{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:00:57Z","timestamp":1760983257276},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and early childhood that occurs mainly in soft tissue and the retroperitoneum. The pathological characteristics of a KHE are fascicles of spindleshaped endothelial cells and slitlike vascular channels with irregular tumor margins. In spite of benign features such as rare mitoses and a low MIB-1 labeling index, a KHE is categorized as an intermediate malignancy because of local invasiveness into adjacent lymph nodes or organs. Resection is the treatment of choice for this type of tumor and adjuvant medical therapy is prepared for the tumor remnants and the associated Kasabach-Merritt syndrome. In this paper the authors report a case of a KHE without Kasabach-Merritt syndrome arising from the right tentorium cerebelli in a 13-month-old male child. The biological behavior of the tumor, including its pathological traits and clinical course, was malignant in nature. This case may be not only the first intracranial extraaxial KHE, but also the first truly malignant variant. Kaposiform hemangioendothelioma should be considered in the differential diagnosis of intracranial and extraaxial tumors.<\/jats:p>","DOI":"10.3171\/2008.11.peds08171","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T12:26:24Z","timestamp":1253622384000},"page":"147-150","source":"Crossref","is-referenced-by-count":14,"title":["Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant"],"prefix":"10.3171","volume":"3","author":[{"given":"Won-Sang","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0030147","series-title":"Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3109\/08880019809014013","article-title":"Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature","volume":"15","author":"Blei","year":"1998"},{"key":"b2-0030147","series-title":"AJNR Am J Neuroradiol","first-page":"931","article-title":"Kaposiform hemangioendothelioma arising from the internal auditory canal","volume":"27","author":"Chang","year":"2006"},{"key":"b3-0030147","series-title":"Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S0194-5998(03)00716-2","article-title":"Successful nonoperative therapy for Kaposiform hemangioendothelioma involving the neck: report of 1 case","volume":"129","author":"Chung","year":"2003"},{"key":"b4-0030147","series-title":"Laryngoscope","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1097\/01.mlg.0000176539.94515.75","article-title":"Kaposiform hemangioendothelioma: case report and literature review","volume":"115","author":"Defatta","year":"2005"},{"key":"b5-0030147","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0022-3476(97)70249-X","article-title":"Infants with Kasabach-Merritt syndrome do not have \u201ctrue\u201d hemangiomas","volume":"130","author":"Enjolras","year":"1997"},{"key":"b6-0030147","series-title":"J Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/00043426-200208000-00010","article-title":"Kasabach-Merritt phenomenon: a retrospective study of treatment with vincristine","volume":"24","author":"Haisley-Royster","year":"2002"},{"key":"b7-0030147","series-title":"Head Neck","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/hed.10074","article-title":"Kaposiform hemangioendothelioma of the external auditory canal in an adult","volume":"24","author":"Hardisson","year":"2002"},{"key":"b8-0030147","series-title":"Pediatr Blood Cancer","first-page":"852","article-title":"Effective treatment of Kaposiform hemangioendotheliomas associated with Kasabach-Merritt phenomenon using four drug regimen","volume":"49","author":"Hauer","year":"2006"},{"key":"b9-0030147","series-title":"An Pediatr (Barc)","first-page":"72","article-title":"Thoracic kaposiform hemangioendothelioma: four consecutive cases with distinct outcome","volume":"63","author":"L\u00f3pez Guti\u00e9rrez","year":"2005"},{"key":"b10-0030147","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00000478-200405000-00001","article-title":"Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma","volume":"28","author":"Lyons","year":"2004"},{"key":"b11-0030147","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1097\/00006534-199711000-00001","article-title":"Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with Kaposiform hemangioendothelioma and not with common infantile hemangioma","volume":"100","author":"Sarkar","year":"1997"},{"key":"b12-0030147","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1097\/00000478-198608000-00001","article-title":"Spindle cell hemangioendothelioma: a low-grade angiosarcoma resembling a cavernous hemangioma and Kaposi's sarcoma","volume":"10","author":"Weiss","year":"1986"},{"key":"b13-0030147","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/00000478-199304000-00001","article-title":"Kaposiform hemangioendothelioma of infancy and childhood: an aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis","volume":"17","author":"Zukerberg","year":"1993"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/3\/2\/article-p147.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/3\/2\/article-p147.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/3\/2\/article-p147.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:44:41Z","timestamp":1681559081000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/3\/2\/article-p147.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":13,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2008.11.peds08171","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}