{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:56:15Z","timestamp":1790646975237,"version":"4.1.0"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The aim of the present study was to evaluate the time course for cerebral autoregulation (AR) recovery following severe traumatic brain injury (TBI)<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty-six patients (27 males and 9 females, mean \u00b1 SEM age 33 \u00b1 15.1 years) with severe TBI underwent serial dynamic AR studies with leg cuff deflation as a stimulus, until recovery of the AR responses was measured.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The AR was impaired (AR index &lt; 2.8) in 30 (83%) of 36 patients on Days 3\u20135 after injury, and in 19 individuals (53%) impairments were found on Days 9\u201311 after the injury. Nine (25%) of 36 patients exhibited a poor AR response (AR index &lt; 1) on postinjury Days 12\u201314, which eventually recovered on Days 15\u201323. Fifty-eight percent of the patients with a Glasgow Coma Scale score of 3\u20135, 50% of those with diffuse brain injury, 54% of those with elevated intracranial pressure, and 40% of those with poor outcome had no AR recovery in the first 11 days after injury.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Autoregulation recovery after severe TBI can be delayed, and failure to recover during the 2nd week after injury occurs mainly in patients with a lower Glasgow Coma Scale score, diffuse brain injury, elevated ICP, or unfavorable outcome. The finding suggests that perfusion pressure management should be considered in some of the patients for a period of at least 2 weeks.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.10.17686","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T14:03:55Z","timestamp":1240581835000},"page":"695-700","source":"Crossref","is-referenced-by-count":70,"title":["Time course for autoregulation recovery following severe traumatic brain injury"],"prefix":"10.3171","volume":"111","author":[{"given":"Gill E.","family":"Sviri","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Rambam Medical Center, The Technion, Israel Institution of Technology, Haifa, Israel; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Aaslid","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington and Swedish Neuroscience Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"Douville","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington and Swedish Neuroscience Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington and Swedish Neuroscience Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Newell","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Washington and Swedish Neuroscience Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1110695","series-title":"J Neurotrauma","first-page":"S7","article-title":"Congress of Neurological Surgeons; Joint Section on Neurotrauma and Critical Care, AANS\/CNS. 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Part 2: Autoregulation","volume":"71","author":"Muizelaar","year":"1989"},{"key":"b10-1110695","series-title":"Acta Neurochir (Wien)","first-page":"804","article-title":"Evaluation of hemodynamic responses in head injury patients with transcranial Doppler monitoring","volume":"139","author":"Newell","year":"1997"},{"key":"b11-1110695","series-title":"Br J Neurosurg","first-page":"471","article-title":"Association between dynamic cerebral autoregulation and mortality in severe head injury","volume":"18","author":"Panerai","year":"2004"},{"key":"b12-1110695","series-title":"Neurosurgery","first-page":"79","article-title":"Transcranial Doppler monitoring in head injury: relations between type of injury, flow velocities, vasoreactivity, and outcome","volume":"34","author":"Steiger","year":"1994"},{"key":"b13-1110695","series-title":"Lancet","first-page":"81","article-title":"Assessment of coma and impaired consciousness. A practical scale","volume":"13","author":"Teasdale","year":"1974"},{"key":"b14-1110695","series-title":"Stroke","first-page":"1014","article-title":"Comparison of static and dynamic cerebral autoregulation measurements","volume":"26","author":"Tiecks","year":"1995"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/4\/article-p695.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/4\/article-p695.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/4\/article-p695.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T09:28:01Z","timestamp":1679909281000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/4\/article-p695.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":14,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2008.10.17686","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}