{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:06:29Z","timestamp":1770714389830,"version":"3.49.0"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,1]]},"abstract":"\nObject<\/jats:title>\nThe extracellular Mg++<\/jats:sup> has a vasodilatory effect on the cerebral artery. The present study investigated the effect of intracisternal injection of MgSO4<\/jats:sub> solution on cerebral vasospasm in a canine model of subarachnoid hemorrhage (SAH).<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nSubarachnoid hemorrhage was induced in 10 beagles using the two-hemorrhage model. Angiography of the vertebrobasilar artery was performed on Day 1 (baseline values before SAH) and on Day 7 (during cerebral vasospasm after induced SAH) before and after intracisternal injection of 0.5 ml\/kg of 15 mmol\/L MgSO4<\/jats:sub> solution into the cerebellomedullary cistern.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThe cerebrospinal fluid Mg++<\/jats:sup> concentration was significantly increased to 3.15 \u00b1 1.14 mEq\/L after intracisternal injection from the preinjection value (1.45 \u00b1 0.09 mEq\/L; p < 0.01). The diameters of the basilar artery, vertebral artery, and superior cerebellar artery on Day 7 were significantly decreased to 58.0 \u00b1 10.9%, 71.0 \u00b1 10.1%, and 60.9 \u00b1 13.8%, respectively, of their baseline diameters on Day 1 (p < 0.01). After intracisternal injection of MgSO4<\/jats:sub>, these diameters significantly increased to 73.8 \u00b1 14.3%, 83.0 \u00b1 14.8%, and 74.1 \u00b1 13.5%, respectively (p < 0.01).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nIntracisternal injection of MgSO4<\/jats:sub> solution causes significant dilation of spastic cerebral arteries in the canine two-hemorrhage model of SAH.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.4.17494","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T14:08:53Z","timestamp":1223042933000},"page":"73-78","source":"Crossref","is-referenced-by-count":21,"title":["Novel vasodilatory effect of intracisternal injection of magnesium sulfate solution on spastic cerebral arteries in the canine two-hemorrhage model of subarachnoid hemorrhage"],"prefix":"10.3171","volume":"110","author":[{"given":"Kentaro","family":"Mori","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery 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