{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:21:46Z","timestamp":1794324106186,"version":"4.9.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,7]]},"abstract":"\n Object<\/jats:title>\n The authors analyzed cerebral perfusion and metabolism in patients with internal carotid artery stenosis before and after carotid artery stenting (CAS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Sixteen patients with internal carotid artery stenosis (> 70%) underwent PET scanning before CAS, 1\u20137 days after CAS, and 3\u20134 months after CAS to assess a variety of parameters related to cerebral perfusion and metabolism.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cerebral blood flow at rest (CBF\n rest<\/jats:sub>\n ) significantly increased in the immediate postoperative stage before returning to normal levels over the long term; this trend was also recognized on the contralateral side. In contrast, there was gradual improvement in the rate of CBF variation on acetazolamide administration (% CBF\n az<\/jats:sub>\n ). Cerebral perfusion pressure (CBF\/cerebral blood volume) increased rapidly during the acute stage and decreased in the long term, and the oxygen extraction fraction decreased slightly during the acute stage before normalizing over the long term. The cerebral metabolic rate of oxygen (CMRO\n 2<\/jats:sub>\n ) increased slightly after stenting over both the short and long term. The ratios of ipsilateral to contralateral values (asymmetry index) for CBF\n rest<\/jats:sub>\n , % CBF\n az<\/jats:sub>\n , cerebral blood volume, oxygen extraction fraction, and CMRO\n 2<\/jats:sub>\n tended to approach 1.0 over time.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Repeated PET scanning revealed improvements in CBF, perfusion pressure, and oxygen metabolism after CAS. In particular, the vascular reserve tended to improve gradually, while CBF, cerebral perfusion pressure, and CMRO\n 2<\/jats:sub>\n increased rapidly and peaked soon after CAS. These results suggest that a large discrepancy between rapidly increased CBF, perfusion pressure, and a small increase in vascular reserve in the acute stage after CAS could cause hyperperfusion syndrome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2008.09.17663","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T09:55:38Z","timestamp":1237542938000},"page":"28-36","source":"Crossref","is-referenced-by-count":35,"title":["Analysis of cerebral perfusion and metabolism assessed with positron emission tomography before and after carotid artery stenting"],"prefix":"10.3171","volume":"111","author":[{"given":"Shunji","family":"Matsubara","sequence":"first","affiliation":[{"name":"Departments of Strokology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junta","family":"Moroi","sequence":"additional","affiliation":[{"name":"Departments of Strokology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Departments of Strokology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Departments of Strokology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Nagata","sequence":"additional","affiliation":[{"name":"Departments of Strokology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Kanno","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels\u2013Akita, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Miura","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels\u2013Akita, Akita, 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