{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:19:18Z","timestamp":1790043558270,"version":"4.0.1"},"reference-count":33,"publisher":"American Dairy Science Association","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008908","name":"Universit\u00e0 degli Studi di Messina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jdscommun.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JDS Communications"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.3168\/jdsc.2026-1068","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:39:34Z","timestamp":1780119574000},"page":"684-690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of rumen-protected standardized dry grape extract supplementation on antioxidant and immune-related gene expression in leukocytes of mid-lactating Fleckvieh cows exposed to natural heat stress"],"prefix":"10.3168","volume":"7","author":[{"given":"Annalisa","family":"Amato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed el Amine","family":"Benarbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Minuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminio","family":"Trevisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Antonella","family":"Spina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Mol\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Ciliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Albenzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Lopreiato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1747","reference":[{"key":"10.3168\/jdsc.2026-1068_bib1","doi-asserted-by":"crossref","first-page":"11586","DOI":"10.3168\/jds.2025-26830","article-title":"Rumen-protected dry grape extract supplementation enhances milk production, behavior traits, and immunometabolism of mid-lactating Fleckvieh cows under naturally occurring heat stress","volume":"108","author":"Amato","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib2","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1002\/eji.200940294","article-title":"Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: Lessons from neutrophils","volume":"40","author":"Bazzoni","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.3168\/jdsc.2026-1068_bib3","first-page":"695","article-title":"Pro- versus anti-inflammatory cytokines: Myth or reality","volume":"47","author":"Cavaillon","year":"2001","journal-title":"Cell. Mol. Biol."},{"key":"10.3168\/jdsc.2026-1068_bib4","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.2527\/jas.2014-8047","article-title":"Dietary antioxidants at supranutritional doses modulate skeletal muscle heat shock protein and inflammatory gene expression in sheep exposed to heat stress","volume":"92","author":"Chauhan","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jdsc.2026-1068_bib5","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.3168\/jds.2021-21098","article-title":"Green extraction of bioactive compounds from wine lees and their bio-responses on immune modulation using in vitro sheep model","volume":"105","author":"Ciliberti","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1182\/blood.V69.2.493.493","article-title":"The role of glutathione reductase in maintaining human granulocyte function and sensitivity to exogenous H2O2","volume":"69","author":"Cohen","year":"1987","journal-title":"Blood"},{"key":"10.3168\/jdsc.2026-1068_bib7","doi-asserted-by":"crossref","first-page":"9807","DOI":"10.3168\/jds.2023-23549","article-title":"Plant polyphenol extract supplementation affects performance, welfare, and the Nrf2-oxidative stress response in adipose tissue of heat-stressed dairy cows","volume":"106","author":"Daddam","year":"2023","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib8","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: Role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.3168\/jdsc.2026-1068_bib9","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.3168\/jds.2015-9478","article-title":"The effect of grape seed and grape marc meal extract on milk performance and the expression of genes of endoplasmic reticulum stress and inflammation in the liver of dairy cows in early lactation","volume":"98","author":"Gessner","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jpn.12579","article-title":"Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals","volume":"101","author":"Gessner","year":"2017","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.3168\/jdsc.2026-1068_bib11","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.3390\/ani13182831","article-title":"Plant extracts to alleviating heat stress in dairy cows","volume":"13","author":"Guo","year":"2023","journal-title":"Animals (Basel)"},{"issue":"Suppl. 2","key":"10.3168\/jdsc.2026-1068_bib12","first-page":"10","article-title":"Dynamic responses of cattle to thermal heat loads","volume":"77","author":"Hahn","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jdsc.2026-1068_bib13","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1002\/jsfa.9584","article-title":"Chemical\u2013nutritional quality and oxidative stability of milk and dairy products obtained from Friesian cows fed with a dietary supplementation of dried grape pomace","volume":"99","author":"Ianni","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"10.3168\/jdsc.2026-1068_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/af\/vfy030","article-title":"Impact of climate change on animal health and welfare","volume":"9","author":"Lacetera","year":"2019","journal-title":"Anim. Front."},{"key":"10.3168\/jdsc.2026-1068_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.vetimm.2016.10.007","article-title":"In vitro assessment of the effects of temperature on phagocytosis, reactive oxygen species production and apoptosis in bovine polymorphonuclear cells","volume":"182","author":"Lecchi","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jdsc.2026-1068_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/af\/vfad052","article-title":"Physiological impact of amino acids during heat stress in ruminants","volume":"13","author":"Loor","year":"2023","journal-title":"Anim. Front."},{"key":"10.3168\/jdsc.2026-1068_bib17","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.3168\/jds.2020-18638","article-title":"Methyl donor supply to heat stress-challenged polymorphonuclear leukocytes from lactating Holstein cows enhances 1-carbon metabolism, immune response, and cytoprotective gene network abundance","volume":"103","author":"Lopreiato","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib18","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.3168\/jds.2024-25988","article-title":"Resveratrol supplementation improves productivity and health in heat-stressed lactating Holstein cows","volume":"108","author":"Nair","year":"2025","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.sbi.2005.10.005","article-title":"Glutathione transferases: New functions","volume":"15","author":"Oakley","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.3168\/jdsc.2026-1068_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fanim.2021.706636","article-title":"Critical temperature-humidity index thresholds for dry cows in a subtropical climate","volume":"2","author":"Ouellet","year":"2021","journal-title":"Front. Anim. Sci."},{"key":"10.3168\/jdsc.2026-1068_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/ars.2007.1528","article-title":"From selenium to selenoproteins: Synthesis, identity, and their role in human health","volume":"9","author":"Papp","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.3168\/jdsc.2026-1068_bib22","first-page":"213","article-title":"Assessment of inflammatory cytokine concentrations during diagnosis and after treatment of postpartum dairy cows with clinical and subclinical endometritis","volume":"28","author":"Peker","year":"2022","journal-title":"Large Anim. Rev."},{"key":"10.3168\/jdsc.2026-1068_bib23","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.3168\/jds.2017-12651","article-title":"Invited review: Effects of heat stress on dairy cattle welfare","volume":"100","author":"Polsky","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib24","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1002\/cam4.1411","article-title":"Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health","volume":"9","author":"Rather","year":"2020","journal-title":"Cancer Med."},{"key":"10.3168\/jdsc.2026-1068_bib25","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1016\/S0021-9258(19)78244-1","article-title":"Glutathione and the hexose monophosphate shunt in phagocytizing and hydrogen peroxide-treated rat leukocytes","volume":"244","author":"Reed","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.3168\/jdsc.2026-1068_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.vetimm.2006.09.009","article-title":"Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species","volume":"115","author":"Rinaldi","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jdsc.2026-1068_bib27","doi-asserted-by":"crossref","first-page":"1407S","DOI":"10.1093\/jn\/130.5.1407S","article-title":"Zinc-altered immune function and cytokine production","volume":"130","author":"Rink","year":"2000","journal-title":"J. Nutr."},{"key":"10.3168\/jdsc.2026-1068_bib28","doi-asserted-by":"crossref","first-page":"8609","DOI":"10.3168\/jds.2022-22256","article-title":"Feeding tannins to dairy cows in different seasons improves the oxidative status of blood plasma and the antioxidant capacity of cheese","volume":"105","author":"Santillo","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.3168\/jdsc.2026-1068_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.3168\/jdsc.2026-1068_bib30","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2527\/1997.7561659x","article-title":"Dietary vitamin E and selenium affect mastitis and milk quality","volume":"75","author":"Smith","year":"1997","journal-title":"J. Anim. Sci."},{"key":"10.3168\/jdsc.2026-1068_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2008.10.305","article-title":"Impact of oxidative stress on the health and immune function of dairy cattle","volume":"128","author":"Sordillo","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.3168\/jdsc.2026-1068_bib32","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.4049\/jimmunol.1102683","article-title":"Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps","volume":"188","author":"Yan","year":"2012","journal-title":"J. Immunol."},{"key":"10.3168\/jdsc.2026-1068_bib33","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.3168\/jds.2014-8811","article-title":"Prepartal dietary energy level affects peripartal bovine blood neutrophil metabolic, antioxidant, and inflammatory gene expression","volume":"98","author":"Zhou","year":"2015","journal-title":"J. Dairy Sci."}],"container-title":["JDS Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666910226001122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666910226001122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:45:35Z","timestamp":1788522335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666910226001122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2666910226001122"],"URL":"https:\/\/doi.org\/10.3168\/jdsc.2026-1068","relation":{},"ISSN":["2666-9102"],"issn-type":[{"value":"2666-9102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of rumen-protected standardized dry grape extract supplementation on antioxidant and immune-related gene expression in leukocytes of mid-lactating Fleckvieh cows exposed to natural heat stress","name":"articletitle","label":"Article Title"},{"value":"JDS Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3168\/jdsc.2026-1068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026","name":"copyright","label":"Copyright"}]}}