{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:18:47Z","timestamp":1773433127392,"version":"3.50.1"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,2]]},"abstract":"\n Object<\/jats:title>\n The authors prospectively studied the occurrence of clinical and nonclinical electroencephalographically verified seizures during treatment with an intracranial pressure (ICP)\u2013targeted protocol in patients with traumatic brain injury (TBI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All patients treated for TBI at the Department of Neurosurgery, University Hospital Ume\u00e5, Sweden, were eligible for the study. The inclusion was consecutive and based on the availability of the electroencephalographic (EEG) monitoring equipment. Patients were included irrespective of pupil size, pupil reaction, or level of consciousness as long as their first measured cerebral perfusion pressure was > 10 mm Hg. The patients were treated in a protocol-guided manner with an ICP-targeted treatment based on the Lund concept. The patients were continuously sedated with midazolam, fentanyl, propofol, or thiopental, or combinations thereof. Five-lead continuous EEG monitoring was performed with the electrodes at F3, F4, P3, P4, and a midline reference. Sensitivity was set at 100 \u03bcV per cm and filter settings 0.5\u201370 Hz. Amplitude-integrated EEG recording and relative band power trends were displayed. The trends were analyzed offline by trained clinical neurophysiologists.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Forty-seven patients (mean age 40 years) were studied. Their median Glasgow Coma Scale score at the time of sedation and intubation was 6 (range 3\u201315). In 8.5% of the patients clinical seizures were observed before sedation and intubation. Continuous EEG monitoring was performed for a total of 7334 hours. During this time neither EEG nor clinical seizures were observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our protocol-guided ICP targeted treatment seems to protect patients with severe TBI from clinical and subclinical seizures and thus reduces the risk of secondary brain injury.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2008.4.17538","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T15:14:46Z","timestamp":1220022886000},"page":"300-305","source":"Crossref","is-referenced-by-count":30,"title":["Absence of electroencephalographic seizure activity in patients treated for head injury with an intracranial pressure\u2013targeted therapy"],"prefix":"10.3171","volume":"110","author":[{"given":"Magnus","family":"Olivecrona","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zetterlund","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Rodling-Wahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Anaesthesiology, University Hospital, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Naredi","sequence":"additional","affiliation":[{"name":"Anaesthesiology, University Hospital, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Owe D.","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1100300","series-title":"Intensive Care Med","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/BF01708961","article-title":"A new therapy of post-trauma brain oedema based on haemodynamic principles for brain volume regulation","volume":"20","author":"Asgeirsson","year":"1994"},{"issue":"1 Suppl","key":"b2-1100300","series-title":"J Neurotrauma","first-page":"S83","article-title":"Guidelines for the management of severe traumatic brain injury. 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