{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:02:49Z","timestamp":1783774969663,"version":"3.55.0"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Pituitary stalk hemangioblastomas are rare, and information on them is limited to a small number of case reports. To gain insight into the incidence, clinical effects, and management of pituitary stalk hemangioblastomas, the authors analyzed a series of patients with von Hippel\u2013Lindau (VHL) disease.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with VHL disease who were enrolled in a prospective National Institutes of Health natural history study were included. Clinical, imaging, and laboratory findings were analyzed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Two hundred fifty patients were included in the study (120 male and 130 female patients). In 8 patients (3%), 8 pituitary stalk hemangioblastomas were identified on MR imaging. This anatomical location was the most common supratentorial site for these lesions; 29% of all supratentorial hemangioblastomas were found there. The mean (\u00b1 standard deviation) pituitary stalk hemangioblastoma volume was 0.5 \u00b1 0.9 cm<jats:sup>3<\/jats:sup> (range 0.08\u20132.8 cm<jats:sup>3<\/jats:sup>). Results of endocrine laboratory profiles were normal in all patients. All patients remained asymptomatic and none required treatment during the follow-up period (mean duration 41.4 \u00b1 14.4 months).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The pituitary stalk is the most common site for the development of supratentorial hemangioblastomas in patients with VHL disease. Pituitary stalk hemangioblastomas often remain asymptomatic and do not require treatment. These findings indicate that pituitary stalk hemangioblastomas in patients with VHL disease may be managed with observation and that surgery for them can be reserved until associated signs or symptoms occur.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.4.17532","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T14:08:53Z","timestamp":1223042933000},"page":"350-353","source":"Crossref","is-referenced-by-count":49,"title":["Pituitary stalk hemangioblastomas in von Hippel\u2013Lindau disease"],"prefix":"10.3171","volume":"110","author":[{"given":"Russell R.","family":"Lonser","sequence":"first","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Butman","sequence":"additional","affiliation":[{"name":"Section of Neuroradiology, Diagnostic Radiology Department, The Clinical Center of the National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwan","family":"Kiringoda","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Song","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Oldfield","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1100350","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1001\/archneur.1976.00500060041009","article-title":"Hemangioblastoma of the spinal cord: review and report of five cases","volume":"33","author":"Browne","year":"1976"},{"key":"b2-1100350","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/jama.298.1.41","article-title":"Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease","volume":"298","author":"Butman","year":"2007"},{"key":"b3-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3171\/jns.1975.42.2.0232","article-title":"Pituitary hemangioblastoma in a patient with von Hippel-Lindau disease. Case report","volume":"42","author":"Dan","year":"1975"},{"key":"b4-1100350","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.clineuro.2006.11.007","article-title":"Pituitary stalk hemangioblastoma: the fourth case report and review of the literature","volume":"109","author":"Fomekong","year":"2007"},{"key":"b5-1100350","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S0090-3019(01)00482-7","article-title":"Suprasellar hemangioblastoma in a patient with von Hippel-Lindau disease confirmed by germline mutation study: case report and review of the literature","volume":"56","author":"Goto","year":"2001"},{"key":"b6-1100350","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0090-3019(84)90010-7","article-title":"Suprasellar hemangioblastoma","volume":"22","author":"Grisoli","year":"1984"},{"key":"b7-1100350","series-title":"No Shinkei Geka","first-page":"679","article-title":"[A case of suprasellar hemangioblastoma with thoracic meningioma.]","volume":"29","author":"Ikeda","year":"2001"},{"key":"b8-1100350","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0090-3019(97)00197-3","article-title":"Sellar-sphenoid sinus hemangioblastoma: case report","volume":"50","author":"Kachhara","year":"1998"},{"key":"b9-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3171\/jns.2000.92.6.1028","article-title":"Resection of suprasellar tumors by using a modified transsphenoidal approach. Report of four cases","volume":"92","author":"Kouri","year":"2000"},{"key":"b10-1100350","series-title":"Science","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993"},{"key":"b11-1100350","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"Lonser","year":"2003"},{"key":"b12-1100350","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1056\/NEJMoa040666","article-title":"Tumors of the endolymphatic sac in von Hippel-Lindau disease","volume":"350","author":"Lonser","year":"2004"},{"key":"b13-1100350","series-title":"Q J Med","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/qjmed\/77.2.1151","article-title":"Clinical features and natural history of von Hippel-Lindau disease","volume":"77","author":"Maher","year":"1990"},{"key":"b14-1100350","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1001\/jama.1997.03540420057030","article-title":"Endolymphatic sac tumors. A source of morbid hearing loss in von Hippel-Lindau disease","volume":"277","author":"Manski","year":"1997"},{"key":"b15-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3171\/jns.1963.20.3.0254","article-title":"Cerebral hemangioblastomas: review of literature and report of two personal cases","volume":"20","author":"Morello","year":"1963"},{"key":"b16-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3171\/jns.1989.70.1.0024","article-title":"Hemangioblastomas of the central nervous system. A 10-year study with special reference to von Hippel-Lindau syndrome","volume":"70","author":"Neumann","year":"1989"},{"key":"b17-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3171\/jns.1996.85.4.0591","article-title":"Gamma knife radiosurgery in 11 hemangioblastomas","volume":"85","author":"Niemela","year":"1996"},{"key":"b18-1100350","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jocn.2004.02.025","article-title":"Suprasellar haemangioblastoma. Report of two cases and review of the literature","volume":"12","author":"Peker","year":"2005"},{"key":"b19-1100350","series-title":"Can Med Assoc J","first-page":"135","article-title":"Von Hippel-Lindau's disease: a report of five cases","volume":"101","author":"Rho","year":"1969"},{"key":"b20-1100350","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.2214\/ajr.180.5.1801480","article-title":"Intrasellar hemangioblastoma: characteristic prominent vessels on MR imaging","volume":"180","author":"Rumboldt","year":"2003"},{"key":"b21-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3171\/jns.1996.84.6.1046","article-title":"Symptomatic intrasellar hemangioblastoma in a child treated with subtotal resection and adjuvant radiosurgery. Case report","volume":"84","author":"Sawin","year":"1996"},{"key":"b22-1100350","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/S0046-8177(97)90075-7","article-title":"von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease","volume":"28","author":"Vortmeyer","year":"1997"},{"key":"b23-1100350","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ana.10807","article-title":"Somatic mutations in VHL germline deletion kindred correlate with mild phenotype","volume":"55","author":"Wait","year":"2004"},{"key":"b24-1100350","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3171\/jns.2003.98.1.0082","article-title":"The natural history of central nervous system hemangioblastomas in patients with von Hippel-Lindau disease","volume":"98","author":"Wanebo","year":"2003"},{"key":"b25-1100350","series-title":"Clin Imaging","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0899-7071(02)00537-5","article-title":"Suprasellar hemangioblastoma in Von Hippel-Lindau disease: a case report","volume":"27","author":"Wasenko","year":"2003"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/110\/2\/article-p350.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/110\/2\/article-p350.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/110\/2\/article-p350.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T04:57:50Z","timestamp":1664168270000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/110\/2\/article-p350.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":25,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2008.4.17532","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}