":"Characterization of glycoprotein PAS6\/7 from membranes of bovine milk fat globules","volume":"240","author":"Hvarregaard","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.3168\/jds.2026-29265_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1021\/acsnutrsci.5c00023","article-title":"Distinct effects of dietary phosphatidylinositol and myo-inositol on obesity and metabolic dysfunction-associated steatotic liver disease in mice","volume":"1","author":"Iwasaki","year":"2026","journal-title":"ACS Nutrition Science"},{"key":"10.3168\/jds.2026-29265_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.memsci.2017.11.012","article-title":"Effect of heat treatment and pH on the efficiency of micro-diafiltration for the separation of native fat globules from cream in butter production","volume":"548","author":"Jukkola","year":"2018","journal-title":"J. Membr. Sci."},{"key":"10.3168\/jds.2026-29265_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3168\/jds.S0022-0302(95)76612-7","article-title":"Heat-induced interactions between the proteins of milk fat globule membrane and skim milk","volume":"78","author":"Kim","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib45","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3168\/jds.2024-25885","article-title":"Characterization of Bifidobacterium bifidum growth and metabolism on whey protein phospholipid concentrate","volume":"108","author":"Kim","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib46","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1021\/jf001380a","article-title":"Reversible conformational change in \u03b2-lactoglobulin A modified with N-ethylmaleimide and resistance to molecular aggregation on heating","volume":"49","author":"Kitabatake","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.3168\/jds.2026-29265_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.foodres.2016.03.002","article-title":"The lipid content and microstructure of industrial whole buttermilk and butter serum affect the efficiency of skimming","volume":"83","author":"Lambert","year":"2016","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2026-29265_bib48","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.idairyj.2011.04.015","article-title":"Physical properties and microstructure of yoghurt enriched with milk fat globule membrane material","volume":"21","author":"Le","year":"2011","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib49","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.3168\/jds.2008-2009","article-title":"Effect of washing conditions on the recovery of milk fat globule membrane proteins during the isolation of milk fat globule membrane from milk","volume":"92","author":"Le","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s13594-014-0160-y","article-title":"Bovine \u03b2-lactoglobulin\/fatty acid complexes: binding, structural, and biological properties","volume":"94","author":"Le Maux","year":"2014","journal-title":"Dairy Sci. Technol."},{"key":"10.3168\/jds.2026-29265_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2736(03)00056-7","article-title":"Lipid\u2013protein interactions in biological membranes: a structural perspective","volume":"1612","author":"Lee","year":"2003","journal-title":"Biochimica et Biophysica Acta (BBA)-. Biochim. Biophys. Acta Biomembr."},{"key":"10.3168\/jds.2026-29265_bib52","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S002202990200571X","article-title":"Chemical changes in bovine milk fat globule membrane caused by heat treatment and homogenization of whole milk","volume":"69","author":"Lee","year":"2002","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2026-29265_bib53","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.3168\/jds.2016-10974","article-title":"Composition and functionality of whey protein phospholipid concentrate and delactosed permeate","volume":"99","author":"Levin","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib54","unstructured":"Li, B. (2017). Selective extraction of phospholipids from dairy powders using supercritical fluid extraction (Doctoral dissertation, Kansas State University)."},{"key":"10.3168\/jds.2026-29265_bib55","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3168\/jds.2012-6072","article-title":"Stability during in vitro digestion of lactoferrin-loaded liposomes prepared from milk fat globule membrane-derived phospholipids","volume":"96","author":"Liu","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cocis.2011.05.007","article-title":"Milk fat globules enveloped by their biological membrane: Unique colloidal assemblies with a specific composition and structure","volume":"16","author":"Lopez","year":"2011","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.3168\/jds.2026-29265_bib57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.foodchem.2009.09.065","article-title":"Lipid rafts in the bovine milk fat globule membrane revealed by the lateral segregation of phospholipids and heterogeneous distribution of glycoproteins","volume":"120","author":"Lopez","year":"2010","journal-title":"Food Chem."},{"key":"10.3168\/jds.2026-29265_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.foodchem.2018.12.015","article-title":"Changes in milk fat globule membrane proteome after pasteurization in human, bovine and caprine species","volume":"279","author":"Ma","year":"2019","journal-title":"Food Chem."},{"key":"10.3168\/jds.2026-29265_bib59","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/BF02542273","article-title":"Sphingomyelin from milk-characterization of liquid crystalline, liposome and emulsion properties","volume":"71","author":"Malmsten","year":"1994","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.3168\/jds.2026-29265_bib60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3168\/jds.S0022-0302(00)74870-3","article-title":"A review and proposed nomenclature for major proteins of the milk-fat globule membrane","volume":"83","author":"Mather","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib61","series-title":"Advanced dairy chemistry: volume 1B: proteins: applied aspects","year":"2015"},{"key":"10.3168\/jds.2026-29265_bib62","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3168\/jds.2018-15951","article-title":"Composition of coproduct streams from dairy processing: Acid whey and milk permeate","volume":"102","author":"Menchik","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib63","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2147\/DDDT.S193424","article-title":"Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers","volume":"13","author":"Min","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.3168\/jds.2026-29265_bib64","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.3390\/nu11102548","article-title":"Plasma kinetics of choline and choline metabolites after a single dose of SuperbaBoostTM krill oil or choline bitartrate in healthy volunteers","volume":"11","author":"M\u00f6dinger","year":"2019","journal-title":"Nutrients"},{"key":"10.3168\/jds.2026-29265_bib65","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.3168\/jds.2006-832","article-title":"Microfiltration of buttermilk and washed cream buttermilk for concentration of milk fat globule membrane components","volume":"90","author":"Morin","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib66","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1021\/bi00067a029","volume":"32","author":"Nakata","year":"1993","journal-title":"Biochemistry"},{"key":"10.3168\/jds.2026-29265_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2021.105220","article-title":"Heat-induced changes in milk salts: A review","volume":"126","author":"Nieuwenhuijse","year":"2022","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib68","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajcnut.2024.11.001","article-title":"Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: A large population-based prospective cohort study","volume":"121","author":"Niu","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"key":"10.3168\/jds.2026-29265_bib69","series-title":"Nutrient intakes from food and beverages: Mean amounts consumed per individual, by gender and age. What We Eat in America","year":"2020"},{"key":"10.3168\/jds.2026-29265_bib70","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0958-6946(00)00087-X","article-title":"Heat-induced interactions of \u03b2-lactoglobulin and \u03b1-lactalbumin with the casein micelle in pH-adjusted skim milk","volume":"10","author":"Oldfield","year":"2000","journal-title":"Int. Dairy J."},{"issue":"1","key":"10.3168\/jds.2026-29265_bib71","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41538-019-0046-8","article-title":"Effects of industrial heat treatments on the kinetics of inactivation of antimicrobial bovine milk xanthine oxidase","volume":"3","author":"Ozturk","year":"2019","journal-title":"npj Science of Food"},{"key":"10.3168\/jds.2026-29265_bib72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3390\/dairy3020022","article-title":"Glycoproteomic and Lipidomic Characterization of Industrially Produced Whey Protein Phospholipid Concentrate with Emphasis on Antimicrobial Xanthine Oxidase, Oxylipins and Small Milk Fat Globules","volume":"3","author":"Ozturk","year":"2022","journal-title":"Dairy"},{"key":"10.3168\/jds.2026-29265_bib73","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3168\/jdsc.2024-0727","article-title":"Towards the Future of Next-Generation Dairy Foods: A Processing Perspective and Economic Analysis","volume":"6","author":"Ozturk","year":"2025","journal-title":"JDS Commun."},{"key":"10.3168\/jds.2026-29265_bib74","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10719-009-9269-2","article-title":"Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells","volume":"27","author":"Parker","year":"2010","journal-title":"Glycoconj. J."},{"key":"10.3168\/jds.2026-29265_bib75","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.3168\/jds.2014-8030","article-title":"Comparison of emulsifying properties of milk fat globule membrane materials isolated from different dairy by-products","volume":"97","author":"Phan","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib76","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.3168\/jds.2018-14950","article-title":"Extraction of phospholipids from a dairy by-product (whey protein phospholipid concentrate) using ethanol","volume":"101","author":"Price","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2019.108531","article-title":"Proteomics analysis of milk fat globule membrane enriched materials derived from by-products during different stages of milk-fat processing","volume":"116","author":"Qu","year":"2019","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2026-29265_bib78","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1388-1981(01)00202-5","article-title":"Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy","volume":"1580","author":"Reo","year":"2002","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.3168\/jds.2026-29265_bib79","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1096\/fj.07-8227com","article-title":"Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes","volume":"21","author":"Resseguie","year":"2007","journal-title":"FASEB J."},{"key":"10.3168\/jds.2026-29265_bib80","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.3168\/jds.2025-27557","article-title":"Impact of Spray Drying and Fluidized Bed Drying on Whey Protein Phospholipid Concentrate: Microstructural Analysis, Bioactivity, and Functionality","volume":"109","author":"Rugji","year":"2026","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib81","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/oxfordjournals.jbchem.a124702","article-title":"Site-specific glycosylation of bovine butyrophilin","volume":"117","author":"Sato","year":"1995","journal-title":"J. Biochem."},{"key":"10.3168\/jds.2026-29265_bib82","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1017\/S002202990003079X","article-title":"Effect of heat treatments on the incorporation of milk serum proteins into the fat globule membrane of homogenized milk","volume":"61","author":"Sharma","year":"1994","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2026-29265_bib83","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1471-0307.2004.00143.x","article-title":"Heat stability of milk","volume":"57","author":"Singh","year":"2004","journal-title":"Int. J. Dairy Technol."},{"key":"10.3168\/jds.2026-29265_bib84","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.3390\/nu11112758","article-title":"Natural choline from egg yolk phospholipids is more efficiently absorbed compared with choline bitartrate: Outcomes of a randomized trial in healthy adults","volume":"11","author":"Smolders","year":"2019","journal-title":"Nutrients"},{"key":"10.3168\/jds.2026-29265_bib85","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.3168\/jds.S0022-0302(05)72906-4","article-title":"Invited review: Bovine milk fat globule membrane as a potential nutraceutical","volume":"88","author":"Spitsberg","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib86","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.3168\/jds.2019-16419","article-title":"Selective extraction of phospholipids from whey protein phospholipid concentrate using supercritical carbon dioxide and ethanol as a co-solvent","volume":"102","author":"Sprick","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jds.2026-29265_bib87","article-title":"A review of factors affecting the structure, compositions, and the techno-functionalities of bovine milk fat globule and membrane","volume":"104570","author":"Sun","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"10.3168\/jds.2026-29265_bib88","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3168\/jdsc.2022-0322","article-title":"Partial enrichment of phospholipids by enzymatic hydrolysis and membrane filtration of whey protein phospholipid concentrate","volume":"4","author":"Swaminathan","year":"2023","journal-title":"JDS Commun."},{"key":"10.3168\/jds.2026-29265_bib89","author":"Sylvestre"},{"key":"10.3168\/jds.2026-29265_bib90","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.70209","article-title":"Approaches for measuring and predicting fouling during thermal processing of dairy solutions","volume":"24","author":"Tarapata","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.3168\/jds.2026-29265_bib91","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1051\/lait:2007012","article-title":"Reaction kinetic pathway of reversible and irreversible thermal denaturation of $\\beta $-lactoglobulin","volume":"87","author":"Tolkach","year":"2007","journal-title":"Lait"},{"key":"10.3168\/jds.2026-29265_bib92","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1194\/jlr.R084004","article-title":"Historical perspective: Phosphatidylserine and phosphatidylethanolamine from the 1800s to the present","volume":"59","author":"Vance","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.3168\/jds.2026-29265_bib93","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.idairyj.2010.12.006","article-title":"Study on the susceptibility of the bovine milk fat globule membrane proteins to enzymatic hydrolysis and organization of some of the proteins","volume":"21","author":"Vanderghem","year":"2011","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib94","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0022029900024195","article-title":"Some comments on the isolation of fat globule membrane material","volume":"52","author":"Walstra","year":"1985","journal-title":"J. Dairy Res."},{"key":"10.3168\/jds.2026-29265_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.111219","article-title":"Comparison of bovine milk fat globule membrane protein retention by different ultrafiltration membranes using a label-free proteomic approach","volume":"144","author":"Wang","year":"2021","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.3168\/jds.2026-29265_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2021.105213","article-title":"Heat-induced changes in milk fat and milk fat globules and its derived effects on acid dairy gelation\u2013a review","volume":"127","author":"Wiking","year":"2022","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib97","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.amjmed.2021.03.016","article-title":"Dietary choline supplements, but not eggs, raise fasting TMAO levels in participants with normal renal function: A randomized clinical trial","volume":"134","author":"Wilcox","year":"2021","journal-title":"Am. J. Med."},{"key":"10.3168\/jds.2026-29265_bib98","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.3168\/jds.2024-25412","article-title":"Dairy Foods: A Matrix for Human Health and Precision Nutrition\u2014The relevance of a potential bioactive ingredient; The milk fat globule membrane","volume":"108","author":"Wilmot","year":"2025","journal-title":"Journal of Dairy Science"},{"key":"10.3168\/jds.2026-29265_bib99","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.3390\/foods11172705","article-title":"Changes in Caprine Milk Fat Globule Membrane Proteins after Heat Treatment Using a Label-Free Proteomics Technique","volume":"11","author":"Yan","year":"2022","journal-title":"Foods"},{"key":"10.3168\/jds.2026-29265_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodres.2018.06.046","article-title":"Changes in bovine milk fat globule membrane proteins caused by heat procedures using a label-free proteomic approach","volume":"113","author":"Yang","year":"2018","journal-title":"Food Res. Int."},{"key":"10.3168\/jds.2026-29265_bib101","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0958-6946(02)00034-1","article-title":"Characterization of protein components of natural and heat-treated milk fat globule membranes","volume":"12","author":"Ye","year":"2002","journal-title":"Int. Dairy J."},{"key":"10.3168\/jds.2026-29265_bib102","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3168\/jdsc.2020-0007","article-title":"Effect of milk phospholipids on the growth and cryotolerance of lactic acid bacteria cultured and stored in acid whey-based media","volume":"1","author":"Zhang","year":"2020","journal-title":"JDS Commun."},{"key":"10.3168\/jds.2026-29265_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2022.104635","article-title":"Variation in both proteome and N-glycoproteome of goat MFGM over lactation","volume":"111","author":"Zhang","year":"2022","journal-title":"J. Food Compos. Anal."},{"key":"10.3168\/jds.2026-29265_bib104","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.foodchem.2018.09.044","article-title":"Label-free quantitative proteomic analysis of milk fat globule membrane proteins of yak and cow and identification of proteins associated with glucose and lipid metabolism","volume":"275","author":"Zhao","year":"2019","journal-title":"Food Chem."}],"container-title":["Journal of Dairy Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226032613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022030226032613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:58:21Z","timestamp":1789070301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022030226032613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":104,"alternative-id":["S0022030226032613"],"URL":"https:\/\/doi.org\/10.3168\/jds.2026-29265","relation":{},"ISSN":["0022-0302"],"issn-type":[{"value":"0022-0302","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whey protein phospholipid concentrate at the interface of function and health: Heat-induced protein interactions, bioactivity, and choline delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Dairy Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jds.2026-29265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s).","name":"copyright","label":"Copyright"}]}}