{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:06:09Z","timestamp":1787965569932,"version":"build-2784847793"},"reference-count":46,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,9]]},"abstract":"\nObject<\/jats:title>\nSurgery on the pituitary gland is increasingly being performed through an endoscopic approach. However, there is little published data on its safety and relative advantages over traditional microscope-based approaches. Published reports are limited by small sample size and nonrandomized study design. A meta-analysis allows for a description of the impact of endoscopic surgery on short-term outcomes.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe authors performed retrospective review of data from their institution as well as a systematic review of the literature. The pooled data were analyzed for descriptive statistics on short-term outcomes.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nNine studies (821 patients) met inclusion criteria. Overall, the pooled rate of gross tumor removal was 78% (95% CI 67\u201389%). Hormone resolution was achieved in 81% (95% CI 71\u201391%) of adrenocorticotropic hormone secreting tumors, 84% (95% CI 76\u201392%) of growth hormone secreting tumors, and 82% (95% CI 70\u201394%) of prolactin secreting tumors. The pooled complication rates were 2% (95% CI 0\u20134%) for CSF leak and 1% (95% CI 0\u20132%) for permanent diabetes insipidus. There were 2 deaths reported in the literature that were both related to vascular injury, giving an overall mortality rate of 0.24%.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe results of this meta-analysis support the safety and short-term efficacy of endoscopic pituitary surgery. Future studies with long-term follow-up are required to determine tumor control.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2007.12.17635","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T13:55:56Z","timestamp":1251813356000},"page":"545-554","source":"Crossref","is-referenced-by-count":254,"title":["Endoscopic pituitary surgery: a systematic review and meta-analysis"],"prefix":"10.3171","volume":"111","author":[{"given":"Abtin","family":"Tabaee","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Anand","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Barr\u00f3n","sequence":"additional","affiliation":[{"name":"Public Health, Division of Biostatistics and Epidemiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Hiltzik","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kacker","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Public Health, Division of Biostatistics and Epidemiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Neurosurgery, New York Presbyterian Hospital\u2013Weill Medical College of Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1110545","series-title":"J Clin Endocrinol Metab","first-page":"4709","article-title":"Transsphenoidal surgery for pituitary tumors in the United States, 1996\u20132000: mortality, morbidity, and the effects of hospital and surgeon volume","volume":"88","author":"Barker","year":"2003"},{"key":"b2-1110545","series-title":"Neurosurgery","first-page":"920","article-title":"Incidence and management of complications of transsphenoidal operation for pituitary adenomas","volume":"20","author":"Black","year":"1987"},{"key":"b3-1110545","series-title":"J Neurosurg","first-page":"293","article-title":"Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas","volume":"97","author":"Cappabianca","year":"2002"},{"key":"b4-1110545","series-title":"Neurosurgery","first-page":"933","article-title":"Endoscopic endonasal transsphenoidal surgery","volume":"55","author":"Cappabianca","year":"2004"},{"key":"b5-1110545","series-title":"Laryngoscope","first-page":"16","article-title":"Endoscopic surgery of the anterior skull base","volume":"115","author":"Casler","year":"2005"},{"key":"b6-1110545","series-title":"J Neurosurg","first-page":"204","article-title":"Surgical treatment of Cushing's disease","volume":"66","author":"Chandler","year":"1987"},{"key":"b7-1110545","series-title":"Horm Res","first-page":"222","article-title":"Surgical treatment of prolactinomas. 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